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WO2009000971A3 - Peptide gacfsiahecga for targeting mtl-mmp - Google Patents

Peptide gacfsiahecga for targeting mtl-mmp Download PDF

Info

Publication number
WO2009000971A3
WO2009000971A3 PCT/FI2008/050386 FI2008050386W WO2009000971A3 WO 2009000971 A3 WO2009000971 A3 WO 2009000971A3 FI 2008050386 W FI2008050386 W FI 2008050386W WO 2009000971 A3 WO2009000971 A3 WO 2009000971A3
Authority
WO
WIPO (PCT)
Prior art keywords
targeting
mmp
gacfsiahecga
mtl
peptide
Prior art date
Application number
PCT/FI2008/050386
Other languages
French (fr)
Other versions
WO2009000971A2 (en
Inventor
Emma PIRILÄ
Juho Suojanen
Timo Sorsa
Tuula Salo
Erkki Koivunen
Original Assignee
Licentia Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Licentia Oy filed Critical Licentia Oy
Publication of WO2009000971A2 publication Critical patent/WO2009000971A2/en
Publication of WO2009000971A3 publication Critical patent/WO2009000971A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to peptid es comprising the amino acid sequence C X1 X 2 X3 X4 X5 X6 C wherein C is cysteine, X1 is Phenylalanine, X2 is Serine, X3 is Isoleusine, X4 is Alanine, X5 is Histidine, X6 is Glutamic acid, or a conservative an alogue of any or each of the amino acids. The peptides are useful as inhibitors of MT1-MMP activity and/or are capable of targeting to a cell or cells ha ving enhanced MT1-MMP activity.
PCT/FI2008/050386 2007-06-25 2008-06-24 A novel peptide WO2009000971A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20075483 2007-06-25
FI20075483A FI20075483A0 (en) 2007-06-25 2007-06-25 New peptide

Publications (2)

Publication Number Publication Date
WO2009000971A2 WO2009000971A2 (en) 2008-12-31
WO2009000971A3 true WO2009000971A3 (en) 2009-11-05

Family

ID=38212454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2008/050386 WO2009000971A2 (en) 2007-06-25 2008-06-24 A novel peptide

Country Status (2)

Country Link
FI (1) FI20075483A0 (en)
WO (1) WO2009000971A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691861B2 (en) 2011-04-13 2014-04-08 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
WO2015073538A2 (en) * 2013-11-12 2015-05-21 Echogen, Inc. Interaction with metalloenzymes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010795A2 (en) * 1996-09-10 1998-03-19 The Burnham Institute Tumor homing molecules, conjugates derived therefrom, and methods of using same
US6491894B1 (en) * 1998-08-25 2002-12-10 The Burnham Institute NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010795A2 (en) * 1996-09-10 1998-03-19 The Burnham Institute Tumor homing molecules, conjugates derived therefrom, and methods of using same
US6491894B1 (en) * 1998-08-25 2002-12-10 The Burnham Institute NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "ANNUAL REPORT 2003", UNIVERSITY OF HELSINKI INSTITUTE OF DENTISTRY, 2003, pages 1 - 64, XP002543262, Retrieved from the Internet <URL:http://www.hammas.helsinki.fi/Laitos/Tiedostot/Toimintakertomukset/toimintakertomus2003.pdf> [retrieved on 20090826] *
ANONYMOUS: "Finska Läkaresällskapets forskningsunderstöd 2003", ÅRGÅNG, vol. 163, no. 1, 2003, pages 46 - 57, XP002543263, Retrieved from the Internet <URL:http://www.fls.fi/files/fls/flsh103/FLS_s46_57.pdf> [retrieved on 20090826] *
BJORKLUND M ET AL: "Gelatinase-mediated migration and invasion of cancer cells", BBA - REVIEWS ON CANCER, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1755, no. 1, 25 May 2005 (2005-05-25), pages 37 - 69, XP004903869, ISSN: 0304-419X *
EMMA PIRILÄ: "Expression and role of matrix metalloproteinases and the laminin-5 ?2-chain in wound healing and cell migration", 2003, pages 1 - 92, XP002543266, Retrieved from the Internet <URL:http://ethesis.helsinki.fi/julkaisut/ela/kliin/vk/pirila/expressi.pdf> [retrieved on 20090826] *
HEIKKILA PIA ET AL: "Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides", INTERNATIONAL JOURNAL OF CANCER, vol. 118, no. 9, May 2006 (2006-05-01), pages 2202 - 2209, XP002543267, ISSN: 0020-7136 *
KOIVUNEN E ET AL: "TUMOR TARGETING WITH A SELECTIVE GELATINASE INHIBITOR", NATURE BIOTECHNOLOGY, vol. 17, no. 8, 1 August 1999 (1999-08-01), NATURE PUBLISHING GROUP, NEW YORK, NY, US, pages 768 - 774, XP000941541, ISSN: 1087-0156 *
SORSA T ET AL.: "Anti-invasive properties of GACFSIAHECGA-peptide", 26 August 2009 (2009-08-26), pages 1 - 1, XP002543265, Retrieved from the Internet <URL:http://www.hus.fi/?Path=59%3B404%3B22990%3B9907%3B9908%3B23643%3B23791%3B24528> [retrieved on 20090826] *
SORSA T ET AL.: "Characterization of anti-invasive properties of GACFSIAHECGA-peptide", 26 August 2009 (2009-08-26), pages 1 - 1, XP002543264, Retrieved from the Internet <URL:http://www.hus.fi/?Path=59%3B404%3B22990%3B9907%3B9908%3B23643%3B23791%3B24528> [retrieved on 20090826] *
SUOJANEN JUHO ET AL: "Peptide G effectively inhibits cancer cell migration, tumor growth and membrane type-1 matrix metalloproteinase (MT1-MMP) activity", TUMOR BIOLOGY, vol. 27, no. suppl. 2, 16 September 2006 (2006-09-16), KARGER, BASEL, CH, pages 43, XP009121897, ISSN: 1010-4283 *

Also Published As

Publication number Publication date
WO2009000971A2 (en) 2008-12-31
FI20075483A0 (en) 2007-06-25

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