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WO2009135949A3 - Process for preparing a very high drug load tablet - Google Patents

Process for preparing a very high drug load tablet Download PDF

Info

Publication number
WO2009135949A3
WO2009135949A3 PCT/EP2009/055629 EP2009055629W WO2009135949A3 WO 2009135949 A3 WO2009135949 A3 WO 2009135949A3 EP 2009055629 W EP2009055629 W EP 2009055629W WO 2009135949 A3 WO2009135949 A3 WO 2009135949A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
drug load
high drug
load tablet
tablet
Prior art date
Application number
PCT/EP2009/055629
Other languages
French (fr)
Other versions
WO2009135949A2 (en
Inventor
Giovanni Politi
Erkki Heilakka
Original Assignee
Atacama Labs Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atacama Labs Oy filed Critical Atacama Labs Oy
Publication of WO2009135949A2 publication Critical patent/WO2009135949A2/en
Publication of WO2009135949A3 publication Critical patent/WO2009135949A3/en
Priority to US12/941,314 priority Critical patent/US8951562B2/en
Priority to US14/582,664 priority patent/US9700513B2/en
Priority to US15/625,696 priority patent/US10265272B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides, inter alia, a method for producing a tablet comprising (a) active ingredient in an amount 90.01 -99.99% w/w and (b) one or more excipients in an amount 0.01 -9.99%.
PCT/EP2009/055629 2006-11-10 2009-05-08 Process for preparing a very high drug load tablet WO2009135949A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/941,314 US8951562B2 (en) 2006-11-10 2010-11-08 Method and apparatus or dry granulation
US14/582,664 US9700513B2 (en) 2006-11-10 2014-12-24 Method and apparatus for dry granulation
US15/625,696 US10265272B2 (en) 2006-11-10 2017-06-16 Method and apparatus for dry granulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20080353 2008-05-09
FI20080353A FI20080353A0 (en) 2008-05-09 2008-05-09 Process for preparing a tablet with extra high drug content

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/055630 Continuation WO2009135950A2 (en) 2006-11-10 2009-05-08 Process for preparing a tablet containing excipients

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/055628 Continuation WO2009135948A2 (en) 2006-11-10 2009-05-08 Process for preparing a high drug load tablet

Publications (2)

Publication Number Publication Date
WO2009135949A2 WO2009135949A2 (en) 2009-11-12
WO2009135949A3 true WO2009135949A3 (en) 2010-10-28

Family

ID=39523021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/055629 WO2009135949A2 (en) 2006-11-10 2009-05-08 Process for preparing a very high drug load tablet

Country Status (2)

Country Link
FI (1) FI20080353A0 (en)
WO (1) WO2009135949A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011161689A1 (en) * 2010-06-21 2011-12-29 Suven Nishtaa Pharma Pvt Ltd Imatinib mesilate pharmaceutical tablet
US9750700B2 (en) * 2011-06-22 2017-09-05 Natco Pharma Limited Imatinib mesylate oral pharmaceutical composition and process for preparation thereof
WO2013081044A1 (en) * 2011-11-30 2013-06-06 富山化学工業株式会社 Tablet containing 1-cyclopropyl-8-(difluoromethoxy)-7-[(1r)-1-methyl-2, 3-dihydro-1h-isoindole-5-yl]-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid methanesulfonic acid hydrate
HK1244265A1 (en) 2014-11-14 2018-09-14 Gemphire Therapeutics Inc. Processes and intermediates for preparing, -dicarboxylic acid-terminated dialkane ethers
RU2018120599A (en) * 2015-11-06 2019-12-09 Джемфир Терапьютикс, Инк. TREATMENT OF MIXED DYSLIPIDEMIA

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1558153A (en) * 1976-03-11 1979-12-19 Ca Minister Nat Defence Granulation of organic dyes
WO1999011261A1 (en) * 1997-08-29 1999-03-11 Dsm N.V. Granules free of excipients
WO1999025343A1 (en) * 1997-11-17 1999-05-27 Gist-Brocades B.V. Granules comprising clavulanate and one or more excipients
WO2000008092A1 (en) * 1998-08-02 2000-02-17 The B.F. Goodrich Company Controlled release polyacrylic acid granules and a process for preparing the same
WO2001082894A2 (en) * 2000-04-27 2001-11-08 Noveon Ip Holdings Corp. Directly compressed solid dosage particles
WO2008056021A2 (en) * 2006-11-10 2008-05-15 Atacama Labs Oy Granules, tablets and granulation
WO2009101258A1 (en) * 2008-02-15 2009-08-20 Atacama Labs Oy Novel pharmaceutical formulation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1558153A (en) * 1976-03-11 1979-12-19 Ca Minister Nat Defence Granulation of organic dyes
WO1999011261A1 (en) * 1997-08-29 1999-03-11 Dsm N.V. Granules free of excipients
WO1999025343A1 (en) * 1997-11-17 1999-05-27 Gist-Brocades B.V. Granules comprising clavulanate and one or more excipients
WO2000008092A1 (en) * 1998-08-02 2000-02-17 The B.F. Goodrich Company Controlled release polyacrylic acid granules and a process for preparing the same
WO2001082894A2 (en) * 2000-04-27 2001-11-08 Noveon Ip Holdings Corp. Directly compressed solid dosage particles
WO2008056021A2 (en) * 2006-11-10 2008-05-15 Atacama Labs Oy Granules, tablets and granulation
WO2009101258A1 (en) * 2008-02-15 2009-08-20 Atacama Labs Oy Novel pharmaceutical formulation

Also Published As

Publication number Publication date
FI20080353A0 (en) 2008-05-09
WO2009135949A2 (en) 2009-11-12

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