| Aβ oligomers cause localized Ca2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines H Zempel, E Thies, E Mandelkow, EM Mandelkow Journal of Neuroscience 30 (36), 11938-11950, 2010 | 871 | 2010 |
| Lost after translation: missorting of Tau protein and consequences for Alzheimer disease H Zempel, E Mandelkow Trends in neurosciences 37 (12), 721-732, 2014 | 365 | 2014 |
| Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin H Zempel, J Luedtke, Y Kumar, J Biernat, H Dawson, E Mandelkow, ... The EMBO journal 32 (22), 2920, 2013 | 340 | 2013 |
| Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration X Li, Y Kumar, H Zempel, EM Mandelkow, J Biernat, E Mandelkow The EMBO journal 30 (23), 4825, 2011 | 273 | 2011 |
| Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture H Zempel, FJA Dennissen, Y Kumar, J Luedtke, J Biernat, EM Mandelkow, ... Journal of Biological Chemistry 292 (29), 12192-12207, 2017 | 165 | 2017 |
| Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting MP Schützmann, F Hasecke, S Bachmann, M Zielinski, S Hänsch, ... Nature communications 12 (1), 4634, 2021 | 132 | 2021 |
| Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton H Zempel, EM Mandelkow Neurodegenerative Diseases 10 (1-4), 64-72, 2012 | 128 | 2012 |
| Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia H Zempel, EM Mandelkow Molecular neurodegeneration 10 (1), 68, 2015 | 114 | 2015 |
| SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability M Bell, H Zempel Reviews in the Neurosciences 33 (1), 1-15, 2022 | 111 | 2022 |
| The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes S Buchholz, H Zempel Alzheimer's & Dementia 20 (5), 3606-3628, 2024 | 101 | 2024 |
| Differential effects of the six human TAU isoforms: somatic retention of 2N-TAU and increased microtubule number induced by 4R-TAU S Bachmann, M Bell, J Klimek, H Zempel Frontiers in Neuroscience 15, 643115, 2021 | 101 | 2021 |
| Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging … T Timm, JP von Kries, X Li, H Zempel, E Mandelkow, EM Mandelkow Journal of Biological Chemistry 286 (48), 41711-41722, 2011 | 53 | 2011 |
| Genetic forms of tauopathies: inherited causes and implications of Alzheimer’s disease-like TAU pathology in primary and secondary tauopathies F Langerscheidt, T Wied, MA Al Kabbani, T van Eimeren, G Wunderlich, ... Journal of Neurology 271 (6), 2992-3018, 2024 | 40 | 2024 |
| Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS M Bell, S Bachmann, J Klimek, F Langerscheidt, H Zempel Neuroscience 461, 155-171, 2021 | 40 | 2021 |
| DNA methylation in genetic and sporadic forms of neurodegeneration: lessons from Alzheimer’s, related tauopathies and genetic tauopathies G Zimmer-Bensch, H Zempel Cells 10 (11), 3064, 2021 | 39 | 2021 |
| Mechanisms of axonal sorting of tau and influence of the axon initial segment on tau cell polarity H Zempel, E Mandelkow Tau Biology, 69-77, 2020 | 39 | 2020 |
| DNA methyltransferase 1 (Dnmt1) shapes neuronal activity of human ipsc-derived glutamatergic cortical neurons S Bachmann, J Linde, M Bell, M Spehr, H Zempel, G Zimmer-Bensch International Journal of Molecular Sciences 22 (4), 2034, 2021 | 31 | 2021 |
| A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons N Tjiang, H Zempel Cellular and Molecular Life Sciences 79 (2), 120, 2022 | 24 | 2022 |
| Tracking Tau in neurons: How to grow, fix, and stain primary neurons for the investigation of Tau in all developmental stages H Zempel, EM Mandelkow Tau Protein: Methods and Protocols, 327-334, 2016 | 21 | 2016 |
| Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes Y Miura, Y Sakurai, M Hayakawa, Y Shimada, H Zempel, Y Sato, ... Biological and Pharmaceutical Bulletin 33 (1), 22-28, 2010 | 21 | 2010 |
