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WO2007028341A8 - Nanomicelles servant de medicaments anticancereux a polyethylene phospholipides glycolyles contenant des vinca alcaloides - Google Patents

Nanomicelles servant de medicaments anticancereux a polyethylene phospholipides glycolyles contenant des vinca alcaloides

Info

Publication number
WO2007028341A8
WO2007028341A8 PCT/CN2006/002327 CN2006002327W WO2007028341A8 WO 2007028341 A8 WO2007028341 A8 WO 2007028341A8 CN 2006002327 W CN2006002327 W CN 2006002327W WO 2007028341 A8 WO2007028341 A8 WO 2007028341A8
Authority
WO
WIPO (PCT)
Prior art keywords
micelles
vinca alkaloids
phospholipids
nano micelles
nano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2006/002327
Other languages
English (en)
French (fr)
Other versions
WO2007028341A1 (fr
Inventor
Wei Liang
Min An Lou
Wei Si
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BEIJING DIACRID MEDICAL Tech Co Ltd
Original Assignee
BEIJING DIACRID MEDICAL Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN200510098381A external-priority patent/CN100594902C/zh
Priority claimed from CN2006101128883A external-priority patent/CN101138548B/zh
Application filed by BEIJING DIACRID MEDICAL Tech Co Ltd filed Critical BEIJING DIACRID MEDICAL Tech Co Ltd
Priority to JP2008529454A priority Critical patent/JP2009507049A/ja
Priority to US12/066,066 priority patent/US8765181B2/en
Publication of WO2007028341A1 publication Critical patent/WO2007028341A1/zh
Anticipated expiration legal-status Critical
Publication of WO2007028341A8 publication Critical patent/WO2007028341A8/zh
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/CN2006/002327 2005-09-09 2006-09-08 Nanomicelles servant de medicaments anticancereux a polyethylene phospholipides glycolyles contenant des vinca alcaloides Ceased WO2007028341A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008529454A JP2009507049A (ja) 2005-09-09 2006-09-08 リン脂質のポリエチレングリコール誘導体に包み込まれたビンカアルカロイド系制癌剤のナノミセル製剤
US12/066,066 US8765181B2 (en) 2005-09-09 2006-09-08 Nano anticancer micelles of vinca alkaloids entrapped in polyethylene glycolylated phospholipids

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200510098381.2 2005-09-09
CN200510098381A CN100594902C (zh) 2005-09-09 2005-09-09 聚乙二醇衍生化磷脂包载的长春花生物碱类抗肿瘤药物的纳米胶束制剂
CN2006101128883A CN101138548B (zh) 2006-09-06 2006-09-06 聚乙二醇衍生化磷脂包载的长春瑞滨纳米胶束制剂
CN200610112888.3 2006-09-06

Publications (2)

Publication Number Publication Date
WO2007028341A1 WO2007028341A1 (fr) 2007-03-15
WO2007028341A8 true WO2007028341A8 (fr) 2008-04-17

Family

ID=39284028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2006/002327 Ceased WO2007028341A1 (fr) 2005-09-09 2006-09-08 Nanomicelles servant de medicaments anticancereux a polyethylene phospholipides glycolyles contenant des vinca alcaloides

Country Status (3)

Country Link
US (1) US8765181B2 (zh)
JP (1) JP2009507049A (zh)
WO (1) WO2007028341A1 (zh)

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DK2774608T3 (da) * 2008-06-16 2020-01-13 Pfizer Lægemiddelladede polymere nanopartikler og fremgangsmåder til fremstilling og anvendelse deraf
WO2010005725A2 (en) * 2008-06-16 2010-01-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
EA201100765A1 (ru) 2008-12-15 2012-04-30 Бинд Биосаиэнсис Наночастицы длительной циркуляции для замедленного высвобождения терапевтических средств
US20110223201A1 (en) * 2009-04-21 2011-09-15 Selecta Biosciences, Inc. Immunonanotherapeutics Providing a Th1-Biased Response
WO2010138193A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
US8357401B2 (en) 2009-12-11 2013-01-22 Bind Biosciences, Inc. Stable formulations for lyophilizing therapeutic particles
US9295649B2 (en) 2009-12-15 2016-03-29 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
WO2011150264A2 (en) 2010-05-26 2011-12-01 Selecta Biosciences, Inc. Synthetic nanocarrier combination vaccines
CA2830948A1 (en) * 2011-03-25 2012-10-04 Selecta Biosciences, Inc. Osmotic mediated release synthetic nanocarriers
CA2843274A1 (en) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses
MY179194A (en) 2012-09-17 2020-10-30 Pfizer Process for preparing therapeutic nanoparticles
CN103720653B (zh) * 2012-10-12 2016-01-20 天津药物研究院 一种长春瑞滨亚微乳注射液及其制备方法
US10220095B2 (en) 2013-03-15 2019-03-05 Taiwan Liposome Company, Ltd Controlled drug release liposome compositions and methods thereof
AP2016009494A0 (en) 2014-03-14 2016-10-31 Pfizer Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
CN104288758B (zh) * 2014-10-22 2018-04-03 中国科学院生物物理研究所 聚乙二醇化磷脂为载体的胶束多肽疫苗
US20200338082A1 (en) * 2017-12-28 2020-10-29 Scott ACKLER Formulations, systems, and methods for therapeutic treatment
CN111617035B (zh) * 2020-06-15 2022-06-14 天津力博生物科技有限公司 一种聚乙二醇衍生物形成的胶束在紫杉醇或其衍生物中的用途
CN111759803B (zh) * 2020-06-15 2022-06-14 天津力博生物科技有限公司 一种聚乙二醇衍生物形成的胶束在本维莫德中的用途
CN111973795B (zh) * 2020-07-10 2022-08-02 中国人民解放军总医院 一种肝癌切除术后止血及防癌复发敷料
CN113209304B (zh) * 2021-05-19 2023-01-24 复旦大学附属金山医院(上海市金山区核化伤害应急救治中心、上海市金山区眼病防治所) 一种螯合钙自组装纳米粒子及其制备方法和应用
CN116172980A (zh) * 2022-12-28 2023-05-30 上海百心安生物技术股份有限公司 一种核壳结构胶束微球及其制备方法和应用
CN116983325A (zh) * 2023-08-18 2023-11-03 首都儿科研究所 共同活性成分在制备用于治疗肿瘤的药物中的应用
CN118717669A (zh) * 2024-08-12 2024-10-01 中国药科大学 一种均一超细的聚合物纳米胶束及其制备方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
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US20050003008A1 (en) * 1997-09-23 2005-01-06 Natalya Rapoport Method of in vivo drug targeting to solid tumors via acoustically triggered drug delivery in polymeric micelles
WO2000062813A2 (en) * 1999-04-20 2000-10-26 The University Of British Columbia Cationic peg-lipids and methods of use
US7217770B2 (en) 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
WO2003018018A2 (en) * 2001-08-24 2003-03-06 Neopharm, Inc. Vinorelbine compositions and methods of use
US7850990B2 (en) * 2001-10-03 2010-12-14 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
JP2003342168A (ja) * 2002-05-24 2003-12-03 Nano Career Kk 注射用薬物含有ポリマーミセル製剤の製造方法
WO2004098569A1 (en) * 2003-04-18 2004-11-18 Northeastern University Micelle delivery system loaded with a pharmaceutical agent
US20050053668A1 (en) * 2003-08-21 2005-03-10 Southwest Research Institute Skeletally targeted nanoparticles
CN100350912C (zh) * 2004-08-27 2007-11-28 中国科学院生物物理研究所 一种新型的聚乙二醇衍生化磷脂包载前列腺素e1的纳米微粒给药系统

Also Published As

Publication number Publication date
JP2009507049A (ja) 2009-02-19
US20090053293A1 (en) 2009-02-26
WO2007028341A1 (fr) 2007-03-15
US8765181B2 (en) 2014-07-01

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