| Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ... Nature 459 (7244), 262-265, 2009 | 8333 | 2009 |
| Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ... Gastroenterology 141 (5), 1762-1772, 2011 | 4355 | 2011 |
| Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ... Nature 469 (7330), 415-418, 2011 | 3110 | 2011 |
| Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ... Cell stem cell 6 (1), 25-36, 2010 | 1918 | 2010 |
| Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011 | 1545 | 2011 |
| Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas AG Schepers, HJ Snippert, DE Stange, M van den Born, JH van Es, ... Science 337 (6095), 730-735, 2012 | 1334 | 2012 |
| Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ... Nature 488 (7413), 665-669, 2012 | 1152 | 2012 |
| Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ... Science 327 (5971), 1385-1389, 2010 | 951 | 2010 |
| The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079, 2012 | 933 | 2012 |
| Transcription factor achaete scute-like 2 controls intestinal stem cell fate LG van der Flier, ME van Gijn, P Hatzis, P Kujala, A Haegebarth, ... Cell 136 (5), 903-912, 2009 | 862 | 2009 |
| A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon K Fellermann, DE Stange, E Schaeffeler, H Schmalzl, J Wehkamp, ... The American Journal of Human Genetics 79 (3), 439-448, 2006 | 731 | 2006 |
| OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells LG Van der Flier, A Haegebarth, DE Stange, M Van de Wetering, ... Gastroenterology 137 (1), 15-17, 2009 | 660 | 2009 |
| Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ... Cell 155 (2), 357-368, 2013 | 591 | 2013 |
| Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling VWY Wong, DE Stange, ME Page, S Buczacki, A Wabik, S Itami, ... Nature cell biology 14 (4), 401-408, 2012 | 482 | 2012 |
| Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012 | 413 | 2012 |
| Human gastric cancer modelling using organoids T Seidlitz, SR Merker, A Rothe, F Zakrzewski, C von Neubeck, ... Gut 68 (2), 207-217, 2019 | 340 | 2019 |
| The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium A Gregorieff, DE Stange, P Kujala, H Begthel, M Van den Born, J Korving, ... Gastroenterology 137 (4), 1333-1345. e3, 2009 | 317 | 2009 |
| Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids A Marsee, FJM Roos, MMA Verstegen, F Roos, M Verstegen, H Clevers, ... Cell Stem Cell 28 (5), 816-832, 2021 | 313 | 2021 |
| Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma F Mendrzyk, B Radlwimmer, S Joos, F Kokocinski, A Benner, DE Stange, ... Journal of Clinical Oncology 23 (34), 8853-8862, 2005 | 290 | 2005 |
| Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine HJ Snippert, JH van Es, M van den Born, H Begthel, DE Stange, N Barker, ... Gastroenterology 136 (7), 2187-2194. e1, 2009 | 257 | 2009 |
Hans CleversProfessor in Molecular Genetics. Utrecht University, Hubrecht Institute & Princess Maxima Center.Verified email at hubrecht.eu
