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WO2011053790A3 - Assay of closely linked genetic targets in fetal diagnosis - Google Patents

Assay of closely linked genetic targets in fetal diagnosis Download PDF

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Publication number
WO2011053790A3
WO2011053790A3 PCT/US2010/054728 US2010054728W WO2011053790A3 WO 2011053790 A3 WO2011053790 A3 WO 2011053790A3 US 2010054728 W US2010054728 W US 2010054728W WO 2011053790 A3 WO2011053790 A3 WO 2011053790A3
Authority
WO
WIPO (PCT)
Prior art keywords
assay
closely linked
genetic targets
linked genetic
fetal diagnosis
Prior art date
Application number
PCT/US2010/054728
Other languages
French (fr)
Other versions
WO2011053790A2 (en
Inventor
Bernhard Georg Zimmermann
Marc Unger
Original Assignee
Fluidigm Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidigm Corporation filed Critical Fluidigm Corporation
Publication of WO2011053790A2 publication Critical patent/WO2011053790A2/en
Publication of WO2011053790A3 publication Critical patent/WO2011053790A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods for detecting chromosomal aneuploidy of a specified chromosome or chromosome region are provided. Also provided are methods for genetic analysis of heterogeneously sized chromosomal DNA fragments. The methods are useful for non-invasive prenatal diagnosis and other genetic analyses.
PCT/US2010/054728 2009-10-30 2010-10-29 Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis WO2011053790A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25651409P 2009-10-30 2009-10-30
US25652209P 2009-10-30 2009-10-30
US61/256,522 2009-10-30
US61/256,514 2009-10-30

Publications (2)

Publication Number Publication Date
WO2011053790A2 WO2011053790A2 (en) 2011-05-05
WO2011053790A3 true WO2011053790A3 (en) 2011-07-07

Family

ID=43923002

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/054728 WO2011053790A2 (en) 2009-10-30 2010-10-29 Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis

Country Status (1)

Country Link
WO (1) WO2011053790A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
CN103884698B (en) 2004-06-07 2017-04-12 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
WO2006060748A2 (en) 2004-12-03 2006-06-08 California Institute Of Technology Microfluidic sieve valves
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
WO2008067552A2 (en) 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
CN102165076B (en) 2008-07-25 2014-07-09 弗卢丁公司 Method and system for manufacturing integrated fluidic chips
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
CN107312844B (en) 2009-11-06 2021-01-22 香港中文大学 Size-based genomic analysis
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
EP2707507B1 (en) 2011-05-09 2017-11-01 Fluidigm Corporation Probe based nucleic acid detection
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US20170211143A1 (en) 2014-07-25 2017-07-27 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
CN107771221B (en) 2015-02-10 2021-11-02 香港中文大学 Mutation Detection for Cancer Screening and Fetal Analysis
CN105039571B (en) * 2015-08-28 2018-12-07 博奥生物集团有限公司 The quality-control product of chromosome aneuploid (T21, T18, T13) detection kit and its application
TWI874916B (en) 2016-10-24 2025-03-01 美商格瑞爾有限責任公司 Methods and systems for tumor detection
DK3574108T3 (en) 2017-01-25 2024-09-16 Univ Hong Kong Chinese DIAGNOSTIC USE USING NUCLEIC ACID FRAGMENTS
CN106967796A (en) * 2017-03-16 2017-07-21 中国科学院南海海洋研究所 A kind of method that rapid batchization determines aquatic animal genome ploidy
ES2959360T3 (en) 2017-07-26 2024-02-23 Univ Hong Kong Chinese Improving cancer screening using acellular viral nucleic acids
WO2019067567A1 (en) * 2017-09-26 2019-04-04 Juno Diagnostics, Inc. Devices, systems and methods for biomarker analysis
CA3080117A1 (en) 2017-10-27 2019-05-02 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
EP4612288A1 (en) * 2022-11-02 2025-09-10 Phase Scientific International, Ltd. Methods for isolating target analytes from biological samples using atps and solid phase media

Citations (6)

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WO2007044091A2 (en) * 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US20090069194A1 (en) * 2007-09-07 2009-03-12 Fluidigm Corporation Copy number variation determination, methods and systems
US20090087847A1 (en) * 2007-07-23 2009-04-02 The Chinese University Of Hong Kong Determining a nucleic acid sequence imbalance
US20090170114A1 (en) * 2006-02-02 2009-07-02 The Board Of Trustees Of The Leland Stanford Junior University Non-Invasive Fetal Genetic Screening by Digital Analysis
US20100203538A1 (en) * 2009-01-28 2010-08-12 Fluidigm Corporation Determination of copy number differences by amplification

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
WO2007044091A2 (en) * 2005-06-02 2007-04-19 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20090170114A1 (en) * 2006-02-02 2009-07-02 The Board Of Trustees Of The Leland Stanford Junior University Non-Invasive Fetal Genetic Screening by Digital Analysis
US20090087847A1 (en) * 2007-07-23 2009-04-02 The Chinese University Of Hong Kong Determining a nucleic acid sequence imbalance
US20090069194A1 (en) * 2007-09-07 2009-03-12 Fluidigm Corporation Copy number variation determination, methods and systems
US20100203538A1 (en) * 2009-01-28 2010-08-12 Fluidigm Corporation Determination of copy number differences by amplification

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAJAGOPALAN ET AL.: "Aneuploidy and cancer", NATURE, vol. 432, no. 7015, 18 November 2004 (2004-11-18), pages 338 - 341 *

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Publication number Publication date
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