| Challenges and opportunities in cancer drug resistance RA Ward, S Fawell, N Floc’h, V Flemington, D McKerrecher, PD Smith Chemical reviews 121 (6), 3297-3351, 2020 | 446 | 2020 |
| Antitumor activity of osimertinib, an irreversible mutant-selective EGFR tyrosine kinase inhibitor, in NSCLC harboring EGFR exon 20 insertions N Floc'h, MJ Martin, JW Riess, JP Orme, AD Staniszewska, L Menard, ... Molecular cancer therapeutics 17 (5), 885-896, 2018 | 122 | 2018 |
| Unexpected reactivity of two-coordinate palladium–carbene complexes; synthetic and catalytic implicationsElectronic supplementary information (ESI) available: details of … LR Titcomb, S Caddick, FGN Cloke, DJ Wilson, D McKerrecher Chemical Communications, 1388-1389, 2001 | 119 | 2001 |
| An improved synthesis of bis (1, 3-di-N-tert-butylimidazol-2-ylidene) palladium (0) and its use in C–C and C–N coupling reactions S Caddick, FGN Cloke, GKB Clentsmith, PB Hitchcock, D McKerrecher, ... Journal of Organometallic Chemistry 617, 635-639, 2001 | 116 | 2001 |
| Design of a potent, soluble glucokinase activator with excellent in vivo efficacy D McKerrecher, JV Allen, PWR Caulkett, CS Donald, ML Fenwick, ... Bioorganic & medicinal chemistry letters 16 (10), 2705-2709, 2006 | 106 | 2006 |
| Predictive blood glucose lowering efficacy by glucokinase activators in high fat fed female Zucker rats GJ Coope, AM Atkinson, C Allott, D McKerrecher, C Johnstone, KG Pike, ... British journal of pharmacology 149 (3), 328-335, 2006 | 98 | 2006 |
| Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation JS Scott, AM Birch, KJ Brocklehurst, A Broo, HS Brown, RJ Butlin, ... Journal of Medicinal Chemistry 55 (11), 5361-5379, 2012 | 85 | 2012 |
| Quinazoline derivatives as angiogenesis inhibitors E Stokes, D McKerrecher, L Hennequin, P Ple US Patent App. 11/169,122, 2006 | 79 | 2006 |
| Discovery, synthesis and biological evaluation of novel glucokinase activators D McKerrecher, JV Allen, SS Bowker, S Boyd, PWR Caulkett, GS Currie, ... Bioorganic & medicinal chemistry letters 15 (8), 2103-2106, 2005 | 70 | 2005 |
| Dissociated non-steroidal glucocorticoid receptor modulators: an update on new compounds H Schäcke, M Berger, TG Hansson, D McKerrecher, H Rehwinkel Expert Opinion on Therapeutic Patents 18 (3), 339-352, 2008 | 48 | 2008 |
| Compounds effecting glucokinase S Boyd, PWR Caulkett, RB Hargreaves, SS Bowker, R James, ... US Patent 7,390,908, 2008 | 45 | 2008 |
| Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life KG Pike, JV Allen, PWR Caulkett, DS Clarke, CS Donald, ML Fenwick, ... Bioorganic & medicinal chemistry letters 21 (11), 3467-3470, 2011 | 40 | 2011 |
| Property based optimisation of glucokinase activators–discovery of the phase IIb clinical candidate AZD1656 MJ Waring, DS Clarke, MD Fenwick, L Godfrey, SD Groombridge, ... MedChemComm 3 (9), 1077-1081, 2012 | 39 | 2012 |
| Matrix-based multiparameter optimisation of glucokinase activators: the discovery of AZD1092 MJ Waring, C Johnstone, D McKerrecher, KG Pike, G Robb MedChemComm 2 (8), 775-779, 2011 | 33 | 2011 |
| Potent and selective inhibitors of the epidermal growth factor receptor to overcome C797S-mediated resistance MRV Finlay, P Barton, S Bickerton, M Bista, N Colclough, DAE Cross, ... Journal of medicinal chemistry 64 (18), 13704-13718, 2021 | 30 | 2021 |
| Quinazoline derivatives as angiogenesis inhibitors ESE Stokes, D McKerrecher, LFA Hennequin, P Ple US Patent 8,492,560, 2013 | 29 | 2013 |
| Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists JS Scott, SS Bowker, KJ Brocklehurst, HS Brown, DS Clarke, A Easter, ... Journal of Medicinal Chemistry 57 (21), 8984-8998, 2014 | 26 | 2014 |
| Quinazoline derivatives as angiogenesis inhibitors ESE Stokes, D McKerrecher, LFA Hennequin, P Ple US Patent 7,074,800, 2006 | 24 | 2006 |
| Amino nicotinate derivatives as glucokinase (GLK) modulators B Hayter, G Currie, R Hargreaves, R James, C Jones, D McKerrecher, ... US Patent App. 10/482,572, 2004 | 24 | 2004 |
| Benzofuran derivatives, process for their preparation and intermediates thereof D McKerrecher, JW Rayner US Patent 7,709,505, 2010 | 23 | 2010 |
