| Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5′-terminal regions of cap0-, cap1-and 5′ ppp-mRNAs P Kumar, TR Sweeney, MA Skabkin, OV Skabkina, CUT Hellen, ... Nucleic acids research 42 (5), 3228-3245, 2014 | 257 | 2014 |
| Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells MS Kim, TR Sweeney, JK Shigenaga, LG Chui, A Moser, C Grunfeld, ... Metabolism 56 (2), 267-279, 2007 | 225* | 2007 |
| The mechanism of translation initiation on T ype 1 picornavirus IRES s TR Sweeney, IS Abaeva, TV Pestova, CUT Hellen The EMBO journal 33 (1), 76-92, 2014 | 204 | 2014 |
| Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication PL Chavali, L Stojic, LW Meredith, N Joseph, MS Nahorski, TJ Sanford, ... Science 357 (6346), 83-88, 2017 | 194 | 2017 |
| Better together: the role of IFIT protein–protein interactions in the antiviral response HV Mears, TR Sweeney Journal of General Virology 99 (11), 1463-1477, 2018 | 147 | 2018 |
| IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA RC Fleith, HV Mears, XY Leong, TJ Sanford, E Emmott, SC Graham, ... Nucleic acids research 46 (10), 5269-5285, 2018 | 135 | 2018 |
| Structural insights into the transcriptional and translational roles of Ebp1 TP Monie, AJ Perrin, JR Birtley, TR Sweeney, I Karakasiliotis, Y Chaudhry, ... The EMBO journal 26 (17), 3936-3944, 2007 | 122 | 2007 |
| Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis TR Sweeney, N Roqué-Rosell, JR Birtley, RJ Leatherbarrow, S Curry Journal of virology 81 (1), 115-124, 2007 | 117 | 2007 |
| A distinct class of internal ribosomal entry site in members of the Kobuvirus and proposed Salivirus and Paraturdivirus genera of the Picornaviridae TR Sweeney, V Dhote, Y Yu, CUT Hellen Journal of virology 86 (3), 1468-1486, 2012 | 96 | 2012 |
| Foot-and-mouth disease virus 2C is a hexameric AAA+ protein with a coordinated ATP hydrolysis mechanism TR Sweeney, V Cisnetto, D Bose, M Bailey, JR Wilson, X Zhang, ... Journal of Biological Chemistry 285 (32), 24347-24359, 2010 | 95 | 2010 |
| The mechanism of translation initiation on Aichivirus RNA mediated by a novel type of picornavirus IRES Y Yu, TR Sweeney, P Kafasla, RJ Jackson, TV Pestova, CUT Hellen The EMBO journal 30 (21), 4423-4436, 2011 | 92 | 2011 |
| Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate PA Zunszain, SR Knox, TR Sweeney, J Yang, N Roqué-Rosell, ... Journal of molecular biology 395 (2), 375-389, 2010 | 90 | 2010 |
| Circularization of flavivirus genomic RNA inhibits de novo translation initiation TJ Sanford, HV Mears, T Fajardo Jr, N Locker, TR Sweeney Nucleic acids research 47 (18), 9789-9802, 2019 | 74 | 2019 |
| Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs V Dhote, TR Sweeney, N Kim, CUT Hellen, TV Pestova Proceedings of the National Academy of Sciences 109 (46), E3150-E3159, 2012 | 55 | 2012 |
| The flavivirus polymerase NS5 regulates translation of viral genomic RNA T Fajardo Jr, TJ Sanford, HV Mears, A Jasper, S Storrie, DS Mansur, ... Nucleic acids research 48 (9), 5081-5093, 2020 | 50 | 2020 |
| Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy TR Sweeney, AH Moser, JK Shigenaga, C Grunfeld, KR Feingold American Journal of Physiology-Endocrinology and Metabolism 290 (6), E1313-E1320, 2006 | 47 | 2006 |
| Inhibition of translation initiation by protein 169: a vaccinia virus strategy to suppress innate and adaptive immunity and alter virus virulence P Strnadova, H Ren, R Valentine, M Mazzon, TR Sweeney, I Brierley, ... PLoS Pathogens 11 (9), e1005151, 2015 | 45 | 2015 |
| Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs? S Curry, N Roque-Rosell, TR Sweeney, PA Zunszain, RJ Leatherbarrow Biochemical Society Transactions 35 (Pt 3), 594-598, 2007 | 35 | 2007 |
| A cell-based fluorescence resonance energy transfer (FRET) sensor reveals inter-and intragenogroup variations in norovirus protease activity and polyprotein cleavage E Emmott, TR Sweeney, I Goodfellow Journal of Biological Chemistry 290 (46), 27841-27853, 2015 | 34 | 2015 |
| Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs TR Sweeney, V Dhote, E Guca, CUT Hellen, Y Hashem, TV Pestova Nucleic acids research 49 (22), 12955-12969, 2021 | 20 | 2021 |
Stephen CurryProfessor of Structural Biology, Imperial CollegeVerified email at imperial.ac.uk
