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WO2002043864A3 - Dispositifs et procedes de multiplexage de puces a adn - Google Patents

Dispositifs et procedes de multiplexage de puces a adn Download PDF

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Publication number
WO2002043864A3
WO2002043864A3 PCT/US2001/044364 US0144364W WO0243864A3 WO 2002043864 A3 WO2002043864 A3 WO 2002043864A3 US 0144364 W US0144364 W US 0144364W WO 0243864 A3 WO0243864 A3 WO 0243864A3
Authority
WO
WIPO (PCT)
Prior art keywords
devices
biochip
methods
nucleic acid
allow
Prior art date
Application number
PCT/US2001/044364
Other languages
English (en)
Other versions
WO2002043864A2 (fr
Inventor
Robert Terbrueggen
Original Assignee
Clinical Micro Sensors Inc
Robert Terbrueggen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/001150 external-priority patent/WO2001054813A2/fr
Priority claimed from US09/760,384 external-priority patent/US7312087B2/en
Priority claimed from US09/904,175 external-priority patent/US20020177135A1/en
Application filed by Clinical Micro Sensors Inc, Robert Terbrueggen filed Critical Clinical Micro Sensors Inc
Priority to CA002427669A priority Critical patent/CA2427669A1/fr
Priority to JP2002545830A priority patent/JP2004515231A/ja
Priority to EP01987105A priority patent/EP1331999A2/fr
Priority to AU2002239354A priority patent/AU2002239354A1/en
Publication of WO2002043864A2 publication Critical patent/WO2002043864A2/fr
Publication of WO2002043864A3 publication Critical patent/WO2002043864A3/fr
Priority to US10/412,660 priority patent/US20040053290A1/en
Priority to AU2005244524A priority patent/AU2005244524A1/en
Priority to US11/532,872 priority patent/US20070098600A1/en
Priority to US11/982,368 priority patent/US20110180425A1/en
Priority to US11/982,334 priority patent/US20100285981A1/en
Priority to US11/982,403 priority patent/US20090057147A1/en
Priority to US11/982,408 priority patent/US20080242553A1/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/54366—Apparatus specially adapted for solid-phase testing
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    • G01—MEASURING; TESTING
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    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/087—Multiple sequential chambers
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B01L2400/0611—Valves, specific forms thereof check valves duck bill valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0661—Valves, specific forms thereof with moving parts shape memory polymer valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N1/02—Devices for withdrawing samples
    • G01N2001/021—Correlating sampling sites with geographical information, e.g. GPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
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    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

La présente invention concerne des dispositifs qui permettent l'analyse simultanée de plusieurs puces à ADN. Notamment, on a conçu les dispositifs pour qu'ils portent des cartouches renfermant des puces à ADN qui contiennent des jeux ordonnés d'échantillons, tels que ceux d'acides nucléiques, et grâce à ces dispositifs, on obtient des analyses d'échantillons à rendement élevé.
PCT/US2001/044364 1999-04-21 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn WO2002043864A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA002427669A CA2427669A1 (fr) 2000-11-03 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn
JP2002545830A JP2004515231A (ja) 2000-11-03 2001-11-05 バイオチップを多重化するための装置および方法
EP01987105A EP1331999A2 (fr) 2000-11-03 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn
AU2002239354A AU2002239354A1 (en) 2000-11-03 2001-11-05 Devices and methods for biochip multiplexing
US10/412,660 US20040053290A1 (en) 2000-01-11 2003-04-11 Devices and methods for biochip multiplexing
AU2005244524A AU2005244524A1 (en) 2000-11-03 2005-12-14 Devices and methods for biochip multiplexing
US11/532,872 US20070098600A1 (en) 1999-04-21 2006-09-18 Devices and methods for biochip multiplexing
US11/982,408 US20080242553A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing
US11/982,368 US20110180425A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing
US11/982,334 US20100285981A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing
US11/982,403 US20090057147A1 (en) 1999-04-21 2007-10-31 Devices and methods for biochip multiplexing

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US24584000P 2000-11-03 2000-11-03
US60/145,840 2000-11-03
USPCT/US01/01150 2001-01-11
US09/760,384 US7312087B2 (en) 2000-01-11 2001-01-11 Devices and methods for biochip multiplexing
US09/760,384 2001-01-11
PCT/US2001/001150 WO2001054813A2 (fr) 2000-01-11 2001-01-11 Dispositifs et procedes pour mettre en oeuvre des reactions multiples sur biopuces
US09/904,175 US20020177135A1 (en) 1999-07-27 2001-07-11 Devices and methods for biochip multiplexing
US09/904,175 2001-07-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/904,175 Continuation-In-Part US20020177135A1 (en) 1999-04-21 2001-07-11 Devices and methods for biochip multiplexing

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US19371202A Continuation-In-Part 1999-04-21 2002-07-11
US10/412,660 Continuation-In-Part US20040053290A1 (en) 1999-04-21 2003-04-11 Devices and methods for biochip multiplexing

Publications (2)

Publication Number Publication Date
WO2002043864A2 WO2002043864A2 (fr) 2002-06-06
WO2002043864A3 true WO2002043864A3 (fr) 2002-08-01

Family

ID=56290216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044364 WO2002043864A2 (fr) 1999-04-21 2001-11-05 Dispositifs et procedes de multiplexage de puces a adn

Country Status (5)

Country Link
EP (1) EP1331999A2 (fr)
JP (1) JP2004515231A (fr)
AU (1) AU2002239354A1 (fr)
CA (1) CA2427669A1 (fr)
WO (1) WO2002043864A2 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
US8431340B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Methods for processing and analyzing nucleic acid samples
US8476063B2 (en) 2004-09-15 2013-07-02 Integenx Inc. Microfluidic devices
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US8557518B2 (en) 2007-02-05 2013-10-15 Integenx Inc. Microfluidic and nanofluidic devices, systems, and applications
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8748165B2 (en) 2008-01-22 2014-06-10 Integenx Inc. Methods for generating short tandem repeat (STR) profiles
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
KR100450818B1 (ko) * 2002-03-09 2004-10-01 삼성전자주식회사 다챔버 ｐｃｒ 칩
EP1385006A3 (fr) * 2002-07-24 2004-09-01 F. Hoffmann-La Roche Ag Système et cartouche pour traiter un échantillon biologique
EP1419821A1 (fr) * 2002-11-14 2004-05-19 F. Hoffmann-La Roche Ag Méthode, dispositifs et enceinte de réaction pour le traitment d'échantillons biologiques
AU2003303594A1 (en) * 2002-12-30 2004-07-29 The Regents Of The University Of California Methods and apparatus for pathogen detection and analysis
EP1593961B1 (fr) * 2003-02-14 2013-01-09 Arkray Inc. Outil d'analyse avec un element a poignée
DE10318139B4 (de) * 2003-04-18 2005-02-17 PRO DESIGN Gesellschaft für Produktentwicklung mbH Selbstkonfigurerbarer Biochip
JP4038575B2 (ja) * 2003-07-25 2008-01-30 独立行政法人産業技術総合研究所 バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法
EP2407243B1 (fr) 2003-07-31 2020-04-22 Handylab, Inc. Dispositif multicouche microfluidique
US7390622B2 (en) * 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
KR101165860B1 (ko) 2003-10-16 2012-07-13 하이 캉 라이프 코포레이션 리미티드 생물학적 샘플에서 핵산을 검출하는 장치 및 방법
JP4750412B2 (ja) * 2003-12-25 2011-08-17 モレックス インコーポレイテド 生体由来分子、ダイオキシン類及び内分泌撹乱物質検出装置及び当該装置を使用した検出方法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
JP2008509387A (ja) * 2004-08-04 2008-03-27 スピンエックス インコーポレイテッド マイクロ流体デバイスを流体処理デバイスと接続する装置及び方法
JP4583937B2 (ja) * 2005-01-07 2010-11-17 積水化学工業株式会社 砒素イオンの電気化学測定方法
JP4714475B2 (ja) * 2005-02-15 2011-06-29 株式会社島津製作所 反応容器、遺伝子多型検出方法及び装置
JP2006223126A (ja) * 2005-02-15 2006-08-31 Shimadzu Corp 反応容器、遺伝子多型検出方法及び装置、並びに診断方法及び装置
JP2006242925A (ja) 2005-03-07 2006-09-14 Seiko Epson Corp 電極基板、該基板を備える検出装置および該装置を含むキット、並びに該キットを用いた検出方法
JP4660662B2 (ja) * 2005-09-06 2011-03-30 アークレイ株式会社 カートリッジ
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
AU2007204589B2 (en) * 2006-01-12 2012-11-01 Mycrolab Diagnostics Pty Ltd New instrumentation systems and methods
WO2007112114A2 (fr) 2006-03-24 2007-10-04 Handylab, Inc. Système intégré de traitement d'échantillons microfluides et son procédé d'utilisation
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8273049B2 (en) * 2007-02-27 2012-09-25 Deka Products Limited Partnership Pumping cassette
US20090291505A1 (en) * 2006-07-14 2009-11-26 Roche Molecular System, Inc. Analytical Device for Thermally Treating a Fluid and/or Monitoring a Property Thereof
EP1878495A1 (fr) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Dispositif analytique pour traiter thermiquement un fluide et/ou pour en surveiller une propriété
EP1886727A1 (fr) * 2006-07-14 2008-02-13 Roche Diagnostics GmbH Dispositif pour analyse
WO2008052138A2 (fr) 2006-10-25 2008-05-02 The Regents Of The University Of California Microdispositif à injection en ligne et système d'analyse d'adn intégré micro-usiné faisant intervenir ce microdispositif
WO2008061165A2 (fr) 2006-11-14 2008-05-22 Handylab, Inc. Cartouche microfluidique et son procédé de fabrication
JP4751302B2 (ja) * 2006-11-21 2011-08-17 株式会社日立製作所 電位差式センサ及び分析用素子
US20090107335A1 (en) 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
EP2028488B1 (fr) * 2007-08-02 2015-02-25 F. Hoffmann-La Roche AG Unité de transfert pour éléments test
JP2009085829A (ja) * 2007-10-01 2009-04-23 Nec Corp 生体材料測定装置
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
WO2013067202A1 (fr) 2011-11-04 2013-05-10 Handylab, Inc. Dispositif de préparation d'échantillons de polynucléotides
WO2014022700A2 (fr) * 2012-08-01 2014-02-06 Prakash Ranjit A Dispositif fonctionnellement intégré pour identification génétique multiplexe et procédé de séparation et de détection de fragments d'adn
US20140200167A1 (en) 2012-08-01 2014-07-17 Nanomdx, Inc. Functionally integrated device for multiplex genetic identification
WO2014036521A1 (fr) 2012-08-30 2014-03-06 Life Technologies Corporation Dispositif de serrage vertical
DE102014205728B3 (de) * 2014-03-27 2015-03-05 Robert Bosch Gmbh Chiplabor-Kartusche für ein mikrofluidisches System zum Analysieren einer Probe biologischen Materials, mikrofluidisches System zum Analysieren einer Probe biologischen Materials sowie Verfahren und Vorrichtung zum Analysieren einer Probe biologischen Materials
GB201510723D0 (en) * 2015-06-18 2015-08-05 Alere Switzerland Gmbh High throughput isothermal nucleic acid amplification
JP7012301B2 (ja) * 2017-09-12 2022-02-14 株式会社八光電機 薬物検出システム
JP7303623B2 (ja) * 2018-12-07 2023-07-05 積水化学工業株式会社 検査用具
CN117859062A (zh) * 2021-04-26 2024-04-09 中尺度技术有限责任公司 多重测定板以及其制备方法
DE102022209418A1 (de) * 2022-09-09 2024-03-14 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und Verfahren zu ihrem Betrieb

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5519635A (en) * 1993-09-20 1996-05-21 Hitachi Ltd. Apparatus for chemical analysis with detachable analytical units
WO1997041425A1 (fr) * 1996-04-25 1997-11-06 Pence, Inc. Biocapteur et methode afferente
WO1998005424A1 (fr) * 1996-08-02 1998-02-12 Caliper Technologies Corporation Dispositif analytique et procede correspondant
WO1998057159A1 (fr) * 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Procedes electroniques de detection d'analytes
US5866345A (en) * 1992-05-01 1999-02-02 The Trustees Of The University Of Pennsylvania Apparatus for the detection of an analyte utilizing mesoscale flow systems
WO1999033559A1 (fr) * 1997-12-24 1999-07-08 Cepheid Cartouche de manipulation de fluide integree
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
WO2000062931A1 (fr) * 1999-04-21 2000-10-26 Clinical Micro Sensors, Inc. Utilisation de systemes microfluidiques pour la detection electrochimique d'analytes cibles

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866345A (en) * 1992-05-01 1999-02-02 The Trustees Of The University Of Pennsylvania Apparatus for the detection of an analyte utilizing mesoscale flow systems
US5519635A (en) * 1993-09-20 1996-05-21 Hitachi Ltd. Apparatus for chemical analysis with detachable analytical units
US6114122A (en) * 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
WO1997041425A1 (fr) * 1996-04-25 1997-11-06 Pence, Inc. Biocapteur et methode afferente
WO1998005424A1 (fr) * 1996-08-02 1998-02-12 Caliper Technologies Corporation Dispositif analytique et procede correspondant
WO1998057159A1 (fr) * 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Procedes electroniques de detection d'analytes
WO1999033559A1 (fr) * 1997-12-24 1999-07-08 Cepheid Cartouche de manipulation de fluide integree
WO2000062931A1 (fr) * 1999-04-21 2000-10-26 Clinical Micro Sensors, Inc. Utilisation de systemes microfluidiques pour la detection electrochimique d'analytes cibles

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9557295B2 (en) 1999-04-21 2017-01-31 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US8431340B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Methods for processing and analyzing nucleic acid samples
US8431390B2 (en) 2004-09-15 2013-04-30 Integenx Inc. Systems of sample processing having a macro-micro interface
US8476063B2 (en) 2004-09-15 2013-07-02 Integenx Inc. Microfluidic devices
US8551714B2 (en) 2004-09-15 2013-10-08 Integenx Inc. Microfluidic devices
US9752185B2 (en) 2004-09-15 2017-09-05 Integenx Inc. Microfluidic devices
US8557518B2 (en) 2007-02-05 2013-10-15 Integenx Inc. Microfluidic and nanofluidic devices, systems, and applications
US11845081B2 (en) 2007-07-13 2023-12-19 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8748165B2 (en) 2008-01-22 2014-06-10 Integenx Inc. Methods for generating short tandem repeat (STR) profiles
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8388908B2 (en) 2009-06-02 2013-03-05 Integenx Inc. Fluidic devices with diaphragm valves
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9731266B2 (en) 2010-08-20 2017-08-15 Integenx Inc. Linear valve arrays

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