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| Short-chain fatty acids protect against high-fat diet–induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation G Den Besten, A Bleeker, A Gerding, K van Eunen, R Havinga, ... Diabetes 64 (7), 2398-2408, 2015 | 1256 | 2015 |
| Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids G den Besten, K Lange, R Havinga, TH van Dijk, A Gerding, K van Eunen, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 305 (12 …, 2013 | 704 | 2013 |
| Measuring enzyme activities under standardized in vivo‐like conditions for systems biology K Van Eunen, J Bouwman, P Daran‐Lapujade, J Postmus, AB Canelas, ... The FEBS journal 277 (3), 749-760, 2010 | 220 | 2010 |
| A systems study reveals concurrent activation of AMPK and mTOR by amino acids P Dalle Pezze, S Ruf, AG Sonntag, M Langelaar-Makkinje, P Hall, ... Nature communications 7 (1), 13254, 2016 | 211 | 2016 |
| Protection against the metabolic syndrome by guar gum-derived short-chain fatty acids depends on peroxisome proliferator-activated receptor γ and glucagon-like peptide-1 G den Besten, A Gerding, TH van Dijk, J Ciapaite, A Bleeker, K van Eunen, ... PloS one 10 (8), e0136364, 2015 | 153 | 2015 |
| Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains AB Canelas, N Harrison, A Fazio, J Zhang, JP Pitkänen, J Van Den Brink, ... Nature communications 1 (1), 145, 2010 | 150 | 2010 |
| Testing Biochemistry Revisited: How In Vivo Metabolism Can Be Understood from In Vitro Enzyme Kinetics K van Eunen, JAL Kiewiet, HV Westerhoff, BM Bakker PLoS computational biology 8 (4), e1002483, 2012 | 139 | 2012 |
| Molecular mechanisms of mTOR regulation by stress AM Heberle, MT Prentzell, K Van Eunen, BM Bakker, SN Grellscheid, ... Molecular & cellular oncology 2 (2), e970489, 2015 | 123 | 2015 |
| The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome G den Besten, R Havinga, A Bleeker, S Rao, A Gerding, K van Eunen, ... PloS one 9 (9), e107392, 2014 | 102 | 2014 |
| A model reduction method for biochemical reaction networks S Rao, A der Schaft, K Eunen, BM Bakker, B Jayawardhana BMC systems biology 8 (1), 52, 2014 | 96 | 2014 |
| Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload K van Eunen, SMJ Simons, A Gerding, A Bleeker, G den Besten, ... PLoS computational biology 9 (8), e1003186, 2013 | 93 | 2013 |
| Translational targeted proteomics profiling of mitochondrial energy metabolic pathways in mouse and human samples JC Wolters, J Ciapaite, K Van Eunen, KE Niezen-Koning, A Matton, ... Journal of proteome research 15 (9), 3204-3213, 2016 | 82 | 2016 |
| The importance and challenges of in vivo-like enzyme kinetics K van Eunen, BM Bakker Perspectives in Science 1 (1-6), 126-130, 2014 | 63 | 2014 |
| Simultaneous induction of glycolysis and oxidative phosphorylation during activation of hepatic stellate cells reveals novel mitochondrial targets to treat liver fibrosis N Smith-Cortinez, K van Eunen, J Heegsma, SA Serna-Salas, S Sydor, ... Cells 9 (11), 2456, 2020 | 58 | 2020 |
| The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation ACMF Martines, K Van Eunen, DJ Reijngoud, BM Bakker PLoS computational biology 13 (4), e1005461, 2017 | 56 | 2017 |
| Gene flow between arrhenotokous and thelytokous populations of Venturia canescens (Hymenoptera) MV Schneider, G Driessen, LW Beukeboom, R Boll, K Van Eunen, ... Heredity 90 (3), 260-267, 2003 | 51 | 2003 |
| Metabolic regulation rather than de novo enzyme synthesis dominates the osmo‐adaptation of yeast J Bouwman, J Kiewiet, A Lindenbergh, K van Eunen, M Siderius, ... Yeast 28 (1), 43-53, 2011 | 48 | 2011 |
| Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders K van Eunen, CML Volker-Touw, A Gerding, A Bleeker, JC Wolters, ... BMC biology 14 (1), 107, 2016 | 41 | 2016 |
| Enzyme kinetics for systems biology: When, why and how M Adamczyk, K van Eunen, BM Bakker, HV Westerhoff Methods in enzymology 500, 233-257, 2011 | 39 | 2011 |
