| A landscape of pharmacogenomic interactions in cancer F Iorio, TA Knijnenburg, DJ Vis, GR Bignell, MP Menden, M Schubert, ... Cell 166 (3), 740-754, 2016 | 2179 | 2016 |
| Machine learning identifies stemness features associated with oncogenic dedifferentiation TM Malta, A Sokolov, AJ Gentles, T Burzykowski, L Poisson, JN Weinstein, ... Cell 173 (2), 338-354. e15, 2018 | 2145 | 2018 |
| Global epigenomic reconfiguration during mammalian brain development R Lister, EA Mukamel, JR Nery, M Urich, CA Puddifoot, ND Johnson, ... Science 341 (6146), 1237905, 2013 | 2142 | 2013 |
| Comparative analysis of single-cell RNA sequencing methods C Ziegenhain, B Vieth, S Parekh, B Reinius, A Guillaumet-Adkins, ... Molecular cell 65 (4), 631-643. e4, 2017 | 1764 | 2017 |
| Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome J Sandoval, H Heyn, S Moran, J Serra-Musach, MA Pujana, M Bibikova, ... Epigenetics 6 (6), 692-702, 2011 | 1238 | 2011 |
| Distinct DNA methylomes of newborns and centenarians H Heyn, N Li, HJ Ferreira, S Moran, DG Pisano, A Gomez, J Diez, ... Proceedings of the National Academy of Sciences 109 (26), 10522-10527, 2012 | 983 | 2012 |
| DNA methylation profiling in the clinic: applications and challenges H Heyn, M Esteller Nature Reviews Genetics 13 (10), 679-692, 2012 | 915 | 2012 |
| SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes M Elosua-Bayes, P Nieto, E Mereu, I Gut, H Heyn Nucleic acids research 49 (9), e50-e50, 2021 | 665 | 2021 |
| Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis S Moran, A Martínez-Cardús, S Sayols, E Musulén, C Balañá, ... The Lancet Oncology 17 (10), 1386-1395, 2016 | 543 | 2016 |
| Benchmarking single-cell RNA-sequencing protocols for cell atlas projects E Mereu, A Lafzi, C Moutinho, C Ziegenhain, DJ McCarthy, ... Nature biotechnology 38 (6), 747-755, 2020 | 496 | 2020 |
| DNA methylation contributes to natural human variation H Heyn, S Moran, I Hernando-Herraez, S Sayols, A Gomez, J Sandoval, ... Genome research 23 (9), 1363-1372, 2013 | 478 | 2013 |
| The emerging landscape of spatial profiling technologies JR Moffitt, E Lundberg, H Heyn Nature Reviews Genetics 23 (12), 741-759, 2022 | 382 | 2022 |
| A prognostic DNA methylation signature for stage I non–small-cell lung cancer J Sandoval, J Mendez-Gonzalez, E Nadal, G Chen, FJ Carmona, ... Journal of clinical oncology 31 (32), 4140-4147, 2013 | 332 | 2013 |
| Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data CH Holland, J Tanevski, J Perales-Patón, J Gleixner, MP Kumar, E Mereu, ... Genome biology 21 (1), 36, 2020 | 330 | 2020 |
| DNA methylation map of human atherosclerosis S Zaina, H Heyn, FJ Carmona, N Varol, S Sayols, E Condom, ... Circulation: Cardiovascular Genetics 7 (5), 692-700, 2014 | 300 | 2014 |
| Dietary palmitic acid promotes a prometastatic memory via Schwann cells G Pascual, D Dominguez, M Elosúa-Bayes, F Beckedorff, C Laudanna, ... Nature 599 (7885), 485-490, 2021 | 285 | 2021 |
| Identity noise and adipogenic traits characterize dermal fibroblast aging MC Salzer, A Lafzi, A Berenguer-Llergo, C Youssif, A Castellanos, ... Cell 175 (6), 1575-1590. e22, 2018 | 274 | 2018 |
| Tutorial: guidelines for the experimental design of single-cell RNA sequencing studies A Lafzi, C Moutinho, S Picelli, H Heyn Nature protocols 13 (12), 2742-2757, 2018 | 253 | 2018 |
| Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease A Garrido-Trigo, AM Corraliza, M Veny, I Dotti, E Melón-Ardanaz, A Rill, ... Nature communications 14 (1), 4506, 2023 | 245 | 2023 |
| Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response I Köllner, B Sodeik, S Schreek, H Heyn, N von Neuhoff, ... Blood 108 (2), 493-500, 2006 | 243 | 2006 |