| AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset D Goertsen, NC Flytzanis, N Goeden, MR Chuapoco, A Cummins, Y Chen, ... Nature neuroscience 25 (1), 106-115, 2022 | 418 | 2022 |
| Adeno-associated virus toolkit to target diverse brain cells RC Challis, S Ravindra Kumar, X Chen, D Goertsen, GM Coughlin, ... Annual review of neuroscience 45 (1), 447-469, 2022 | 144 | 2022 |
| Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates X Chen, DA Wolfe, DS Bindu, M Zhang, N Taskin, D Goertsen, TF Shay, ... Nature communications 14 (1), 3345, 2023 | 83 | 2023 |
| Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral vectors TF Shay, EE Sullivan, X Ding, X Chen, S Ravindra Kumar, D Goertsen, ... Science advances 9 (16), eadg6618, 2023 | 49 | 2023 |
| Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the AAV capsid D Goertsen, N Goeden, NC Flytzanis, V Gradinaru Molecular Therapy Methods & Clinical Development 26, 331-342, 2022 | 29 | 2022 |
| Broad gene expression throughout the mouse and marmoset brain after intravenous delivery of engineered AAV capsids NC Flytzanis, N Goeden, D Goertsen, A Cummins, J Pickel, V Gradinaru BioRxiv, 2020.06. 16.152975, 2020 | 23 | 2020 |
| Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates. Nat. Commun. 14, 3345 X Chen, DA Wolfe, DS Bindu, M Zhang, N Taskin, D Goertsen, TF Shay, ... | 7 | 2023 |
| AAV capsid variants with brain-wide transgene expression and 615 decreased liver targeting after intravenous delivery in mouse and marmoset D Goertsen Nat 606, 106-115, 2022 | 6 | 2022 |
| CAP-002: Systemic AAV gene therapy with next generation capsids for treatment of STXBP1 encephalopathy A Knoll, AJ Lopez, T Sandberg, B Wheeler, K Whitley, L Grigoryeva, ... Mol. Ther. 32, 268, 2024 | 4 | 2024 |
| Primate-conserved Carbonic Anhydrase IV and murine-restricted Ly6c1 are new targets for crossing the blood-brain barrier TF Shay, EE Sullivan, X Ding, X Chen, SR Kumar, D Goertsen, D Brown, ... bioRxiv, 2023.01. 12.523632, 2023 | 3 | 2023 |
| Systemic Gene Therapy CAP-002 Demonstrates Potential for Disease-Modifying Treatment of Seizures and Motor and Cognitive Deficits of STXBP1-DEE Using an Engineered, CNS … A Knoll, A Lopez, B Wheeler, K Whitley, L Grigoryeva, D Goertsen, ... MOLECULAR THERAPY 33 (4), 2025 | | 2025 |
| Identification of Multiple Novel Blood-Brain-Barrier Receptors for CNS Gene Therapy and Other Drug Modalities via an Integrated AAV Capsid Engineering Platform X Shi, S Gross, E Springfield, K Lam, M Ling, D Goertsen, E Walsh, ... MOLECULAR THERAPY 33 (4), 2025 | | 2025 |
| Parallel Engineering and Recombination of Adeno-Associated Virus Variable Regions Enables Multisite Library Production D Goertsen, V Gradinaru MOLECULAR THERAPY 31 (4), 21-21, 2023 | | 2023 |
| Expanding adeno-associated viral capsid engineering to multiple variable regions for diversified tropism DG Goertsen California Institute of Technology, 2023 | | 2023 |
| Transduction Profiles of Engineered Adeno-Associated Viral Capsids in Mouse and Marmoset D Goertsen, NC Flytzanis, N Goeden, A Cummins, J Pickel, V Gradinaru MOLECULAR THERAPY 28 (4), 269-270, 2020 | | 2020 |
