| The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer AK Najumudeen, F Ceteci, SK Fey, G Hamm, RT Steven, H Hall, ... Nature genetics 53 (1), 16-26, 2021 | 251 | 2021 |
| NOTUM from Apc-mutant cells biases clonal competition to initiate cancer DJ Flanagan, N Pentinmikko, K Luopajärvi, NJ Willis, K Gilroy, AP Raven, ... Nature 594 (7863), 430-435, 2021 | 239 | 2021 |
| Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia EG Vazquez, N Nasreddin, GN Valbuena, EJ Mulholland, ... Cell Stem Cell 29 (8), 1213-1228. e8, 2022 | 114 | 2022 |
| Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition G Sharbeen, JA McCarroll, A Akerman, C Kopecky, J Youkhana, ... Cancer research 81 (13), 3461-3479, 2021 | 108 | 2021 |
| Cancer stem cell drugs target K-ras signaling in a stemness context AK Najumudeen, A Jaiswal, B Lectez, C Oetken-Lindholm, C Guzmán, ... Oncogene 35 (40), 5248-5262, 2016 | 103 | 2016 |
| MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression JRP Knight, C Alexandrou, GL Skalka, N Vlahov, K Pennel, L Officer, ... Cancer discovery 11 (5), 1228-1247, 2021 | 92 | 2021 |
| Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis JDG Leach, N Vlahov, P Tsantoulis, RA Ridgway, DJ Flanagan, K Gilroy, ... Nature communications 12 (1), 3464, 2021 | 78 | 2021 |
| Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer SB Malla, RM Byrne, MW Lafarge, SM Corry, NC Fisher, PK Tsantoulis, ... Nature Genetics 56 (3), 458-472, 2024 | 54 | 2024 |
| Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target J Vande Voorde, RT Steven, AK Najumudeen, CA Ford, A Dexter, ... Nature metabolism 5 (8), 1303-1318, 2023 | 53 | 2023 |
| Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ C Kiourtis, M Terradas-Terradas, LM Gee, S May, A Georgakopoulou, ... Nature Cell Biology 26 (12), 2075-2083, 2024 | 46 | 2024 |
| Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT FP Coxon, Ł Joachimiak, AK Najumudeen, G Breen, J Gmach, ... European Journal of Medicinal Chemistry 84, 77-89, 2014 | 34 | 2014 |
| Cellular FRET-biosensors to detect membrane targeting inhibitors of N-myristoylated proteins AK Najumudeen, M Köhnke, M Šolman, K Alexandrov, D Abankwa PLoS One 8 (6), e66425, 2013 | 34 | 2013 |
| KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo AK Najumudeen, SK Fey, LM Millett, CA Ford, K Gilroy, N Gunduz, ... Nature Communications 15 (1), 100, 2024 | 20 | 2024 |
| A RAC-GEF network critical for early intestinal tumourigenesis KA Pickering, K Gilroy, JW Cassidy, SK Fey, AK Najumudeen, LB Zeiger, ... Nature Communications 12 (1), 56, 2021 | 19 | 2021 |
| Receptor tyrosine kinase transmembrane domain interactions: potential target for “interceptor” therapy AK Najumudeen Science signaling 3 (138), jc6-jc6, 2010 | 14 | 2010 |
| Training a neural network to learn other dimensionality reduction removes data size restrictions in bioinformatics and provides a new route to exploring data representations A Dexter, SA Thomas, RT Steven, KN Robinson, AJ Taylor, E Elia, ... bioRxiv, 2020.09. 03.269555, 2020 | 9 | 2020 |
| Australian pancreatic cancer genome I (2021) Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition G Sharbeen, JA McCarroll, A Akerman, C Kopecky, J Youkhana, ... Cancer Res 81 (13), 3461-3479, 0 | 9 | |
| Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition AK Holt, AK Najumudeen, TJ Collard, H Li, LM Millett, AJ Hoskin, ... Cancer & Metabolism 11 (1), 18, 2023 | 8 | 2023 |
| Phenotypic screening identifies protein synthesis inhibitors as H-Ras-nanocluster-increasing tumor growth inducers AK Najumudeen, IMD Posada, B Lectez, Y Zhou, SKJ Landor, A Fallarero, ... Biochemistry 54 (49), 7212-7221, 2015 | 8 | 2015 |
| SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers J Lilja, J Kaivola, JRW Conway, J Vuorio, H Parkkola, P Roivas, M Dibus, ... Nature Communications 15 (1), 8002, 2024 | 6 | 2024 |
