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WO2007031559A3 - Human coagulation factor vii polypeptides - Google Patents

Human coagulation factor vii polypeptides Download PDF

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Publication number
WO2007031559A3
WO2007031559A3 PCT/EP2006/066373 EP2006066373W WO2007031559A3 WO 2007031559 A3 WO2007031559 A3 WO 2007031559A3 EP 2006066373 W EP2006066373 W EP 2006066373W WO 2007031559 A3 WO2007031559 A3 WO 2007031559A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor vii
coagulation factor
human coagulation
vii polypeptides
inactivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2006/066373
Other languages
French (fr)
Other versions
WO2007031559A2 (en
Inventor
Henrik Oestergaard
Ole Hvilsted Olsen
Katrine Skaarup Larsen
Henning Stennicke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk Health Care AG
Original Assignee
Novo Nordisk Health Care AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Health Care AG filed Critical Novo Nordisk Health Care AG
Priority to EP06793524A priority Critical patent/EP1926817A2/en
Priority to JP2008530534A priority patent/JP5690047B2/en
Priority to US12/066,619 priority patent/US20090055942A1/en
Publication of WO2007031559A2 publication Critical patent/WO2007031559A2/en
Publication of WO2007031559A3 publication Critical patent/WO2007031559A3/en
Anticipated expiration legal-status Critical
Priority to US15/442,075 priority patent/US20170198274A1/en
Priority to US16/576,814 priority patent/US20200010820A1/en
Priority to US17/228,130 priority patent/US20220073895A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to novel human coagulation Factor Vila variants having substitutions of one or more amino acids at a position selected from the group consisting of position 172, 173, 175, 176, 177, 196, 197, 198, 199, 200, 203, 235, 237, 238, 239, 240, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 297, 299, 319, 320, 321, 327, 341, 363, 364, 365, 366, 367, 370, 373 corresponding to amiino acid positions of SEQ ID NO:1 and wherein said Factor VII polypeptide exhibits increased resistance to inactivation by an endogenous inhibitor of said FVII polypeptide relative to wild- type human FVIIa.
PCT/EP2006/066373 2005-09-14 2006-09-14 Human coagulation factor vii polypeptides Ceased WO2007031559A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06793524A EP1926817A2 (en) 2005-09-14 2006-09-14 Human coagulation factor vii polypeptides
JP2008530534A JP5690047B2 (en) 2005-09-14 2006-09-14 Human coagulation factor VII polypeptide
US12/066,619 US20090055942A1 (en) 2005-09-14 2006-09-14 Human Coagulation Factor VII Polypeptides
US15/442,075 US20170198274A1 (en) 2005-09-14 2017-02-24 Human Coagulation Factor VII Polypeptides
US16/576,814 US20200010820A1 (en) 2005-09-14 2019-09-20 Human coagulation factor vii polypeptides
US17/228,130 US20220073895A1 (en) 2005-09-14 2021-04-12 Human coagulation factor vii polypeptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05108433.3 2005-09-14
EP05108433 2005-09-14
EP06117378.7 2006-07-18
EP06117378 2006-07-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/066,619 A-371-Of-International US20090055942A1 (en) 2005-09-14 2006-09-14 Human Coagulation Factor VII Polypeptides
US15/442,075 Continuation US20170198274A1 (en) 2005-09-14 2017-02-24 Human Coagulation Factor VII Polypeptides

Publications (2)

Publication Number Publication Date
WO2007031559A2 WO2007031559A2 (en) 2007-03-22
WO2007031559A3 true WO2007031559A3 (en) 2007-11-08

Family

ID=37865301

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/066373 Ceased WO2007031559A2 (en) 2005-09-14 2006-09-14 Human coagulation factor vii polypeptides

Country Status (4)

Country Link
US (4) US20090055942A1 (en)
EP (2) EP2316930A1 (en)
JP (2) JP5690047B2 (en)
WO (1) WO2007031559A2 (en)

Cited By (2)

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CN102083971B (en) * 2008-04-11 2015-08-05 催化剂生物科学公司 Modified factor VII polypeptide and its application
US11266724B2 (en) 2019-08-15 2022-03-08 Catalyst Biosciences, Inc. Modified factor VII polypeptides for subcutaneous administration and on-demand treatment

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US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7157277B2 (en) * 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
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MXPA04012496A (en) * 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Pegylated factor vii glycoforms.
CN102212019B (en) * 2003-03-14 2015-05-27 蔚所番有限公司 Branched water-soluble polymers and their conjugates
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
SG155777A1 (en) * 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
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US7842661B2 (en) * 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
US20070254834A1 (en) * 2003-11-24 2007-11-01 Defrees Shawn Glycopegylated Erythropoietin
US8633157B2 (en) * 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) * 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
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JP5743368B2 (en) * 2004-01-08 2015-07-01 ラショファーム ゲーエムベーハー O-linked glycosylation of peptides
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WO2006020372A2 (en) * 2004-07-23 2006-02-23 Neose Technologies, Inc. Enzymatic modification of glycopeptides
US8268967B2 (en) * 2004-09-10 2012-09-18 Novo Nordisk A/S Glycopegylated interferon α
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WO2006074279A1 (en) * 2005-01-06 2006-07-13 Neose Technologies, Inc. Glycoconjugation using saccharyl fragments
US9029331B2 (en) * 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (en) 2005-04-08 2010-03-31 Biogenerix Ag Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20110003744A1 (en) * 2005-05-25 2011-01-06 Novo Nordisk A/S Glycopegylated Erythropoietin Formulations
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US20090048440A1 (en) * 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
US20080248959A1 (en) * 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
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RS52845B (en) * 2007-04-03 2013-12-31 Biogenerix Ag TREATMENT PROCEDURES USING GLYCOPEGILATED G-CSF
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JP2010531135A (en) * 2007-06-04 2010-09-24 ノボ ノルディスク アクティーゼルスカブ O-linked glycosylation using N-acetylglucosaminyltransferase
JP5876649B2 (en) * 2007-06-12 2016-03-02 ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ Improved process for producing nucleotide sugars
US7968811B2 (en) * 2007-06-29 2011-06-28 Harley-Davidson Motor Company Group, Inc. Integrated ignition and key switch
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EP2242505A4 (en) * 2008-01-08 2012-03-07 Biogenerix Ag Glycoconjugation of polypeptides using oligosaccharyltransferases
ES2476690T3 (en) 2008-02-27 2014-07-15 Novo Nordisk A/S Factor VIII conjugated molecules
AU2013203608B2 (en) * 2008-04-11 2015-06-25 Catalyst Biosciences, Inc. Factor vii polypeptides that are modified and uses thereof
US9234192B2 (en) 2010-02-16 2016-01-12 Novo Nordisk A/S Conjugated proteins
TWI595004B (en) 2010-11-03 2017-08-11 介控生化科技公司 Modified ninth factor multi-peptide and use thereof
AU2012222366A1 (en) 2011-03-02 2013-08-01 Novo Nordisk A/S Coagulation factor-targeting to TLT-1 on activated platelets
WO2014060401A1 (en) 2012-10-15 2014-04-24 Novo Nordisk Health Care Ag Coagulation factor vii polypeptides
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Cited By (4)

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CN102083971B (en) * 2008-04-11 2015-08-05 催化剂生物科学公司 Modified factor VII polypeptide and its application
CN105039291A (en) * 2008-04-11 2015-11-11 催化剂生物科学公司 Factor vii polypeptides that are modified and uses thereof
US9476037B2 (en) 2008-04-11 2016-10-25 Catalyst Biosciences, Inc. Factor VII polypeptides that are modified and uses thereof
US11266724B2 (en) 2019-08-15 2022-03-08 Catalyst Biosciences, Inc. Modified factor VII polypeptides for subcutaneous administration and on-demand treatment

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US20200010820A1 (en) 2020-01-09
JP5690047B2 (en) 2015-03-25
WO2007031559A2 (en) 2007-03-22
US20220073895A1 (en) 2022-03-10
US20170198274A1 (en) 2017-07-13
JP2009507508A (en) 2009-02-26
EP2316930A1 (en) 2011-05-04
US20090055942A1 (en) 2009-02-26
EP1926817A2 (en) 2008-06-04
JP2013013409A (en) 2013-01-24

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