| The 14-3-3 proteins in regulation of cellular metabolism R Kleppe, A Martinez, SO Døskeland, J Haavik Seminars in cell & developmental biology 22 (7), 713-719, 2011 | 191 | 2011 |
| Regulation of tyrosine hydroxylase by stress‐activated protein kinases K Toska, R Kleppe, CG Armstrong, NA Morrice, P Cohen, J Haavik Journal of neurochemistry 83 (4), 775-783, 2002 | 141 | 2002 |
| Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding I Winge, JA Mckinney, M Ying, CS D'Santos, R Kleppe, PM Knappskog, ... Biochemical Journal 410 (1), 195-204, 2008 | 104 | 2008 |
| Interaction of phosphorylated tyrosine hydroxylase with 14‐3‐3 proteins: evidence for a phosphoserine 40‐dependent association R Kleppe, K Toska, J Haavik Journal of neurochemistry 77 (4), 1097-1107, 2001 | 100 | 2001 |
| Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation MT Bueno-Carrasco, J Cuéllar, MI Flydal, C Santiago, TA Kråkenes, ... Nature communications 13 (1), 74, 2022 | 96 | 2022 |
| Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease K Waløen, R Kleppe, A Martinez, J Haavik Expert opinion on therapeutic targets 21 (2), 167-180, 2017 | 84 | 2017 |
| Does Isoform Diversity Explain Functional Differences in the 14-3-3Protein Family? E Kjarland, TJ Keen, R Kleppe Current pharmaceutical biotechnology 7 (3), 217-223, 2006 | 81 | 2006 |
| The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models HJ MacDonald, R Kleppe, PD Szigetvari, J Haavik Frontiers in Psychiatry 15, 1492126, 2024 | 69 | 2024 |
| ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications SC Homaei, H Barone, R Kleppe, N Betari, A Reif, J Haavik Neuroscience & biobehavioral reviews 132, 838-856, 2022 | 68 | 2022 |
| Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes Ø Halskau, M Ying, A Baumann, R Kleppe, D Rodriguez-Larrea, B Almås, ... Journal of Biological Chemistry 284 (47), 32758-32769, 2009 | 58 | 2009 |
| Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa‐responsive dystonia A Fossbakk, R Kleppe, PM Knappskog, A Martinez, J Haavik Human mutation 35 (7), 880-890, 2014 | 57 | 2014 |
| Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1 L Herfindal, L Myhren, R Kleppe, C Krakstad, F Selheim, J Jokela, ... Molecular Pharmaceutics 8 (2), 360-367, 2011 | 51 | 2011 |
| GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production E Mahootchi, S Cannon Homaei, R Kleppe, I Winge, TA Hegvik, ... Science advances 6 (29), eabb3713, 2020 | 46 | 2020 |
| Exome chip analyses in adult attention deficit hyperactivity disorder T Zayats, KK Jacobsen, R Kleppe, CP Jacob, S Kittel-Schneider, ... Translational psychiatry 6 (10), e923-e923, 2016 | 45 | 2016 |
| Increased microvascular permeability in mice lacking Epac1 (Rapgef3) RK Kopperud, CB Rygh, TV Karlsen, C Krakstad, R Kleppe, EA Hoivik, ... Acta physiologica 219 (2), 441-452, 2017 | 42 | 2017 |
| Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression I Winge, K Teigen, A Fossbakk, E Mahootchi, R Kleppe, F Sköldberg, ... Neurochemistry international 90, 173-184, 2015 | 42 | 2015 |
| Urea-induced denaturation of human phenylalanine hydroxylase R Kleppe, K Uhlemann, PM Knappskog, J Haavik Journal of Biological Chemistry 274 (47), 33251-33258, 1999 | 42 | 1999 |
| Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis G Gausdal, A Wergeland, J Skavland, E Nguyen, F Pendino, N Rouhee, ... Cell Death & Disease 4 (2), e516-e516, 2013 | 39 | 2013 |
| Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription S Huseby, G Gausdal, TJ Keen, E Kjaerland, C Krakstad, L Myhren, ... Cell death & disease 2 (12), e237-e237, 2011 | 36 | 2011 |
| Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: association with YWHAE KK Jacobsen, R Kleppe, S Johansson, T Zayats, J Haavik American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168 …, 2015 | 35 | 2015 |
Jan HaavikUniversity of BergenVerified email at biomed.uib.no
