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WO2002000165A3 - Agent for reversal of drug resistance in mycobacterium tuberculosis - Google Patents

Agent for reversal of drug resistance in mycobacterium tuberculosis Download PDF

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Publication number
WO2002000165A3
WO2002000165A3 PCT/IB2001/001136 IB0101136W WO0200165A3 WO 2002000165 A3 WO2002000165 A3 WO 2002000165A3 IB 0101136 W IB0101136 W IB 0101136W WO 0200165 A3 WO0200165 A3 WO 0200165A3
Authority
WO
WIPO (PCT)
Prior art keywords
inh
resistance
isoniazid
present
tuberculous
Prior art date
Application number
PCT/IB2001/001136
Other languages
French (fr)
Other versions
WO2002000165A2 (en
Original Assignee
Bakulesh Mafatlal Khamar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bakulesh Mafatlal Khamar filed Critical Bakulesh Mafatlal Khamar
Priority to EA200200290A priority Critical patent/EA004875B1/en
Priority to APAP/P/2002/002454A priority patent/AP2002002454A0/en
Priority to AU66257/01A priority patent/AU6625701A/en
Publication of WO2002000165A2 publication Critical patent/WO2002000165A2/en
Publication of WO2002000165A3 publication Critical patent/WO2002000165A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Multidrug resistance to anti-tuberculous drugs poses threat in the treatment of tuberculosis. These strains are resistant to at least two first line anti-tuberculous drugs such as INH and rifampicin. Frequently, such MDR strains show resistance to all commonly used first-line agent i.e. INH, rifamcpicin, streptomycin, ethambutol and pyrazinamide. Isoniazid is the most widely used anti-tuberculous drug. Resistance to isoniazid can occur by increased expression in inhA or by mutations that lower the enzyme's affinity to NADH. Mutations in katG, which encodes catalase peroxidase, is the most common source of resistance. Another mechanism of isoniazid resistance occurs by defects in NADH dehydrogenase (Ndh) of the respiratory chain. Increases expression of AphC has been suggested as another mechanism of INH resistance in mycobacteria. The present invention overcomes INH resistance by the use of penicillins with INH. According to present invention, penicillins when used in effective amount, reduces the MIC of INH in multi-drug resistant strains of M. tuberculosis. The improved INH sensitivity, as brought by the present invention, falls within the range which can be exploited for effective therapeutic intervention.
PCT/IB2001/001136 2000-06-28 2001-06-26 Agent for reversal of drug resistance in mycobacterium tuberculosis WO2002000165A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EA200200290A EA004875B1 (en) 2000-06-28 2001-06-26 Use an agent for reversal of drug resistance in mycobacterium tuberculosis
APAP/P/2002/002454A AP2002002454A0 (en) 2000-06-28 2001-06-26 Agents for reversal of drug resistance in mycobacterium tuberculosis.
AU66257/01A AU6625701A (en) 2000-06-28 2001-06-26 Agent for reversal of drug resistance in mycobacterium tuberculosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN597/MUM/2000 2000-06-28
IN597MU2000 2000-06-28

Publications (2)

Publication Number Publication Date
WO2002000165A2 WO2002000165A2 (en) 2002-01-03
WO2002000165A3 true WO2002000165A3 (en) 2002-06-20

Family

ID=11097261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001136 WO2002000165A2 (en) 2000-06-28 2001-06-26 Agent for reversal of drug resistance in mycobacterium tuberculosis

Country Status (4)

Country Link
AP (1) AP2002002454A0 (en)
AU (1) AU6625701A (en)
EA (1) EA004875B1 (en)
WO (1) WO2002000165A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
CN101987871A (en) 2002-09-27 2011-03-23 赞科股份有限公司 Optimized fc variants and methods for their generation
EP1610825A2 (en) 2003-03-31 2006-01-04 Xencor, Inc. Methods for rational pegylation of proteins
US7642340B2 (en) 2003-03-31 2010-01-05 Xencor, Inc. PEGylated TNF-α variant proteins
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
WO2005056759A2 (en) 2003-12-04 2005-06-23 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
CA2561264A1 (en) 2004-03-24 2005-10-06 Xencor, Inc. Immunoglobulin variants outside the fc region
BRPI0510674A (en) 2004-07-15 2007-12-26 Xencor Inc optimized fc variants
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
EP1817340B1 (en) 2004-11-12 2012-05-16 Xencor, Inc. Fc variants with altered binding to fcrn
AU2008345242B2 (en) 2007-10-31 2014-02-27 Xencor, Inc. Fc variants with altered binding to FcRn
CN101810610B (en) * 2010-04-19 2012-09-26 海南美兰史克制药有限公司 Amoxicillin sodium flucloxacillin sodium medicine compound liposome injection
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
WO2013096948A1 (en) 2011-12-23 2013-06-27 Lydon Nicholas B Immunoglobulins and variants directed against pathogenic microbes
CN109385439A (en) * 2018-09-18 2019-02-26 上海晶诺生物科技有限公司 The one recombination TM4 phage library and its application for constructing nadh dehydrogenase gene family missing mycobacterium tuberculosis

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633131A (en) * 1992-04-30 1997-05-27 Institut Pasteur Rapid detection of isoniazid resistance in mycobacterium tuberculosis probes for selecting nucleic acid encoding isoniazid resistance, and methods and kits
US5686590A (en) * 1993-05-14 1997-11-11 Agresearch, New Zealand Pastoral Agriculture Research Institute Ltd. Methods and compositions for detecting and treating mycobacterial infections using an INHA gene
US5851763A (en) * 1992-09-17 1998-12-22 Institut Pasteur Rapid detection of antibiotic resistance in mycobacterium tuberculosis
US5871912A (en) * 1992-04-30 1999-02-16 Institut Pasteur Nucleic acid probes, sequences and methods for detecting mycobacterium tuberculosis resistant to isoniazid
US6200754B1 (en) * 1998-03-19 2001-03-13 Variagenics, Inc. Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes
US6329138B1 (en) * 1994-06-09 2001-12-11 Innogenetics, N.V. Method for detection of the antibiotic resistance spectrum of mycobacterium species

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633131A (en) * 1992-04-30 1997-05-27 Institut Pasteur Rapid detection of isoniazid resistance in mycobacterium tuberculosis probes for selecting nucleic acid encoding isoniazid resistance, and methods and kits
US5871912A (en) * 1992-04-30 1999-02-16 Institut Pasteur Nucleic acid probes, sequences and methods for detecting mycobacterium tuberculosis resistant to isoniazid
US6124098A (en) * 1992-04-30 2000-09-26 Institut Pasteur Rapid detection of antibiotic resistance in mycobacterium tuberculosis
US5851763A (en) * 1992-09-17 1998-12-22 Institut Pasteur Rapid detection of antibiotic resistance in mycobacterium tuberculosis
US5686590A (en) * 1993-05-14 1997-11-11 Agresearch, New Zealand Pastoral Agriculture Research Institute Ltd. Methods and compositions for detecting and treating mycobacterial infections using an INHA gene
US6329138B1 (en) * 1994-06-09 2001-12-11 Innogenetics, N.V. Method for detection of the antibiotic resistance spectrum of mycobacterium species
US6200754B1 (en) * 1998-03-19 2001-03-13 Variagenics, Inc. Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes

Also Published As

Publication number Publication date
EA004875B1 (en) 2004-08-26
AP2002002454A0 (en) 2002-06-30
EA200200290A1 (en) 2002-12-26
AU6625701A (en) 2002-01-08
WO2002000165A2 (en) 2002-01-03

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