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Jeffrey Holt
Jeffrey Holt
Professor, Harvard Medical School / Boston Children's Hospital
Verified email at childrens.harvard.edu - Homepage
Title
Cited by
Cited by
Year
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
DP Corey, J García-Añoveros, JR Holt, KY Kwan, SY Lin, MA Vollrath, ...
Nature 432 (7018), 723-730, 2004
9262004
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
X Gao, Y Tao, V Lamas, M Huang, WH Yeh, B Pan, YJ Hu, JH Hu, ...
Nature 553 (7687), 217-221, 2018
6242018
Continuous evolution of base editors with expanded target compatibility and improved activity
BW Thuronyi, LW Koblan, JM Levy, WH Yeh, C Zheng, GA Newby, ...
Nature biotechnology 37 (9), 1070-1079, 2019
4862019
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel–like genes
Y Kawashima, GSG Géléoc, K Kurima, V Labay, A Lelli, Y Asai, ...
The Journal of clinical investigation 121 (12), 4796-4809, 2011
4642011
TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear
B Pan, GS Géléoc, Y Asai, GC Horwitz, K Kurima, K Ishikawa, ...
Neuron 79 (3), 504-515, 2013
4632013
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear
K Oshima, CM Grimm, CE Corrales, P Senn, R Martinez Monedero, ...
Journal of the Association for Research in Otolaryngology 8 (1), 18-31, 2007
4152007
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells
JR Holt, SKH Gillespie, DW Provance, K Shah, KM Shokat, DP Corey, ...
Cell 108 (3), 371-381, 2002
4012002
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
LD Landegger, B Pan, C Askew, SJ Wassmer, SD Gluck, A Galvin, ...
Nature biotechnology 35 (3), 280-284, 2017
3832017
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells
KR Koehler, J Nie, E Longworth-Mills, XP Liu, J Lee, JR Holt, E Hashino
Nature biotechnology 35 (6), 583-589, 2017
3602017
TMC1 forms the pore of mechanosensory transduction channels in vertebrate inner ear hair cells
B Pan, N Akyuz, XP Liu, Y Asai, C Nist-Lund, K Kurima, BH Derfler, ...
Neuron 99 (4), 736-753. e6, 2018
3522018
Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links
W Denk, JR Holt, GMG Shepherd, DP Corey
Neuron 15 (6), 1311-1321, 1995
3351995
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c
B Pan, C Askew, A Galvin, S Heman-Ackah, Y Asai, AA Indzhykulian, ...
Nature biotechnology 35 (3), 264-272, 2017
3282017
Sound strategies for hearing restoration
GSG Géléoc, JR Holt
Science 344 (6184), 1241062, 2014
2782014
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles
JA McGee, RJ Goodyear, DR McMillan, EA Stauffer, JR Holt, KG Locke, ...
Journal of Neuroscience 26 (24), 6543-6553, 2006
2502006
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
B György, C Nist-Lund, B Pan, Y Asai, KD Karavitaki, BP Kleinstiver, ...
Nature medicine 25 (7), 1123-1130, 2019
2272019
TMC1 and TMC2 localize at the site of mechanotransduction in mammalian inner ear hair cell stereocilia
K Kurima, S Ebrahim, B Pan, M Sedlacek, P Sengupta, BA Millis, R Cui, ...
Cell reports 12 (10), 1606-1617, 2015
2172015
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
WH Yeh, O Shubina-Oleinik, JM Levy, B Pan, GA Newby, M Wornow, ...
Science translational medicine 12 (546), eaay9101, 2020
2072020
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea
A Lelli, Y Asai, A Forge, JR Holt, GSG Géléoc
Journal of neurophysiology 101 (6), 2961-2973, 2009
1902009
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells
M Senften, M Schwander, P Kazmierczak, C Lillo, JB Shin, T Hasson, ...
Journal of Neuroscience 26 (7), 2060-2071, 2006
1842006
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
CA Nist-Lund, B Pan, A Patterson, Y Asai, T Chen, W Zhou, H Zhu, ...
Nature communications 10 (1), 236, 2019
1822019
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