| Alzheimer’s disease risk genes and mechanisms of disease pathogenesis CM Karch, AM Goate Biological psychiatry 77 (1), 43-51, 2015 | 1722 | 2015 |
| Tau kinetics in neurons and the human central nervous system C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ... Neuron 97 (6), 1284-1298. e7, 2018 | 681 | 2018 |
| A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ... Nature medicine 26 (3), 398-407, 2020 | 668 | 2020 |
| Alzheimer’s disease genetics: from the bench to the clinic CM Karch, C Cruchaga, AM Goate Neuron 83 (1), 11-26, 2014 | 593 | 2014 |
| Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ... Nature 505 (7484), 550-554, 2014 | 576 | 2014 |
| An efficient platform for astrocyte differentiation from human induced pluripotent stem cells TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ... Stem cell reports 9 (2), 600-614, 2017 | 496 | 2017 |
| Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ... PLoS medicine 14 (3), e1002258, 2017 | 461 | 2017 |
| GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ... Neuron 78 (2), 256-268, 2013 | 451 | 2013 |
| Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ... Stem cell reports 9 (4), 1221-1233, 2017 | 432 | 2017 |
| Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate PloS one 7 (11), e50976, 2012 | 422 | 2012 |
| Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy S Da Mesquita, Z Papadopoulos, T Dykstra, L Brase, FG Farias, M Wall, ... Nature 593 (7858), 255-260, 2021 | 380 | 2021 |
| Coding variants in TREM2 increase risk for Alzheimer's disease SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ... Human molecular genetics 23 (21), 5838-5846, 2014 | 374 | 2014 |
| An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ... Nature neuroscience 22 (11), 1903-1912, 2019 | 349 | 2019 |
| Cholesterol and matrisome pathways dysregulated in astrocytes and microglia TCW Julia, L Qian, NH Pipalia, MJ Chao, SA Liang, Y Shi, BR Jain, ... Cell 185 (13), 2213-2233. e25, 2022 | 343 | 2022 |
| The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ... Science translational medicine 11 (505), eaau2291, 2019 | 308 | 2019 |
| Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology M Suárez-Calvet, E Morenas-Rodríguez, G Kleinberger, K Schlepckow, ... Molecular neurodegeneration 14 (1), 1, 2019 | 287 | 2019 |
| Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid A Drieu, S Du, SE Storck, J Rustenhoven, Z Papadopoulos, T Dykstra, ... Nature 611 (7936), 585-593, 2022 | 265 | 2022 |
| Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ... elife 5, e20391, 2016 | 257 | 2016 |
| Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009 | 244 | 2009 |
| Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice B Caballero, M Bourdenx, E Luengo, A Diaz, PD Sohn, XU Chen, C Wang, ... Nature communications 12 (1), 2238, 2021 | 238 | 2021 |
Alison GoateProfessor of Genetics & Genomic Sciences, Icahn School of Medicine at Mount SinaiVerified email at mssm.edu
