| An allosteric mechanism for potent inhibition of human ATP-citrate lyase J Wei, S Leit, J Kuai, E Therrien, S Rafi, HJ Harwood Jr, B DeLaBarre, ... Nature 568 (7753), 566-570, 2019 | 167 | 2019 |
| Synthesis of functionally diverse bicyclic sulfonamides as constrained proline analogues and application to the design of potential thrombin inhibitors S Hanessian, H Sailes, E Therrien Tetrahedron 59 (35), 7047-7056, 2003 | 115 | 2003 |
| N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1) M Allan, S Manku, E Therrien, N Nguyen, S Styhler, MF Robert, AC Goulet, ... Bioorganic & medicinal chemistry letters 19 (4), 1218-1223, 2009 | 109 | 2009 |
| Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics S Hanessian, H Yun, Y Hou, G Yang, M Bayrakdarian, E Therrien, ... Journal of medicinal chemistry 48 (16), 5175-5190, 2005 | 97 | 2005 |
| A method for induced-fit docking, scoring, and ranking of flexible ligands. Application to peptidic and pseudopeptidic β-secretase (BACE 1) inhibitors N Moitessier, E Therrien, S Hanessian Journal of medicinal chemistry 49 (20), 5885-5894, 2006 | 94 | 2006 |
| Medicinal chemistry projects requiring imaginative structure-based drug design methods N Moitessier, J Pottel, E Therrien, P Englebienne, Z Liu, A Tomberg, ... Accounts of Chemical Research 49 (9), 1646-1657, 2016 | 87 | 2016 |
| Integrating medicinal chemistry, organic/combinatorial chemistry, and computational chemistry for the discovery of selective estrogen receptor modulators with Forecaster, a … E Therrien, P Englebienne, AG Arrowsmith, R Mendoza-Sanchez, ... Journal of chemical information and modeling 52 (1), 210-224, 2012 | 82 | 2012 |
| Virtual screening and computational optimization for the discovery of covalent prolyl oligopeptidase inhibitors with activity in human cells S De Cesco, S Deslandes, E Therrien, D Levan, M Cueto, R Schmidt, ... Journal of Medicinal Chemistry 55 (14), 6306-6315, 2012 | 72 | 2012 |
| 1, 2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1) E Therrien, G Larouche, S Manku, M Allan, N Nguyen, S Styhler, ... Bioorganic & medicinal chemistry letters 19 (23), 6725-6732, 2009 | 69 | 2009 |
| Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation S Hanessian, H Sailes, A Munro, E Therrien The Journal of Organic Chemistry 68 (19), 7219-7233, 2003 | 67 | 2003 |
| Development of a Computational Tool to Rival Experts in the Prediction of Sites of Metabolism of Xenobiotics by P450s V Campagna-Slater, J Pottel, E Therrien, LD Cantin, N Moitessier Journal of chemical information and modeling 52 (9), 2471-2483, 2012 | 66 | 2012 |
| Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones S Hanessian, E Therrien, K Granberg, I Nilsson Bioorganic & medicinal chemistry letters 12 (20), 2907-2911, 2002 | 65 | 2002 |
| Docking ligands into flexible and solvated macromolecules. 6. Development and application to the docking of HDACs and other zinc metalloenzymes inhibitors J Pottel, E Therrien, JL Gleason, N Moitessier Journal of Chemical Information and Modeling 54 (1), 254-265, 2014 | 57 | 2014 |
| Peptide coupling of unprotected amino acids through in situ p-nitrophenyl ester formation P Gagnon, X Huang, E Therrien, JW Keillor Tetrahedron letters 43 (43), 7717-7719, 2002 | 57 | 2002 |
| Amines as small molecule inhibitors A Wahhab, E Therrien, M Allan, S Manku US Patent 8,338,437, 2012 | 55 | 2012 |
| Sulfamides as novel histone deacetylase inhibitors A Wahhab, D Smil, A Ajamian, M Allan, Y Chantigny, E Therrien, ... Bioorganic & medicinal chemistry letters 19 (2), 336-340, 2009 | 52 | 2009 |
| Docking ligands into flexible and solvated macromolecules. 7. Impact of protein flexibility and water molecules on docking-based virtual screening accuracy E Therrien, N Weill, A Tomberg, CR Corbeil, D Lee, N Moitessier Journal of Chemical Information and Modeling 54 (11), 3198-3210, 2014 | 43 | 2014 |
| A comparative docking study and the design of potentially selective MMP inhibitors S Hanessian, N Moitessier, E Therrien Journal of computer-aided molecular design 15 (10), 873-881, 2001 | 39 | 2001 |
| Synthesis of 310-Helix-Inducing Constrained Analogues of l-Proline S Hanessian, G Papeo, K Fettis, E Therrien, MTP Viet The Journal of Organic Chemistry 69 (15), 4891-4899, 2004 | 38 | 2004 |
| Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors AM Taylor, BR Williams, F Giordanetto, EH Kelley, A Lescarbeau, ... Journal of Medicinal Chemistry 66 (19), 13384-13399, 2023 | 37 | 2023 |
