| 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist F Gasparini, K Lingenhöhl, N Stoehr, PJ Flor, M Heinrich, I Vranesic, ... Neuropharmacology 38 (10), 1493-1503, 1999 | 875 | 1999 |
| Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor … DS Lorrain, CS Baccei, LJ Bristow, JJ Anderson, MA Varney Neuroscience 117 (3), 697-706, 2003 | 519 | 2003 |
| 3-[(2-Methyl-1, 3-thiazol-4-yl) ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity NDP Cosford, L Tehrani, J Roppe, E Schweiger, ND Smith, J Anderson, ... Journal of medicinal chemistry 46 (2), 204-206, 2003 | 465 | 2003 |
| Differential distribution of voltage‐gated calcium channel alpha‐2 delta (α2δ) subunit mRNA‐containing cells in the rat central nervous system and the dorsal root … RL Cole, SM Lechner, ME Williams, P Prodanovich, L Bleicher, ... Journal of Comparative Neurology 491 (3), 246-269, 2005 | 263 | 2005 |
| SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5 MA Varney, NDP Cosford, C Jachec, SP Rao, A Sacaan, FF Lin, ... The Journal of pharmacology and experimental therapeutics 290 (1), 170-181, 1999 | 245 | 1999 |
| Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function: I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain K Walker, M Bowes, M Panesar, A Davis, C Gentry, A Kesingland, ... Neuropharmacology 40 (1), 1-9, 2001 | 210 | 2001 |
| (R, S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo F Gasparini, V Bruno, G Battaglia, S Lukic, T Leonhardt, W Inderbitzin, ... The Journal of pharmacology and experimental therapeutics 289 (3), 1678-1687, 1999 | 206 | 1999 |
| Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2 H Schaffhauser, BA Rowe, S Morales, LE Chavez-Noriega, R Yin, ... Molecular pharmacology 64 (4), 798-810, 2003 | 202 | 2003 |
| Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics MA Varney, IV Gereau Current Drug Targets-CNS & Neurological Disorders 1 (3), 283-296, 2002 | 198 | 2002 |
| The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1, 3-thiazol-4-yl) ethynyl] pyridine (MTEP) in rodent models of anxiety CS Busse, J Brodkin, D Tattersall, JJ Anderson, N Warren, L Tehrani, ... Neuropsychopharmacology 29 (11), 1971-1979, 2004 | 196 | 2004 |
| Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone J Brodkin, C Busse, SJ Sukoff, MA Varney Pharmacology Biochemistry and Behavior 73 (2), 359-366, 2002 | 178 | 2002 |
| [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor NDP Cosford, J Roppe, L Tehrani, EJ Schweiger, TJ Seiders, A Chaudary, ... Bioorganic & medicinal chemistry letters 13 (3), 351-354, 2003 | 173 | 2003 |
| Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and-insensitive G-proteins S Phaneuf, GN Europe-Finner, M Varney, IZ MacKenzie, SP Watson, ... Journal of endocrinology 136 (3), 497-NP, 1993 | 168 | 1993 |
| In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H] 3-methoxy-5-(pyridin-2-ylethynyl) pyridine JJ Anderson, MJ Bradbury, DR Giracello, DF Chapman, G Holtz, J Roppe, ... European journal of pharmacology 473 (1), 35-40, 2003 | 166 | 2003 |
| Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity J Roppe, ND Smith, D Huang, L Tehrani, B Wang, J Anderson, J Brodkin, ... Journal of medicinal chemistry 47 (19), 4645-4648, 2004 | 161 | 2004 |
| Selective antagonism of opioid‐induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia BG Oertel, L Felden, PV Tran, MH Bradshaw, MS Angst, H Schmidt, ... Clinical Pharmacology & Therapeutics 87 (2), 204-211, 2010 | 153 | 2010 |
| Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5 LP Daggett, AI Sacaan, M Akong, SP Rao, SD Hess, C Liaw, A Urrutia, ... Neuropharmacology 34 (8), 871-886, 1995 | 147 | 1995 |
| [3H] Methoxymethyl-3-[(2-methyl-1, 3-thiazol-4-yl) ethynyl] pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization JJ Anderson, SP Rao, B Rowe, DR Giracello, G Holtz, DF Chapman, ... The Journal of pharmacology and experimental therapeutics 303 (3), 1044-1051, 2002 | 120 | 2002 |
| Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice MJ Bradbury, U Campbell, D Giracello, D Chapman, C King, L Tehrani, ... The Journal of pharmacology and experimental therapeutics 313 (1), 395-402, 2005 | 112 | 2005 |
| Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge DS Lorrain, H Schaffhauser, UC Campbell, CS Baccei, LD Correa, ... Neuropsychopharmacology 28 (9), 1622-1632, 2003 | 102 | 2003 |
