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WO2002018638A3 - Detection of cyp2d6 polymorphisms - Google Patents

Detection of cyp2d6 polymorphisms Download PDF

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Publication number
WO2002018638A3
WO2002018638A3 PCT/IB2001/001544 IB0101544W WO0218638A3 WO 2002018638 A3 WO2002018638 A3 WO 2002018638A3 IB 0101544 W IB0101544 W IB 0101544W WO 0218638 A3 WO0218638 A3 WO 0218638A3
Authority
WO
WIPO (PCT)
Prior art keywords
detection
cyp2d6 polymorphisms
cyp2d6
polymorphisms
metabolize
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/001544
Other languages
French (fr)
Other versions
WO2002018638A9 (en
WO2002018638A2 (en
Inventor
Carl Risinger
Maria Kristina Andersson
Tommy Lewander
Erik Oliasson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Gemini Ltd
Original Assignee
Sequenom Gemini Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Gemini Ltd filed Critical Sequenom Gemini Ltd
Priority to AU2001282379A priority Critical patent/AU2001282379A1/en
Priority to CA002420322A priority patent/CA2420322A1/en
Priority to EP01960995A priority patent/EP1360321A2/en
Publication of WO2002018638A2 publication Critical patent/WO2002018638A2/en
Anticipated expiration legal-status Critical
Publication of WO2002018638A3 publication Critical patent/WO2002018638A3/en
Publication of WO2002018638A9 publication Critical patent/WO2002018638A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measurement Of Mechanical Vibrations Or Ultrasonic Waves (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Combined Controls Of Internal Combustion Engines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Stereo-Broadcasting Methods (AREA)

Abstract

The invention provides methods, PCR primers, sequence determination oligonucleotides, and kits for predicting a human's capacity to metabolize a substrate of the CYP2D6 enzyme using genetic analysis.
PCT/IB2001/001544 2000-08-30 2001-08-27 Detection of cyp2d6 polymorphisms Ceased WO2002018638A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001282379A AU2001282379A1 (en) 2000-08-30 2001-08-27 Detection of CYP2D6 polymorphisms
CA002420322A CA2420322A1 (en) 2000-08-30 2001-08-27 Detection of cyp2d6 polymorphisms
EP01960995A EP1360321A2 (en) 2000-08-30 2001-08-27 Detection of cyp2d6 polymorphisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0021286.0A GB0021286D0 (en) 2000-08-30 2000-08-30 Identification of drug metabolic capacity
GB0021286.0 2000-08-30

Publications (3)

Publication Number Publication Date
WO2002018638A2 WO2002018638A2 (en) 2002-03-07
WO2002018638A3 true WO2002018638A3 (en) 2003-08-28
WO2002018638A9 WO2002018638A9 (en) 2003-12-31

Family

ID=9898526

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/IB2001/001544 Ceased WO2002018638A2 (en) 2000-08-30 2001-08-27 Detection of cyp2d6 polymorphisms
PCT/IB2001/001552 Ceased WO2002018639A2 (en) 2000-08-30 2001-08-28 Detection of cyp2c19 polymorphisms
PCT/IB2001/001580 Ceased WO2002018641A2 (en) 2000-08-30 2001-08-30 Detection of cyp3a4 and cyp2c9 polymorphisms

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/IB2001/001552 Ceased WO2002018639A2 (en) 2000-08-30 2001-08-28 Detection of cyp2c19 polymorphisms
PCT/IB2001/001580 Ceased WO2002018641A2 (en) 2000-08-30 2001-08-30 Detection of cyp3a4 and cyp2c9 polymorphisms

Country Status (6)

Country Link
US (3) US20030044797A1 (en)
EP (3) EP1360321A2 (en)
AU (3) AU2001282379A1 (en)
CA (3) CA2420322A1 (en)
GB (1) GB0021286D0 (en)
WO (3) WO2002018638A2 (en)

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Also Published As

Publication number Publication date
CA2420096A1 (en) 2002-03-07
WO2002018638A9 (en) 2003-12-31
GB0021286D0 (en) 2000-10-18
EP1366186A2 (en) 2003-12-03
CA2428305A1 (en) 2002-03-07
WO2002018639A9 (en) 2003-10-30
EP1360321A2 (en) 2003-11-12
CA2420322A1 (en) 2002-03-07
WO2002018641A3 (en) 2003-10-02
EP1360320A2 (en) 2003-11-12
AU2001282379A1 (en) 2002-03-13
AU2001280012A1 (en) 2002-03-13
US20030059774A1 (en) 2003-03-27
US20030044797A1 (en) 2003-03-06
US20030017469A1 (en) 2003-01-23
WO2002018638A2 (en) 2002-03-07
AU2001284326A1 (en) 2002-03-13
WO2002018639A2 (en) 2002-03-07
WO2002018639A3 (en) 2003-07-17
WO2002018641A2 (en) 2002-03-07

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