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Melanie A Higgins
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A heme-dependent enzyme forms the nitrogen–nitrogen bond in piperazate
YL Du, HY He, MA Higgins, KS Ryan
Nature Chemical Biology 13 (8), 836-838, 2017
1542017
The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity
LK Shewell, RM Harvey, MA Higgins, CJ Day, LE Hartley-Tassell, ...
Proceedings of the National Academy of Sciences 111 (49), E5312-E5320, 2014
1532014
Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors
AL Van Bueren, M Higgins, D Wang, RD Burke, AB Boraston
Nature structural & molecular biology 14 (1), 76-84, 2007
1052007
The molecular basis of glycogen breakdown and transport in Streptococcus pneumoniae
DW Abbott, MA Higgins, S Hyrnuik, B Pluvinage, A Lammerts van Bueren, ...
Molecular microbiology 77 (1), 183-199, 2010
982010
Unravelling the Multiple Functions of the Architecturally Intricate Streptococcus pneumoniae β-galactosidase, BgaA
AK Singh, B Pluvinage, MA Higgins, AB Dalia, SA Woodiga, M Flynn, ...
PLoS pathogens 10 (9), e1004364, 2014
882014
Toward efficient enzymes for the generation of universal blood through structure-guided directed evolution
DH Kwan, I Constantinescu, R Chapanian, MA Higgins, MP Kötzler, ...
Journal of the American Chemical Society 137 (17), 5695-5705, 2015
772015
The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor
AL van Bueren, E Ficko-Blean, B Pluvinage, JH Hehemann, MA Higgins, ...
Structure 19 (5), 640-651, 2011
632011
Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis
B Pluvinage, MA Higgins, DW Abbott, C Robb, AB Dalia, L Deng, ...
Structure 19 (11), 1603-1614, 2011
562011
Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases
MA Higgins, GE Whitworth, N El Warry, M Randriantsoa, E Samain, ...
Journal of Biological Chemistry 284 (38), 26161-26173, 2009
542009
Blood group antigen recognition by a solute-binding protein from a serotype 3 strain of Streptococcus pneumoniae
MA Higgins, DW Abbott, MJ Boulanger, AB Boraston
Journal of molecular biology 388 (2), 299-309, 2009
332009
Structural and functional analysis of fucose-processing enzymes from Streptococcus pneumoniae
MA Higgins, MD Suits, C Marsters, AB Boraston
Journal of molecular biology 426 (7), 1469-1482, 2014
302014
A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival
J Batra, CM Nagle, T O'Mara, M Higgins, Y Dong, OL Tan, F Lose, ...
BMC cancer 11 (1), 119, 2011
302011
The overall architecture and receptor binding of pneumococcal carbohydrate-antigen-hydrolyzing enzymes
MA Higgins, E Ficko-Blean, PJ Meloncelli, TL Lowary, AB Boraston
Journal of Molecular Biology 411 (5), 1017-1036, 2011
292011
A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans
M Robb, CS Robb, MA Higgins, JK Hobbs, JC Paton, AB Boraston
Journal of Biological Chemistry 290 (52), 30888-30900, 2015
272015
Structure aided design of a Neu5Gc specific lectin
CJ Day, AW Paton, MA Higgins, LK Shewell, FEC Jen, BL Schulz, ...
Scientific reports 7 (1), 1495, 2017
222017
Comparative Genomics Identified a Genetic Locus in Plant-Associated Pseudomonas spp. That Is Necessary for Induced Systemic Susceptibility
P Beskrovnaya, RA Melnyk, Z Liu, Y Liu, MA Higgins, Y Song, KS Ryan, ...
MBio 11 (3), 10.1128/mbio. 00575-20, 2020
202020
Production of a D-glycero-D-manno-heptosyltransferase mutant of Mannheimia haemolytica displaying a veterinary pathogen specific conserved LPS structure; development and …
SM Logan, W Chen, A Aubry, MAJ Gidney, S Lacelle, FS Michael, ...
Veterinary microbiology 116 (1-3), 175-186, 2006
202006
Convergent biosynthetic transformations to a bacterial specialized metabolite
YL Du, MA Higgins, G Zhao, KS Ryan
Nature Chemical Biology 15 (11), 1043-1048, 2019
132019
Structure and mechanism of haem-dependent nitrogen–nitrogen bond formation in piperazate synthase
MA Higgins, X Shi, J Soler, JB Harland, T Parkkila, N Lehnert, ...
Nature Catalysis 8 (3), 207-217, 2025
122025
Generating a fucose permease deletion mutant in Bifidobacterium longum subspecies infantis ATCC 15697
MA Higgins, KS Ryan
Anaerobe 68, 102320, 2021
112021
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Articles 1–20