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Leah C Kottyan
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Genetic associations with gestational duration and spontaneous preterm birth
G Zhang, B Feenstra, J Bacelis, X Liu, LM Muglia, J Juodakis, DE Miller, ...
New England Journal of Medicine 377 (12), 1156-1167, 2017
4972017
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
JB Harley, X Chen, M Pujato, D Miller, A Maddox, C Forney, ...
Nature genetics 50 (5), 699-707, 2018
4702018
Transancestral mapping and genetic load in systemic lupus erythematosus
CD Langefeld, HC Ainsworth, DSC Graham, JA Kelly, ME Comeau, ...
Nature communications 8 (1), 16021, 2017
4432017
Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis
ES Alexander, LJ Martin, MH Collins, LC Kottyan, H Sucharew, H He, ...
Journal of allergy and clinical immunology 134 (5), 1084-1092. e1, 2014
3602014
Gene–environment interactions and their impact on human health
SJ Virolainen, A VonHandorf, KCMF Viel, MT Weirauch, LC Kottyan
Genes & Immunity 24 (1), 1-11, 2023
3382023
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
LC Kottyan, BP Davis, JD Sherrill, K Liu, M Rochman, K Kaufman, ...
Nature genetics 46 (8), 895-900, 2014
3382014
X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47, XXX in systemic lupus erythematosus and Sjögren's syndrome
K Liu, BT Kurien, SL Zimmerman, KM Kaufman, DH Taft, LC Kottyan, ...
Arthritis & Rheumatology 68 (5), 1290-1300, 2016
2002016
Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications
MJ Ombrello, VL Arthur, EF Remmers, A Hinks, I Tachmazidou, AA Grom, ...
Annals of the rheumatic diseases 76 (5), 906-913, 2017
1982017
HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
MJ Ombrello, EF Remmers, I Tachmazidou, A Grom, D Foell, JP Haas, ...
Proceedings of the National Academy of Sciences 112 (52), 15970-15975, 2015
1952015
Eosinophilic esophagitis–linked calpain 14 is an IL-13–induced protease that mediates esophageal epithelial barrier impairment
BP Davis, EM Stucke, ME Khorki, VA Litosh, JK Rymer, M Rochman, ...
JCI insight 1 (4), e86355, 2016
1882016
Imputation and quality control steps for combining multiple genome-wide datasets
SS Verma, M De Andrade, G Tromp, H Kuivaniemi, E Pugh, ...
Frontiers in genetics 5, 370, 2014
1742014
Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus
X Yin, K Kim, H Suetsugu, SY Bang, L Wen, M Koido, E Ha, L Liu, ...
Annals of the rheumatic diseases 80 (5), 632-640, 2021
1712021
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
NJ Lennon, LC Kottyan, C Kachulis, NS Abul-Husn, J Arias, G Belbin, ...
Nature Medicine 30 (2), 480-487, 2024
1682024
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
K Kiryluk, E Sanchez-Rodriguez, XJ Zhou, F Zanoni, L Liu, N Mladkova, ...
Nature genetics 55 (7), 1091-1105, 2023
1652023
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra, YF Lin, HK Tiwari, ...
Genome Medicine 14 (1), 70, 2022
1512022
Eosinophil viability is increased by acidic pH in a cAMP-and GPR65-dependent manner
LC Kottyan, AR Collier, KH Cao, KA Niese, M Hedgebeth, CG Radu, ...
Blood, The Journal of the American Society of Hematology 114 (13), 2774-2782, 2009
1362009
Calpain-14 and its association with eosinophilic esophagitis
VA Litosh, M Rochman, JK Rymer, A Porollo, LC Kottyan, ME Rothenberg
Journal of Allergy and Clinical Immunology 139 (6), 1762-1771. e7, 2017
1312017
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
MG Levin, NL Tsao, P Singhal, C Liu, HMT Vy, I Paranjpe, JD Backman, ...
Nature communications 13 (1), 6914, 2022
1282022
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses
NP Azouz, MA Ynga-Durand, JM Caldwell, A Jain, M Rochman, ...
Science translational medicine 10 (444), eaap9736, 2018
1152018
The transcription factor ZEB2 drives the formation of age-associated B cells
D Dai, S Gu, X Han, H Ding, Y Jiang, X Zhang, C Yao, S Hong, J Zhang, ...
Science 383 (6681), 413-421, 2024
1132024
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