| Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome H Sharif, L Wang, WL Wang, VG Magupalli, L Andreeva, Q Qiao, ... Nature 570 (7761), 338-343, 2019 | 828 | 2019 |
| The NLRP3 inflammasome: Mechanism of action, role in disease and therapies L Wang, AV Hauenstein Molecular aspects of medicine 76, 100889, 2020 | 424 | 2020 |
| HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation VG Magupalli, R Negro, Y Tian, AV Hauenstein, G Di Caprio, W Skillern, ... Science 369 (6510), eaas8995, 2020 | 389 | 2020 |
| A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation S Polley, DB Huang, AV Hauenstein, AJ Fusco, X Zhong, D Vu, ... PLoS biology 11 (6), e1001581, 2013 | 136 | 2013 |
| K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair P Liu, W Gan, S Su, AV Hauenstein, T Fu, B Brasher, C Schwerdtfeger, ... Science signaling 11 (533), eaar8133, 2018 | 135 | 2018 |
| The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines AV Hauenstein, L Zhang, H Wu Current opinion in structural biology 31, 75-83, 2015 | 83 | 2015 |
| X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster CF Lee, AV Hauenstein, JK Fleming, WC Gasper, V Engelke, B Sankaran, ... Structure 19 (3), 397-408, 2011 | 49 | 2011 |
| Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics J Sadek, MG Wuo, D Rooklin, A Hauenstein, SH Hong, A Gautam, H Wu, ... Nature Communications 11 (1), 1786, 2020 | 45 | 2020 |
| Evidence for M1-linked polyubiquitin-mediated conformational change in NEMO AV Hauenstein, G Xu, V Kabaleeswaran, H Wu Journal of molecular biology 429 (24), 3793-3800, 2017 | 42 | 2017 |
| Probing kinase activation and substrate specificity with an engineered monomeric IKK2 AV Hauenstein, WE Rogers, JD Shaul, DB Huang, G Ghosh, T Huxford Biochemistry 53 (12), 2064-2073, 2014 | 13 | 2014 |
| Full wwPDB X-ray Structure Validation Report i H Wang, E Gouaux Word wide protein data bank, 2009 | 2 | 2009 |
| Crystal Structure of Drosophila Unc-45, a Putative Myosin Chaperone CF Lee, AV Hauenstein, WC Gasper, B Sankaran, SI Bernstein, T Huxford Biophysical Journal 98 (3), 34a, 2010 | 1 | 2010 |
| Monomeric IKK: Probing activation and specificty WE Rogers, A Hauenstein, T Huxford ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014 | | 2014 |
| A Structural Basis for IkB Kinase 2 Activation Via Oligomerization-Dependent Trans S Polley, DB Huang, AV Hauenstein, AJ Fusco, X Zhong | | 2013 |
| The Role of Oligomerization in Human IKK2 Activation as Revealed by Structural and Biophysical Studies A Van Hauenstein University of California, San Diego, 2013 | | 2013 |
Hao WuAsa and Patricia Springer Professor, Boston Children's Hospital and Harvard Medical SchoolVerified email at crystal.harvard.edu
