| The nuclear receptor superfamily: A structural perspective ER Weikum, X Liu, EA Ortlund Protein Science 27 (11), 1876-1892, 2018 | 652 | 2018 |
| Rapid generation of neutralizing antibody responses in COVID-19 patients MS Suthar, MG Zimmerman, RC Kauffman, G Mantus, SL Linderman, ... Cell Reports Medicine 1 (3), 2020 | 618 | 2020 |
| Glucocorticoid receptor control of transcription: precision and plasticity via allostery ER Weikum, MT Knuesel, EA Ortlund, KR Yamamoto Nature reviews Molecular cell biology 18 (3), 159-174, 2017 | 587 | 2017 |
| Crystal structure of an ancient protein: evolution by conformational epistasis EA Ortlund, JT Bridgham, MR Redinbo, JW Thornton Science 317 (5844), 1544-1548, 2007 | 535 | 2007 |
| An epistatic ratchet constrains the direction of glucocorticoid receptor evolution JT Bridgham, EA Ortlund, JW Thornton Nature 461 (7263), 515-519, 2009 | 484 | 2009 |
| APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes JW Blanchard, LA Akay, J Davila-Velderrain, D von Maydell, H Mathys, ... Nature 611 (7937), 769-779, 2022 | 458 | 2022 |
| The structure, function and evolution of proteins that bind DNA and RNA WH Hudson, EA Ortlund Nature reviews Molecular cell biology 15 (11), 749-760, 2014 | 458 | 2014 |
| Evolutionary history and metabolic insights of ancient mammalian uricases JT Kratzer, MA Lanaspa, MN Murphy, C Cicerchi, CL Graves, PA Tipton, ... Proceedings of the National Academy of Sciences 111 (10), 3763-3768, 2014 | 439 | 2014 |
| Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans A Folick, HD Oakley, Y Yu, EH Armstrong, M Kumari, L Sanor, DD Moore, ... Science 347 (6217), 83-86, 2015 | 302 | 2015 |
| A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects JM Lee, YK Lee, JL Mamrosh, SA Busby, PR Griffin, MC Pathak, ... Nature 474 (7352), 506-510, 2011 | 302 | 2011 |
| Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily G Schaaf, EA Ortlund, KR Tyeryar, CJ Mousley, KE Ile, TA Garrett, J Ren, ... Molecular cell 29 (2), 191-206, 2008 | 288 | 2008 |
| Molecular transducers of physical activity consortium (MoTrPAC): mapping the dynamic responses to exercise JA Sanford, CD Nogiec, ME Lindholm, JN Adkins, D Amar, S Dasari, ... Cell 181 (7), 1464-1474, 2020 | 278 | 2020 |
| Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor JT Bridgham, GN Eick, C Larroux, K Deshpande, MJ Harms, ... PLoS biology 8 (10), e1000497, 2010 | 278 | 2010 |
| The structural basis of direct glucocorticoid-mediated transrepression WH Hudson, C Youn, EA Ortlund Nature structural & molecular biology 20 (1), 53-58, 2013 | 254 | 2013 |
| Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP EA Ortlund, Y Lee, IH Solomon, JM Hager, R Safi, Y Choi, Z Guan, ... Nature structural & molecular biology 12 (4), 357-363, 2005 | 240 | 2005 |
| Identification of a lipid scrambling domain in ANO6/TMEM16F K Yu, JM Whitlock, K Lee, EA Ortlund, Y Yuan Cui, HC Hartzell elife 4, e06901, 2015 | 213 | 2015 |
| Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway EH Armstrong, D Goswami, PR Griffin, N Noy, EA Ortlund Journal of Biological Chemistry 289 (21), 14941-14954, 2014 | 169 | 2014 |
| Hydrophobic environment is a key factor for the stability of thermophilic proteins MM Gromiha, MC Pathak, K Saraboji, EA Ortlund, EA Gaucher Proteins: Structure, Function, and Bioinformatics 81 (4), 715-721, 2013 | 161 | 2013 |
| Evolution of minimal specificity and promiscuity in steroid hormone receptors GN Eick, JK Colucci, MJ Harms, EA Ortlund, JW Thornton PLoS genetics 8 (11), e1003072, 2012 | 152 | 2012 |
| Interleukin-13 drives metabolic conditioning of muscle to endurance exercise NH Knudsen, KJ Stanya, AL Hyde, MM Chalom, RK Alexander, YH Liou, ... Science 368 (6490), eaat3987, 2020 | 145 | 2020 |
Xu LiuEmory UniversityVerified email at emory.edu
