| OPA1‐dependent cristae modulation is essential for cellular adaptation to metabolic demand DA Patten, J Wong, M Khacho, V Soubannier, RJ Mailloux, ... The EMBO journal 33 (22), 2676-2691, 2014 | 479 | 2014 |
| Reactive oxygen species: stuck in the middle of neurodegeneration DA Patten, M Germain, MA Kelly, RS Slack Journal of Alzheimer’s Disease 20 (s2), S357-S367, 2010 | 370 | 2010 |
| Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer A Franovic, L Gunaratnam, K Smith, I Robert, D Patten, S Lee Proceedings of the National Academy of Sciences 104 (32), 13092-13097, 2007 | 338 | 2007 |
| Reactive oxygen species and oxidative stress in obesity—recent findings and empirical approaches F McMurray, DA Patten, ME Harper Obesity 24 (11), 2301-2310, 2016 | 322 | 2016 |
| Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival M Khacho, M Tarabay, D Patten, P Khacho, JG MacLaurin, J Guadagno, ... Nature communications 5 (1), 3550, 2014 | 217 | 2014 |
| Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species DA Patten, VN Lafleur, GA Robitaille, DA Chan, AJ Giaccia, DE Richard Molecular biology of the cell 21 (18), 3247-3257, 2010 | 204 | 2010 |
| Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals G Antoun, F McMurray, AB Thrush, DA Patten, AC Peixoto, RS Slack, ... Diabetologia 58 (12), 2861-2866, 2015 | 126 | 2015 |
| Tumor metabolism regulating chemosensitivity in ovarian cancer CY Han, DA Patten, RB Richardson, ME Harper, BK Tsang Genes & Cancer 9 (5-6), 155-175, 2018 | 62 | 2018 |
| Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer S McGuirk, Y Audet-Delage, MG Annis, Y Xue, M Vernier, K Zhao, ... Elife 10, e65150, 2021 | 58 | 2021 |
| IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation L Nadeau, DA Patten, A Caron, L Garneau, E Pinault-Masson, M Foretz, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1863 (2), 395-407, 2019 | 56 | 2019 |
| p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer CY Han, DA Patten, SG Lee, RJ Parks, DW Chan, ME Harper, BK Tsang Molecular Carcinogenesis 58 (11), 2161-2174, 2019 | 41 | 2019 |
| Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies GN Kanaan, B Ichim, L Gharibeh, W Maharsy, DA Patten, JY Xuan, ... Redox Biology 14, 509-521, 2018 | 39 | 2018 |
| Atrial fibrillation is associated with impaired atrial mitochondrial energetics and supercomplex formation in adults with type 2 diabetes GN Kanaan, DA Patten, CJ Redpath, ME Harper Canadian Journal of Diabetes 43 (1), 67-75. e1, 2019 | 33 | 2019 |
| Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism AB Thrush, G Antoun, M Nikpay, DA Patten, C DeVlugt, JF Mauger, ... International Journal of Obesity 42 (3), 353-362, 2018 | 29 | 2018 |
| The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity A Labbé, VN Lafleur, DA Patten, GA Robitaille, C Garand, L Lamalice, ... Experimental cell research 318 (14), 1620-1632, 2012 | 27 | 2012 |
| Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity CA Pileggi, DP Blondin, BG Hooks, G Parmar, I Alecu, DA Patten, ... EBioMedicine 83, 2022 | 26 | 2022 |
| LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction M Germain, AP Nguyen, M Khacho, DA Patten, RA Screaton, DS Park, ... Human Molecular Genetics 22 (5), 952-962, 2013 | 26 | 2013 |
| MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions U Anilkumar, M Khacho, A Cuillerier, R Harris, DA Patten, M Bilen, ... Cell death & disease 11 (5), 321, 2020 | 23 | 2020 |
| Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production DA Patten, S McGuirk, U Anilkumar, G Antoun, K Gandhi, G Parmar, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1868 (1), 118854, 2021 | 21 | 2021 |
| Maternal diet‐induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity F McMurray, M MacFarlane, K Kim, DA Patten, L Wei‐LaPierre, ... The FASEB Journal 33 (12), 13515-13526, 2019 | 20 | 2019 |
Mary-Ellen HarperProfessor, Faculty of Medicine, University of OttawaVerified email at uottawa.ca
