| Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival BC Özdemir, T Pentcheva-Hoang, JL Carstens, X Zheng, CC Wu, ... Cancer cell 25 (6), 719-734, 2014 | 3017 | 2014 |
| Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer X Zheng, JL Carstens, J Kim, M Scheible, J Kaye, H Sugimoto, CC Wu, ... Nature 527 (7579), 525-530, 2015 | 2374 | 2015 |
| Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis S Lovisa, VS LeBleu, B Tampe, H Sugimoto, K Vadnagara, JL Carstens, ... Nature medicine 21 (9), 998-1009, 2015 | 1050 | 2015 |
| Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer JL Carstens, P Correa de Sampaio, D Yang, S Barua, H Wang, A Rao, ... Nature communications 8 (1), 15095, 2017 | 700 | 2017 |
| Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer KM McAndrews, Y Chen, JK Darpolor, X Zheng, S Yang, JL Carstens, B Li, ... Cancer discovery 12 (6), 1580-1597, 2022 | 259 | 2022 |
| Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression B Tampe, U Steinle, D Tampe, JL Carstens, P Korsten, EM Zeisberg, ... Kidney international 91 (1), 157-176, 2017 | 133 | 2017 |
| Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer JL Carstens, S Yang, PC de Sampaio, X Zheng, S Barua, KM McAndrews, ... Cell reports 35 (2), 2021 | 84 | 2021 |
| Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program Y Chen, VS LeBleu, JL Carstens, H Sugimoto, X Zheng, S Malasi, D Saur, ... EMBO molecular medicine 10 (10), e9085, 2018 | 83 | 2018 |
| Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity AM Khaliq, M Rajamohan, O Saeed, K Mansouri, A Adil, C Zhang, A Turk, ... Nature genetics 56 (11), 2455-2465, 2024 | 74 | 2024 |
| FGFR1–WNT–TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma JL Carstens, P Shahi, S Van Tsang, B Smith, CJ Creighton, Y Zhang, ... Cancer research 74 (2), 609-620, 2014 | 49 | 2014 |
| Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch JL Carstens, S Lovisa, R Kalluri The Journal of clinical investigation 124 (4), 1458-1460, 2014 | 43 | 2014 |
| Spatial multiplexing and omics JL Carstens, SN Krishnan, A Rao, AG Sorace, EH Seeley, ... Nature Reviews Methods Primers 4 (1), 54, 2024 | 34 | 2024 |
| Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis P Shahi, D Park, AC Pond, M Seethammagari, SH Chiou, K Cho, ... PloS one 7 (1), e30814, 2012 | 23 | 2012 |
| A pan-RAS inhibitor with a unique mechanism of action blocks tumor growth and induces antitumor immunity in gastrointestinal cancer JB Foote, TE Mattox, AB Keeton, X Chen, FT Smith, K Berry, TW Holmes, ... Cancer Research 85 (5), 956-972, 2025 | 15 | 2025 |
| ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma DSR Bandi, GP Nagaraju, S Sarvesh, JL Carstens, JB Foote, EC Graff, ... Molecular cancer 24 (1), 76, 2025 | 14 | 2025 |
| Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine GP Nagaraju, MS Saddala, JB Foote, AM Khaliq, A Masood, Y Golivi, ... Cell Reports Medicine 6 (1), 2025 | 13 | 2025 |
| A novel Pan-RAS inhibitor with a unique mechanism of action blocks tumor growth in mouse models of GI cancer JB Foote, TE Mattox, AB Keeton, X Chen, FT Smith, KL Berry, T Holmes, ... bioRxiv, 2023.05. 17.541233, 2023 | 11 | 2023 |
| BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis HP Eikesdal, LM Becker, Y Teng, A Kizu, JL Carstens, K Kanasaki, ... Molecular Cancer Research 16 (10), 1568-1578, 2018 | 10 | 2018 |
| Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival (vol 25, pg 719, 2014) BC Oezdemir, T Pentcheva-Hoang, JL Carstens, X Zheng, CC Wu, ... Cancer Cell 28 (6), 831-833, 2015 | 9 | 2015 |
| Epithelial-to-mesenchymal transition drives cancer genomic instability JL Carstens, S Lovisa Journal of Experimental & Clinical Cancer Research 44 (1), 135, 2025 | 4 | 2025 |
