| Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice RCL Ng, OY Cheng, M Jian, JSC Kwan, PWL Ho, KKY Cheng, ... Molecular neurodegeneration 11 (1), 71, 2016 | 198 | 2016 |
| CRAF methylation by PRMT6 regulates aerobic glycolysis–driven hepatocarcinogenesis via ERK‐dependent PKM2 nuclear relocalization and activation TL Wong, KY Ng, KV Tan, LH Chan, L Zhou, N Che, RLC Hoo, TK Lee, ... Hepatology 71 (4), 1279-1296, 2020 | 121 | 2020 |
| Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib M Tong, N Che, L Zhou, ST Luk, PW Kau, S Chai, ES Ngan, CM Lo, ... Journal of Hepatology 69 (4), 826-839, 2018 | 120 | 2018 |
| PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation LH Chan, L Zhou, KY Ng, TL Wong, TK Lee, R Sharma, JH Loong, ... Cell reports 25 (3), 690-701. e8, 2018 | 102 | 2018 |
| Glucose deprivation–induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma JHC Loong, TL Wong, M Tong, R Sharma, L Zhou, KY Ng, HJ Yu, CH Li, ... The Journal of clinical investigation 131 (11), 2021 | 97 | 2021 |
| Caspase-3–induced activation of SREBP2 drives drug resistance via promotion of cholesterol biosynthesis in hepatocellular carcinoma EHK Mok, CON Leung, L Zhou, MML Lei, HW Leung, M Tong, TL Wong, ... Cancer Research 82 (17), 3102-3115, 2022 | 96 | 2022 |
| ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer TL Wong, JJ Loh, S Lu, HHN Yan, HC Siu, R Xi, D Chan, MJF Kam, ... Nature Communications 14 (1), 2861, 2023 | 86 | 2023 |
| FSTL1 secreted by activated fibroblasts promotes hepatocellular carcinoma metastasis and stemness JJ Loh, TW Li, L Zhou, TL Wong, X Liu, VWS Ma, CM Lo, K Man, TK Lee, ... Cancer research 81 (22), 5692-5705, 2021 | 86 | 2021 |
| N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression X Zhang, T Su, Y Wu, Y Cai, L Wang, C Liang, L Zhou, S Wang, XX Li, ... Cancer research 84 (6), 827-840, 2024 | 80 | 2024 |
| Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression L Zhou, HO Ken, TL Wong, Z Zhang, CH Chan, JHC Loong, N Che, HJ Yu, ... Gut 71 (8), 1656-1668, 2022 | 74 | 2022 |
| Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac L Zhou, SL Ma, PKK Yeung, YH Wong, KWK Tsim, KF So, LCW Lam, ... Translational psychiatry 6 (9), e881-e881, 2016 | 53 | 2016 |
| Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer M Tong, TL Wong, H Zhao, Y Zheng, YN Xie, CH Li, L Zhou, N Che, ... Cell reports 36 (8), 2021 | 42 | 2021 |
| PSCs reveal PUFA-provoked mitochondrial stress as a central node potentiating RPE degeneration in Bietti’s crystalline dystrophy Z Zhang, B Yan, F Gao, Q Li, X Meng, P Chen, L Zhou, W Deng, C Li, ... Molecular Therapy 28 (12), 2642-2661, 2020 | 38 | 2020 |
| SERPINA12 promotes the tumorigenic capacity of HCC stem cells through hyperactivation of AKT/β-catenin signaling H Yu, L Zhou, JHC Loong, KH Lam, TL Wong, KY Ng, M Tong, VWS Ma, ... Hepatology 78 (6), 1711-1726, 2023 | 26 | 2023 |
| SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma KF Man, L Zhou, H Yu, KH Lam, W Cheng, J Yu, TK Lee, JP Yun, ... Nature communications 14 (1), 7863, 2023 | 25 | 2023 |
| Protein tyrosine kinase 7 (PTK7) promotes metastasis in hepatocellular carcinoma via SOX9 regulation and TGF-β Signaling TLM Wong, TL Wong, L Zhou, K Man, J Purcell, TK Lee, JP Yun, S Ma Cellular and Molecular Gastroenterology and Hepatology 15 (1), 13-37, 2023 | 22 | 2023 |
| The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma S Wang, Y Zeng, L Zhu, M Zhang, L Zhou, W Yang, W Luo, L Wang, Y Liu, ... Cancer Discovery 14 (11), 2279-2299, 2024 | 18 | 2024 |
| Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma CON Leung, M Tong, KPS Chung, L Zhou, N Che, KH Tang, J Ding, ... Hepatology, 2020 | 13 | 2020 |
| Deficiency in embryonic stem cell marker REX1 activates MKK6-dependent p38 MAPK signaling to drive hepatocarcinogenesis ST Luk, KY Ng, L Zhou, M Tong, TL Wong, H Yu, CM Lo, K Man, XY Guan, ... Hepatology 72, 183-197, 2019 | 8 | 2019 |
| Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet PD Virwani, L Cai, PKK Yeung, G Qian, Y Chen, L Zhou, JWH Wong, ... Microbiome 10 (1), 187, 2022 | 7 | 2022 |
Stephanie MaThe University of Hong KongVerified email at hku.hk
