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WO2008034388A8 - Virus-like particles of capsid proteins from human papillomavirus type 16/58/18/6/11 and the method for preparation and the uses thereof - Google Patents

Virus-like particles of capsid proteins from human papillomavirus type 16/58/18/6/11 and the method for preparation and the uses thereof Download PDF

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Publication number
WO2008034388A8
WO2008034388A8 PCT/CN2007/070715 CN2007070715W WO2008034388A8 WO 2008034388 A8 WO2008034388 A8 WO 2008034388A8 CN 2007070715 W CN2007070715 W CN 2007070715W WO 2008034388 A8 WO2008034388 A8 WO 2008034388A8
Authority
WO
WIPO (PCT)
Prior art keywords
hpv
genes
virus
optimized
those
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2007/070715
Other languages
English (en)
French (fr)
Other versions
WO2008034388A1 (fr
Inventor
Xuemei Xu
Ting Zhang
Yufei Xu
Dongsheng Fan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC
Original Assignee
Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC filed Critical Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC
Priority to US12/441,393 priority Critical patent/US8735561B2/en
Publication of WO2008034388A1 publication Critical patent/WO2008034388A1/zh
Anticipated expiration legal-status Critical
Publication of WO2008034388A8 publication Critical patent/WO2008034388A8/zh
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
PCT/CN2007/070715 2006-09-18 2007-09-18 Particules virales de protéines de la capside provenant du papillomavirus humain de type 16/58/18/6/11 et leur procédé de préparation et leurs utilisations Ceased WO2008034388A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/441,393 US8735561B2 (en) 2006-09-18 2007-09-18 Virus-like particles of capsid proteins from human papillomavirus type 16/58/18/6/11 and the method for preparation and the uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200610127387.2 2006-09-18
CN2006101273872A CN101148661B (zh) 2006-09-18 2006-09-18 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途

Publications (2)

Publication Number Publication Date
WO2008034388A1 WO2008034388A1 (fr) 2008-03-27
WO2008034388A8 true WO2008034388A8 (en) 2009-07-09

Family

ID=39200193

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/070715 Ceased WO2008034388A1 (fr) 2006-09-18 2007-09-18 Particules virales de protéines de la capside provenant du papillomavirus humain de type 16/58/18/6/11 et leur procédé de préparation et leurs utilisations

Country Status (3)

Country Link
US (1) US8735561B2 (zh)
CN (1) CN101148661B (zh)
WO (1) WO2008034388A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102321635B (zh) * 2011-09-02 2014-02-26 中国农业科学院生物技术研究所 人类乳头瘤病毒空衣壳粒子的制备方法及其产品
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
EP4218805A1 (en) 2015-07-21 2023-08-02 ModernaTX, Inc. Infectious disease vaccines
AU2016342376A1 (en) 2015-10-22 2018-06-07 Modernatx, Inc. Sexually transmitted disease vaccines
WO2017070624A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Tropical disease vaccines
CN107188932B (zh) * 2016-03-15 2020-02-11 中国医学科学院基础医学研究所 截短型人乳头瘤病毒16型l1蛋白及其应用
CN107188966B (zh) 2016-03-15 2020-03-31 中国医学科学院基础医学研究所 一种乳头瘤病毒嵌合蛋白及其用途
CN107188931B (zh) * 2016-03-15 2020-02-11 中国医学科学院基础医学研究所 截短型人乳头瘤病毒58型l1蛋白及其应用
EP3653638A4 (en) * 2017-07-14 2021-05-05 Xiamen University MUTANT OF L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 16
CN114716560B (zh) 2021-01-04 2024-02-02 中国医学科学院基础医学研究所 一种人乳头瘤病毒18型嵌合蛋白及其用途
CN114716561B (zh) 2021-01-04 2024-03-12 中国医学科学院基础医学研究所 一种人乳头瘤病毒31型嵌合蛋白及其用途
CN114716562B (zh) * 2021-01-04 2023-11-10 中国医学科学院基础医学研究所 一种人乳头瘤病毒58型嵌合蛋白及其用途
AU2022208435A1 (en) 2021-01-18 2023-08-10 Conserv Bioscience Limited Coronavirus immunogenic compositions, methods and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2149970Y (zh) * 1993-02-22 1993-12-22 王雅谷 卧螺离心式固液和液液分离装置
AU4270196A (en) * 1994-10-07 1996-05-02 Lutz Gissmann Papilloma virus-like particles, fusion proteins and process for producing the same
WO2003068163A2 (en) * 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
CN1498963A (zh) * 2002-11-08 2004-05-26 中国医学科学院基础医学研究所 人乳头瘤病毒的病毒样颗粒的生产方法
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
CN1683010A (zh) * 2005-02-06 2005-10-19 哈尔滨医科大学 人乳头瘤病毒型双价病毒样颗粒混合蛋白抗原及构建方法

Also Published As

Publication number Publication date
US20120107350A1 (en) 2012-05-03
US8735561B2 (en) 2014-05-27
CN101148661B (zh) 2013-01-02
CN101148661A (zh) 2008-03-26
WO2008034388A1 (fr) 2008-03-27

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