| GDC-0449—a potent inhibitor of the hedgehog pathway KD Robarge, SA Brunton, GM Castanedo, Y Cui, MS Dina, R Goldsmith, ... Bioorganic & medicinal chemistry letters 19 (19), 5576-5581, 2009 | 480 | 2009 |
| Optimized arylomycins are a new class of Gram-negative antibiotics PA Smith, MFT Koehler, HS Girgis, D Yan, Y Chen, Y Chen, JJ Crawford, ... Nature 561 (7722), 189-194, 2018 | 394 | 2018 |
| Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ... ACS medicinal chemistry letters 5 (10), 1088-1093, 2014 | 371 | 2014 |
| The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of δ-catenin and ARVCF RP Laura, AS Witt, HA Held, R Gerstner, K Deshayes, MFT Koehler, ... Journal of Biological Chemistry 277 (15), 12906-12914, 2002 | 209 | 2002 |
| Origins of PDZ domain ligand specificity: structure determination and mutagenesis of the Erbin PDZ domain NJ Skelton, MFT Koehler, K Zobel, WL Wong, S Yeh, MT Pisabarro, ... Journal of Biological Chemistry 278 (9), 7645-7654, 2003 | 200 | 2003 |
| Structural basis for dual-mode inhibition of the ABC transporter MsbA H Ho, A Miu, MK Alexander, NK Garcia, A Oh, I Zilberleyb, M Reichelt, ... Nature 557 (7704), 196-201, 2018 | 186 | 2018 |
| Synthesis of the first members of a new class of biologically active bryostatin analogues PA Wender, J De Brabander, PG Harran, JM Jimenez, MFT Koehler, ... Journal of the American Chemical Society 120 (18), 4534-4535, 1998 | 161 | 1998 |
| Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists C Ndubaku, E Varfolomeev, L Wang, K Zobel, K Lau, LO Elliott, B Maurer, ... ACS chemical biology 4 (7), 557-566, 2009 | 154 | 2009 |
| The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1 PA Wender, J DeBrabander, PG Harran, JM Jimenez, MFT Koehler, ... Proceedings of the National Academy of Sciences 95 (12), 6624-6629, 1998 | 149 | 1998 |
| The rational design of potential chemotherapeutic agents: synthesis of bryostatin analogues PA Wender, KW Hinkle, MFT Koehler, B Lippa Medicinal research reviews 19 (5), 388-407, 1999 | 116 | 1999 |
| Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity BE Sleebs, PE Czabotar, WJ Fairbrother, WD Fairlie, JA Flygare, ... Journal of medicinal chemistry 54 (6), 1914-1926, 2011 | 92 | 2011 |
| Tricyclic heterocyclic compounds, compositions and methods of use thereof S Babu, P Bergeron, P Dragovich, HJ Dyke, P Gibbons, S Gradl, E Hanan, ... US Patent 8,461,328, 2013 | 91 | 2013 |
| Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2 M Zak, CA Hurley, SI Ward, P Bergeron, K Barrett, M Balazs, WS Blair, ... Journal of medicinal chemistry 56 (11), 4764-4785, 2013 | 88 | 2013 |
| Development of a potent, specific CDK8 kinase inhibitor which phenocopies CDK8/19 knockout cells MFT Koehler, P Bergeron, EM Blackwood, K Bowman, KR Clark, ... ACS medicinal chemistry letters 7 (3), 223-228, 2016 | 86 | 2016 |
| Disrupting gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA MK Alexander, A Miu, A Oh, M Reichelt, H Ho, C Chalouni, S Labadie, ... Antimicrobial Agents and Chemotherapy 62 (11), 10.1128/aac. 01142-18, 2018 | 83 | 2018 |
| Albumin affinity tags increase peptide half-life in vivo MFT Koehler, K Zobel, MH Beresini, LD Caris, D Combs, BD Paasch, ... Bioorganic & medicinal chemistry letters 12 (20), 2883-2886, 2002 | 79 | 2002 |
| Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2 M Zak, R Mendonca, M Balazs, K Barrett, P Bergeron, WS Blair, C Chang, ... Journal of Medicinal Chemistry 55 (13), 6176-6193, 2012 | 72 | 2012 |
| Design and development of a series of potent and selective type II inhibitors of CDK8 P Bergeron, MFT Koehler, EM Blackwood, K Bowman, K Clark, ... ACS medicinal chemistry letters 7 (6), 595-600, 2016 | 66 | 2016 |
| A new synthetic approach to the C ring of known as well as novel bryostatin analogues PA Wender, MFT Koehler, M Sendzik Organic Letters 5 (24), 4549-4552, 2003 | 61 | 2003 |
| Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres F Cohen, MFT Koehler, P Bergeron, LO Elliott, JA Flygare, MC Franklin, ... Bioorganic & medicinal chemistry letters 20 (7), 2229-2233, 2010 | 55 | 2010 |
