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WO2003050087A2 - Novel herbicides - Google Patents

Novel herbicides Download PDF

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Publication number
WO2003050087A2
WO2003050087A2 PCT/EP2002/014006 EP0214006W WO03050087A2 WO 2003050087 A2 WO2003050087 A2 WO 2003050087A2 EP 0214006 W EP0214006 W EP 0214006W WO 03050087 A2 WO03050087 A2 WO 03050087A2
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Prior art keywords
alkyl
hydrogen
substituted
halogen
substituents
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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PCT/EP2002/014006
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French (fr)
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WO2003050087A3 (en
Inventor
Jürgen Schaetzer
Jean Wenger
Sabine Berteina-Raboin
André Stoller
Kurt Nebel
Roger Graham Hall
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Syngenta Participations AG
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Syngenta Participations AG
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Priority to US10/497,976 priority Critical patent/US20050107437A1/en
Priority to BR0214891-9A priority patent/BR0214891A/en
Priority to AU2002366620A priority patent/AU2002366620A1/en
Priority to CA002468445A priority patent/CA2468445A1/en
Priority to EP02804585A priority patent/EP1453807A2/en
Publication of WO2003050087A2 publication Critical patent/WO2003050087A2/en
Publication of WO2003050087A3 publication Critical patent/WO2003050087A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Definitions

  • the present invention relates to novel, herbicidally active pyridylalkynes, to processes for their preparation, to compositions comprising those compounds, and to their use in controlling weeds, especially in crops of useful plants, or in inhibiting plant growth.
  • Phenyl- and pyridyl-alkynes having herbicidal action are described, for example, in JP-A-11 147 866, WO 01/55066, WO 02/28182 and PCT Application No. EP02/08878.
  • the present invention accordingly relates to compounds of formula I
  • phenyl which may in turn be substituted by one or more halogen, d-C 4 alkyl, C C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 , C C 4 alkylthio, C C 4 alkyl- sulfinyl or C C 4 alkylsulfonyl substituents; or two adjacent Ri together form a d-C 7 alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by d-C 6 alkyl or d-C 6 alkoxy, the total number of ring atoms being at least 5 and at most 9; or two adjacent R ⁇ together form a C 2 -C 7 alkenylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by d-C 6 alkyl or d-C 6 alkoxy, the total number of ring atoms being at least 5
  • R 3 and R are each independently of the other hydrogen, halogen, -CN, d-C 4 alkyl or d-C - alkoxy; or
  • R 3 and R together are C 2 -C 5 alkylene
  • R 5 is hydrogen, C C 8 alkyl or -C(O)C ⁇ -C 8 alkyl
  • R 6 is hydrogen, C C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl; wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C 4 aIkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, C C 4 alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or
  • R 5 and R 6 together are a C 2 -C 5 alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
  • R 7 is hydrogen, C C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or is d-C 8 alkyl, C 3 -C 8 alkenyl or
  • R 8 is hydrogen or d-C 8 alkyl
  • R 9 is hydrogen or d-C 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH,
  • R 9 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyI, d-C 4 alkoxy, -CN, -NO 2) d-C 4 alkylthio, C C 4 alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or
  • R 8 and R 9 together are C 2 -C 5 alkylene
  • R 10 is hydrogen, C C 4 alkyl, C C 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • Rn is hydrogen, C C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, d-C 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • R 12 is hydrogen, C C 4 aIkyl, C C 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 13 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl; or
  • R 13 is phenyl or phenyl-d-C 6 alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C 4 alkyl, C C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 , d-C 8 alkyh:hio, d-C 8 alkylsulfinyl or C ⁇ -C 8 alkylsulfonyl substituents, or R 13 is d-C 8 alkyl substituted by one or more halogen, -CN, d-C 6 alkylamino, di(d-C 6 alkyl)- amino or C ⁇ -C 4 alkoxy substituents;
  • R 14 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or is C Csalkyl substituted by one or more halogen, -CN or C C 4 alkoxy substituents;
  • R 15 , R 16 and R 17 are each independently of the others C Csalkyl, C 3 -C 8 alkenyl or C 3 -C 8 - alkynyl, or C C 8 alkyl substituted by one or more halogen, -CN or C C 4 alkoxy substituents;
  • R 18 is hydrogen or d-C 8 alkyl
  • R 19 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C alkyl, d-C 4 haloalkyl, d-C 4 - alkoxy, -CN, -NO 2 , C C 4 alkylthio, d-C 4 alkylsulfinyl or CrC 4 alkylsuIfonyl substituents; or
  • R ⁇ 8 and R ⁇ 9 together are a C 2 -C 5 alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
  • R 2 o is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 - alkoxy, -CN, -NO 2 , d-dalkylthio, CrC 4 alkylsulfinyl or CrC 4 alkylsulfonyl substituents;
  • R 21 is hydrogen or d-C 8 alkyl
  • R 22 is hydrogen or CrC 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, C C 8 - alkoxycarbonyl or -CN substituents, or
  • R 22 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, d-C 4 alkylsulfinyl or CrC 4 alkylsulfonyl substituents; or
  • R 21 and R 22 together are C 2 -C 5 alkylene
  • R 23 is hydrogen, d-C 4 alkyl, d-C haloalkyl or C 3 -C 6 cycloaIkyl;
  • R 24 is hydrogen, CrC 4 alkyl, d-C 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 25 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, d-C 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • R 26 is hydrogen or d-C 8 alkyl
  • R 27 is hydrogen or d-C 8 alkyl, or is CrC 8 alkyl substituted by one or more -COOH, C C 8 - alkoxycarbonyl or -CN substituents, or
  • R 27 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 aIkyl, d-C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 , d-C alkylthio, d-C 4 alkylsulfinyl or d-C alkylsulfonyl substituents; or
  • R 26 and R 27 together are C 2 -C 5 alkylene
  • R 28 is hydrogen or d-C 8 alkyl
  • R 29 and R 30 are each independently of the other hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or
  • R 31 and R 32 are each independently of the other CrC 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or C ⁇ -C 8 alkyl substituted by one or more halogen, -CN or d-C 4 alkoxy substituents;
  • R 2 is a 5- to 7-membered heterocyclic ring system, which may be aromatic or partially or fully saturated and may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C 4 alkyl, C C haloalkyl, hydroxy-d-C 4 alkyl, d-C alkoxy, d-C alkoxy- d-C 4 alkyl, -CN, -NO 2 , d-C 6 alkylthio, C r C 6 alkylsulfinyl or d-C 6 alkylsulfonyl substituents;
  • R 33 is hydrogen or d-C 8 alkyl; and
  • R 34 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 - alkoxy, -CN, -NO 2 , d-C 4 alkylthio, C C 4 alkylsulfinyl or d-C alkylsulfonyl substituents; or R 33 and R JM together are a C 2 -C 5 alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
  • R 35 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or is C C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl substituted by one or more halogen, d-C 4 alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 halo- alkyl, C C 4 alkoxy, -CN, -NO 2) d-C 4 alkylthio, d-C 4 alkylsulfinyl or d-C 4 alkylsulfonyl substituents;
  • R 36 is hydrogen or CrC 8 alkyl
  • R 37 is hydrogen or d-C 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, d-C 8 - alkoxycarbonyl or -CN substituents, or
  • R 37 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C 4 alkyl, C C 4 haloalkyl, C ⁇ -C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, d-C alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or R 36 and R 37 together are C 3 -C 5 alkylene; R 38 is hydrogen, C C 4 alkyl, d-C 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 39 is hydrogen, C C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, C C 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • R 40 is hydrogen, C C 4 alkyl, d-C 4 haloalkyl, d-C 8 alkylthio, -C(O)-C(O)OC C 4 alkyl or C 3 -C 6 - cycloalkyl;
  • R 41 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, CrC 6 alkoxy-CrC 6 aikyl, d-C 8 alkyl- carbonyl, CrC 8 alkoxycarbonyl, C 3 -C 8 alkenyloxycarbonyl, CrC 6 alkoxy-CrC 6 alkoxycarbonyl, d-Cealkylthio-d-
  • R 41 is phenyl or phenyl-CrC 6 alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C 4 alkyl, C C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 or -S(O) 2 C C 8 alkyl substituents, or
  • R 4 ⁇ is d-C 8 alkyl substituted by one or more halogen, -COOH, CrC 8 alkoxycarbonyl,
  • R 42 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or is C C 8 alkyl substituted by one or more halogen, -CN or C C 4 alkoxy substituents;
  • R ⁇ and R ⁇ j are each independently of the other d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or d-C 8 alkyl substituted by one or more halogen, -CN or C C 4 alkoxy substituents;
  • R ⁇ is d-C 8 alkyl, CrC 8 alkyl substituted by one or more halogen, -CN or d-C 4 alkoxy substituents, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or
  • R 45 is phenyl, it being possible for the phenyl ring to be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 8 aIkylthio, C C 8 alkylsulfinyl or d-
  • R ⁇ is hydrogen, CrC 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl or CrC 4 haloalkyl;
  • R 47 is hydrogen, d-C 8 alkyl, d-C 4 alkoxy, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or is CrC 8 alkyl substituted by one or more halogen, -CN, d-C 4 alkoxy, d-C 8 alkoxycarbonyl, -NH 2 , C C 4 - alkylamino, di(CrC alkyl)amino, -NR ⁇ COR ⁇ , -NR 50 SO 2 R 51 or -NR 52 CO 2 R 53 substituents, or
  • R 47 is phenyl or benzyl, each of which may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 , C C 4 alkylthio, C C 4 alkylsulfinyl or d-C alkylsulfonyl substituents; p is 0 or 1 ; ⁇ , R 4 9 > R ⁇ o, R5i > R5 2 and R 53 are each independently of the others hydrogen, d-C 8 alkyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic radicals in turn to be substituted by one or more halogen, d-C 8 alkyl, d-C 4 haloalkyl, d-C alkoxy, d-C 4 alkylamino, di(d-C 4 alkyl)amino,
  • R ⁇ and R 55 are each independently of the other hydrogen, d-C 8 alkyl or phenyl, which may in turn be substituted by one or more halogen, C C 4 alkyl, d-C haloalkyl, C C 4 aIkoxy, -CN,
  • R 56 is hydrogen, CrC 8 alkyl, d-C 4 haloalkyl, C r C 4 alkoxy, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl or benzyl, it being possible for benzyl in turn to be substituted by one or more halogen, d-C 4 alkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 8 alkylthio, C C 8 alkylsulfinyl or d-C 8 alkylsulfonyl substituents;
  • R 57 is d-C 8 alkyl, C C 4 haloalkyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic rings to be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, d-C 4 alkylamino, di(C C 4 alkyl)amino, -NH 2 , -CN, -NO 2 , CrC 4 alkylthio, d-C 4 alkylsulfinyl or d-C 4 alkyIsulfonyl substituents;
  • R 58 and R 59 are each independently of the other d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic rings
  • R 60 and R 6 ⁇ are each independently of the other hydrogen or d-C 6 alkyl;
  • R 62 , R 63 and R M are each independently of the others hydrogen or C C 8 alkyl, or R 63 and R 64 together form a C 2 -C 5 alkylene bridge;
  • Res, ee, Re 7 , Res, eg an R 70 are each independently of the others hydrogen or d-C 8 alkyl, or
  • R 72 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , CrC 4 alkylthio, d-C 4 alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or
  • R 71 and R 72 together are a C 2 -C 5 alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
  • R 73 is hydrogen, C C 8 aIkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, or is d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl substituted by one or more halogen, d-C 4 alkoxy or phenyl substituents, it being possible for phenyl in turn to be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 , C C 4 alkylthio, C r C 4 alkylsulfinyl or C r C 4 alkyl- sulfonyl substituents; R 74 is hydrogen or d-C 8 alkyl;
  • R 75 is hydrogen, d-C 8 alkyl or C 3 -C 7 cycloalkyl, or is d-C 8 alkyl substituted by one or more -COOH, CrC 8 alkoxycarbonyl, CrC 6 alkoxy or -CN substituents; or
  • R 75 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, C C 4 alkoxy, -CN, -NO 2 , CrC 4 alkylthio, d-C alkylsulfinyl or CrC alkylsulfonyl substituents; or R 74 and R 75 together are a C 2 -C 5 alkylene chain, which may be interrupted by an oxygen or sulfur atom;
  • R 76 is hydrogen, d-C 4 alkyl, d-C 4 haloalkyl or C 3 -C 6 cycloalkyl
  • R 77 is hydrogen, C C 4 alkyl, CrC haloalkyl or C 3 -C 6 cycloalkyl
  • R 78 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, C C 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • R 79 is hydrogen or d-C 8 alkyl
  • R 80 is hydrogen or C C 8 alkyl, or is d-C 8 aIkyl substituted by one or more -COOH, C C 8 - alkoxycarbonyl or -CN substituents; or R 80 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, C C 4 aIkylsulfinyl or d-C 4 alkylsulfonyl substituents; or R 79 and R 80 together are C 2 -C 3 alkylene; R 81 is hydrogen or d-C 8 alkyl;
  • R 82 is -Si(d-C 6 alkyl) 3 , C 3 -C 8 alkenyl, C 3 -C 8 alkynyl or d-C 8 alkyl, which is mono- or poly- substituted by halogen, -CN, -NH 2 , CrC 6 alkylamino, di(d-C 6 alkyl)amino or d-C 4 alkoxy;
  • R 83 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl or d-C 8 alkyl, which is mono- or poly- substituted by halogen, -CN, -NH 2 , d-C 6 alkylamino, di(d-C 6 alkyl)amino or CrC 4 alkoxy;
  • R ⁇ , Res and R 86 are each independently of the others d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C
  • R 87 and R 89 are each independently of the other hydrogen, C C 8 alkyl or d-C 8 alkoxy; R 88 is d-C 8 alkyl; Rgo is hydrogen or d-C 8 alkyl; R 91 is d-C alkyl;
  • R 92 and R 93 are each independently of the other d-C 6 alkyl
  • R 94 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, d-C 4 alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , C C 4 alkylthio, C C 4 alkylsulfinyl or C C 4 alkylsulfonyl substituents; R 95 is hydrogen or CrC 8 alkyl;
  • R 96 is hydrogen or CrC 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, C C 8 - alkoxycarbonyl or -CN substituents; or
  • R 96 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, C r C alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or R 95 and R 96 together are C 2 -C 5 alkylene;
  • R 97 and R 98 are each independently of the other hydrogen, C C 4 alkyl, CrC 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 99 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 aIkynyl,»CrC 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • R 100 is hydrogen or C C 8 alkyI;
  • R 10 ⁇ is hydrogen or d-C 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, C C 8 - alkoxycarbonyl or -CN substituents; or R 10 ⁇ is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, d-C 4 alkylsulfinyl or CrC 4 alkylsulfonyl substituents; or
  • R 100 and R 10 ⁇ together are C 2 -C 5 alkylene
  • R 102 is hydrogen or C C 8 alkyl
  • R 103 is hydrogen, d-C 8 alkyl, -Si(CrC 6 alkyl) 3 , C 3 -C 8 alkenyl or C 3 -C 8 alkynyl;
  • R 104 is C C 6 alkyl
  • R 105 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, CrC 4 alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, C C 4 alkyl,
  • R 106 is hydrogen or C C 8 alkyI
  • R 10 is hydrogen or d-C 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, d-C 8 - alkoxycarbonyl or -CN substituents; or
  • R 107 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 ,
  • R 108 and R 07 together are C 2 -C 5 alkylene
  • R 108 is hydrogen, CrC 4 alkyl, C C 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 109 is hydrogen, CrC 4 alkyl, d-C 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 110 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, d-C 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • Rm is hydrogen or C C 8 alkyl
  • R 112 is hydrogen or C C 8 alkyl, or is CrC 8 alkyl substituted by one or more -COOH, d-C 8 - alkoxycarbonyl or -CN substituents; or
  • R 112 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C 4 alkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 aIkylthio, d-C 4 alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or
  • Rm and Rn 2 together are C 2 -C 5 alkylene
  • R 13 is hydrogen or CrC 8 alkyI
  • R 114 is hydrogen, CrC 8 alkyl, -Si(CrC 6 alkyl) 3 , C 3 -C 8 alkenyl or C 3 -C 8 alkynyl;
  • R ⁇ 15 is d-C 6 alkyl
  • R 116 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, CrC alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, d-C 4 alkylsulfinyl or C
  • R 117 is hydrogen or C C 8 alkyl
  • R 118 is hydrogen or C C 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, d-C 8 - alkoxycarbonyl or -CN substituents; or
  • R 118 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C 4 alkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, C C 4 alkylsulfinyl or C C 4 alkylsuIfonyl substituents; or
  • R 117 and R 118 together are C 2 -C 5 alkylene
  • R 119 is hydrogen, C C alkyl, C C 4 haloalkyl or C 3 -C 6 cycloalkyl
  • R 120 is hydrogen, CrC 4 alkyl, CrC 4 haloalkyl or C 3 -C 6 cycloalkyl;
  • R 121 is hydrogen, d-C 8 alkyl, C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, CrC 4 haloalkyl or C 3 -C 6 haloalkenyl;
  • R 122 is hydrogen or d-C 8 alkyl
  • R 123 is hydrogen or d-C 8 alkyl, or is d-C 8 alkyl substituted by one or more -COOH, C C 8 - alkoxycarbonyl or -CN substituents; or
  • R 123 is C 3 -C 8 alkenyl, C 3 -C 8 alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C 4 alkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 , d-C 4 alkylthio, d-C 4 alkylsulfinyl or d-C 4 alkylsulfonyl substituents; or
  • R 122 and R 123 together are C 2 -C 5 alkylene
  • R 124 is hydrogen or CrC 8 alkyl, and to the agrochemically acceptable salts and all stereoisomers and tautomers of the compounds of formula I.
  • substituents that are formed when R 5 and R 6 together or R 18 and R 19 together or R 33 and R 34 together or R 71 and R 72 together or R 74 and R 75 together are a C 2 -C 5 alkylene chain, which may be interrupted by an oxygen or a sulfur atom, are piperidine, morpholine, thiomorpholine and pyrrolidine.
  • heterocyclic ring systems which may be aromatic or partially or fully saturated, in the definition of R 2 are:
  • alkyl groups appearing in the definitions of substituents may be straight-chain or branched and are, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, and also the pentyl, hexyl, heptyl and octyl isomers.
  • Halogen is fluorine, chlorine, bromine and iodine, preferably fluorine and chlorine.
  • Haloalkyl is, for example, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 2-fluoroethyl, 2-chloroethyl, pentafluoroethyl, 1,1-difluoro- 2,2,2-trichloroethyl, 2,2,3,3-tetrafluoroethyl and 2,2,2-trichloroethyl; preferably trichloromethyl, difluorochloromethyl, difluoromethyl, trifluoromethyl and dichlorofluoromethyl.
  • Alkoxy groups have preferably a chain length of from 1 to 6, especially from 1 to 4, carbon atoms.
  • Alkoxy is, for example, methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, and also the pentyloxy and hexyloxy isomers; preferably methoxy and ethoxy.
  • Alkoxy, alkenyl, alkynyl, alkoxyalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, alkylaminoalkoxy, alkoxycarbonyl, alkylcarbonyloxy, alkenylthio, alkenylsulfonyl, alkenylsulfinyl, alkynylsulfonyl, alkynylthio and alkynylsulfinyl groups are derived from the mentioned alkyl radicals.
  • the alkenyl and alkynyl groups can be mono- or poly-unsaturated.
  • Alkenyl is to be understood as being, for example, vinyl, allyl, methallyl, 1 -methylvinyl or but-2-en-1 -yl.
  • Alkynyl is, for example, ethynyl, propargyl, but-2-yn-1 -yl, 2-methylbutyn-2-yl or but-3-yn-2-yl.
  • Alkylthio groups have preferably a chain length of from 1 to 4 carbon atoms.
  • Alkylthio is, for example, methylthio, ethyithio, propylthio, isopropylthio, n-butylthio, isobutylthio, sec-butylthio or tert-butylthio, preferably methylthio and ethyithio.
  • Alkylsulfinyl is, for example, methyl- sulfinyl, ethylsulfinyl, propylsulfinyl, isopropylsulfinyl, n-butylsulfinyl, isobutylsulfinyl, sec- butylsulfinyl or tert-butylsulfinyl; preferably methylsulfinyl or ethylsulfinyl.
  • Alkylsulfonyl is, for example, methylsulfonyl, ethylsulfonyl, propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl or tert-butylsulfonyl; preferably methylsulfonyl or ethylsulfonyl.
  • Alkoxyalkyl groups have preferably from 1 to 6 carbon atoms.
  • Alkoxyalkyl is, for example, methoxymethyl, methoxyethyl, ethoxymethyl, ethoxyethyl, n-propoxymethyl, n-propoxyethyl, isopropoxymethyl or isopropoxyethyl.
  • the cycloalkyl groups preferably have from 3 to 6 ring carbon atoms, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. These cycloalkyl groups may be poly- substituted, especially mono- to tri-substituted, by the substituents mentioned, such as, for example, halogen.
  • haloalkenyl mono- or poly-halo-substituted alkenyl groups are suitable, the halogen being fluorine, chlorine, bromine or iodine, especially fluorine or chlorine, for example 2,2- difluoro-1 -methylvinyl, 3-fluoropropenyl, 3-chloropropenyl, 3-bromopropenyl, 2,3,3- trif luoropropenyl, 2,3,3-trichloropropenyl and 4,4,4-trif luorobut-2-en-1 -yl.
  • the mono-, di- or tri-halo-substituted C 3 -C 6 alkenyl groups preference is given to those having a chain length of from 3 to 5 carbon atoms.
  • Alkylcarbonyl is preferably acetyl or propionyl.
  • Alkoxycarbonyl is, for example, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl or tert- butoxycarbonyl; preferably methoxycarbonyl or ethoxycarbonyl.
  • Alkenyloxycarbonyl is, for example, allyloxycarbonyl, methallyloxycarbonyl, but-2-en-1 -yl- oxycarbonyl, pentenyloxycarbonyl and 2-hexenyloxycarbonyl.
  • Hydroxyalkyl is, for example, hydroxymethyl, 2-hydroxyethyl or 3-hydroxypropyl.
  • Alkylamino is, for example, methylamino, ethylamino, n-propylamino, isopropylamino or the butylamino isomers.
  • Dialkylamino is, for example, dimethylamino, methylethylamino, diethylamino, n-propyl- methylamino, dibutylamino and diisopropylamino. Preference is given to alkylamino groups having a chain length of from 1 to 4 carbon atoms.
  • Phenyl including phenyl as part of a substituent such as benzyl or phenylalkyl, may be in substituted form, in which case the substituents may be in the ortho-, meta- and/or para- position(s). Preferred substituent positions are the ortho- and para-positions to the ring attachment position.
  • R-i for example, the phrases "...cycloalkyl substituted by one or more halogen, -CN, -NO 2 , ... substituents" and “independently of any others is phenyl, which may in turn be substituted by one or more halogen, d-C 4 alkyl, d-C 4 haloalkyl ...
  • substituents are to be understood as meaning that the cycloalkyl and phenyl, respectively, can be mono- or poly-substituted, up to and including per-substituted, especially mono- to tri-substituted, by the mentioned substituents, wherein, for halogen, per-halogenation such as, for example, in the case of pentafluorophenyl may also be a preferred pattern of substitution.
  • R 6 , R 7 , R 9 , R ⁇ 3 , R ⁇ 5 , Rie, R 17 , etc. such as, for example: "...is d-C 8 alkyl, C 3 -C 8 alkenyl or C 3 -C 8 alkynyl substituted by one or more halogen, d-C 4 alkoxy or phenyl substituents ##.
  • R 2 is a 5- to 7-membered heterocyclic ring system ..., it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C 4 alkyl, C C 4 haloalkyl, ... substituents" means that such heterocyclic ring systems may be especially mono- to tri-substituted at the ring carbon atoms by the mentioned substituents.
  • the invention relates also to the salts which the compounds of formula I are able to form especially with amines, alkali metal and alkaline earth metal bases or quaternary ammonium bases. Suitable salt-formers are described, for example, in WO 98/41089.
  • the invention relates also to the salts which the compounds of formula I are able to form with amines, alkali metal and alkaline earth metal bases or quaternary ammonium bases.
  • alkali metal and alkaline earth metal hydroxides as salt formers, special mention should be made of the hydroxides of lithium, sodium, potassium, magnesium and calcium, but especially the hydroxides of sodium and potassium.
  • amines suitable for ammonium salt formation include ammonia as well as primary, secondary and tertiary d-C 8 alkylamines, d-C 4 hydroxyalkylamines and C 2 -C 4 - alkoxyalkylamines, for example methylamine, ethylamine, n-propylamine, isopropylamine, the four butylamine isomers, n-amylamine, isoamylamine, hexylamine, heptylamine, octyl- amine, nonylamine, decylamine, pentadecylamine, hexadecylamine, heptadecylamine, octa- decylamine, methylethylamine, methylisopropylamine, methylhexylamine, methylnonylamine, methylpentadecylamine, methyloctadecylamine, methyl
  • Preferred quaternary ammonium bases suitable for salt formation correspond e.g. to the formula [N(R a R R c Rd )]OH wherein R a , R b , R c and R d are each independently of the others d-C alkyl.
  • Other suitable tetraalkylammonium bases with other anions can be obtained, for example, by anion exchange reactions.
  • R 1 is hydrogen, d-C 8 alkyl, C 3 -C 8 - alkenyl, C 3 -C 8 alkynyl, CrC 6 alkoxy-CrC 6 alkyl, d-C 8 alkylcarbonyl, CrC 8 alkoxycarbonyl,
  • R 4 ⁇ is phenyl or phenyI-d-C 6 alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C 4 alkyl, C C 4 haloalkyl, d-C 4 alkoxy, -CN, -NO 2 or -5(0) 2 0 ! -C 8 alkyl substituents, or
  • R 41 is d-C 8 aIkyl substituted by one or more -COOH, d-C 8 alkoxycarbonyl, CrC 6 alkylamino, di(CrC 6 alkyl)amino or -CN substituents.
  • R 16 are as defined in claim 1 ; and the group occupies the 2-position on the pyridine ring.
  • R 10 is hydrogen or d-C 4 alkyl
  • Rn is hydrogen, d-C 4 alkyl or d-C 4 haloalkyl
  • R 13 is C C 4 alkyl, C 3 - or C 4 -alkenyl, C 3 - or C 4 - alkynyl, or d-C 4 aIkyl substituted by one or more halogen substituents.
  • R 2 is -SCN, -OCN, -N 3 , d-C 4 alkyl; or d-C 4 alkyl mono- or poly-substituted by halogen, -CN, -N 3 or by -SCN.
  • the compounds of formula I can be prepared by methods known per se described, for example, in J. Org. Chem. 62, 1491-1500 (1997); idem 66, 605-608 (2001); idem 62, 2774- 2781 (1997); idem 63, 1109-1118 (1998); Tetrahedron Organic Chemistry 2000 (20), 209- 213; Synlett 2001 (5), 649-651; and K. Sonogashira, Comprehensive Organic Synthesis 1991 , Vol. 3, page 521 , for example by reacting a compound of formula II
  • R 3 and R 4 are as defined for formula I and X-i is O-tosyl, O-mesyl, chlorine, bromine or iodine, to form a compound of formula IV wherein R ⁇ R 3 , R and n are as defined for formula I, and then coupling that compound with a compound of formula V
  • R 2 and m are as defined for formula I and A is a leaving group, e.g. halogen or trifluoromethanesulfonate, in the presence of a palladium catalyst.
  • the compounds of formula I can be obtained, for example, from substituted pyridyl propargyl ethers of formula IV.
  • the pyridyl propargyl ethers of formula IV can be obtained beforehand by etherification of hydroxypyridines of formula II, which are reacted in the presence of a base with acetylene derivatives of formula 111.
  • Such etherification reactions are standard procedures and can be carried out, for example, analogously to J. Chem. Soc, Perkin Trans I, 1979, 2756-2761 ; Synth. Communic. 18, 1111 -1118 (1998); J. Chem. Soc, Chem. Communic. 1990, 297-300; J. Org. Chem. 61 , 4258-4261 (1996); and Synth. Communic. 24, 1367-1379 (1994).
  • the propargyl ethers of formula IV are coupled with substituted pyridine derivatives of formula V under typical Sonogashira conditions (K.Sonogashira, Comprehensive Organic Synthesis 1991 , Vol. 3, page 521 ; J. Org. Chem. 1998 (63), 8551- 8553).
  • Catalyst mixtures that come into consideration are, for example, tetrakistriphenyl- phosphine-palladium or bistriphenylphosphine-palladium dichloride together with copper iodide, and bases that come into consideration (for the reductive elimination) are especially amines, for example triethylamine, diethylamine and diisopropylethylamine.
  • the pyridines of formula V preferably carry a leaving group A, wherein A is, for example, halogen or trifluoromethanesulfonate (Tetrahedron Organic Chemistry 2000 (20), 209-213; J. Org. Chem. 63, 1109-1118 (1998); Tetrahedron Lett. 27(10), 1171 -1174 (1986)).
  • solvents for the Sonogashira reaction there are customarily used ethers, for example tetrahydrofuran or dioxane, chlorinated hydrocarbons, for example chloroform, or dipolar aprotic solvents, for example dimethylformamide or dimethyl sulfoxide, or amines, for example triethylamine or piperidine.
  • the sulfonylation of the alcohol of formula VII is a standard reaction and can be carried out e.g. with a sulfonic acid chloride, for example mesyl chloride or para- toluenesulfonic acid chloride (p-TosCI), in the presence of a tertiary amine, for example triethylamine, or an aromatic amine, for example pyridine, in a solvent, e.g. a chlorinated hydrocarbon, for example carbon tetrachloride or methylene chloride, or an amine, for example pyridine.
  • a solvent e.g. a chlorinated hydrocarbon, for example carbon tetrachloride or methylene chloride, or an amine, for example pyridine.
  • Such reactions are generally known and are described, for example, in J. Org. Chem. 1997 (62), 8987; J. Het. Chem. 1995 (32), 875-882; and Tetrahedron Lett.
  • the halogenation of the alcohol of formula VII can be carried out analogously to standard procedures.
  • the bromination is carried out with carbon tetrabromide in the presence of triphenylphosphine (Synthesis 1998, 1015-1018) in methylene chloride.
  • the chlorination is carried out with mineral acids, for example with concentrated hydrochloric acid (J. Org. Chem. 1955 (20), 95) or with para-toluenesulfonic acid chloride in the presence of an amine, for example triethylamine in a solvent, for example methylene chloride (Tetrahedron Lett. 1984 (25), 2295).
  • a further method of preparing the desired target compounds of formula I is direct reaction of the propargyl alcohol of formula VII with the hydroxypyridine of formula II according to the Mitsunobu reaction in the presence of azodicarboxylic acid diethyl ester (DEAD), triphenylphosphine and a solvent such as, for example, an ether, e.g. diethyl ether or tetrahydrofuran (THF) (variant b) in Scheme 2).
  • Etherification reactions according to Mitsunobu are described, for example, in Tetrahedron Lett. 35, 2819-2822 (1994).
  • Suitable solvents are dimethylformamide and acetonitrile, and suitable bases are especially potassium carbonate and 1 ,8-diazabicyclo[5.4.0]undec-7-ene (DBU).
  • Pyridylacetylene esters of formula X can be obtained by means of Sonogashira coupling, starting from the compounds of formula IX and activated pyridine derivatives of formula V, analogously to Synthetic Communic. 1998 (28), 327-335.
  • the esters of formula X can then be reduced or reacted with organometallic compounds, for example Grignard reagents, to form the alcohols of formula VII.
  • the reduction of the acetylene esters of formula X to the alcohols of formula VII can be carried out especially with hydrides by standard methods, for example with lithium aluminium hydride or sodium borohydride in a solvent, e.g. an ether, for example diethyl ether, dioxane or tetrahydrofuran, or an alcohol, for example methanol or ethanol.
  • a solvent e.g. an ether, for example diethyl ether, dioxane or tetrahydrofuran
  • an alcohol for example methanol or ethanol.
  • organometallic compounds e.g. Grignard reagents
  • X 2 is halogen
  • n is 1 , 2, 3 or 4 and, especially in those cases where X 2 is bonded in the ⁇ - or ⁇ -position to the ring nitrogen
  • R 1 is a substituent having an electron-withdrawing effect (-M and/or -I effect), e.g. -NO 2 , -CN, CF 3 or COR 12 , to form compounds of formula XVI and then in the next synthesis step carrying out a Sonogashira reaction with activated pyridine derivatives of formula V (Reaction Scheme 5).
  • the reactions to form compounds of formula I are advantageously performed in aprotic, inert organic solvents.
  • solvents are hydrocarbons, such as benzene, toluene, xylene and cyclohexane, chlorinated hydrocarbons, such as dichloromethane, trichloromethane, tetra- chloromethane and chlorobenzene, ethers, such as diethyl ether, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, tetrahydrofuran and dioxane, nitriles, such as acetonitrile and propionitrile, amides, such as N,N-dimethyIformamide, diethylformamide and N-methylpyrrolidinone.
  • the reaction temperatures are preferably from -20°C to +120°C.
  • the reactions generally proceed slightly exothermically and can generally be carried out at room temperature.
  • the reaction mixture may, if appropriate, be heated to its boiling point for a short time.
  • the reaction times may likewise be shortened by the addition of a few drops of base as reaction catalyst.
  • Suitable bases are especially tertiary amines, such as trimethylamine, triethylamine, quinuclidine, 1 ,4-diazabicyclo[2.2.2]octane, 1 ,5-diazabicyclo[4.3.0]non-5-ene and 1 ,5-diaza- bicyclo[5.4.0]undec-7-ene, but it is also possible to use inorganic bases, such as hydrides, e.g. sodium or calcium hydride, hydroxides, such as sodium or potassium hydroxide, carbonates, such as sodium or potassium carbonate, or hydrogen carbonates, such as potassium or sodium hydrogen carbonate.
  • hydrides e.g. sodium or calcium hydride
  • hydroxides such as sodium or potassium hydroxide
  • carbonates such as sodium or potassium carbonate
  • hydrogen carbonates such as potassium or sodium hydrogen carbonate.
  • the compounds of formula I can be isolated in customary manner by concentration and/or evaporation of the solvent and can be purified by recrystallisation or trituration of the solid residue in solvents in which they are not readily soluble, such as ethers, aromatic hydrocarbons or chlorinated hydrocarbons.
  • reagents of formulae II, III, V, VI, IX, XI, XII, XIV and XV used in Reaction Schemes 1 to 5 are known or can be prepared analogously to known methods.
  • the halogenated pyridine derivatives of formulae V and XIV can be obtained in analogous manner to that described in US-A-5468 863, and the subsequent cyanomethylation of those bromopyridines is carried out, for example, by means of nucleophilic substitution using lithium acetonitriles in analogous manner to that described in Synlett 2000(10), 1488-1490.
  • Pyridylacetylene derivatives of formula XI and their preparation are described, for example, in Tetrahedron Organic Chemistry 20, 209-231 (2000).
  • the compounds of formula I may be used as herbicides in their unmodified form, that is to say as obtained in the synthesis, but they are preferably formulated in customary manner together with the adjuvants conventionally employed in formulation technology, for example into emulsifiable concentrates, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granules or microcapsules.
  • Such formulations are described, for example, on pages 9 to 13 of WO 97/34485.
  • the methods of application such as spraying, atomising, dusting, wetting, scattering or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances.
  • compositions, preparations or mixtures comprising the compound (active ingredient) of formula I or at least one compound of formula I and, usually, one or more solid or liquid formulation adjuvants, are prepared in known manner, e.g. by homogeneously mixing and/or grinding the active ingredients with the formulation adjuvants, for example solvents or solid carriers.
  • formulation adjuvants for example solvents or solid carriers.
  • Surface-active compounds surfactants
  • solvents and solid carriers are given, for example, on page 6 of WO 97/34485.
  • suitable surface- active compounds are non-ionic, cationic and/or anionic surfactants and surfactant mixtures having good emulsifying, dispersing and wetting properties.
  • suitable anionic, non-ionic and cationic surfactants are listed, for example, on pages 7 and 8 of WO 97/34485.
  • surfactants conventionally employed in formulation technology which are described, inter alia, in "McCutcheon's Detergents and Emulsifiers Annual” MC Publishing Corp., Ridgewood New Jersey, 1981 , Stache, H., "Tensid- Taschenbuch", Carl Hanser Verlag, Kunststoff/Vienna 1981 , and M. and J. Ash, "Encyclopedia of Surfactants", Vol. Mil, Chemical Publishing Co., New York, 1980-81 , are also suitable for the preparation of the herbicidal compositions according to the invention.
  • the herbicidal formulations generally contain from 0.1 to 99 % by weight, especially from 0.1 to 95 % by weight, of herbicide, from 1 to 99.9 % by weight, especially from 5 to 99.8 % by weight, of a solid or liquid formulation adjuvant, and from 0 to 25 % by weight, especially from 0.1 to 25 % by weight, of a surfactant.
  • a surfactant especially from 0.1 to 25 % by weight
  • compositions may also comprise further ingredients, such as stabilisers, for example vegetable oils or epoxidised vegetable oils (epoxidised coconut oil, rapeseed oil or soybean oil), anti-foams, for example silicone oil, preservatives, viscosity regulators, binders, tackifiers, and also fertilisers or other active ingredients.
  • stabilisers for example vegetable oils or epoxidised vegetable oils (epoxidised coconut oil, rapeseed oil or soybean oil), anti-foams, for example silicone oil, preservatives, viscosity regulators, binders, tackifiers, and also fertilisers or other active ingredients.
  • the compounds of formula I are generally applied to plants or the locus thereof at rates of application of from 0.001 to 4 kg/ha, especially from 0.005 to 2 kg/ha.
  • the concentration required to achieve the desired effect can be determined by experiment. It is dependent on the nature of the action, the stage of development of the cultivated plant and of the weed and on the application
  • the compounds of formula I are distinguished by herbicidal and growth-inhibiting properties, allowing them to be used in crops of useful plants, especially cereals, cotton, soybeans, sugar beet, sugar cane, plantation crops, rape, maize and rice, and also for non-selective weed control.
  • crops of useful plants especially cereals, cotton, soybeans, sugar beet, sugar cane, plantation crops, rape, maize and rice, and also for non-selective weed control.
  • crops is to be understood as including also crops that have been made tolerant to herbicides or classes of herbicides as a result of conventional methods of breeding or genetic techniques.
  • the weeds to be controlled may be either monocotyl- edonous or dicotyledonous weeds, such as, for example, Stellaria, Nasturtium, Agrostis, Digitaria, Avena, Setaria, Sinapis, Lolium, Solanum, Echinochloa, Scirpus, Monochoria, Sagittaria, Bromus, Alopecurus, Sorghum halepense, Rottboellia, Cyperus, Abutilon, Sida, Xanthium, Amaranthus, Chenopodium, Ipomoea, Chrysanthemum, Galium, Viola and Veronica.
  • Stellaria Nasturtium, Agrostis, Digitaria, Avena, Setaria, Sinapis, Lolium, Solanum, Echinochloa, Scirpus, Monochoria, Sagittaria, Bromus, Alopecurus, Sorghum halepense, Rottboellia, Cyperus, Ab
  • the reaction mixture is poured onto 40 ml of saturated ammonium chloride solution and, after stirring briefly, is extracted with diethyl ether; the organic phase is separated off and dried over magnesium sulfate.
  • the crude product is subjected to flash chromatography over silica gel using ethyl acetate/hexane (1/10 to 1/4) as gradient eluant.
  • 2.1 g of the desired target compound 2-[3- (6-chloro-pyrid-3-yl)-prop-2-ynyloxy]-5-fluoro-3-methoxy-pyridine are obtained in the form of white crystals having a melting point of 101-102°C.
  • Example P7 Preparation of S-chloro ⁇ -fS-fe-chloro-pyrid-S-vD-prop ⁇ -vnyloxyl-S-methoxy- pyridine
  • reaction mixture After stirring for a further 2 hours at a temperature of 20°C, the reaction mixture is poured onto 40 ml of saturated ammonium chloride solution and, after stirring for half an hour, is extracted with diethyl ether, and the organic phase is separated off. The organic phase is then washed twice with saturated ammonium chloride solution and brine and is dried over sodium sulfate.
  • the crude product is chromatographed over silica gel using ethyl acetate/hexane as eluant.
  • the resulting reaction mixture is stirred for 6 hours at 50°C under an argon atmosphere and is then allowed to cool to 20°C.
  • the solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/3).
  • the desired title compound is obtained, in a yield of 390 mg (42 % of theory), in the form of a yellow solid having a melting point of 118°C.
  • a solution of 4.74 g (53.2 mmol) of 2-(dimethyIamino)-ethanol in 30 ml of THF is cooled to -5°C, and 66.5 ml (106.4 mmol) of n-butyllithium are added dropwise under an argon atmosphere. The temperature is maintained at 0°C for 30 minutes and is then cooled to -78°C, and a solution of 1.5 g (13.3 mmol) of 4-chloropyridine in 30 ml of THF is added dropwise. Stirring is carried out at -78°C for 1 hour, and a solution of 16.9 g (66.5 mmol) of iodine in 30 ml of THF is added dropwise to the mixture.
  • the reaction mixture After 30 minutes at -78°C, the reaction mixture is allowed to warm slowly, within the course of 1 hour, up to 20°C and, at 0°C, is hydrolysed with 60 ml of water.
  • the aqueous phase is extracted with dichloromethane, and the combined organic phases are washed with a solution of sodium bisulfite (Na 2 S 2 O 3 ) and dried over magnesium sulfate; the solvent is concentrated under reduced pressure.
  • the desired title compound is obtained, in a yield of 1.72 g (54 % of theory), in the form of a brown oil.
  • the resulting reaction mixture is stirred at 50°C under an argon atmosphere for 4 hours and is then allowed to cool to 20°C.
  • the solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2).
  • the desired title compound is obtained, in a yield of 285 mg (44 % of theory), in the form of a yellow solid having a melting point of 94°C.
  • the resulting reaction mixture is stirred at 50°C under an argon atmosphere for 5 hours and is then allowed to cool to 20°C.
  • the solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2).
  • the desired title compound is obtained, in a yield of 275 mg (55 % of theory), in the form of a beige solid having a melting point of
  • the resulting reaction mixture is stirred at 50°C under an argon atmosphere for 4 hours and is then allowed to cool to 20°C.
  • the solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2).
  • the desired title compound is obtained, in a yield of 450 mg (59 % of theory), in the form of a beige solid having a melting point of 114°C.
  • N-bromosuccinimide 1.24 g (7.0 mmol) of N-bromosuccinimide are added to a solution of 1.0 g (5.8 mmol) of commercial 2-bromo-5-methylpyridine in 10 ml of carbon tetrachloride under argon gas. The mixture is heated to reflux temperature, and 100 mg (0.6 mmol) of azobisisobutyronitrile
  • N-bromosuccinimide 6.21 g (34.9 mmol) of N-bromosuccinimide are added to a solution of 5.0 g (29.1 mmol) of commercial 2-bromo-4-methylpyridine in 50 ml of carbon tetrachloride under argon gas. The resulting mixture is heated to reflux temperature, and 750 mg (0.9 mmol) of azobisisobutyro- nitrile (AIBN) are then added in 3 portions at intervals of 4 hours. After heating for 20 hours at reflux temperature, the reaction mixture is cooled to 20°C, and the mixture is filtered.
  • AIBN azobisisobutyro- nitrile
  • the solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2).
  • the desired target compound is obtained, in a yield of 1.85 g (25 % of theory), in the form of a white solid.
  • Example B1 Herbicidal action prior to emergence of the plants (pre-emerqence action)
  • test plants Monocotyledonous and dicotyledonous test plants are sown in standard soil in pots.
  • the test compounds in the form of an aqueous suspension (prepared from a wettable powder (Example F3, b) according to WO 97/34485) or in the form of an emulsion (prepared from an emulsif iable concentrate (Example F1 , c) according to WO 97/34485), are applied by spraying in an optimum concentration (500 litres of water/ha).
  • Test plants Setaria (Seta), Panicum (Pani), Echinochloa (Ds) (Echino), Amaranthus (Amar), Chenopodium (Cheno), Stellaria (Stella), Veronica, Euphorbia (Eupho), Brachiaria (Brachi).
  • test plants Monocotyledonous and dicotyledonous test plants are sown in standard soil in pots.
  • the test compounds in the form of an aqueous suspension (prepared from a wettable powder (Example F3, b) according to WO 97/34485) or in the form of an emulsion (prepared from an emulsifiable concentrate (Example F1 , c) according to WO 97/34485), are applied by spraying in an optimum concentration (500 litres of water/ha).
  • Test plants Setaria (Seta), Panicum (Pani), Echinochloa (Ds) (Echino), Amaranthus (Amar), Chenopodium (Cheno), Stellaria (Stella), Veronica, Euphorbia (Eupho).

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Abstract

Compounds of formula I wherein the substituents R1, R2, R3, and R4 and the suffixes n and m are defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomers of those compounds are suitable for use as herbicides.

Description

PH/5-60132A
Novel herbicides
The present invention relates to novel, herbicidally active pyridylalkynes, to processes for their preparation, to compositions comprising those compounds, and to their use in controlling weeds, especially in crops of useful plants, or in inhibiting plant growth.
Phenyl- and pyridyl-alkynes having herbicidal action are described, for example, in JP-A-11 147 866, WO 01/55066, WO 02/28182 and PCT Application No. EP02/08878.
Novel pyridylalkynes having herbicidal and growth-inhibiting properties have now been found.
The present invention accordingly relates to compounds of formula I
Figure imgf000002_0001
wherein n is 0, 1 , 2, 3 or 4; each P independently of any others is halogen, -CN, -SCN, -SF5, -NO2, -NR5R6, -CO2R7, -CONR8R9, -C(R10)=NORn, -COR12, -OR13, -SR14, -SOR15, -SO2R16, -OSO2R17, d-Cgalkyl, C2-C8alkenyl, C2-C8alkynyl or C3-C6cycloalkyl; or is d-C8alkyl, C2-C8alkenyl or C2-C8alkynyl substituted by one or more halogen, -CN, -NO2, -NR18R19, -CO2R2o, -CONRaiRa≥, -COR23, -C(R24)=NOR25, -C(S)NR26R27, -C(C1-C4alkylthio)=NR28, -OR29, -SR30, -SOR31, -SO2R32 or C3-C6cycloalkyl substituents; or each RT independently of any others is C3-C6cycloalkyl substituted by one or more halogen, -CN, -NO2, -NR18R19J -CO2R20, -CONR^, -COR23, -C(R24)=NOR25, -C(S)NR26R27,
Figure imgf000002_0002
-SR30, -SOR31, -SO2R32 or C3-C6cycloalkyl substituents; or each R! independently of any others is phenyl, which may in turn be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, C C4alkoxy, -CN, -NO2, C C4alkylthio, C C4alkyl- sulfinyl or C C4alkylsulfonyl substituents; or two adjacent Ri together form a d-C7alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by d-C6alkyl or d-C6alkoxy, the total number of ring atoms being at least 5 and at most 9; or two adjacent R^ together form a C2-C7alkenylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by d-C6alkyl or d-C6alkoxy, the total number of ring atoms being at least 5 and at most 9;
R3 and R are each independently of the other hydrogen, halogen, -CN, d-C4alkyl or d-C - alkoxy; or
R3 and R together are C2-C5alkylene;
R5 is hydrogen, C C8alkyl or -C(O)Cι-C8alkyl;
R6 is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl; wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4aIkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, C C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R5 and R6 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R7 is hydrogen, C C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is d-C8alkyl, C3-C8alkenyl or
C3-C8alkynyl substituted by one or more halogen, d-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4halo- alkyl, C C4alkoxy, -CN, -NO2, d-C4alkylthio, C C4alkylsulfinyl or C C4alkylsulfonyl substituents;
R8 is hydrogen or d-C8alkyl;
R9 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH,
C C8alkoxycarbonyl or -CN substituents, or
R9 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyI, d-C4alkoxy, -CN, -NO2) d-C4alkylthio, C C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R8 and R9 together are C2-C5alkylene;
R10 is hydrogen, C C4alkyl, C C4haloalkyl or C3-C6cycloalkyl;
Rn is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, d-C4haloalkyl or C3-C6haloalkenyl;
R12 is hydrogen, C C4aIkyl, C C4haloalkyl or C3-C6cycloalkyl;
R13 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl; or
R13 is phenyl or phenyl-d-C6alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, C C4alkoxy, -CN, -NO2, d-C8alkyh:hio, d-C8alkylsulfinyl or Cι-C8alkylsulfonyl substituents, or R13 is d-C8alkyl substituted by one or more halogen, -CN, d-C6alkylamino, di(d-C6alkyl)- amino or Cι-C4alkoxy substituents;
R14 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is C Csalkyl substituted by one or more halogen, -CN or C C4alkoxy substituents;
R15, R16 and R17 are each independently of the others C Csalkyl, C3-C8alkenyl or C3-C8- alkynyl, or C C8alkyl substituted by one or more halogen, -CN or C C4alkoxy substituents;
R18 is hydrogen or d-C8alkyl;
R19 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C alkyl, d-C4haloalkyl, d-C4- alkoxy, -CN, -NO2, C C4alkylthio, d-C4alkylsulfinyl or CrC4alkylsuIfonyl substituents; or
Rι8 and Rι9 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R2o is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4- alkoxy, -CN, -NO2, d-dalkylthio, CrC4alkylsulfinyl or CrC4alkylsulfonyl substituents;
R21 is hydrogen or d-C8alkyl;
R22 is hydrogen or CrC8alkyl, or is d-C8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents, or
R22 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C4alkylsulfinyl or CrC4alkylsulfonyl substituents; or
R21 and R22 together are C2-C5alkylene;
R23 is hydrogen, d-C4alkyl, d-C haloalkyl or C3-C6cycloaIkyl;
R24 is hydrogen, CrC4alkyl, d-C4haloalkyl or C3-C6cycloalkyl;
R25 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, d-C4haloalkyl or C3-C6haloalkenyl;
R26 is hydrogen or d-C8alkyl;
R27 is hydrogen or d-C8alkyl, or is CrC8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents, or
R27 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4aIkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, d-C alkylthio, d-C4alkylsulfinyl or d-C alkylsulfonyl substituents; or
R26 and R27 together are C2-C5alkylene;
R28 is hydrogen or d-C8alkyl;
R29 and R30 are each independently of the other hydrogen, d-C8alkyl, C3-C8alkenyl or
C3-C8alkynyl, or d-C8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents; R31 and R32 are each independently of the other CrC8alkyl, C3-C8alkenyl or C3-C8alkynyl, or Cι-C8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents; m is 0, 1 , 2, 3 or 4; each R2 independently of any others is halogen, -CN, -SCN, -OCN, -N3, -SF5, -NO2, -NRasR^, -CO2R35, -CONR36R37, -C(R38)=NOR39, -COR^, -OR41, -SR42, -SOR^, -SO^, -OSO2R45, -N([CO]pR46)COR47, -N(OR54)COR55, -N(R56)SO2R57, -N(SO2R58)SO2R59, -N=C(OR6o)R6ι, -CRe^OReaJOR^, -OC(O)NR65R66, -SC(O)NR67R68, -OC(S)NR69R70 or -N-phthalimide; or
R2 is a 5- to 7-membered heterocyclic ring system, which may be aromatic or partially or fully saturated and may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C4alkyl, C C haloalkyl, hydroxy-d-C4alkyl, d-C alkoxy, d-C alkoxy- d-C4alkyl, -CN, -NO2, d-C6alkylthio, CrC6alkylsulfinyl or d-C6alkylsulfonyl substituents; R33 is hydrogen or d-C8alkyl; and
R34 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4- alkoxy, -CN, -NO2, d-C4alkylthio, C C4alkylsulfinyl or d-C alkylsulfonyl substituents; or R33 and RJM together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R35 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is C C8alkyl, C3-C8alkenyl or C3-C8alkynyl substituted by one or more halogen, d-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4halo- alkyl, C C4alkoxy, -CN, -NO2) d-C4alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents;
R36 is hydrogen or CrC8alkyl;
R37 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents, or
R37 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, Cι-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C alkylsulfinyl or d-C4alkylsulfonyl substituents; or R36 and R37 together are C3-C5alkylene; R38 is hydrogen, C C4alkyl, d-C4haloalkyl or C3-C6cycloalkyl;
R39 is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C C4haloalkyl or C3-C6haloalkenyl; R40 is hydrogen, C C4alkyl, d-C4haloalkyl, d-C8alkylthio, -C(O)-C(O)OC C4alkyl or C3-C6- cycloalkyl; R41 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, CrC6alkoxy-CrC6aikyl, d-C8alkyl- carbonyl, CrC8alkoxycarbonyl, C3-C8alkenyloxycarbonyl, CrC6alkoxy-CrC6alkoxycarbonyl, d-Cealkylthio-d-Cealkyl, d-Cealkylsulfinyl-d-Cealkyl or CrC6alkylsulfonyl-CrC6alkyl; or
R41 is phenyl or phenyl-CrC6alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, C C4alkoxy, -CN, -NO2 or -S(O)2C C8alkyl substituents, or
R4ι is d-C8alkyl substituted by one or more halogen, -COOH, CrC8alkoxycarbonyl,
CrC6alkylamino, di(d-C6alkyl)amino or -CN substituents;
R42 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is C C8alkyl substituted by one or more halogen, -CN or C C4alkoxy substituents;
R^ and Rψj are each independently of the other d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or d-C8alkyl substituted by one or more halogen, -CN or C C4alkoxy substituents;
R^ is d-C8alkyl, CrC8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents, C3-C8alkenyl or C3-C8alkynyl, or
R45 is phenyl, it being possible for the phenyl ring to be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C8aIkylthio, C C8alkylsulfinyl or d-
C8alkylsulfonyl substituents;
R^ is hydrogen, CrC8alkyl, C3-C8alkenyl, C3-C8alkynyl or CrC4haloalkyl;
R47 is hydrogen, d-C8alkyl, d-C4alkoxy, C3-C8alkenyl or C3-C8alkynyl, or is CrC8alkyl substituted by one or more halogen, -CN, d-C4alkoxy, d-C8alkoxycarbonyl, -NH2, C C4- alkylamino, di(CrC alkyl)amino, -NR^COR^, -NR50SO2R51 or -NR52CO2R53 substituents, or
R47 is phenyl or benzyl, each of which may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, C C4alkylthio, C C4alkylsulfinyl or d-C alkylsulfonyl substituents; p is 0 or 1 ; ^, R49> Rδo, R5i> R52 and R53 are each independently of the others hydrogen, d-C8alkyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic radicals in turn to be substituted by one or more halogen, d-C8alkyl, d-C4haloalkyl, d-C alkoxy, d-C4alkylamino, di(d-C4alkyl)amino, -NH2, -CN, -NO2, CrC4alkylthio, CrC4alkylsulfinyl or
C C4alkylsulfonyl substituents;
R^ and R55 are each independently of the other hydrogen, d-C8alkyl or phenyl, which may in turn be substituted by one or more halogen, C C4alkyl, d-C haloalkyl, C C4aIkoxy, -CN,
-NO2, d-C8alkylthio, d-C8alkylsulfinyI or CrC8alkylsulfonyl substituents;
R56 is hydrogen, CrC8alkyl, d-C4haloalkyl, CrC4alkoxy, C3-C8alkenyl, C3-C8alkynyl or benzyl, it being possible for benzyl in turn to be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C8alkylthio, C C8alkylsulfinyl or d-C8alkylsulfonyl substituents;
R57 is d-C8alkyl, C C4haloalkyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic rings to be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, d-C4alkylamino, di(C C4alkyl)amino, -NH2, -CN, -NO2, CrC4alkylthio, d-C4alkylsulfinyl or d-C4alkyIsulfonyl substituents; R58 and R59 are each independently of the other d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic rings to be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C alkoxy, C C4alkyl- amino, di(C C4alkyl)amino, -NH2, -CN, -NO2, C C4alkylthio, C C4alkylsulfinyl or C C4alkyl- sulfonyl substituents;
R60 and R6ι are each independently of the other hydrogen or d-C6alkyl; R62, R63 and RM are each independently of the others hydrogen or C C8alkyl, or R63 and R64 together form a C2-C5alkylene bridge;
Res, ee, Re7, Res, eg an R70 are each independently of the others hydrogen or d-C8alkyl, or
R65 and R66 together or R67 and R68 together or R69 and R70 together form a C2-C5alkylene bridge; or each R2 independently of any others is d-C8alkyl, or is CrC8alkyl mono- or poly-substituted by halogen, -CN, -N3, -SCN, -NO2, -NR71R72, -CO2R73, -CONR74R75, -COR76, -C(R77)=NOR78, -C(S)NR79R80, -C(C C4alkylthio)=NR81, -OR82, -SR∞, -SOR^, -SO2R85> -O(SO2)R86) -N(R87)CO2R88) -N(R89)COR90J -S+(R91)2, -N+(R92)3, -Si(R93)3 or C3-C6cycloalkyl; or each R2 independently of any others is C C8alkyl substituted by a 5- to 7-membered heterocyclic ring system, which may be aromatic or partially or fully saturated and may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C4aIkyl, d-C4haloalkyl, hydroxy-C C4alkyl, d-dalkoxy, C C4alkoxy-CrC4alkyl, -CN, -NO2, CrC6alkylthio, d-C6alkylsulfinyl or d-C6alkylsulfonyI substituents; or each R2 independently of any others is C2-C8alkenyl, or is C2-C8alkenyl mono- or poly- substituted by -CN, -NO2, -CO2R94, -CONR95R96, -COR97) -C(R98)=NOR99, -C(S)NR100Rιoι, -C(C C alkylthio)=NRιo2, -OR103, -Si(R10 )3 or C3-C6cycloalkyl; or each R2 independently of any others is C2-C8alkynyl, or is C2-C8alkynyl mono- or poly- substituted by halogen, -CN, -CO2R105, -CONR106Rιo7, -COR108, -C(R109)=NORno, -C(S)NR111R112, -C(d-C4alkylthio)=NR113, -OR114, -Si(R115)3 or C3-C6cycloalkyl; or each R2 independently of any others is C3-C6cycloalkyl, or is C3-C6cycloalkyl mono- or poly- substituted by halogen, -CN, -CO2R116, -CONR117R118, -CORι19, -C(R120)=NOR121,
Figure imgf000008_0001
or -C(CrC4alkylthio)=NR124; or two adjacent R2 together form a d-C7alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by cyano, d-C6alkyl or d-C6aIkoxy, the total number of ring atoms being at least 5 and at most 9; or two adjacent R2 together form a C2-C alkenylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by cyano, d-C6alkyl or d-C6alkoxy, the total number of ring atoms being at least 5 and at most 9; R7ι is hydrogen or d-C8alkyl;
R72 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, CrC4alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R71 and R72 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R73 is hydrogen, C C8aIkyl, C3-C8alkenyl or C3-C8alkynyl, or is d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl substituted by one or more halogen, d-C4alkoxy or phenyl substituents, it being possible for phenyl in turn to be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, C C4alkylthio, CrC4alkylsulfinyl or CrC4alkyl- sulfonyl substituents; R74 is hydrogen or d-C8alkyl;
R75 is hydrogen, d-C8alkyl or C3-C7cycloalkyl, or is d-C8alkyl substituted by one or more -COOH, CrC8alkoxycarbonyl, CrC6alkoxy or -CN substituents; or
R75 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, CrC4alkylthio, d-C alkylsulfinyl or CrC alkylsulfonyl substituents; or R74 and R75 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or sulfur atom;
R76 is hydrogen, d-C4alkyl, d-C4haloalkyl or C3-C6cycloalkyl; R77 is hydrogen, C C4alkyl, CrC haloalkyl or C3-C6cycloalkyl;
R78 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C C4haloalkyl or C3-C6haloalkenyl; and
R79 is hydrogen or d-C8alkyl;
R80 is hydrogen or C C8alkyl, or is d-C8aIkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents; or R80 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, C C4aIkylsulfinyl or d-C4alkylsulfonyl substituents; or R79 and R80 together are C2-C3alkylene; R81 is hydrogen or d-C8alkyl;
R82 is -Si(d-C6alkyl)3, C3-C8alkenyl, C3-C8alkynyl or d-C8alkyl, which is mono- or poly- substituted by halogen, -CN, -NH2, CrC6alkylamino, di(d-C6alkyl)amino or d-C4alkoxy; R83 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl or d-C8alkyl, which is mono- or poly- substituted by halogen, -CN, -NH2, d-C6alkylamino, di(d-C6alkyl)amino or CrC4alkoxy; R^, Res and R86 are each independently of the others d-C8alkyl, C3-C8alkenyl or C3-C8- alkynyl, or d-C8alkyl which is substituted by one or more halogen, -CN or C C4alkoxy substituents;
R87 and R89 are each independently of the other hydrogen, C C8alkyl or d-C8alkoxy; R88 is d-C8alkyl; Rgo is hydrogen or d-C8alkyl; R91 is d-C alkyl;
R92 and R93 are each independently of the other d-C6alkyl;
R94 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, d-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, C C4alkylthio, C C4alkylsulfinyl or C C4alkylsulfonyl substituents; R95 is hydrogen or CrC8alkyl;
R96 is hydrogen or CrC8alkyl, or is d-C8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents; or
R96 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, CrC alkylsulfinyl or d-C4alkylsulfonyl substituents; or R95 and R96 together are C2-C5alkylene;
R97 and R98 are each independently of the other hydrogen, C C4alkyl, CrC4haloalkyl or C3-C6cycloalkyl;
R99 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8aIkynyl,»CrC4haloalkyl or C3-C6haloalkenyl; R100 is hydrogen or C C8alkyI;
R10ι is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents; or R10ι is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C4alkylsulfinyl or CrC4alkylsulfonyl substituents; or
R100 and R10ι together are C2-C5alkylene;
R102 is hydrogen or C C8alkyl;
R103 is hydrogen, d-C8alkyl, -Si(CrC6alkyl)3, C3-C8alkenyl or C3-C8alkynyl;
R104 is C C6alkyl;
R105 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, CrC4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, C C4alkyl,
C C4haloalkyl, d-C4alkoxy, -CN, -NO2l C C4aikylthio, C C4alkylsulfinyl or C
C4alkylsulfonyl substituents;
R106 is hydrogen or C C8alkyI;
R10 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or
R107 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2,
CrC4alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R108 and R 07 together are C2-C5alkylene;
R108 is hydrogen, CrC4alkyl, C C4haloalkyl or C3-C6cycloalkyl;
R109 is hydrogen, CrC4alkyl, d-C4haloalkyl or C3-C6cycloalkyl;
R110 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, d-C4haloalkyl or C3-C6haloalkenyl;
Rm is hydrogen or C C8alkyl;
R112 is hydrogen or C C8alkyl, or is CrC8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or
R112 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4aIkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
Rm and Rn2 together are C2-C5alkylene;
R 13 is hydrogen or CrC8alkyI;
R114 is hydrogen, CrC8alkyl, -Si(CrC6alkyl)3, C3-C8alkenyl or C3-C8alkynyl;
Rι15 is d-C6alkyl;
R116 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, CrC alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C4alkylsulfinyl or C
C4alkylsulfonyl substituents;
R117 is hydrogen or C C8alkyl;
R118 is hydrogen or C C8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or
R118 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, C C4alkylsulfinyl or C C4alkylsuIfonyl substituents; or
R117 and R118 together are C2-C5alkylene;
R119 is hydrogen, C C alkyl, C C4haloalkyl or C3-C6cycloalkyl; and
R120 is hydrogen, CrC4alkyl, CrC4haloalkyl or C3-C6cycloalkyl;
R121 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, CrC4haloalkyl or C3-C6haloalkenyl;
R122 is hydrogen or d-C8alkyl;
R123 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents; or
R123 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R122 and R123 together are C2-C5alkylene; and
R124 is hydrogen or CrC8alkyl, and to the agrochemically acceptable salts and all stereoisomers and tautomers of the compounds of formula I.
When n is 0, all the free valencies on the pyridyl ring of the compounds of formula I are substituted by hydrogen. When m is 0, all the free valencies on the pyridyl ring of the compounds of formula I are substituted by hydrogen.
Examples of substituents that are formed when R5 and R6 together or R18 and R19 together or R33 and R34 together or R71 and R72 together or R74 and R75 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom, are piperidine, morpholine, thiomorpholine and pyrrolidine.
Examples of heterocyclic ring systems, which may be aromatic or partially or fully saturated, in the definition of R2 are:
Figure imgf000012_0001
The alkyl groups appearing in the definitions of substituents may be straight-chain or branched and are, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, and also the pentyl, hexyl, heptyl and octyl isomers.
Halogen is fluorine, chlorine, bromine and iodine, preferably fluorine and chlorine. Haloalkyl is, for example, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 2-fluoroethyl, 2-chloroethyl, pentafluoroethyl, 1,1-difluoro- 2,2,2-trichloroethyl, 2,2,3,3-tetrafluoroethyl and 2,2,2-trichloroethyl; preferably trichloromethyl, difluorochloromethyl, difluoromethyl, trifluoromethyl and dichlorofluoromethyl.
Alkoxy groups have preferably a chain length of from 1 to 6, especially from 1 to 4, carbon atoms. Alkoxy is, for example, methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, and also the pentyloxy and hexyloxy isomers; preferably methoxy and ethoxy. Alkoxy, alkenyl, alkynyl, alkoxyalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, alkylaminoalkoxy, alkoxycarbonyl, alkylcarbonyloxy, alkenylthio, alkenylsulfonyl, alkenylsulfinyl, alkynylsulfonyl, alkynylthio and alkynylsulfinyl groups are derived from the mentioned alkyl radicals. The alkenyl and alkynyl groups can be mono- or poly-unsaturated. Alkenyl is to be understood as being, for example, vinyl, allyl, methallyl, 1 -methylvinyl or but-2-en-1 -yl. Alkynyl is, for example, ethynyl, propargyl, but-2-yn-1 -yl, 2-methylbutyn-2-yl or but-3-yn-2-yl.
Alkylthio groups have preferably a chain length of from 1 to 4 carbon atoms. Alkylthio is, for example, methylthio, ethyithio, propylthio, isopropylthio, n-butylthio, isobutylthio, sec-butylthio or tert-butylthio, preferably methylthio and ethyithio. Alkylsulfinyl is, for example, methyl- sulfinyl, ethylsulfinyl, propylsulfinyl, isopropylsulfinyl, n-butylsulfinyl, isobutylsulfinyl, sec- butylsulfinyl or tert-butylsulfinyl; preferably methylsulfinyl or ethylsulfinyl. Alkylsulfonyl is, for example, methylsulfonyl, ethylsulfonyl, propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl or tert-butylsulfonyl; preferably methylsulfonyl or ethylsulfonyl.
Alkoxyalkyl groups have preferably from 1 to 6 carbon atoms. Alkoxyalkyl is, for example, methoxymethyl, methoxyethyl, ethoxymethyl, ethoxyethyl, n-propoxymethyl, n-propoxyethyl, isopropoxymethyl or isopropoxyethyl.
The cycloalkyl groups preferably have from 3 to 6 ring carbon atoms, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. These cycloalkyl groups may be poly- substituted, especially mono- to tri-substituted, by the substituents mentioned, such as, for example, halogen.
As haloalkenyl, mono- or poly-halo-substituted alkenyl groups are suitable, the halogen being fluorine, chlorine, bromine or iodine, especially fluorine or chlorine, for example 2,2- difluoro-1 -methylvinyl, 3-fluoropropenyl, 3-chloropropenyl, 3-bromopropenyl, 2,3,3- trif luoropropenyl, 2,3,3-trichloropropenyl and 4,4,4-trif luorobut-2-en-1 -yl. Among the mono-, di- or tri-halo-substituted C3-C6alkenyl groups preference is given to those having a chain length of from 3 to 5 carbon atoms.
Alkylcarbonyl is preferably acetyl or propionyl. Alkoxycarbonyl is, for example, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, sec-butoxycarbonyl or tert- butoxycarbonyl; preferably methoxycarbonyl or ethoxycarbonyl.
Alkenyloxycarbonyl is, for example, allyloxycarbonyl, methallyloxycarbonyl, but-2-en-1 -yl- oxycarbonyl, pentenyloxycarbonyl and 2-hexenyloxycarbonyl.
Hydroxyalkyl is, for example, hydroxymethyl, 2-hydroxyethyl or 3-hydroxypropyl.
Alkylamino is, for example, methylamino, ethylamino, n-propylamino, isopropylamino or the butylamino isomers.
Dialkylamino is, for example, dimethylamino, methylethylamino, diethylamino, n-propyl- methylamino, dibutylamino and diisopropylamino. Preference is given to alkylamino groups having a chain length of from 1 to 4 carbon atoms.
Phenyl, including phenyl as part of a substituent such as benzyl or phenylalkyl, may be in substituted form, in which case the substituents may be in the ortho-, meta- and/or para- position(s). Preferred substituent positions are the ortho- and para-positions to the ring attachment position.
Corresponding meanings may also be given to the substituents in combined definitions, for example alkoxy-alkoxycarbonyl, alkylthio-alkyl, alkylsulfinyl-alkyl, alkylsulfonyl-alkyl and alkoxy-alkyl.
Substituents wherein two adjacent RT together form a d-C7alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by d-C6alkyl or C C6alkoxy, the total number of ring atoms being at least 5 and at most 9, or two adjacent Ri together form a C2-C7alkenylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by d-C6alkyl or d-C6alkoxy, the total number of ring atoms being at least 5 and at most 9, have, for example, the following structures:
Figure imgf000015_0001
Figure imgf000015_0002
Figure imgf000015_0003
Substituents wherein two adjacent R2 together form a d-C7alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by cyano, CrCealkyl or CrC6alkoxy, the total number of ring atoms being at least 5 and at most 9, or two adjacent R2 together form a C2-C7alkenylene bridge, which may be interrupted by 1 or 2 non- adjacent oxygen atoms and may be substituted by cyano, C C6alkyl or CrC6alkoxy, the total number of ring atoms being at least 5 and at most 9, have, for example, the following structures:
Figure imgf000016_0001
Figure imgf000016_0002
Figure imgf000016_0003
In the definitions of R-i, for example, the phrases "...cycloalkyl substituted by one or more halogen, -CN, -NO2, ... substituents" and "independently of any others is phenyl, which may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl ... substituents" are to be understood as meaning that the cycloalkyl and phenyl, respectively, can be mono- or poly-substituted, up to and including per-substituted, especially mono- to tri-substituted, by the mentioned substituents, wherein, for halogen, per-halogenation such as, for example, in the case of pentafluorophenyl may also be a preferred pattern of substitution. This is also true analogously for the definitions of R6, R7, R9, Rι3, Rι5, Rie, R17, etc., such as, for example: "...is d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl substituted by one or more halogen, d-C4alkoxy or phenyl substituents ...".
In the definition of R2, for example, the phrase: "R2 is a 5- to 7-membered heterocyclic ring system ..., it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, ... substituents" means that such heterocyclic ring systems may be especially mono- to tri-substituted at the ring carbon atoms by the mentioned substituents. The invention relates also to the salts which the compounds of formula I are able to form especially with amines, alkali metal and alkaline earth metal bases or quaternary ammonium bases. Suitable salt-formers are described, for example, in WO 98/41089.
The invention relates also to the salts which the compounds of formula I are able to form with amines, alkali metal and alkaline earth metal bases or quaternary ammonium bases. Among the alkali metal and alkaline earth metal hydroxides as salt formers, special mention should be made of the hydroxides of lithium, sodium, potassium, magnesium and calcium, but especially the hydroxides of sodium and potassium.
Examples of amines suitable for ammonium salt formation include ammonia as well as primary, secondary and tertiary d-C 8alkylamines, d-C4hydroxyalkylamines and C2-C4- alkoxyalkylamines, for example methylamine, ethylamine, n-propylamine, isopropylamine, the four butylamine isomers, n-amylamine, isoamylamine, hexylamine, heptylamine, octyl- amine, nonylamine, decylamine, pentadecylamine, hexadecylamine, heptadecylamine, octa- decylamine, methylethylamine, methylisopropylamine, methylhexylamine, methylnonylamine, methylpentadecylamine, methyloctadecylamine, ethylbutylamine, ethylheptylamine, ethyloctylamine, hexylheptylamine, hexyloctylamine, dimethylamine, diethylamine, di-n- propylamine, diisopropylamine, di-n-butylamine, di-n-amylamine, diisoamylamine, dihexylamine, diheptylamine, dioctylamine, ethanolamine, n-propanolamine, isopropanol- amine, N,N-diethanolamine, N-ethylpropanolamine, N-butylethanolamine, allylamine, n-butenyl-2-amine, n-pentenyl-2-amine, 2,3-dimethylbutenyl-2-amine, dibutenyl-2-amine, n-hexenyl-2-amine, propylenediamine, trimethylamine, triethylamine, tri-n-propylamine, triisopropylamine, tri-n-butylamine, triisobutylamine, tri-sec-butylamine, tri-n-amylamine, methoxyethylamine and ethoxyethylamine; heterocyclic amines, for example pyridine, quinoline, isoquinoline, morpholine, piperidine, pyrrolidine, indoline, quinuclidine and azepine; primary arylamines, for example anilines, methoxyanilines, ethoxyanilines, o-, m- and p-toluidines, phenylenediamines, benzidines, naphthylamines and o-, m- and p- chloroanilines; but especially triethylamine, isopropylamine and diisopropylamine.
Preferred quaternary ammonium bases suitable for salt formation correspond e.g. to the formula [N(Ra R RcRd )]OH wherein Ra, Rb, Rc and Rd are each independently of the others d-C alkyl. Other suitable tetraalkylammonium bases with other anions can be obtained, for example, by anion exchange reactions. Preference is given to compounds of formula I wherein R 1 is hydrogen, d-C8alkyl, C3-C8- alkenyl, C3-C8alkynyl, CrC6alkoxy-CrC6alkyl, d-C8alkylcarbonyl, CrC8alkoxycarbonyl,
C3-C8alkenyloxycarbonyl, CrC6alkoxy-CrC6alkoxycarbonyl, CrC6alkylthio-CrC6alkyl,
Cι-C6alkylsulfinyl-CrC6alkyl or CrC6alkylsulfonyl-d-C6alkyI; or
R4ι is phenyl or phenyI-d-C6alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2 or -5(0)20! -C8alkyl substituents, or
R41 is d-C8aIkyl substituted by one or more -COOH, d-C8alkoxycarbonyl, CrC6alkylamino, di(CrC6alkyl)amino or -CN substituents.
Preference is also given to compounds of formula I wherein each RT independently of any others is halogen, -CN, -NO2, -C(R10)=NORn, -OR13, -S(O)2R16, C C8alkyl or C2-C8alkenyl; or d-C8alkyl substituted by one or more halogen or -CN substituents; n is 0, 1 , 2, 3 or 4; and Rio, R11, Rι3 and R 6 are as defined for formula I. Of those compounds, special preference is given to those wherein n is 1 , 2 or 3.
Of particular interest are compounds of formula I wherein the group
occupies the 2-position on the pyridine ring.
Figure imgf000018_0001
Special preference is given to compounds of formula I wherein each RT independently of any others is halogen, -CN, -NO2, -C(R10)=NORn, -OR13, -SO2R16, CrC8alkyl or C2-C8alkenyl; or CrC8alkyl substituted by one or more halogen or -CN substituents; n is 1 or 2; R10, Rn, R13
and R16 are as defined in claim 1 ; and the group occupies
Figure imgf000018_0002
the 2-position on the pyridine ring. Of those, very special preference is given to those compounds wherein R, is -CN, -C(R10)=NORn, -OR13, d-C alkyl; or d-C alkyl substituted by one or more halogen or -CN substituents, and R10 is hydrogen or d-C4alkyl, Rn is hydrogen, d-C4alkyl or d-C4haloalkyl, and R13 is C C4alkyl, C3- or C4-alkenyl, C3- or C4- alkynyl, or d-C4aIkyl substituted by one or more halogen substituents. Preference is likewise given to compounds of formula I wherein each R2 independently of any others is -CN, -SCN, -OCN, -N3, -CONR36R37, -C(R38)=NOR39, -COR^, -OR41, -OSO^, -N([CO]pR46)COR47, -N(R56)SO2R57) -N(SO2R58)SO2R59, -N=C(OR6o)R6ι or d-C8aIkyl; or d-C8alkyl mono- or poly-substituted by halogen, -CN, -N3, -SCN, -CONR74R75, -COR76, -C(R77)=NOR78, -C(S)NR79R80) -OR82, -SOR^, -SO2R85 or by -N(R89)COR90; m is 0, 1 , 2, 3 or 4; and R36 to R41, R^ to R 7, R5e to R6-i, R74 to R80, R82, R^, R85, Rs9, R90 and p are as defined for formula I. Of those compounds, special preference is given to those wherein m is 1 or 2.
Especially preferred compounds of formula I are those wherein each R2 independently of any others is -CN, -SCN, -OCN, -N3, -CONR36R37, -OR41, -C(R38)=NOR39 or d-C8alkyl; or d-C8alkyl mono- or poly-substituted by halogen, -CN, -N3, -SCN or by -C(S)NR79R80; m is 0, 1 , 2, 3 or 4, and R36 is hydrogen or d-C4alkyl; R37 is C C4alkyl or CrC4alkyl substituted by one or more d-C4alkoxycarbonyl or -CN substituents; R38 is hydrogen or d-C4alkyl; R39 is hydrogen, C C4alkyl or CrC4haloalkyl; and R41 is C C4alkyl, C3- or C4-alkenyl, C3- or C4- alkynyl, phenyl; or phenyl substituted by one or more halogen or -CN substituents. Of those compounds, very special preference is given to those wherein R2 is -SCN, -OCN, -N3, d-C4alkyl; or d-C4alkyl mono- or poly-substituted by halogen, -CN, -N3 or by -SCN.
The compounds of formula I can be prepared by methods known per se described, for example, in J. Org. Chem. 62, 1491-1500 (1997); idem 66, 605-608 (2001); idem 62, 2774- 2781 (1997); idem 63, 1109-1118 (1998); Tetrahedron Organic Chemistry 2000 (20), 209- 213; Synlett 2001 (5), 649-651; and K. Sonogashira, Comprehensive Organic Synthesis 1991 , Vol. 3, page 521 , for example by reacting a compound of formula II
Figure imgf000019_0001
wherein R^ and n are as defined for formula I, in the presence of a base, with a compound of formula III
Figure imgf000019_0002
wherein R3 and R4 are as defined for formula I and X-i is O-tosyl, O-mesyl, chlorine, bromine or iodine, to form a compound of formula IV
Figure imgf000020_0001
wherein R^ R3, R and n are as defined for formula I, and then coupling that compound with a compound of formula V
Figure imgf000020_0002
wherein R2 and m are as defined for formula I and A is a leaving group, e.g. halogen or trifluoromethanesulfonate, in the presence of a palladium catalyst.
The preparation of the compounds of formula I can be carried out, for example, according to the individual Schemes 1 , 2, 3, 4 and 5. For the individual synthesis schemes it is generally true that various substituents Ri and/or R2 are either already present in compounds of formulae II and/or V at the outset or can be introduced later, for example by nucleophilic or electrophilic aromatic substitution.
According to Reaction Scheme 1 , the compounds of formula I can be obtained, for example, from substituted pyridyl propargyl ethers of formula IV.
The pyridyl propargyl ethers of formula IV can be obtained beforehand by etherification of hydroxypyridines of formula II, which are reacted in the presence of a base with acetylene derivatives of formula 111. Such etherification reactions are standard procedures and can be carried out, for example, analogously to J. Chem. Soc, Perkin Trans I, 1979, 2756-2761 ; Synth. Communic. 18, 1111 -1118 (1998); J. Chem. Soc, Chem. Communic. 1990, 297-300; J. Org. Chem. 61 , 4258-4261 (1996); and Synth. Communic. 24, 1367-1379 (1994).
In the next step, the propargyl ethers of formula IV are coupled with substituted pyridine derivatives of formula V under typical Sonogashira conditions (K.Sonogashira, Comprehensive Organic Synthesis 1991 , Vol. 3, page 521 ; J. Org. Chem. 1998 (63), 8551- 8553). Catalyst mixtures that come into consideration are, for example, tetrakistriphenyl- phosphine-palladium or bistriphenylphosphine-palladium dichloride together with copper iodide, and bases that come into consideration (for the reductive elimination) are especially amines, for example triethylamine, diethylamine and diisopropylethylamine. The pyridines of formula V preferably carry a leaving group A, wherein A is, for example, halogen or trifluoromethanesulfonate (Tetrahedron Organic Chemistry 2000 (20), 209-213; J. Org. Chem. 63, 1109-1118 (1998); Tetrahedron Lett. 27(10), 1171 -1174 (1986)). As solvents for the Sonogashira reaction there are customarily used ethers, for example tetrahydrofuran or dioxane, chlorinated hydrocarbons, for example chloroform, or dipolar aprotic solvents, for example dimethylformamide or dimethyl sulfoxide, or amines, for example triethylamine or piperidine.
Scheme 1
alkylation:
Figure imgf000021_0001
Sonogashira coupling:
Figure imgf000021_0002
V: A = halogen, -O-SO2-CF3
Pd catalyst, Cul, base
Figure imgf000021_0003
The Pd-catalysed cross-coupling of suitably substituted pyridine derivatives of formula V with terminal acetylenes, for example with propargyl alcohols of formula VI, as shown diagrammatically in Reaction Scheme 2, is known generally as the Sonogashira reaction. That reaction is documented, for example, in Tetrahedron Organic Chemistry 2000 (20), 209-213; Synthesis 1984, 571 ; and J. Org. Chem. 53, 386 (1988) and can likewise be used for the preparation of the pyridyl propargyl alcohols of formula VII. The activation of the alcohol of formula VII is carried out e.g. by sulfonylation or halogenation. The sulfonylation of the alcohol of formula VII is a standard reaction and can be carried out e.g. with a sulfonic acid chloride, for example mesyl chloride or para- toluenesulfonic acid chloride (p-TosCI), in the presence of a tertiary amine, for example triethylamine, or an aromatic amine, for example pyridine, in a solvent, e.g. a chlorinated hydrocarbon, for example carbon tetrachloride or methylene chloride, or an amine, for example pyridine. Such reactions are generally known and are described, for example, in J. Org. Chem. 1997 (62), 8987; J. Het. Chem. 1995 (32), 875-882; and Tetrahedron Lett. 1997 (38), 8671-8674.
The halogenation of the alcohol of formula VII can be carried out analogously to standard procedures. For example, the bromination is carried out with carbon tetrabromide in the presence of triphenylphosphine (Synthesis 1998, 1015-1018) in methylene chloride. The chlorination is carried out with mineral acids, for example with concentrated hydrochloric acid (J. Org. Chem. 1955 (20), 95) or with para-toluenesulfonic acid chloride in the presence of an amine, for example triethylamine in a solvent, for example methylene chloride (Tetrahedron Lett. 1984 (25), 2295).
The preparation of the pyridyl-propynyloxy-pyridines of formula I can be carried out analogously to J. Org. Chem. 61, 4258-4261 (1996); or J. Chem. Soc, Perkin Trans 1, 1979, 2756-2761 by means of etherification of the hydroxypyridines of formula II in the presence of the tosylate or mesylate or halide of formula VIII (variant a) in Scheme 2). A further method of preparing the desired target compounds of formula I is direct reaction of the propargyl alcohol of formula VII with the hydroxypyridine of formula II according to the Mitsunobu reaction in the presence of azodicarboxylic acid diethyl ester (DEAD), triphenylphosphine and a solvent such as, for example, an ether, e.g. diethyl ether or tetrahydrofuran (THF) (variant b) in Scheme 2). Etherification reactions according to Mitsunobu are described, for example, in Tetrahedron Lett. 35, 2819-2822 (1994). Suitable solvents are dimethylformamide and acetonitrile, and suitable bases are especially potassium carbonate and 1 ,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Scheme 2
Variant a): Sonogashira:
sulfonylation or halogenation
Figure imgf000023_0001
V: A = halogen, O-SO2-CF3 VII
Figure imgf000023_0002
VIII: X, = halogen, OTs, OMs Variant b): Mitsunobu:
Figure imgf000023_0003
Compounds of formula I can also be obtained by further methods (see Scheme 3). Scheme 3
Figure imgf000024_0001
V: A = -I, -OTs, -0-S02CF3
Figure imgf000024_0002
XIII: X, = halogen, OTs
Pyridylacetylene esters of formula X can be obtained by means of Sonogashira coupling, starting from the compounds of formula IX and activated pyridine derivatives of formula V, analogously to Synthetic Communic. 1998 (28), 327-335. The esters of formula X can then be reduced or reacted with organometallic compounds, for example Grignard reagents, to form the alcohols of formula VII.
The reduction of the acetylene esters of formula X to the alcohols of formula VII can be carried out especially with hydrides by standard methods, for example with lithium aluminium hydride or sodium borohydride in a solvent, e.g. an ether, for example diethyl ether, dioxane or tetrahydrofuran, or an alcohol, for example methanol or ethanol. Such reductions are described, for example, in C. Ferri, "Reaktionen der organischen Synthese" 1978, pages 98- 102.
Reactions of carboxylic acid esters with Grignard reagents are standard in organic synthesis chemistry and are described in detail, for example, in "Organikum" 1976, pages 617-625. The subsequent etherification of the hydroxypyridines of formula II to form the compounds of formula I has already been described in detail in Scheme 2.
Further methods of preparing the compounds of formula I are shown in Scheme 4 (variant of Scheme 3).
Scheme 4
Figure imgf000025_0001
base, e.g. n-BuLi, THF
Figure imgf000025_0002
Figure imgf000025_0003
reduction, e.g. LiAIH4, or organometallic compounds, e.g. Grignard reagents
Figure imgf000025_0004
The reaction of pyridylacetylenes of formula XI with n-butyllithium (n-BuLi) and subsequent reaction with chioroformic acid methyl ester of formula XII results in the ester of formula Xa, which can be converted into the compounds of formula I entirely analogously to the method already described in Scheme 3, via an alcohol of formula VII (J. Org. Chem. 1988 (53), 4166-4171).
Compounds of formula I can also be prepared by first reacting the propargyl alcohols of formula XV with activated pyridine derivatives of formula XIV
Figure imgf000025_0005
wherein X2 is halogen, n is 1 , 2, 3 or 4 and, especially in those cases where X2 is bonded in the β- or γ-position to the ring nitrogen, R1 is a substituent having an electron-withdrawing effect (-M and/or -I effect), e.g. -NO2, -CN, CF3 or COR12, to form compounds of formula XVI and then in the next synthesis step carrying out a Sonogashira reaction with activated pyridine derivatives of formula V (Reaction Scheme 5).
Scheme 5
nucleophilic substitution:
Figure imgf000026_0001
XIV: χ2 = halogen XVI
Sonogashira coupling:
Figure imgf000026_0002
V: A = halogen, 0-S02-CF3 Pd catalyst, Cul
Figure imgf000026_0003
The following comments apply to the individual reaction steps (Schemes 1 to 5): The reactions to form compounds of formula I are advantageously performed in aprotic, inert organic solvents. Such solvents are hydrocarbons, such as benzene, toluene, xylene and cyclohexane, chlorinated hydrocarbons, such as dichloromethane, trichloromethane, tetra- chloromethane and chlorobenzene, ethers, such as diethyl ether, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, tetrahydrofuran and dioxane, nitriles, such as acetonitrile and propionitrile, amides, such as N,N-dimethyIformamide, diethylformamide and N-methylpyrrolidinone. The reaction temperatures are preferably from -20°C to +120°C. The reactions generally proceed slightly exothermically and can generally be carried out at room temperature. In order to shorten the reaction time or alternatively to initiate the reaction, the reaction mixture may, if appropriate, be heated to its boiling point for a short time. The reaction times may likewise be shortened by the addition of a few drops of base as reaction catalyst. Suitable bases are especially tertiary amines, such as trimethylamine, triethylamine, quinuclidine, 1 ,4-diazabicyclo[2.2.2]octane, 1 ,5-diazabicyclo[4.3.0]non-5-ene and 1 ,5-diaza- bicyclo[5.4.0]undec-7-ene, but it is also possible to use inorganic bases, such as hydrides, e.g. sodium or calcium hydride, hydroxides, such as sodium or potassium hydroxide, carbonates, such as sodium or potassium carbonate, or hydrogen carbonates, such as potassium or sodium hydrogen carbonate.
The compounds of formula I can be isolated in customary manner by concentration and/or evaporation of the solvent and can be purified by recrystallisation or trituration of the solid residue in solvents in which they are not readily soluble, such as ethers, aromatic hydrocarbons or chlorinated hydrocarbons.
The reagents of formulae II, III, V, VI, IX, XI, XII, XIV and XV used in Reaction Schemes 1 to 5 are known or can be prepared analogously to known methods. For example, the halogenated pyridine derivatives of formulae V and XIV can be obtained in analogous manner to that described in US-A-5468 863, and the subsequent cyanomethylation of those bromopyridines is carried out, for example, by means of nucleophilic substitution using lithium acetonitriles in analogous manner to that described in Synlett 2000(10), 1488-1490. Pyridylacetylene derivatives of formula XI and their preparation are described, for example, in Tetrahedron Organic Chemistry 20, 209-231 (2000).
For the use according to the invention of the compounds of formula I, or of compositions comprising them, there come into consideration all methods of application customary in agriculture, for example pre-emergence application, post-emergence application and seed dressing, and also various methods and techniques such as, for example, the controlled release of active ingredient. For that purpose a solution of the active ingredient is applied to mineral granule carriers or polymerised granules (urea/formaldehyde) and dried. If required, it is also possible to apply a coating (coated granules), which allows the active ingredient to be released in metered amounts over a specific period of time.
The compounds of formula I may be used as herbicides in their unmodified form, that is to say as obtained in the synthesis, but they are preferably formulated in customary manner together with the adjuvants conventionally employed in formulation technology, for example into emulsifiable concentrates, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granules or microcapsules. Such formulations are described, for example, on pages 9 to 13 of WO 97/34485. As with the nature of the compositions, the methods of application, such as spraying, atomising, dusting, wetting, scattering or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances.
The formulations, that is to say the compositions, preparations or mixtures comprising the compound (active ingredient) of formula I or at least one compound of formula I and, usually, one or more solid or liquid formulation adjuvants, are prepared in known manner, e.g. by homogeneously mixing and/or grinding the active ingredients with the formulation adjuvants, for example solvents or solid carriers. Surface-active compounds (surfactants) may also be used in addition in the preparation of the formulations. Examples of solvents and solid carriers are given, for example, on page 6 of WO 97/34485.
Depending upon the nature of the compound of formula I to be formulated, suitable surface- active compounds are non-ionic, cationic and/or anionic surfactants and surfactant mixtures having good emulsifying, dispersing and wetting properties. Examples of suitable anionic, non-ionic and cationic surfactants are listed, for example, on pages 7 and 8 of WO 97/34485. In addition, the surfactants conventionally employed in formulation technology, which are described, inter alia, in "McCutcheon's Detergents and Emulsifiers Annual" MC Publishing Corp., Ridgewood New Jersey, 1981 , Stache, H., "Tensid- Taschenbuch", Carl Hanser Verlag, Munich/Vienna 1981 , and M. and J. Ash, "Encyclopedia of Surfactants", Vol. Mil, Chemical Publishing Co., New York, 1980-81 , are also suitable for the preparation of the herbicidal compositions according to the invention.
The herbicidal formulations generally contain from 0.1 to 99 % by weight, especially from 0.1 to 95 % by weight, of herbicide, from 1 to 99.9 % by weight, especially from 5 to 99.8 % by weight, of a solid or liquid formulation adjuvant, and from 0 to 25 % by weight, especially from 0.1 to 25 % by weight, of a surfactant. Whereas commercial products will preferably be formulated as concentrates, the end user will normally employ dilute formulations. The compositions may also comprise further ingredients, such as stabilisers, for example vegetable oils or epoxidised vegetable oils (epoxidised coconut oil, rapeseed oil or soybean oil), anti-foams, for example silicone oil, preservatives, viscosity regulators, binders, tackifiers, and also fertilisers or other active ingredients. The compounds of formula I are generally applied to plants or the locus thereof at rates of application of from 0.001 to 4 kg/ha, especially from 0.005 to 2 kg/ha. The concentration required to achieve the desired effect can be determined by experiment. It is dependent on the nature of the action, the stage of development of the cultivated plant and of the weed and on the application (place, time, method) and may vary within wide limits as a function of those parameters.
The compounds of formula I are distinguished by herbicidal and growth-inhibiting properties, allowing them to be used in crops of useful plants, especially cereals, cotton, soybeans, sugar beet, sugar cane, plantation crops, rape, maize and rice, and also for non-selective weed control. The term "crops" is to be understood as including also crops that have been made tolerant to herbicides or classes of herbicides as a result of conventional methods of breeding or genetic techniques. The weeds to be controlled may be either monocotyl- edonous or dicotyledonous weeds, such as, for example, Stellaria, Nasturtium, Agrostis, Digitaria, Avena, Setaria, Sinapis, Lolium, Solanum, Echinochloa, Scirpus, Monochoria, Sagittaria, Bromus, Alopecurus, Sorghum halepense, Rottboellia, Cyperus, Abutilon, Sida, Xanthium, Amaranthus, Chenopodium, Ipomoea, Chrysanthemum, Galium, Viola and Veronica.
The following Examples further illustrate but do not limit the invention.
Preparation Examples:
Example P1 : Preparation of 2-chloro-5-iodo-pyridine
Figure imgf000029_0001
22.0 g (0.1 mol) of 2-hydroxy-5-iodo-pyridine, together with 31.0 g (0.2 mol) of phosphorus oxytrichloride, are dissolved in 100 ml of toluene at 20°C. The solution is then heated for
1 hour at reflux temperature. After the reaction is complete, excess phosphorus oxytrichloride is distilled off together with toluene, and the residue is taken up in ether. The ethereal solution is filtered over silica gel. After concentration by evaporation, 14 g of the desired title compound 2-chloro-5-iodo-pyridine are obtained in the form of light-yellow crystals having a melting point of 94-95°C.
1H-NMR (CDCI3): δ (ppm) = 7.1-7.2 (d); 7.9-8.0 (dxd); 8.55-8.65 (d). Example P2: Preparation of 5-chloro-3-fluoro-2-(prop-2-vnyloxy)-pyridine
Figure imgf000030_0001
8.0 g (0.167 mol) of sodium hydride (NaH; 55 %) are suspended in 200 ml of absolute tetrahydrofuran (THF) under a nitrogen atmosphere. Then, within the course of about 10 minutes, 9.9 ml (0.167 mol) of propargyl alcohol dissolved in 10 ml of absolute THF are added dropwise at a temperature of 0°C; the ice cooling is then removed and stirring is carried out at room temperature for 45 minutes, until the evolution of gas has ceased. Then 25.0 g (0.167 mol) of 5-chloro-2,3-difluoropyridine dissolved in 50 ml of THF are added dropwise at 20-30°C, with stirring and ice cooling. Stirring at room temperature is then carried out for a further 3 hours, until gas chromatography indicates that the conversion is complete. The reaction mixture is then poured cautiously into 250 ml of water and extracted a total of three times with ethyl acetate. After separating off the organic phase, drying over sodium sulfate and filtration, concentration by evaporation is carried out; the yellow residue is purified by chromatography (eluant: ethyl acetate/hexane 1/4). 19.1 g of the desired title compound 5-chloro-3-fluoro-2-(prop-2-ynyloxy)-pyridine are obtained in the form of a colourless oil.
Example P3: Preparation of 3,5-difluoro-2-(prop-2-vnyloxy)-pyridine
Figure imgf000030_0002
3.3 g (75.1 mmol) of NaH (55 %) are suspended in 90 ml of absolute THF under a nitrogen atmosphere. Then, within the course of about 10 minutes, 4.4 ml (75.1 mmol) of propargyl alcohol dissolved in 10 ml of absolute THF are added dropwise at a temperature of 0°C; the ice cooling is then removed and stirring is subsequently carried out at room temperature until the evolution of gas has ceased. 10.0 g (75.1 mmol) of 2,3,5-trifluoropyridine are then added at 20°C, with stirring, and stirring is carried out for a further 5 hours at room temperature until gas chromatography indicates that the reaction is complete. The reaction mixture is then poured cautiously into water and extracted with ethyl acetate; the organic phase is separated off and is washed twice with water and once with brine (saturated). The crude product obtained is dried over sodium sulfate and is then purified by column chromatography over silica gel (eluant: ethyl acetate/hexane (1/12). 6.6 g of the desired title compound 3,5- difluoro-2-(prop-2-ynyloxy)-pyridine are obtained in the form of a colourless oil. 1H-NMR (CDCI3): δ (ppm) = 2.25 (t); 4.8 (d); 7.0 (m); 7.6 (d).
Example P4: Preparation of 5-fluoro-3-methoxy-2-(prop-2-vnyloxy)-pyridine
Figure imgf000031_0001
14.4 g (85.1 mmol) of 3,5-difluoro-2-(prop-2-ynyloxy)-pyridine (Example P3) are introduced into 100 ml of THF under a nitrogen atmosphere. Then, within the course of about 5 minutes, 15.8 ml (85.1 mmol) of a 30 % solution (5.4M) of sodium methanolate in methanol are added dropwise at room temperature, and the reaction mixture is heated at reflux for 4 hours. The reaction mixture is cooled to room temperature and water is cautiously added. The mixture is then extracted three times with ethyl acetate; the organic phase is separated off, washed with water and brine (saturated), dried over sodium sulfate and concentrated by evaporation. The residue obtained is purified by column chromatography (eluant: ethyl acetate/hexane 1/20). 10.1 g of 5-fluoro-3-methoxy-2-(prop-2-ynyloxy)-pyridine are obtained in the form of colourless crystals having a melting point of 67-69°C.
1H-NMR (CDCI3): δ (ppm) = 2.2 (t); 3.65 (s); 4.8 (s); 6.68 (dxd); 7.39 (d).
Figure imgf000031_0002
1.0 g (5.4 mmol) of 5-chloro-3-fluoro-2-(prop-2-ynyloxy)-pyridine (Example P2) is introduced into 15 ml of methanol under a nitrogen atmosphere. Then, within the course of about 5 minutes, 2.0 ml (10.8 mmol) of a 30 % solution of sodium methanolate in methanol are added dropwise at room temperature; the reaction mixture is then heated to reflux temperature and stirred at that temperature for a further 18 hours. The reaction mixture is cooled to room temperature and 30 ml of water are cautiously added; the mixture is extracted three times with ethyl acetate. After being separated off, the organic phase is dried over sodium sulfate, filtered and concentrated by evaporation. The yellowish residue obtained is purified by chromatography (eluant: ethyl acetate/hexane 1/4). 0.65 g of the desired title compound 5-chloro-3-methoxy-2-(prop-2-ynyloxy)-pyridine is obtained in the form of colourless crystals having a melting point of 62-64°C.
1H-NMR (CDCI3): δ (ppm) = 2.45 (t); 3.85 (s); 5.0 (s); 7.05 (d); 7.7 (d).
Example P6: Preparation of 2-f3-(6-chloro-pyrid-3-yl)-prop-2-vnyloxyl-5-fluoro-3-methoxy- pyridine
(Compound No. 2.005)
Figure imgf000032_0001
2.4 g (10.0 mmol) of 2-chloro-5-iodo-pyridine (Example P1), 1.8 g (10.06 mmol) of 5-fluoro- 3-methoxy-2-(prop-2-ynyloxy)-pyridine (Example P4) and 0.58 g (0.5 mmol) of tetrakis- (triphenylphosphine)-palladium (Pd(PPh3)4) are dissolved at a temperature of 20°C in 20 ml of piperidine under an argon atmosphere. After stirring for 5 minutes, 164 mg (0.86 mmol) of copper(l) iodide (Cul) are added, whereupon the temperature rises momentarily to about 55°C. After stirring for a further 2 hours at a temperature of 20°C, the reaction mixture is poured onto 40 ml of saturated ammonium chloride solution and, after stirring briefly, is extracted with diethyl ether; the organic phase is separated off and dried over magnesium sulfate. The crude product is subjected to flash chromatography over silica gel using ethyl acetate/hexane (1/10 to 1/4) as gradient eluant. 2.1 g of the desired target compound 2-[3- (6-chloro-pyrid-3-yl)-prop-2-ynyloxy]-5-fluoro-3-methoxy-pyridine are obtained in the form of white crystals having a melting point of 101-102°C.
1H-NMR (CDCI3): δ (ppm) = 3.9 (s); 5.25 (s); 6.95 (dxd); 7.3 (d); 7.66 (d); 7.7 (dxd); 8.46(d).
Example P7: Preparation of S-chloro^-fS-fe-chloro-pyrid-S-vD-prop^-vnyloxyl-S-methoxy- pyridine
(Compound No. 2.006)
Figure imgf000032_0002
2.4 g (10.0 mmol) of 2-chloro-5-iodo-pyridine (Example P1), 1.99 g (10.06 mmol) of 5-chloro- 3-methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5) and 0.58 g (0.5 mmol) of Pd(PPh3)4 are dissolved at a temperature of 20°C in 20 ml of piperidine under an argon atmosphere. After stirring for 5 minutes, 164 mg (0.86 mmol) of Cul are added, whereupon the temperature rises momentarily to about 40°C and a precipitate forms. After stirring for a further 2 hours at a temperature of 20°C, the reaction mixture is poured onto 40 ml of saturated ammonium chloride solution and, after stirring for half an hour, is extracted with diethyl ether, and the organic phase is separated off. The organic phase is then washed twice with saturated ammonium chloride solution and brine and is dried over sodium sulfate. The crude product is chromatographed over silica gel using ethyl acetate/hexane as eluant. 1.4 g of the desired target compound 5-chloro-2-[3-(6-chloro-pyrid-3-yl-prop-2-ynyloxy)-3- methoxy-pyridine are obtained in the form of white crystals having a melting point of 100- 101°C.
1H-NMR (CDCI3): δ (ppm) = 4.05 (s); 5.4 (s); 7.25 (d); 7.45 (d); 7.83 (dxd); 7.87 (d); 8.6(d).
Example P8: Preparation of 2-r3-(6-cvanomethoxy-pyrid-2-yl)-prop-2-vnyloxyl-5-chloro-3-
(Compound No. 1.063)
Figure imgf000033_0001
5.63 ml of tetrabutylammonium fluoride (1 M solution in THF) are added to a solution of 600 mg (2.82 mmol) of [(6-bromopyrid-2-yI)oxy]acetonitrile (Example P10), 557 mg (4.22 mmol) of 5-chloro-3-methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5), 107 mg (0.56 mmol) of copper(l) iodide and 198 mg (0.282 mmol) of bis-triphenylphosphine- palladium dichloride (Pd(PPh3)2CI2) in 15 ml of dioxane. The resulting reaction mixture is stirred for 6 hours at 50°C under an argon atmosphere and is then allowed to cool to 20°C. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/3). The desired title compound is obtained, in a yield of 390 mg (42 % of theory), in the form of a yellow solid having a melting point of 118°C. Rf = 0.50 in ethyl acetate/petroleum ether 1/3; 1H-NMR (CDCI3): δ(ppm)= 3.89 (s, 3H); 5.04 (s, 2H); 5.26 (s, 2H); 6.80 (d, J=8.5 Hz, 1 H); 7.07 (d, J=1.9 Hz, 1 H); 7.16 (d, J=7.6 Hz, 1 H); 7.60 (dxd, J=7.6 and 8.5 Hz, 1 H); 7.71 (d, J=2.2 Hz, 1H).
Example P9: Preparation of 2-hvdroxy-6-bromopyridine
Figure imgf000034_0001
4.67 ml of sulfuric acid 98 % are added to a solution of 4.0 g (23.12 mmol) of 6-bromo-2- aminopyridine in 67 ml of water at 0-5°C. The reaction temperature is maintained at 0-5°C and 1.75 g (25.43 mmol) of sodium nitrite in 15 ml of water are added dropwise. After being left to stand at 0°C for 30 minutes, the mixture is added to an aqueous solution of 23.12 g (92.48 mmol in 40 ml of water) of copper sulfate (CuSO4 • 5 H2O) and heated to 100°C. The mixture is maintained at that temperature for 1.5 hours, is then cooled to 20°C and extracted with dichloromethane. The organic phase is separated off and dried over magnesium sulfate, the drying medium is filtered off and the solvent is removed under reduced pressure. The title compound is obtained, in a yield of 3.476 g (86 % of theory), in the form of a yellow solid having a melting point of 110°C. R = 0.06 in ethyl acetate/petroleum ether 1/1 ;
1H-NMR (CDCI3): δ(ppm)= 6.71 (d, J=8.5 Hz, 1H); 6.83 (d, J=7.5 Hz, 1 H); 7.44 (dxd, J= 7.5 and 8.5 Hz, 1 H).
Example P10: Preparation of r(6-bromopyrid-2-yl)oxylacetonitrile Brk /N. .OCH N
1.9 g (13.79 mmol) of potassium carbonate and 0.57 ml (0.67 g, 8.96 mmol) of chloro- acetonitrile are added to a solution of 1.2 g (6.9 mmol) of 6-bromopyridin-2-ol (Example P9) in 10 ml of 1 -methyl-2-pyrrolidone (NMP). The reaction mixture is stirred for 2.5 hours at 20°C under argon gas. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/3). The desired title compound is obtained in a yield of 1.13 g (77 % of theory). Rf = 0.52 in ethyl acetate/petroleum ether 1/3;
1H-NMR (CDCI3): δ(ppm)= 5.03 (s, 2H); 6.80 (d, J=8.2 Hz, 1 H); 7.19 (d, J=7.5 Hz, 1 H); 7.52 (dxd, J=7.5 and 8.2 Hz, 1 H). 13C-NMR (CDCI3): δ(ppm)= 50.67 (OCH2); 109.48; 122.35 and 141.38 (arom. CH). xample P11 : Preparation of 4-chloro-2-iodopyridine (Eur. J. Org. Chem. 2001 , 603-606)
Figure imgf000035_0001
Commercial 4-chloropyridine hydrochloride is neutralised by adding potassium carbonate and is then extracted with dichloromethane.
A solution of 4.74 g (53.2 mmol) of 2-(dimethyIamino)-ethanol in 30 ml of THF is cooled to -5°C, and 66.5 ml (106.4 mmol) of n-butyllithium are added dropwise under an argon atmosphere. The temperature is maintained at 0°C for 30 minutes and is then cooled to -78°C, and a solution of 1.5 g (13.3 mmol) of 4-chloropyridine in 30 ml of THF is added dropwise. Stirring is carried out at -78°C for 1 hour, and a solution of 16.9 g (66.5 mmol) of iodine in 30 ml of THF is added dropwise to the mixture. After 30 minutes at -78°C, the reaction mixture is allowed to warm slowly, within the course of 1 hour, up to 20°C and, at 0°C, is hydrolysed with 60 ml of water. The aqueous phase is extracted with dichloromethane, and the combined organic phases are washed with a solution of sodium bisulfite (Na2S2O3) and dried over magnesium sulfate; the solvent is concentrated under reduced pressure. The desired title compound is obtained, in a yield of 1.72 g (54 % of theory), in the form of a brown oil.
1 H-NMR (CDCI3): δ(ppm)= 7.30 (dxd, J=1.5 and 5.3 Hz, 1 H); 7.77 (d, J=1.5 Hz, 1 H); 8.26 (d, J= 5.3 Hz, 1H).
Example P12: Preparation of 2-r3-(4-chloro-pyrid-2-v0-prop-2-vnyloxyl-5-chloro-3-
(Compound No. 1.070)
Figure imgf000035_0002
2.1 ml of tetrabutylammonium fluoride (1 M solution in THF) is added to a solution of 250 mg (1.04 mmol) of 4-chloro-2-iodopyridine (Example P11 ), 309 mg (1.56 mmol) of 5-chloro-3- methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5), 40 mg (0.21 mmol) of copper(l) iodide and 74 mg (0.105 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 7 ml of dioxane. The resulting reaction mixture is stirred at 50°C under an argon atmosphere for 4 hours and is then allowed to cool to 20°C. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). The desired title compound is obtained, in a yield of 205 mg (63 % of theory), in the form of a beige solid having a melting point of 129°C. Rt = 0.38 in ethyl acetate/petroleum ether 1/2;
1 H-NMR (CDCI3): δ(ppm)= 3.88 (s, 3H); 5.25 (s, 2H); 7.06 (d, J=1.9 Hz, 1 H); 7.24 (dxd, J=2.2 and 5.3 Hz, 1 H); 7.44 (d, J=2.2 Hz, 1 H); 7.70 (d, J=1.9 Hz, 1 H); 8.45 (d, J=5.3 Hz, 1 H).
Example P13: Preparation of 2-r3-(6-chloro-pyrid-3-yl)-prop-2-vnyloxyl-5-chloro-3-
(Compound No. 2.006)
Figure imgf000036_0001
4.81 ml of tetrabutylammonium fluoride (1 M solution in THF) is added to a solution of 500 mg (2.08 mmol) of commercial 2-chloro-5-iodopyridine, 619 mg (3.13 mmol) of 5-chloro- 3-methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5), 79 mg (0.42 mmol) of copper(l) iodide and 147 mg (0.21 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 14 ml of dioxane. The resulting reaction mixture is stirred at 50°C under an argon atmosphere for 4 hours and is then allowed to cool to 20°C. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). The desired title compound is obtained, in a yield of 285 mg (44 % of theory), in the form of a yellow solid having a melting point of 94°C.
Rf = 0.58 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCI3): δ(ppm)= 3.89 (s, 3H); 5.24 (s, 2H); 7.07 (d, J=2.1 Hz, 1 H); 7.26 (dxd, J=0.7 and 4.1 Hz, 1 H); 7.66 (dxd, J=1.9 and 4.1 Hz, 1 H); 7.70 (d, J=2.1 Hz, 1 H); 8.45 (d, J=1.9 Hz, 1 H). Example P14: Preparation of 2-F2-(4-methyl-pyrid-2-yl)-prop-2-vnyloxy1-5-chloro-3-
(Compound No. 1.064)
Figure imgf000037_0001
3.5 ml of tetrabutylammonium fluoride (1 M solution in THF) is added to a solution of 300 mg (1.74 mmol) of commercial 2-bromo-4-methylpyridine, 517 mg (2.62 mmol) of 5-chloro-3- methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5), 66 mg (0.35 mmol) of copper(l) iodide and 122 mg (0.17 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 12 ml of dioxane. The resulting reaction mixture is stirred at 50°C under an argon atmosphere for 16 hours and is then allowed to cool to 20°C. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromato-. graphy (eluant: ethyl acetate/petroleum ether 1/2). The desired title compound is obtained in a yield of 235 mg (47 % of theory), having a melting point of 106-108°C. Rt = 0.27 in ethyl acetate/petroleum ether 1/2;
1 H-NMR (CDCI3): δ(ppm)= 2.29 (s, 3H); 3.85 (s, 3H); 5.23 (s, 2H); 7.03 (d, J=2.1 Hz, 1H); 7.04 (d, J=4.1 H); 7.26 (s, 1 H); 7.68 (d, J=2.1 Hz, 1 H); 8.38 (d, J=4.1 Hz, 1 H).
Example P15: Preparation of 2-r2-(5-methyl-pyrid-2-yl)-prop-2-vnyloxy1-5-chloro-3- methoxypyridine
(Compound No. 1.065)
Figure imgf000037_0002
3.5 ml of tetrabutylammonium fluoride (1 M solution in THF) are added to a solution of 300 mg (1.74 mmol) of commercial 2-bromo-5-methylpyridine, 517 mg (2.62 mmol) of 5- chloro-3-methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5), 66 mg (0.35 mmol) of copper(l) iodide and 122 mg (0.17 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 12 ml of dioxane. The resulting reaction mixture is stirred at 50°C under an argon atmosphere for 5 hours and is then allowed to cool to 20°C. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). The desired title compound is obtained, in a yield of 275 mg (55 % of theory), in the form of a beige solid having a melting point of
113°C.
Rf = 0.25 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCI3): δ(ppm)= 2.32 (s, 3H); 3.87 (s, 3H); 5.24 (s, 2H); 7.04 (d, J=1.9 Hz, 1 H);
7.32 (d, J=7.9 Hz, 1 H); 7.40 (d, J=7.9 Hz, 1 H); 7.70 (d, J=1.9 Hz, 1 H); 8.38 (s, 1 H).
Example P16: Preparation of 2-F2-(5-trifluoromethyl-pyrid-2-yl)-prop-2-vnyloxy1-5-chloro-3-
(Compound No. 1.066)
Figure imgf000038_0001
4.5 ml of tetrabutylammonium fluoride (1 M solution in THF) is added to a solution of 500 mg (2.21 mmol) of commercial 2-bromo-5-trifluoromethylpyridine, 655 mg (3.32 mmol) of 5- chloro-3-methoxy-2-(prop-2-ynyloxy)-pyridine (Example P5), 84 mg (0.44 mmol) of copper(l) iodide and 155 mg (0.22 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 15 ml of dioxane. The resulting reaction mixture is stirred at 50°C under an argon atmosphere for 4 hours and is then allowed to cool to 20°C. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). The desired title compound is obtained, in a yield of 450 mg (59 % of theory), in the form of a beige solid having a melting point of 114°C.
Rf = 0.48 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCI3): δ(ppm)= 3.88 (s, 3H); 5.27 (s, 2H); 7.06 (d, J=2.1 Hz, 1 H); 7.55 (d, J=8.1 Hz, 1 H); 7.85 (dxd, J=8.1 and 1.5 Hz, 1 H); 7.70 (d, J=2.1 Hz, 1 H); 8.82 (s, 1 H).
Example P17: Preparation of 2-r2-(6-methoxy-pyrid-2-yl)-prop-2-vnyloxy1-5-chloro-3- methoxypyridine
(Compound No. 1.067)
Figure imgf000038_0002
5.3 ml of tetrabutylammonium fluoride (1 M solution in THF), 500 mg (2.66 mmol) of 2- bromo-6-methoxypyridine, 788 mg (3.99 mmol) of 5-chloro-3-methoxy-2-(prop-2-ynyloxy)- pyridine (Example P5), 101 mg (0.53 mmol) of copper(l) iodide and 187 mg (0.26 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 18 ml of dioxane are reacted in analogous manner to that described in the previous Examples and are then worked up and purified. The desired title compound is obtained, in a yield of 385 mg (48 % of theory) in the form of a white solid having a melting point of 116°C. Rt = 0.52 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCI3): δ(ppm)= 3.88 (s, 3H); 3.92 (s, 3H); 5.26 (s, 2H); 6.68 (d, J=8.2 Hz, 1 H); 7.04 (d, J=8.2 Hz, 1 H); 7.06 (d, J=2.2 Hz, 1 H); 7.48 (d, J=8.2 Hz, 1 H); 7.70 (d, J=2.2 Hz, 1 H).
Example P18: Preparation of 2-r2-(6-methyl-pyrid-2-yl)-prop-2-vnyloxyl-5-chloro-3-
(Compound No. 1.068)
Figure imgf000039_0001
5.8 ml of tetrabutylammonium fluoride (1 M solution in THF), 500 mg (2.90 mmol) of commercial 2-bromo-6-methylpyridine, 861 mg (4.36 mmol) of 5-chloro-3-methoxy-2-(prop- 2-ynyloxy)-pyridine (Example P5), 110 mg (0.58 mmol) of copper(l) iodide and 204 mg (0.29 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 18 ml of dioxane are reacted in analogous manner to that described in the previous Examples and are then worked up and purified. The desired title compound is obtained, in a yield of 530 mg (63 % of theory), in the form of a beige solid having a melting point of 96°C. Rf = 0.39 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCI3): δ(ppm)= 2.53 (s, 3H); 3.87 (s, 3H); 5.25 (s, 2H); 7.05 (d, J=2.2 Hz, 1 H); 7.08 (d, J=7.8 Hz, 1 H); 7.24 (d, J=7.8 Hz, 1 H); 7.50 (d, J=7.8 Hz, 1 H); 7.69 (d, J=2.2 Hz, 1 H).
Example P19: Preparation of 2-r2-(5-cvanomethylene-pyrid-2-yl)-prop-2-vnyloxyl-5-chloro-3-
(Compound No. 1.069)
Figure imgf000039_0002
6.1 ml of tetrabutylammonium fluoride (1 M solution in THF), 600 mg (3.04 mmol) of (6- bromopyrid-3-yl)acetonitrile (Example P21 ), 902 mg (4.56 mmol) of 5-chloro-3-methoxy-2- (prop-2-ynyloxy)-pyridine (Example P5), 116 mg (0.61 mmol) of copper(l) iodide and 214 mg (0.30 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 20 ml of dioxane are reacted in analogous manner to that described in the previous Examples and are then worked up and purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/1 ). The desired title compound is obtained, in a yield of 585 mg (61 % of theory), in the form of a beige solid having a melting point of 127°C. Rf = 0.19 in ethyl acetate/petroleum ether 1/1;
1 H-NMR (CDCI3): δ(ppm)= 3.77 (s, 2H); 3.88 (s, 3H); 5.26 (s, 2H); 7.06 (d, J=1.9 Hz, 1H); 7.47 (d, J=8.2 Hz, 1 H); 7.66 (dxd, J=8.2 and 2.2 Hz, 1H); 7.70 (d, J=1.9 Hz, 1 H); 8.51 (d, J=2.2 Hz, 1 H).
Example P20: Preparation of 2-bromo-5-(bromomethyl)pyridine
Figure imgf000040_0001
1.24 g (7.0 mmol) of N-bromosuccinimide are added to a solution of 1.0 g (5.8 mmol) of commercial 2-bromo-5-methylpyridine in 10 ml of carbon tetrachloride under argon gas. The mixture is heated to reflux temperature, and 100 mg (0.6 mmol) of azobisisobutyronitrile
(AIBN) are then added. After heating at reflux temperature for 18 hours, the reaction mixture is cooled to 20°C and filtered. The solvent is removed under reduced pressure, and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/3). The desired title compound is obtained in a yield of 825 mg
(56 % of theory).
Rf=0.60 in ethyl acetate/petroleum ether 1/3;
1H-NMR (CDCIs): δ(ppm)= 4.40 (s, 2H); 7.45 (d, J=8.0 Hz, 1 H); 7.57 (dxd, J=2.5 and 8.0 Hz,
1 H); 8.36 (d, J=2.5 Hz, 1 H).
Example P21 : Preparation of (6-bromopyrid-3-yl)acetonitrile
Figure imgf000040_0002
0.52 g (8.0 mmol) of potassium cyanide is added to a solution of 0.80 g (3.2 mmol) of 2- bromo-5-(bromomethyl)pyridine (Example P20) in a mixture of 8 ml of acetonitrile/water 8/2. The resulting mixture is then heated at reflux temperature for 18 hours. After cooling to 20°C, the reaction mixture is extracted with dichloromethane, the combined organic extracts are washed with a solution of sodium bicarbonate (NaHCO3) and dried over magnesium sulfate, and the solvent is removed under reduced pressure. The crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/3). The desired title compound is obtained, in a yield of 390 mg (62 % of theory), in the form of a yellow solid having a melting point of 64°C.
Rf = 0.20 in ethyl acetate/petroleum ether 1/3;
1H-NMR (CDCI3): δ(ppm)= 3.73 (s, 2H); 7.51 (d, J=8.5 Hz, 1 H); 7.55 (dxd, J=2.5 and 8.5 Hz,
1 H); 8.33 (d, J=2.5 Hz, 1 H).
Example P22: Preparation of 2-r2-(4-cvanomethylene-pyrid-2-yl)-prop-2-vnyloxy1-5-chloro-3- methoxypyridine
(Compound No. 1.016)
Figure imgf000041_0001
3.9 ml of tetrabutylammonium fluoride (1 M solution in THF), 380 mg (1.93 mmol) of (2- bromopyrid-4-yl)acetonitrile (Example P24), 571 mg (2.89 mmol) of 5-chloro-3-methoxy-2- (prop-2-ynyloxy)-pyridine (Example P5), 73 mg (0.38 mmol) of copper(l) iodide and 135 mg (0.19 mmol) of bis-triphenylphosphine-palladium dichloride (Pd(PPh3)2CI2) in 20 ml of dioxane are reacted in analogous manner to that described in the previous Examples and are then worked up and purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/1 ). The desired title compound is obtained, in a yield of 210 mg (34 % of theory), in the form of a yellow viscous mass. Rf = 0.27 in ethyl acetate/petroleum ether 1/1 ;
1 H-NMR (CDCI3): δ(ppm)= 3.47 (s, 2H); 3.86 (s, 3H); 5.24 (s, 2H); 7.05 (d, J=2.2 Hz, 1 H); 7.19 (dxd, J=5.1 and 1.6 Hz, 1 H); 7.40 (d, J=1.6 Hz, 1 H); 7.68 (d, J=2.2 Hz, 1 H); 8.54 (d, J=5.1 Hz, 1 H).
Example P23: Preparation of 2-bromo-4-(bromomethyl)pyridine
Figure imgf000041_0002
6.21 g (34.9 mmol) of N-bromosuccinimide are added to a solution of 5.0 g (29.1 mmol) of commercial 2-bromo-4-methylpyridine in 50 ml of carbon tetrachloride under argon gas. The resulting mixture is heated to reflux temperature, and 750 mg (0.9 mmol) of azobisisobutyro- nitrile (AIBN) are then added in 3 portions at intervals of 4 hours. After heating for 20 hours at reflux temperature, the reaction mixture is cooled to 20°C, and the mixture is filtered. The solvent is removed under reduced pressure and the crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). The desired target compound is obtained, in a yield of 1.85 g (25 % of theory), in the form of a white solid.
Rf=0.67 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCIg): δ(ppm)= 4.33 (s, 2H); 7.26 (dxd, J=5.1 and 1.5 Hz, 1 H); 7.51 (d, J=1.5 Hz,
1 H); 8.34 (d, J=5.1 Hz, 1 H).
Example P24: Preparation of (2-bromopyrid-4-yl)acetonitrile
Figure imgf000042_0001
1.44 g (22.1 mmol) of potassium cyanide are added to a solution of 1.85 g (7.37 mmol) of 2- bromo-4-(bromomethyl)pyridine (Example P23) in a mixture of 20 ml of acetonitrile/water 8/2. The resulting mixture is then heated at reflux temperature for 4 hours. After cooling to 20°C, the reaction mixture is extracted with dichloromethane, the combined organic extracts are washed with a solution of sodium bicarbonate (NaHCO3) and dried over magnesium sulfate, and the solvent is removed under reduced pressure. The crude product obtained is purified by means of flash chromatography (eluant: ethyl acetate/petroleum ether 1/2). The desired title compound is obtained in a yield of 420 mg (29 % of theory). Rf = 0.25 in ethyl acetate/petroleum ether 1/2;
1H-NMR (CDCI3): δ(ppm)= 3.76 (s, 2H); 7.26 (dxd, J=5.1 and 0.7 Hz, 1 H); 7.51 (d, J=0.7 Hz, 1H); 8.39 (d, J=5.1 Hz, 1 H).
In a manner analogous to that described in Examples P1 to P24 or in accordance with the methods as shown in Reaction Schemes 1 -5 and in the references indicated, it is also possible to obtain the preferred compounds listed in the following Tables. In the column headed "Phys. data", the temperatures indicate the melting point (m.p.) of the compounds in question. able 1 : Compounds of formula
Figure imgf000043_0001
Comp. Ri R2 R3 R Phys. data
No. m.p. (°C)
1.001 3-F 4-CH2CN H H
1.002 3-CI 4-CH2CN H H
1.003 3-F, 5-F 4-CI H H
1.004 3-F, 5-F 4-Br H H
1.005 3-F, 5-F 4-CH2CN H H
1.006 3-F, 5-F 4-CH3 H H
1.007 3-F, 5-CI 4-CI H H
1.008 3-F, 5-CI 4-Br H H
1.009 3-F, 5-CI 4-CH2CN H H
1.010 3-F, 5-F 4-CH(CH3)CN CH3 H
1.011 3-F, 5-F 4-CH2CN CH3 CH3
1.012 3-F, 5-CI 4-CH(CH3)CN CH3 H
1.013 3-F, 5-CI 4-CH2CN CH3 CH3
1.014 3-F, 5-CI 4-CH2CN F H
1.015 3-OCH3, 5-F 4-CH2CN H H
1.016 3-OCH3, 5-CI 4-CH2CN H H 1H-NMR
(Example
P22)
1.017 3-OCH3, 5-Br 4-CH2CN H H
1.018 3-OCH3, 5-CN 4-CH2CN H H
1.019 3-OCH3, 5-F 4-CH(CH3)CN H H
1.020 3-OCH3> 5-CI 4-CH(CH3)CN H H
1.021 3-OCH3, 5-Br 4-CH(CH3)CN H H
1.022 3-OCH3, 4-CH(CH3)CN H H 5-CH=NOCH3
1.023 3-OCH3, 5-CN 4-CH(CH3)CN H H
1.024 3-OCH3, 5-F 4-C(CH3)2CN H H
1.025 3-OCH3, 5-CI 4-C(CH3)2CN H H Comp. Ri R2 R3 R4 Phys. data
No. m.p. (°C)
1.026 3-F, 5-F 5-CI H H
1.027 3-F, 5-F 6-CI H H
1.028 3-OCH3, 5-F 5-CI H H
1.029 3-OCH3, 5-F 6-CI H H
1.030 3-F, 5-F 6-CH2CN H H
1.031 3-OCH3, 5-F 6-CH2CN H H
1.032 3-OCH3, 5-CI 6-CH2CN H H solid
1.033 3-OCH3, 5-F 6-CH(CH3)CN H H
1.034 3-OCH3, 5-Cl 6-CH(CH3)CN H H
1.035 3-OCH3, 5-F 4-CHF2 H H
1.036 3-OCH3, 5-CI 4-CHF2 H H
1.037 3-OCH3) 4-CHF2 H H 5-CH=NOCH3
1.038 3-OCH3, 5-F 6-CH2CN CH3 CH3
1.039 3-OCH3, 5-CI 6-CH2CN CH3 CH3
1.040 3-F, 5-F 6-CH2CN F F
1.041 3-F, 5-CI 6-CH2CN F F
1.042 3-OCH3, 5-F 6-CF3 H H
1.043 3-OCH3, 5-CI 6-CF3 H H
1.044 3-OCH3, 6-CF3 H H 5-CH=NOCH3
1.045 3-F, 5-F 6-NHCOCH3 H H
1.046 3-OCH3, 5-F 6-NHCOCH3 H H
1.047 3-OCH3, 5-CI 6-NHCOCH3 H H
1.048 3-OCH3, 5-F 6-NHSO2CH3 H H
1.049 3-OCH3, 5-CI 6-NHSO2CH3 H H
1.050 3-OCH3> 5-F 6-CHF2 H H
1.051 3-OCH3, 5-CI 6-CHF2 H H
1.052 3-F, 5-CI 5-CI OCH3 H
1.053 3-F, 5-CI 5-CI CN H
1.054 3-OCH3, 5-F 3-CI H H
1.055 3-OCH3, 5-F 3-Br H H
1.056 3-F, 5-F 4-NO2 H H Comp. Ri R2 R3 R4 Phys. data
No. m.p. (°C)
1.057 3-OCH3, 5-F 4-NO2 H H
1.058 3-F, 5-CF3 4-CH2CN H H
1.059 3-CI, 5-CF3 4-CH2CN H H
1.060 3-F, 5-CF3 4-CH(CH3)CN H H
1.061 3-CI, 5-CF3 4-CH(CH3)CN H H
1.062 3-OCH3, 5-CF3 6-CH2CN H H
1.063 3-OCH3) 5-CI 6-OCH2CN H H 118; 1H-NMR (Example
P8)
1.064 3-OCH3, 5-CI 4-CH3 H H 106-108;
1H-NMR
(Example
P14)
1.065 3-OCH3, 5-CI 5-CH3 H H 113
1.066 3-OCH3, 5-CI 5-CF3 H H 114
1.067 3-OCH3, 5-CI 6-OCH3 H H 116
1.068 3-OCH3, 5-CI 6-CH3 H H 96
1.069 3-OCH3, 5-CI 5-CH2CN H H 127
1.070 3-OCH3) 5-CI 4-CI H H 129
1.071 3-OCH3, 5-F 4-CH3 H H resin
1.072 3-F, 5-CI 4-CH3 H H
1.073 3-OCH3> 5-CF3 4-CH3 H H
1.074 3-OCH3, 5-CN 4-CH3 H H
Figure imgf000045_0001
5-CH=NOCH3
1.076 3-OCH3, 5-F 4-CI H H
1.077 3-OCH3, 5-CF3 4-CI H H
1.078 3-OCH3, 5-CN 4-CI H H
Figure imgf000045_0002
5-CH=NOCH3
1.080 3-OCH3) 5-CF3 4-CH2CN H H
1.081 3-OCH3, 5-CH2F 4-CH2CN H H Comp. Ri R2 R3 R4 Phys. data
No. m.p. (°C)
1.082 3-OCH3, 5-CHF2 4-CH2CN H H
1.083 3-OCH3, 5-CF3 4-OCH2CN H H
1.084 3-OCH3> 4-OCH2CN H H
5-CH=NOCH3
1.085 3-F, 5-CI 4-OCH2CN H H
1.086 3-OCH3, 5-F 4-OCH2CN H H
1.087 3-OCH3, 5-CI 4-OCH2CN H H
1.088 3-OCH3, 5-Br 4-OCH2CN H H
1.089 3-OCH3, 5-CN 4-OCH2CN H H
1.090 3-F, 5-F 6-OCH2CN H H
1.091 3-OCH3, 5-F 6-OCH2CN H H
1.092 3-OCH3, 5-CF3 6-OCH2CN H H
1.093 3-OCH3, 5-Br 6-OCH2CN H H
1.094 3-OCH3, 5-CN 6-OCH2CN H H
1.095 3-F, 5-F 6-OCH2CN H H
1.096 3-F, 5-CI 6-CH2CN H H
1.097 3-OCH3> 5-CH2F 6-CH2CN H H
1.098 3-OCH3, 5-CHF2 6-CH2CN H H
1.099 3-OCH3, 5-CN 6-CH2CN H H
1.100 3-CI, 5-CF3 6-CH2CN H H
1.101 3-OCH3, 6-CH2CN H H
5-CH=NOCH3
1.102 3-OCH3, 5-CF3 6-CH3 H H
Figure imgf000046_0001
1.104 3-OCH3, 5-F 6-CH3 H H
1.105 3-OCH3, 5-CI 6-CH3 H H
1.106 3-OCH3, 5-Br 6-CH3 H H
1.107 3-OCH3, 5-CN 6-CH3 H H
1.108 3-OCH3) 6-CH3 H H
5-CH=NOCH3
1.109 3-OCH3, 5-CF3 4-CH3, 5-F H H
1.110 3-F, 5-F 4-CH3, 5-F H H
1.111 3-OCH3, 5-F 4-CH3, 5-F H H Comp. Ri R2 R3 R4 Phys. data
No. m.p. (°C)
1.112 3-OCH3, 5-CI 4-CH3, 5-F H H
1.113 3-OCH3, 5-Br 4-CHg, 5-F H H
1.114 3-OCH3, 5-CN 4-CH3, 5-F H H
1.115 3-OCH3, 4-CH3, 5-F H H 5-CH=NOCH3
1.116 3-OCH3, 5-CF3 4-CH2CN CN H
1.117 3-F, 5-F 4-CH2CN CN H
1.118 3-OCH3, 5-F 4-CH2CN CN H
1.119 3-OCH3, 5-CI 4-CH2CN CN H
1.120 3-OCH3, 5-Br 4-CH2CN CN H
1.121 3-OCH3, 5-CN 4-CH2CN CN H
1.122 3-OCH3, 4-CH2CN CN H 5-CH=NOCH3
1.123 3-OCH3, 5-CF3 4-CH2C(S)NH2 H H
1.124 3-F, 5-F 4-CH2C(S)NH2 H H
1.125 3-OCH3, 5-F 4-CH2C(S)NH2 H H
1.126 3-OCH3, 5-CI 4-CH2C(S)NH2 H H
1.127 3-OCH3, 5-Br 4-CH2C(S)NH2 H H
1.128 3-OCH3, 5-CN 4-CH2C(S)NH2 H H
1.129 3-OCHg, 4-CH2C(S)NH2 H H 5-CH=NOCH3
Table 2: Compounds of formula I?
Figure imgf000047_0001
Comp. Ri R2 R3 R Phys. data
No. m.p. (°C)
2.001 3-F 5-CH2CN H H
2.002 3-CI 5-CH2CN H H
2.003 3-F, 5-F 6-CI H H
2.004 3-F, 5-CI 6-CI H H Comp. Ri R2 R3 R4 Phys. data
No. m.p. CC)
2.005 3-OCH3, 5-F 6-CI H H 101-102
2.006 3-OCH3, 5-CI 6-CI H H 100-101
2.007 3-OCH3, 5-CN 6-CI H H
2.008 3-OCH3, 5-CF3 6-CI H H
2.009 3-OCH3, 6-CI H H 5-CH=NOCH3
2.010 3-F, 5-F 5-CH(CH3)CN H H
2.011 3-OCH3, 5-F 5-CH(CH3)CN H H
2.012 3-OCH3, 5-CI 5-CH(CH3)CN H H
2.013 3-F, 5-F 5-CH2CN H H
2.014 3-OCH3, 5-F 5-CH2CN H H
2.015 3-OCH3, 5-CI 5-CH2CN H H
2.016 3-OCH3, 5-CH2CN H H 5-CH=NOCH3
2.017 3-F, 5-F 6-Br H H
2.018 3-F, 5-CI 6-Br H H
2.019 3-OCH3, 5-F 6-Br H H
2.020 3-OCH3, 5-CI 6-Br H H
2.021 3-OCH3, 5-CN 6-Br H H
2.022 3-OCH3> 5-CF3 6-Br H H
2.023 3-OCH3> 6-Br H H 5-CH=NOCH3
2.024 3-OCH3, 5-F 6-CI CH3 H
2.025 3-OCH3, 5-F 6-CI CH3 CH3
2.026 3-OCH3, 5-F 6-CI CN H
2.027 3-OCH3, 5-F 6-CI OCH3 H
2.028 3-F, 5-F 5-NHCOCH3 H H
2.029 3-F, 5-CI 5-NHCOCH3 H H
2.030 3-OCH3, 5-CI 5-NHCOCH3 H H
2.031 3-F, 5-CI 5-CHF2 H H
2.032 3-OCH3, 5-F 5-CHF2 H H
2.033 3-OCH3, 5-CI 5-CHF2 H H
2.034 3-F, 5-F 5-C(CH3)2CN H H Comp. Ri R2 R3 R4 Phys. data
No. m.p. (°C)
2.035 3-OCH3, 5-F 5-C(CH3)2CN H H
2.036 3-OCH3, 5-CI 5-C(CH3)2CN H H
2.037 3-F, 5-F 5-CH2CN F F
2.038 3-OCH3, 5-F 5-CH2CN F F
2.039 3-OCH3, 5-F 5-CF3 H H
2.040 3-OCH3, 5-CI 5-CF3 H H
2.041 3-OCH3, 5-F 5-NO2 H H
2.042 3-OCH3, 5-CI 5-NO2 H H
2.043 3-OCH3, 5-CF3 5-NO2 H H
2.044 5-CF3 5-CH2CN H H
2.045 5-CF3 5-CH(CH3)CN H H
2.046 3-OCH3, 5-CI 6-OCH3 H H crystalline
2.047 3-OCH3) 5-CI H (m=0) H H solid
2.048 3-OCH3, 5-F 2-CI H H 109-110
2.049 3-OCH3, 5-F 6-OCH3 H H
2.050 3-OCH3, 5-CF3 6-OCH3 H H
2.051 3-F, 5-F 2-CI H H
2.052 3-F, 5-CI 2-CI H H
2.053 3-OCH3, 5-CI 2-CI H H 109-110
2.054 3-OCH3, 5-CN 2-CI H H
2.055 3-OCH3, 5-CF3 2-CI H H
2.056 3-F, 5-F 6-CH3 H H
2.057 3-F, 5-CI 6-CH3 H H
2.058 3-OCH3, 5-F 6-CH3 H H
2.059 3-OCH3, 5-CI 6-CH3 H H
2.060 3-OCH3, 5-CN 6-CH3 H H
2.061 3-OCH3, 5-CF3 6-CH3 H H
Figure imgf000049_0001
5-CH=NOCH3
2.063 3-OCH3, 5-CH2F 6-CI H H
2.064 3-OCH3, 5-CHF2 6-CI H H
2.065 3-CI, 5-CF3 6-CI H H
2.066 3-CI, 5-CCI3 6-CI H H
Figure imgf000050_0001
X X X X X X X X X X X X X x x x x x x x x x x x X X X X
X X X X X X X X X X X X X X X x x x x x x x x x x x X X X X
LL LL LL LL LL LL LL X X X X X X X CO CD CO CO CO CO CD ϋ ϋ ϋ ϋ o o o
LO IT) lO LO lO LO LT)
Figure imgf000050_0002
Figure imgf000050_0003
Comp. Ri R2 R3 R Phys. data
No. m.p. CO
2.097 3-OCH3, 5-CF3 6-OCH2CN H H
2.098 3-OCH3, 6-OCH2CN H H 5-CH=NOCH3
2.099 3-F, 5-F 6-CH2CN H H
2.100 3-F, 5-CI 6-CH2CN H H
2.101 3-OCH3, 5-F 6-CH2CN H H
2.102 3-OCH3, 5-CI 6-CH2CN H H
2.103 3-OCH3, 5-CN 6-CH2CN H H
2.104 3-OCH3, 5-CF3 6-CH2CN H H
2.105 3-OCH3, 6-CH2CN H H 5-CH=NOCH3
2.106 3-F, 5-F 6-CI CN H
2.107 3-F, 5-CI 6-CI CN H
2.108 3-CI, 5-CF3 6-CI CN H
2.109 3-OCH3, 5-CI 6-CI CN H
2.110 3-OCH3, 5-CN 6-CI CN H
2.111 3-OCH3, 5-CF3 6-CI CN H
2.112 3-OCH3, 6-CI CN H 5-CH=NOCH3
2.113 3-F, 5-F 5-CH2C(S)NH2 H H
2.114 3-F, 5-CI 5-CH2C(S)NH2 H H
2.115 3-CI, 5-CF3 5-CH2C(S)NH2 H H
2.116 3-OCH3, 5-CI 5-CH2C(S)NH2 H H
2.117 3-OCH3, 5-CN 5-CH2C(S)NH2 H H
2.118 3-OCH3, 5-CF3 5-CH2C(S)NH2 H H
2.119 3-OCH3, 5-CH2C(S)NH2 H H 5-CH=NOCH3 able 3: Compounds of formula h
Figure imgf000052_0001
Comp. Ri R2 R3 R4 Phys. data
No. m.p. CC)
3.001 3-F 2-CI H H
3.002 3-CI 2-CI H H
3.003 3-F, 5-F 2-CI H H
3.004 3-F, 5-CI 2-CI H H
3.005 3-OCH3, 5-F 2-CI H H
3.006 3-OCHg, 5-CI 2-CI H H
3.007 3-OCH3> 5-CN 2-CI H H
3.008 3-OCH3, 5-CF3 2-CI H H
3.009 3-OCH3, 2-CI H H 5-CH=NOCH3
Figure imgf000052_0002
3.012 3-OCH3> 5-F 2-CH3 H H
3.013 3-OCH3, 5-CI 2-CH3 H H
3.014 3-OCH3) 5-CN 2-CH3 H H
3.015 3-OCH3, 5-CF3 2-CH3 H H
3.016 3-OCH3, 5-CF3 2-CH(CH3)CN H H
3.017 3-OCH3, 2-CH(CH3)CN H H 5-CH=NOCH3
3.018 3-F, 5-F 2-CH(CH3)CN H H
3.019 3-F, 5-CI 2-CH(CH3)CN H H
3.020 3-OCH3, 5-F 2-CH(CH3)CN H H
3.021 3-OCH3, 5-CI 2-CH(CH3)CN H H
3.022 3-OCH3, 5-CN 2-CH(CH3)CN H H
3.023 3-OCH3, 5-F 3-CI, 6-CI CH3 H
3.024 3-OCH3, 5-CI 3-CI, 6-CH3 CH3 H
3.025 3-OCH3, 5-CN 3-CI, 6-CHF2 CH3 H
3.026 3-OCH3, 5-CF3 3-CI, 6-OCH2CN CH3 H Comp. Ri R2 R3 R4 Phys. data
No. m.p. (°C)
3.027 3-OCH3, 3-CI, 6-CH2CN CH3 H 5-CH=NOCH3
3.028 3-F, 5-F 2-CI, 6-F H H
3.029 3-F, 5-CI 2-CI, 6-F H H
3.030 3-OCH3, 5-F 2-CI, 6-F H H
3.031 3-OCH3, 5-CI 2-CI, 6-F H H
3.032 3-OCH3> 5-CN 2-CI, 6-F H H
3.033 3-F, 5-F 2-CH(CH3)CN F F
3.034 3-F, 5-CI 2-CH(CH3)CN F F
3.035 3-OCH3l 5-F 2-CH(CH3)CN F F
3.036 3-OCH3, 5-CI 2-CH(CH3)CN F F
3.037 3-OCH3, 5-CN 2-CH(CH3)CN F F
3.038 3-F 2-CH2CN H H
3.039 3-CI 2-CH2CN H H
3.040 3-F, 5-F 2-CH2CN H H
3.041 3-F, 5-CI 2-CH2CN H H
3.042 3-OCH3, 5-F 2-CH2CN H H
3.043 3-OCH3, 5-CI 2-CH2CN H H
3.044 3-OCH3, 5-CN 2-CH2CN H H
3.045 3-OCH3, 5-CF3 2-CH2CN H H
3.046 3-OCH3, 2-CH2CN H H 5-CH=NOCH3
3.047 3-OCH3, 5-F 2-OCH2CN H H
3.048 3-OCH3) 5-CI 2-OCH2CN H H
3.049 3-OCH3, 5-CN 2-OCH2CN H H
3.050 3-OCH3, δ-CFg 2-OCH2CN H H
3.051 3-OCH3, 2-OCH2CN H H 5-CH=NOCH3
3.052 3-F, 5-F 2-CHF2 H H
3.053 3-F, 5-CI 2-CHF2 H H
3.054 3-OCH3, 5-F 2-CHF2 H H
3.055 3-OCH3, 5-CI 2-CHF2 H H
3.056 3-OCH3, 5-CN 2-CHF2 H H ©o O CO O o -α α. ω to ci
H U α. x x x x x x x x x x x x x x x x x x x x x X X X X X X X X
X x x x x x x x x x x x x x x x x x x x x x X X X X X X X
Figure imgf000054_0001
Figure imgf000054_0002
Comp. Ri R2 R3 R4 Phys. data
No. m.p. CC)
3.087 3-OCH3, 5-F 2-CH2C(S)NH2 H H
3.088 3-OCH3, 5-CI 2-CH2C(S)NH2 H H
3.089 3-OCH3, 5-CN 2-CH2C(S)NH2 H H
. 3.090 3-OCH3, 5-CF3 2-CH2C(S)NH2 H H
3.091 3-OCH3) 2-CH2C(S)NH2 H H 5-CH=NOCH3
3.092 3-F, 5-CI 2-CH2CO2H H H
3.093 3-OCH3, 5-F 2-CH2CO2H H H
3.094 3-OCH3, 5-CI 2-CH2CO2H H H
3.095 3-OCH3, 5-CN 2-CH2CO2H H H
3.096 3-OCH3, 5-CF3 2-CH2CO2H H H
3.097 3-OCH3, 2-CH2CO2H H H 5-CH=NOCH3
Bioloqical Examples
Example B1 : : Herbicidal action prior to emergence of the plants (pre-emerqence action)
Monocotyledonous and dicotyledonous test plants are sown in standard soil in pots. Immediately after sowing, the test compounds, in the form of an aqueous suspension (prepared from a wettable powder (Example F3, b) according to WO 97/34485) or in the form of an emulsion (prepared from an emulsif iable concentrate (Example F1 , c) according to WO 97/34485), are applied by spraying in an optimum concentration (500 litres of water/ha). The test plants are then grown in a greenhouse under optimum conditions. After a test duration of 4 weeks, the test is evaluated in accordance with a scale of nine ratings (1 = total damage, 9 = no action). Ratings of from 1 to 4 (especially from 1 to 3) indicate good to very good herbicidal action.
Test plants: Setaria (Seta), Panicum (Pani), Echinochloa (Ds) (Echino), Amaranthus (Amar), Chenopodium (Cheno), Stellaria (Stella), Veronica, Euphorbia (Eupho), Brachiaria (Brachi).
Figure imgf000056_0001
The same results are obtained when the compounds of formula I are formulated in accordance with the other Examples analogously to WO 97/34485.
Example B2: Post-emergence herbicidal action
Monocotyledonous and dicotyledonous test plants are sown in standard soil in pots. When the test plants are at the 2- to 3-leaf stage, the test compounds, in the form of an aqueous suspension (prepared from a wettable powder (Example F3, b) according to WO 97/34485) or in the form of an emulsion (prepared from an emulsifiable concentrate (Example F1 , c) according to WO 97/34485), are applied by spraying in an optimum concentration (500 litres of water/ha). The test plants are then grown on in a greenhouse under optimum conditions. After a test duration of 2 to 3 weeks, the test is evaluated in accordance with a scale of nine ratings (1 = total damage, 9 = no action). Ratings of from 1 to 4 (especially from 1 to 3) indicate good to very good herbicidal action.
Test plants: Setaria (Seta), Panicum (Pani), Echinochloa (Ds) (Echino), Amaranthus (Amar), Chenopodium (Cheno), Stellaria (Stella), Veronica, Euphorbia (Eupho).
Figure imgf000056_0002
In the above Tables B1 and B2 " - " means that no data are available for that indication.
The same results are obtained when the compounds of formula I are formulated in accordance with the other Examples analogously to WO 97/34485.

Claims

What is claimed is:
1. A compound of formula
Figure imgf000057_0001
wherein n is 0, 1 , 2, 3 or 4; each R independently of any others is halogen, -CN, -SCN, -SF5, -NO2, -NR5R6, -CO2R7,
-CONR8R9> -C(Rιo)=NORn, -COR12, -OR13, -SR14, -SOR15, -SO2R16, -OSO2R17, C C8alkyl,
C2-C8alkenyl, C2-C8alkynyl or C3-C6cycloalkyl; or is C C8alkyl, C2-C8alkenyl or C2-C8alkynyl substituted by one or more halogen, -CN, -NO2, -NR18R19, -CO2R20, -CONR21R22, -COR23,
-C(R24)=NOR25l -C(S)NR26R27, -C(C1-C4alkylthio)=NR28, -OR29, -SR30> -SOR31, -SO2R32 or
C3-C6cycloalkyl substituents; or each Ri independently of any others is C3-C6cycloalkyl substituted by one or more halogen,
-CN, -NO2, -NR18R19, -CO2R20, -CONR21R22, -COR23, -C(R24)=NOR25, -C(S)NR26R27,
-C(C C4alkylthio)=NR28, -SR30, -SOR31 > -SO2R32 or C3-C6cycloalkyl substituents; or each T. independently of any others is phenyl, which may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, C C4alkoxy, -CN, -NO2) 0-C alkylthio, C C4alkyl- sulfinyl or C C4alkylsulfonyl substituents; or two adjacent R1 together form a C C7alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by O-Cealkyl or CrC6alkoxy, the total number of ring atoms being at least 5 and at most 9; or two adjacent Ri together form a C2-C7alkenylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by O-Cβalkyl or CrC6alkoxy, the total number of ring atoms being at least 5 and at most 9;
R3 and R4 are each independently of the other hydrogen, halogen, -CN, d-C4alkyl or d-C4- alkoxy; or
R3 and R4 together are C2-C5alkylene;
R5 is hydrogen, C C8alkyI or -C(O)CrC8alkyl;
R6 is hydrogen, C Csalkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl; wherein phenyl and benzyl may in turn be substituted by one or more halogen, CrC4alkyl, 0-C4haloalkyl, 0-C4alkoxy, -CN, -NO2, 0-C4alkylthio, C C4alkylsulfinyl or C C4alkylsulfonyl substituents; or
R5 and R6 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R7 is hydrogen, Cι-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is C C8alkyl, C3-C8alkenyl or
C3-C8alkynyl substituted by one or more halogen, CrC4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, C C4alkyl, C C4halo- alkyl, C C4alkoxy, -CN, -NO2, C C4alkylthio, CrC4alkyIsulfinyl or C C4alkylsulfonyl substituents;
R8 is hydrogen or CrC8alkyl;
R9 is hydrogen or CrC8alkyl, or is O-Csalkyl substituted by one or more -COOH,
0-C8alkoxycarbonyl or -CN substituents, or
R9 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, CrC4haloalkyl, C C4alkoxy, -CN, -NO2,
C C4alkylthio, 0-C4alkylsulfinyl or 0-C4aIkylsulfonyl substituents; or
R8 and R9 together are C2-C5alkylene;
R10 is hydrogen, CrC alkyl, C C4haloalkyl or C3-C6cycloalkyl;
R-n is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C C4haloalkyl or C3-C6haloalkenyl;
R12 is hydrogen, Cι-C4alkyl, 0-C4haloalkyl or C3-C6cycloalkyl;
R13 is hydrogen, 0-C8alkyI, C3-C8alkenyl or C3-C8alkynyl; or
R13 is phenyl or phenyl-CrCβalkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, C C4alkyl, C C4haloalkyl, CrC4alkoxy, -CN, -NO2, O-Csalkylthio,
0-C8alkylsulfinyl or 0-C8aIkylsulfonyl substituents, or
R13 is C Cealkyl substituted by one or more halogen, -CN, CrC6alkylamino, di(C C6alkyl)- amino or d-C aIkoxy substituents;
R14 is hydrogen, C C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is C C8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents;
R15. Rie and R 7 are each independently of the others CrC8alkyl, C3-C8alkenyl or C3-C8- alkynyl, or C C8alkyl substituted by one or more halogen, -CN or CrC4alkoxy substituents;
R18 is hydrogen or d-Csalkyl;
R19 is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, 0-C haloalkyl, C C4- alkoxy, -CN, -NO2, C C4alkylthio, Ci -C aikylsulf inyl or d-C alkylsulfonyl substituents; or
R18 and R19 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom; R20 is hydrogen, Cn-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, d-C4haloalkyl, C C4- alkoxy, -CN, -NO2, C C alkylthio, C C4alkylsulfinyl or d-C4alkylsulfonyl substituents;
R21 is hydrogen or C C8alkyl;
R22 is hydrogen or CrC8alkyl, or is CrC8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents, or
R22 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, Cι-C alkyl, Cι-C4haloalkyl, C C4alkoxy, -CN, -NO2,
0-C4alkylthio, d-C4alkylsulfinyl or d-C4alkylsuffonyl substituents; or
R21 and R22 together are C2-C5alkylene;
R23 is hydrogen, C C4alkyl, C C4haloalkyl or C3-C6cycloalkyl;
R2 is hydrogen, C -C4alkyl, C C4haloalkyl or C3-C6cycloalkyl;
R25 is hydrogen, CrC8alkyl, C3-C8alkenyl, C3-C8alkynyl, d-C4haloalkyl or C3-C6haloalkenyl;
R26 is hydrogen or C C8alkyl;
R27 is hydrogen or d-C8aIkyl, or is d-C8alky! substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents, or
R27 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C4aIkylsulfinyl or d-C alkylsulfonyl substituents; or
R26 and R27 together are C2-C5alkylene;
R28 is hydrogen or d-C8alkyl;
R29 and R30 are each independently of the other hydrogen, C C8alkyl, C3-C8alkenyl or
C3-C8alkynyl, or Cι-C8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents;
R31 and R32 are each independently of the other d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or d-C8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents; m is O, 1 , 2, 3 or 4; each R2 independently of any others is halogen, -CN, -SCN, -OCN, -N3, -SF5, -NO2,
-NR33R34, -CO2R35, -CONR36R37> -C(R38)=NOR39, -COR^, -OR41, -SR42, -SOR^, -SO^,
-OSO2R45, -N([CO]pR46)COR47, -N(OR54)COR55, -N(R56)SO2R57) -N(SO2R58)SO2R59,
Figure imgf000059_0001
-CR62(OR63)OR64, -OC(O)NR65R66, -SC(O)NR67R68, -OC(S)NR69R70 or
-N-phthalimide; or
R2 is a 5- to 7-membered heterocyclic ring system, which may be aromatic or partially or fully saturated and may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, hydroxy-Cι-C alkyl, C C alkoxy, C C4alkoxy- d-C4alkyl, -CN, -NO2, d-C6alkylthio, d-C6alkylsulfinyl or d-C6alkylsulfonyl substituents; R33 is hydrogen or d-C8alkyl; and
R34 is hydrogen, CrC8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, C C - alkoxy, -CN, -NO2, C C4alkylthio, d-C4alkylsulfinyl or d-C alkylsulfonyl substituents; or R33 and Ru together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R35 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is C C8alkyl, C3-C8alkenyl or C3-C8alkynyl substituted by one or more halogen, Cι-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, C C4alkyl, d-C4halo- alkyl, C C4alkoxy, -CN, -NO2, C C4alkylthio, d-C4alkylsulfinyl or C C4alkylsulfonyl substituents;
R36 is hydrogen or Cι-C8alkyl;
R37 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents, or
R37 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, Cι-C4alkyl, C C4haloalkyl, d-C alkoxy, -CN, -NO2, d-C alkylthio, Cι-C alkylsulfinyl or d-C4alkylsulfonyl substituents; or R36 and R37 together are C3-C5alkylene; R38 is hydrogen, d-C4alkyl, C C haloalkyl or C3-C6cycloalkyl;
R39 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C C4haloaIkyl or C3-C6haIoalkenyl; R4o is hydrogen, C C4alkyl, C C4haloalkyl, C C8alkylthio, -C(O)-C(O)OC C4aIkyl or C3-C6- cycloalkyl;
R41 is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, d-Cealkoxy-d-Cealkyl, d-C8alkyl- carbonyl, d-C8alkoxycarbonyl, C3-C8alkenyloxycarbonyl, Ci-Cealkoxy-d-Cβalkoxycarbonyl, C Cealkylthio-CrCealkyl, d-C6alkylsulfinyl-d-C6alkyl or d-Cealkylsulfonyl-d-Cealkyl; or R41 is phenyl or phenyl-d-C6alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, d-C4alkyl, C C4haIoalkyl, C C4alkoxy, -CN, -NO2 or -8(0)20! -C8alkyl substituents, or
R41 is CrC8alkyl substituted by one or more halogen, -COOH, d-C8alkoxycarbonyl, d-Cealkylamino, di(d-C6alkyl)amino or -CN substituents;
R42 is hydrogen, C C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is d-C8alkyl substituted by one or more halogen, -CN or Cι-C4alkoxy substituents;
R^ and Rψi are each independently of the other C C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or d-C8alkyl substituted by one or more halogen, -CN or d-C4alkoxy substituents; R^ is d-C8alkyl, d-C8alkyl substituted by one or more halogen, -CN or C C4alkoxy substituents, C3-C8alkenyl or C3-C8alkynyl, or
R45 is phenyl, it being possible for the phenyl ring to be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, C C4alkoxy, -CN, -NO2, d-C8alkylthio, Cι-C8alkylsulfinyl or d-
C8alkylsulfonyl substituents;
R 6 is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl or d-C4haloalkyl;
R47 is hydrogen, d-C8alkyl, C C4alkoxy, C3-C8alkenyl or C3-C8alkynyl, or is d-C8alkyl substituted by one or more halogen, -CN, d-C4alkoxy, d-C8alkoxycarbonyl, -NH2, d-C4- alkylamino, di(C C4alkyl)amino,
Figure imgf000061_0001
-NR50SO2R51 or -NR52CO2R53 substituents, or
R47 is phenyl or benzyl, each of which may in turn be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, C C4a)kylthio, C C4alkylsulfinyl or
C C4alkylsulfonyl substituents; p is 0 or 1 ;
R^, R49> Rδo, R51, R52 and R53 are each independently of the others hydrogen, C C8alkyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic radicals in turn to be substituted by one or more halogen, d-C8alkyl, C C4haloalkyl, d-C4alkoxy,
C C4alkylamino, di(d-C4alkyl)amino, -NH2| -CN, -NO2, C C4alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents;
R^ and R55 are each independently of the other hydrogen, C C8alkyl or phenyl, which may in turn be substituted by one or more halogen, CrC4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN,
-NO2, CrC8alkylthio, d-C8alkylsulfinyl or Cι-C8alkylsulfonyl substituents;
R56 is hydrogen, d-C8alkyl, d-C4haloalkyl, CrC4alkoxy, C3-C8alkenyl, C3-C8alkynyl or benzyl, it being possible for benzyl in turn to be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, C C4alkoxy, -CN, -NO2, C C8aIkylthio, d-C8alkylsulfinyl or d-C8alkylsulfonyl substituents;
R57 is d-C8alkyl, Cι-C4haloalkyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic rings to be substituted by one or more halogen, d-C alkyl, d-C4haloalkyl, Cι-C4alkoxy, d-C4alkylamino, di(C C4alkyI)amino, -NH2, -CN, -NO2, d-C4alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents;
R58 and R59 are each independently of the other d-C8alkyI, C3-C8alkenyl, C3-C8alkynyl, phenyl, benzyl or naphthyl, it being possible for the three last-mentioned aromatic rings to be substituted by one or more halogen, d-C4alkyl, C C4haloalkyl, d-C4alkoxy, d-C4alkyl- amino, di(C1-C4alkyl)amino, -NH2, -CN, -NO2, C C4alkylthio, d-C4alkylsulfinyl or C C4alkyl- sulfonyl substituents;
R60 and R6ι are each independently of the other hydrogen or d-C6alkyl;
R62, Rβ3 and R^ are each independently of the others hydrogen or d-C8alkyl, or R63 and R^ together form a C2-C5alkylene bridge;
Res, Ree, Re7, Res. Reg and R70 are each independently of the others hydrogen or C C8alkyl, or
R65 and R66 together or R67 and R68 together or R69 and R70 together form a C2-C5alkylene bridge; or each R2 independently of any others is d-C8alkyl, or is CrC8alkyl mono- or poly-substituted by halogen, -CN, -N3, -SCN, -NO2, -NR71R72, -CO2R73, -CONR74R75, -COR76, -C(R77)=NOR78, -C(S)NR79R80, -C(C C4alkylthio)=NR81, -OR82, -SR83) -SOR84, -SO2R85, -O(SO2)R86, -N(R87)CO2R88, -N(R89)COR90, -S+(R91)2, -N+(R92)3, -Si(R93)3 or C3-C6cycloalkyl; or each R2 independently of any others is C C8alkyl substituted by a 5- to 7-membered heterocyclic ring system, which may be aromatic or partially or fully saturated and may contain from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulfur, it being possible for that heterocyclic ring system in turn to be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, hydroxy-C C4alkyl, C C4alkoxy, d-Oalkoxy-d-dalkyl, -CN, -NO2, d-C6alkylthio, d-C6alkylsulfinyl or d-C6alkylsulfonyl substituents; or each R2 independently of any others is C2-C8alkenyl, or is C2-C8alkenyl mono- or poly- substituted by -CN, -NO2, -CO2R94, -CONR95R96, -COR97, -C(R98)=NOR99, -C(S)NR100Rιoι, -C(Cι-C4alkylthio)=NR102, -OR103, -Si(R104)3 or C3-C6cycloalkyl; or each R2 independently of any others is C2-C8alkynyl, or is C2-C8alkynyl mono- or poly- substituted by halogen, -CN, -CO2R 05, -CONR106Rιo7, -COR108, -C(Rι09)=NOR110, ^(SJNRmRns, -C(C C4alkylthio)=NR113, -OR114, -Si(R115)3 or C3-C6cycloalkyl; or each R2 independently of any others is C3-C6cycloalkyl, or is C3-C6cycloalkyl mono- or poly- substituted by halogen, -CN, -CO2R116, -CONR117R118, -CORn9, -C(R120)=NOR121, -C(S)NR122R123 or -C(C C4alkylthio)=NR124; or two adjacent R2 together form a d-C7alkylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by cyano, d-C6alkyl or d-C6alkoxy, the total number of ring atoms being at least 5 and at most 9; or two adjacent R2 together form a C2-C7alkenylene bridge, which may be interrupted by 1 or 2 non-adjacent oxygen atoms and may be substituted by cyano, d-C6alkyl or d-C6alkoxy, the total number of ring atoms being at least 5 and at most 9; R71 is hydrogen or C C8alkyl;
R72 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C alkylthio, d-C4alkylsulfinyl or C C4alkylsulfonyl substituents; or R71 and R72 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or a sulfur atom;
R73 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, or is d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl substituted by one or more halogen, d-C4alkoxy or phenyl substituents, it being possible for phenyl in turn to be substituted by one or more halogen, C C4alkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, C C4alkylthio, C C4alkyIsulfinyl or C C4alkyl- sulfonyl substituents; R74 is hydrogen or d-C8alkyl;
R75 is hydrogen, d-C8alkyl or C3-C7cycloalkyl, or is Cι-C8alkyl substituted by one or more -COOH, d-C8alkoxycarbonyl, d-C6alkoxy or -CN substituents; or
R75 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4aIkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C alkylsulfinyl or Cι-C4aIkylsulfonyl substituents; or R74 and R75 together are a C2-C5alkylene chain, which may be interrupted by an oxygen or sulfur atom;
R76 is hydrogen, d-C4alkyl, Cι-C4haloalkyl or C3-C6cycloaIkyl; Rrr is hydrogen, d-C4alkyl, d-C4haloalkyl or C3-C6cycloalkyl;
R78 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, d-C4haloalkyl or C3-C6haloalkenyl; and
R79 is hydrogen or d-C8alkyl;
R80 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or
R80 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C haloalkyl, C C alkoxy, -CN, -NO2, C C4aIkylthio, d-C alkylsulfinyl or d-C4alkylsulfonyl substituents; or R79 and R80 together are C2-C5alkylene; R81 is hydrogen or Cι-C8alkyl;
R82 is -Si(d-C6alkyl)3, C3-C8alkenyl, C3-C8alkynyl or d-C8alkyl, which is mono- or poly- substituted by halogen, -CN, -NH2, d-Cealkylamino, di(d-C6alkyl)amino or C C4alkoxy; R83 is hydrogen, Cι-C8alkyl, C3-C8alkenyl, C3-C8alkynyl or CrCsalkyl, which is mono- or poly- substituted by halogen, -CN, -NH2, d-C6alkylamino, di(C1-C6alkyl)amino or C C4alkoxy; R^, Res and R86 are each independently of the others Cι-C8alkyl, C3-C8alkenyl or C3-C8- alkynyl, or d-C8alkyl which is substituted by one or more halogen, -CN or d-C4alkoxy substituents;
R87 and R89 are each independently of the other hydrogen, d-C8alkyl or d-C8alkoxy; R88 is C C8alkyl; R90 is hydrogen or CrCsalkyl;
R91 is d-C4alkyl;
R92 and R93 are each independently of the other d-C6alkyl;
R94 is hydrogen, d-C8alkyl, C3-C8alkenyl or C3-C8alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, d-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C4alky!, d-Ohaloalkyl, CrC4alkoxy, -CN, -NO2, C C4alkylthio, C C4alkylsulfinyl or Cr
C4alkylsulfonyl substituents;
R95 is hydrogen or C C8alkyl;
R96 is hydrogen or d-C8alkyl, or is CrC8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or
Rge is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, Cι-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2) d-C4alkylthio, CrC4alkylsulfinyl or d-C alkylsulfonyl substituents; or
R95 and Rg6 together are C2-C5alkylene;
Rg7 and Rg8 are each independently of the other hydrogen, d-C alkyl, d-C4haloalkyl or
C3-C6cycloalkyl;
R99 is hydrogen, C C8alkylr C3-C8alkenyl, C3-C8alkynyl, C C4haloalkyl or C3-C6haloalkenyl;
R100 is hydrogen or d-C8alkyl;
R10ι is hydrogen or C C8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or
R10ι is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, C C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, CrC4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R100 and R10ι together are C2-C5alkylene;
R102 is hydrogen or d-C8alkyl;
R103 is hydrogen, C C8alkyl, -Si(CrC6alkyl)3, C3-C8alkenyl or C3-C8alkynyl;
Ri04 is C C6alkyl;
R105 is hydrogen, CrC8alkyl, C3-C8alkenyl or C3-C8alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, d-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, d-C4alkylthio, d-C4alkylsulfinyl or C
C4alkylsulfonyl substituents;
R106 is hydrogen or C C8alkyl;
R107 is hydrogen or CrC8alkyl, or is d-C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or R107 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C4alkylthio, CrC alkylsulfinyl or CrC4alkylsulfonyl substituents; or
R106 and R107 together are C2-C5alkylene;
R108 is hydrogen, CrC4alkyl, C C4haloalkyl or C3-C6cycloalkyl;
R109 is hydrogen, d-C4alkyl, d-C haloalkyl or C3-C6cycloalkyl;
R110 is hydrogen, C C8alkyl, C3-C8alkenyl, C3-C8alkynyl, C C4haloalkyl or C3-C6haloalkenyl;
Rni is hydrogen or d-C8alkyl;
R1 2 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents; or
R112 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, C C4alkoxy, -CN, -NO2, d-C4alkylthio, C C alkylsulfinyl or d-C4aIkylsulfonyl substituents; or
Rm and R112 together are C2-C5alkylene;
R113 is hydrogen or d-C8alkyl;
R114 is hydrogen, d-C8alkyl, -Si(CrC6alkyl)3, C3-C8alkenyl or C3-C8alkynyl;
R115 is CrC6aIkyl;
R116 is hydrogen, CrC8alkyl, C3-C8alkenyl or C3-C8alkynyl, wherein the last 3 substituents may be mono- or poly-substituted by one or more halogen, d-C4alkoxy or phenyl substituents, wherein phenyl may in turn be substituted by one or more halogen, 0-C4alkyl,
C C4haloalkyl, C C4alkoxy, -CN, -NO2) C C4alkylthio, C C4alkylsulfinyl or d-
C4alkylsulfonyl substituents;
R1 7 is hydrogen or d-C8alkyl;
R118 is hydrogen or d-C8alkyl, or is d-C8alkyl substituted by one or more -COOH, C C8- alkoxycarbonyl or -CN substituents; or
Rue is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloalkyl, d-C4alkoxy, -CN, -NO2, d-C alkylthio, d-C4alkylsulfinyl or d-C4alkylsulfonyl substituents; or
R117 and R118 together are C2-C5alkylene;
R119 is hydrogen, Cι-C4alkyl, C C4haloalkyl or C3-C6cycloalkyl; and
R120 is hydrogen, d-C4alkyl, CrC4haloalkyl or C3-C6cycloalkyl;
R121 is hydrogen, d-C8aIkyl, C3-C8alkenyl, C3-C8alkynyl, C C4haloalkyl or C3-C6haloalkenyl;
R122 is hydrogen or d-C8alkyl;
R123 is hydrogen or d-C8alkyl, or is C C8alkyl substituted by one or more -COOH, d-C8- alkoxycarbonyl or -CN substituents; or R123 is C3-C8alkenyl, C3-C8alkynyl, phenyl or benzyl, wherein phenyl and benzyl may in turn be substituted by one or more halogen, d-C4aIkyl, C C4haloalkyl, d-C4alkoxy, -CN, -NO2,
CrC alkylthio, d-C alkylsulfinyl or CrC4alkylsulfonyl substituents; or
R122 and R123 together are C2-C5alkylene; and
R124 is hydrogen or d-C8alkyl, or an agrochemically acceptable salt or any stereoisomer or tautomer of a compound of formula I.
2. A process for the preparation of a compound of formula I according to claim 1 , which process comprises re
Figure imgf000066_0001
wherein Ri and n are as defined in claim 1 , in the presence of a base, with a compound of formula III
Figure imgf000066_0002
wherein R3 and R4 are as defined in claim 1 and XΛ is O-tosyl, O-mesyl, chlorine, bromine or iodine, to form a compound of formula IV
Figure imgf000066_0003
wherein R-i, R3, R4 and n are as defined in claim 1 , and then coupling that compound with a compound of formula V
Figure imgf000066_0004
wherein R2 and m are as defined in claim 1 and A is a leaving group such as, for example, halogen or trifluoromethanesulfonate, in the presence of a palladium catalyst.
3. A herbicidal and plant-growth-inhibiting composition, comprising a herbicidally effective amount of a compound of formula I on an inert carrier.
4. A method of controlling undesired plant growth, which method comprises applying a compound of formula I, or a composition comprising such a compound, in a herbicidally effective amount to plants or to the locus thereof.
5. A method of inhibiting plant growth, which method comprises applying a compound of formula I, or a composition comprising such a compound, in a herbicidally effective amount to plants or to the locus thereof.
6. A compound according to claim 1 , wherein R41 is hydrogen, d-C8alkyl, C3-C8alkenyl, C3-C8alkynyl, CrC6alkoxy-CrCealkyl, d-C8alkylcarbonyl, d-C8alkoxycarbonyl, C3-C8alkenyloxycarbonyl, CrC6alkoxy-CrC6alkoxycarbonyl, CrC6alkyIthio-CrC6alkyl, CrC6alkylsulfinyI-CrC6alkyl or CrC6alkylsulfonyl-CrC6alkyl; or
R41 is phenyl or phenyl-CrC6alkyl, wherein the phenyl ring may in turn be substituted by one or more halogen, d-C4alkyl, d-C4haloaIkyl, C C4alkoxy, -CN, -NO2 or -S(O)2d-C8alkyl substituents, or
R4ι is CrC8alkyl substituted by one or more -COOH, d-C8alkoxycarbonyl, d-C6alkylamino, di(CrC6alkyl)amino or -CN substituents.
7. A compound according to claim 1 , wherein each Ri independently of any others is halogen, -CN, -NO2, -C(Rι0)=NORn, -OR13, -S(O)2R16) d-C8alkyl or C2-C8alkenyl; or d-C8alkyl substituted by one or more halogen or -CN substituents; n is 0, 1 , 2, 3 or 4; and R10, Rιι, Rι3 and R 6 are as defined in claim 1.
8. A compound according to claim 7, wherein n is 1 , 2 or 3.
9. A compound according to claim 1 , wherein the group
Figure imgf000067_0001
occupies the 2-position on the pyridine ring.
10. A compound according to claim 1 , wherein each RΛ independently of any others is halogen, -CN, -NO2, -C(R10)=NOR11, -OR13, -SO2R16, d-C8alkyi or C2-C8alkenyl; or d-C8alkyl substituted by one or more halogen or -CN substituents; n is 1 or 2; R10, Rn, R13
and Rie are as defined in claim 1 ; and the group occupies
Figure imgf000068_0001
the 2-position on the pyridine ring.
11. A compound according to claim 1 , wherein each R2 independently of any others is -CN, -SCN, -OCN, -N3, -CONR36R37> -C(R38)=NOR39, -COR^, -OR*, -OSO2R45, -N([CO]pR46)COR47, -N(R56)SO2R57, -N(SO2R58)SO2R59, -N=C(OR60)R6ι or CrC8alkyl; or d-C8alkyl mono- or poly-substituted by halogen, -CN, -N3, -SCN, -CONR74R75, -COR76> -C(R77)=NOR78, -C(S)NR79R80, -OR82, -SOR^, -SO2R85 or by -N(R89)COR90; m is 0, 1 , 2, 3 or 4; and R36 to R41, R45 to R47, R56 to R61, R74 to R80, Rβ2, R&4, Rss, Rs9, R9o and p are as defined in claim 1.
12. A compound according to claim 11 , wherein m is 1 or 2.
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AR037754A1 (en) 2004-12-01
EP1453807A2 (en) 2004-09-08
CA2468445A1 (en) 2003-06-19
RU2004121680A (en) 2005-06-27
WO2003050087A3 (en) 2003-11-20
US20050107437A1 (en) 2005-05-19
AU2002366620A1 (en) 2003-06-23

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