| Chimeric peptidomimetic antibiotics against Gram-negative bacteria A Luther, M Urfer, M Zahn, M Müller, SY Wang, M Mondal, A Vitale, ... Nature 576 (7787), 452-458, 2019 | 327 | 2019 |
| General structural motifs of amyloid protofilaments N Ferguson, J Becker, H Tidow, S Tremmel, TD Sharpe, G Krause, ... Proceedings of the National Academy of Sciences 103 (44), 16248-16253, 2006 | 209 | 2006 |
| Targeting protein–protein interactions and fragment-based drug discovery E Valkov, T Sharpe, M Marsh, S Greive, M Hyvönen Fragment-Based Drug Discovery and X-Ray Crystallography, 145-179, 2011 | 135 | 2011 |
| Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family N Ferguson, TD Sharpe, PJ Schartau, S Sato, MD Allen, CM Johnson, ... Journal of molecular biology 353 (2), 427-446, 2005 | 123 | 2005 |
| FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile S Kleeb, L Pang, K Mayer, D Eris, A Sigl, RC Preston, P Zihlmann, ... American Chemical Society, 2015 | 111 | 2015 |
| Distinguishing between cooperative and unimodal downhill protein folding F Huang, S Sato, TD Sharpe, L Ying, AR Fersht Proceedings of the National Academy of Sciences 104 (1), 123-127, 2007 | 109 | 2007 |
| Rapid amyloid fiber formation from the fast-folding WW domain FBP28 N Ferguson, J Berriman, M Petrovich, TD Sharpe, JT Finch, AR Fersht Proceedings of the National Academy of Sciences 100 (17), 9814-9819, 2003 | 105 | 2003 |
| One-state downhill versus conventional protein folding N Ferguson, PJ Schartau, TD Sharpe, S Sato, AR Fersht Journal of molecular biology 344 (2), 295-301, 2004 | 99 | 2004 |
| Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger cyclic di-GMP A Sundriyal, C Massa, D Samoray, F Zehender, T Sharpe, U Jenal, ... Journal of Biological Chemistry 289 (10), 6978-6990, 2014 | 97 | 2014 |
| Sensitive, high throughput detection of proteins in individual, surfactant-stabilized picoliter droplets using nanoelectrospray ionization mass spectrometry CA Smith, X Li, TH Mize, TD Sharpe, EI Graziani, C Abell, WTS Huck Analytical chemistry 85 (8), 3812-3816, 2013 | 94 | 2013 |
| A DNA‐Encoded Chemical Library Incorporating Elements of Natural Macrocycles CJ Stress, B Sauter, LA Schneider, T Sharpe, D Gillingham Angewandte Chemie International Edition 58 (28), 9570-9574, 2019 | 91 | 2019 |
| CDKL family kinases have evolved distinct structural features and ciliary function P Canning, K Park, J Gonçalves, C Li, CJ Howard, TD Sharpe, LJ Holt, ... Cell reports 22 (4), 885-894, 2018 | 89 | 2018 |
| Syrosingopine sensitizes cancer cells to killing by metformin D Benjamin, M Colombi, SK Hindupur, C Betz, HA Lane, ... Science advances 2 (12), e1601756, 2016 | 88 | 2016 |
| Structural basis for Par-4 recognition by the SPRY domain-and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 P Filippakopoulos, A Low, TD Sharpe, J Uppenberg, S Yao, Z Kuang, ... Journal of molecular biology 401 (3), 389-402, 2010 | 82 | 2010 |
| A molecular mechanism of chaperone-client recognition L He, T Sharpe, A Mazur, S Hiller Science advances 2 (11), e1601625, 2016 | 80 | 2016 |
| A high-resolution description of β 1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR A Grahl, LA Abiko, S Isogai, T Sharpe, S Grzesiek Nature communications 11 (1), 1-13, 2020 | 61 | 2020 |
| The dynamic dimer structure of the chaperone Trigger Factor L Morgado, BM Burmann, T Sharpe, A Mazur, S Hiller Nature communications 8 (1), 1-11, 2017 | 60 | 2017 |
| A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, ... Cell chemical biology 28 (6), 835-847. e5, 2021 | 57 | 2021 |
| Analysis of'downhill'protein folding N Ferguson, TD Sharpe, CM Johnson, PJ Schartau, AR Fersht Nature 445 (7129), E14-E15, 2007 | 54 | 2007 |
| Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16 SE Dixon-Clarke, SN Shehata, T Krojer, TD Sharpe, F von Delft, ... Biochemical Journal 474 (5), 699-713, 2017 | 49 | 2017 |
