| Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion–Positive Lung Cancer JJ Lin, NJ Choudhury, S Yoda, VW Zhu, TW Johnson, R Sakhtemani, ... Clinical Cancer Research 27 (10), 2899-2909, 2021 | 144 | 2021 |
| Therapy-induced APOBEC3A drives evolution of persistent cancer cells H Isozaki, R Sakhtemani, A Abbasi, N Nikpour, M Stanzione, S Oh, ... Nature 620 (7973), 393-401, 2023 | 126 | 2023 |
| An extended APOBEC3A mutation signature in cancer A Langenbucher, D Bowen, R Sakhtemani, E Bournique, JF Wise, L Zou, ... Nature communications 12 (1), 1602, 2021 | 122 | 2021 |
| Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes A Sanchez, P Ortega, R Sakhtemani, L Manjunath, S Oh, E Bournique, ... Nature Communications 15 (1), 2370, 2024 | 33 | 2024 |
| Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing R Sakhtemani, V Senevirathne, J Stewart, MLW Perera, R Pique-Regi, ... Journal of Biological Chemistry 294 (41), 15037-15051, 2019 | 28 | 2019 |
| Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations Y Butt, R Sakhtemani, R Mohamad-Ramshan, MS Lawrence, AS Bhagwat bioRxiv, 2023.08. 01.551518, 2023 | 19 | 2023 |
| A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers S Wei, MLW Perera, R Sakhtemani, AS Bhagwat PloS one 12 (9), e0185010, 2017 | 15 | 2017 |
| Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops R Sakhtemani, MLW Perera, D Hübschmann, R Siebert, MS Lawrence, ... Nucleic Acids Research 50 (9), 5145-5157, 2022 | 8 | 2022 |
| Epigenetic regulation of APOBEC3A mutagenesis and tumor evolution during targeted therapy in non-small cell lung cancer H Isozaki, R Sakhtemani, N Nikpour, S Monroe, J Lin, L Sequist, ... Cancer Research 83 (7_Supplement), 137-137, 2023 | 1 | 2023 |
| Nucleotide level mapping of uracils in murine heavy chain switch regions shows correlation between uracilation and positions of switch junctions created during class-switch … R Mohamad-Ramshan, R Sakhtemani, Y Butt, MS Lawrence, AS Bhagwat NAR Molecular Medicine 2 (1), ugaf003, 2025 | | 2025 |
| APOBEC3A drives tumor evolution through activation of ERVs in non small cell lung cancer H Isozaki, R Sakhtemani, N Nikpour, S Monroe, M Lawrence, A Hata Cancer Research 84 (6_Supplement), 3289-3289, 2024 | | 2024 |
| Impact of therapy induced APOBEC3A mutagenesis on tumor evolution in non small cell lung cancer H Isozaki, A Abbasi, N Nikpour, M Stanzione, R Sakhtemani, SL Monroe, ... Cancer Research 82 (12_Supplement), 657-657, 2022 | | 2022 |
| Using Upd-Seq To Understand Genome-Wide Targeting By The Human Aid/apobec3 Enzymes R Sakhtemani | | 2020 |
Michael S. LawrenceMassachusetts General HospitalVerified email at mgh.harvard.edu
