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WO2002063028A1 - Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique - Google Patents

Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique Download PDF

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Publication number
WO2002063028A1
WO2002063028A1 PCT/JP2002/000835 JP0200835W WO02063028A1 WO 2002063028 A1 WO2002063028 A1 WO 2002063028A1 JP 0200835 W JP0200835 W JP 0200835W WO 02063028 A1 WO02063028 A1 WO 02063028A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
dihydroxyhept
quinolin
fluorophenyl
cyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/000835
Other languages
English (en)
French (fr)
Inventor
Mari Hara
Yuki Takuma
Manabu Katsurada
Akemi Hosokawa
Youichi Matsumoto
Yuzo Kasuga
Naoyuki Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Nissan Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2001331480A external-priority patent/JP2003137870A/ja
Application filed by Mitsubishi Chemical Corp, Nissan Chemical Corp filed Critical Mitsubishi Chemical Corp
Priority to EP02710461A priority Critical patent/EP1365029A4/en
Priority to KR1020037010128A priority patent/KR100883874B1/ko
Priority to AU2002228413A priority patent/AU2002228413B8/en
Priority to CA2437312A priority patent/CA2437312C/en
Publication of WO2002063028A1 publication Critical patent/WO2002063028A1/ja
Priority to US10/629,865 priority patent/US6965031B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PCT/JP2002/000835 2001-02-02 2002-02-01 Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique Ceased WO2002063028A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02710461A EP1365029A4 (en) 2001-02-02 2002-02-01 "PROCESS FOR PREPARING (3R, 5S) - (E) -7-2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLINE-3-YL-3,5-DIHYDROXY-HEPT-6-ACID ESTERS"
KR1020037010128A KR100883874B1 (ko) 2001-02-02 2002-02-01 (3ｒ,5ｓ)-(ｅ)-7-[2-시클로프로필-4-(4-플루오로페닐)-퀴노린-3-일]-3,5-디하이드록시헵트-6-엔산 에스테르류의 제조방법
AU2002228413A AU2002228413B8 (en) 2001-02-02 2002-02-01 Process for producing (3R,5S)-(E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-Quinolin-3-yl]-3,5-Dihydroxyhept -6-enic acid esters
CA2437312A CA2437312C (en) 2001-02-02 2002-02-01 Process for producing (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enic acid esters
US10/629,865 US6965031B2 (en) 2001-02-02 2003-07-30 Process for producing (3R,5S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin- 3-yl]-3,5-dihydroxyhept-6-enic acid esters

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001-26316 2001-02-02
JP2001026316 2001-02-02
JP2001331480A JP2003137870A (ja) 2001-10-29 2001-10-29 ３，５−ジオキソ−６−ヘプテン酸誘導体類の製造方法及びその中間体
JP2001-331480 2001-10-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/629,865 Continuation US6965031B2 (en) 2001-02-02 2003-07-30 Process for producing (3R,5S)-(E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin- 3-yl]-3,5-dihydroxyhept-6-enic acid esters

Publications (1)

Publication Number Publication Date
WO2002063028A1 true WO2002063028A1 (fr) 2002-08-15

Family

ID=26608822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000835 Ceased WO2002063028A1 (fr) 2001-02-02 2002-02-01 Procede de production d'esters d'acide (3r,5s)-(e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-3,5-dihydroxyhept-6-enique

Country Status (8)

Country Link
US (1) US6965031B2 (ja)
EP (1) EP1365029A4 (ja)
KR (1) KR100883874B1 (ja)
CN (1) CN1329520C (ja)
AU (1) AU2002228413B8 (ja)
CA (1) CA2437312C (ja)
TW (1) TWI322829B (ja)
WO (1) WO2002063028A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078634A1 (en) * 2002-03-19 2003-09-25 Mitsubishi Chemical Corporation Novel carbonyl reductase, gene encoding it and process for producing optically active alcohols using the same
JP2015074622A (ja) * 2013-10-08 2015-04-20 ダイト株式会社 ピタバスタチンカルシウム塩の分解抑制方法
WO2015119261A1 (ja) * 2014-02-06 2015-08-13 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1365029A4 (en) * 2001-02-02 2009-07-29 Mitsubishi Chem Corp "PROCESS FOR PREPARING (3R, 5S) - (E) -7-2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLINE-3-YL-3,5-DIHYDROXY-HEPT-6-ACID ESTERS"
WO2002081451A1 (en) * 2001-04-05 2002-10-17 Nissan Chemical Industries, Ltd. Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate
US7371865B2 (en) * 2002-01-31 2008-05-13 Novartis Pharmaceuticals Corporation Process for the manufacture of HMG-CoA reductase inhibitors
ITMI20100753A1 (it) * 2010-04-30 2011-10-31 Dipharma Francis Srl Procedimento per la preparazione di statine
EP2383260A3 (en) * 2010-04-30 2011-12-28 Dipharma Francis S.r.l. Process for the preparation of statins
CN103848784B (zh) * 2012-12-05 2016-12-21 安徽省庆云医药化工有限公司 匹伐他汀酯的晶型及其制备方法
US10676441B2 (en) 2015-08-05 2020-06-09 Api Corporation Method for producing pitavastatin calcium
CN105481838A (zh) * 2015-11-18 2016-04-13 北京万全德众医药生物技术有限公司 一种制备匹伐他汀内酯杂质的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304063A2 (en) * 1987-08-20 1989-02-22 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones
EP0569998A2 (en) 1992-05-15 1993-11-18 E.R. SQUIBB & SONS, INC. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
JPH0892217A (ja) * 1994-09-06 1996-04-09 Ube Ind Ltd 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
JPH08127585A (ja) * 1994-09-06 1996-05-21 Ube Ind Ltd 光学活性な３−オキシ−５−オキソ−６−ヘプテン酸誘導体及びその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3149265B2 (ja) 1992-05-12 2001-03-26 鐘淵化学工業株式会社 光学活性な３，５−ジヒドロキシ脂肪酸エステル誘導体の製造法
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
EP1365029A4 (en) * 2001-02-02 2009-07-29 Mitsubishi Chem Corp "PROCESS FOR PREPARING (3R, 5S) - (E) -7-2-CYCLOPROPYL-4- (4-FLUORPHENYL) CHINOLINE-3-YL-3,5-DIHYDROXY-HEPT-6-ACID ESTERS"

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304063A2 (en) * 1987-08-20 1989-02-22 Nissan Chemical Industries Ltd. Quinoline type mevalonolactones
EP0569998A2 (en) 1992-05-15 1993-11-18 E.R. SQUIBB & SONS, INC. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
JPH0892217A (ja) * 1994-09-06 1996-04-09 Ube Ind Ltd 光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
JPH08127585A (ja) * 1994-09-06 1996-05-21 Ube Ind Ltd 光学活性な３−オキシ−５−オキソ−６−ヘプテン酸誘導体及びその製造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., vol. 8, 1998, pages 1403
NAGAMATSU, S. ET AL.: "Chiral separation of a pharmaceutical intermediate by a simulated moving bed process", J. CHROMATOGR. A, vol. 832, 1999, pages 55 - 65, XP004156166 *
See also references of EP1365029A4 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078634A1 (en) * 2002-03-19 2003-09-25 Mitsubishi Chemical Corporation Novel carbonyl reductase, gene encoding it and process for producing optically active alcohols using the same
CN1322129C (zh) * 2002-03-19 2007-06-20 三菱化学株式会社 新型羰基还原酶及其编码基因、以及利用它们制备光学活性醇的方法
US7335757B2 (en) 2002-03-19 2008-02-26 Mitsubishi Chemical Corporation Carbonyl reductase, gene encoding the same, and process for producing optically active alcohols using the same
JP2015074622A (ja) * 2013-10-08 2015-04-20 ダイト株式会社 ピタバスタチンカルシウム塩の分解抑制方法
US9695130B2 (en) 2014-02-06 2017-07-04 Api Corporation Rosuvastatin calcium and process for producing intermediate thereof
CN106029895A (zh) * 2014-02-06 2016-10-12 株式会社Api 瑞舒伐他汀钙及其中间体的生产方法
JPWO2015119261A1 (ja) * 2014-02-06 2017-03-30 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
WO2015119261A1 (ja) * 2014-02-06 2015-08-13 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
EP3103878A4 (en) * 2014-02-06 2017-08-16 API Corporation Rosuvastatin calcium and process for producing intermediate thereof
US10377722B2 (en) 2014-02-06 2019-08-13 Api Corporation Rosuvastatin calcium and process for producing intermediate thereof
JP2019205429A (ja) * 2014-02-06 2019-12-05 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
JP2021063087A (ja) * 2014-02-06 2021-04-22 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
CN106029895B (zh) * 2014-02-06 2021-07-16 株式会社Api 瑞舒伐他汀钙及其中间体的生产方法
JP7042323B2 (ja) 2014-02-06 2022-03-25 株式会社エーピーアイ コーポレーション ロスバスタチンカルシウム及びその中間体の製造方法
US12091390B2 (en) 2014-02-06 2024-09-17 Api Corporation Rosuvastatin calcium and process for producing intermediate thereof
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法
JPWO2016056658A1 (ja) * 2014-10-10 2017-07-20 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法

Also Published As

Publication number Publication date
EP1365029A1 (en) 2003-11-26
AU2002228413B2 (en) 2007-02-22
KR100883874B1 (ko) 2009-02-17
CN1329520C (zh) 2007-08-01
KR20030072618A (ko) 2003-09-15
CN1633502A (zh) 2005-06-29
US20040030139A1 (en) 2004-02-12
EP1365029A4 (en) 2009-07-29
AU2002228413A1 (en) 2002-08-19
TWI322829B (ja) 2010-04-01
AU2002228413B8 (en) 2007-03-22
US6965031B2 (en) 2005-11-15
CA2437312C (en) 2010-03-23
CA2437312A1 (en) 2002-08-15

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