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WO1998030255A3 - Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels - Google Patents

Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels Download PDF

Info

Publication number
WO1998030255A3
WO1998030255A3 PCT/US1998/000491 US9800491W WO9830255A3 WO 1998030255 A3 WO1998030255 A3 WO 1998030255A3 US 9800491 W US9800491 W US 9800491W WO 9830255 A3 WO9830255 A3 WO 9830255A3
Authority
WO
WIPO (PCT)
Prior art keywords
restenosis
blood vessels
inhibition
intravascular delivery
antioxidant substances
Prior art date
Application number
PCT/US1998/000491
Other languages
French (fr)
Other versions
WO1998030255A2 (en
WO1998030255A9 (en
Inventor
Aaron V Kaplan
Original Assignee
Localmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Localmed Inc filed Critical Localmed Inc
Priority to AU59593/98A priority Critical patent/AU5959398A/en
Publication of WO1998030255A2 publication Critical patent/WO1998030255A2/en
Publication of WO1998030255A3 publication Critical patent/WO1998030255A3/en
Publication of WO1998030255A9 publication Critical patent/WO1998030255A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/104—Balloon catheters used for angioplasty

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Restenosis in re-canalized blood vessels is inhibited by an antioxidant substance, such as probucol, intramurally at a target site within the blood vessel. Usually, the antioxidant substance is delivered using a catheter having infusion ports at its distal end. Optionally, the distal end of the catheter (110) is radially expanded to engage the infusion ports directly against the blood vessel wall. Delivery of the antioxidant substance may be effected before, during, or after the re-canalization procedure.
PCT/US1998/000491 1997-01-09 1998-01-07 Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels WO1998030255A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59593/98A AU5959398A (en) 1997-01-09 1998-01-07 Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3469397P 1997-01-09 1997-01-09
US60/034,693 1997-01-09

Publications (3)

Publication Number Publication Date
WO1998030255A2 WO1998030255A2 (en) 1998-07-16
WO1998030255A3 true WO1998030255A3 (en) 1998-11-12
WO1998030255A9 WO1998030255A9 (en) 1998-12-23

Family

ID=21878006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000491 WO1998030255A2 (en) 1997-01-09 1998-01-07 Localized intravascular delivery of antioxidant substances for inhibition of restenosis in recanalized blood vessels

Country Status (2)

Country Link
AU (1) AU5959398A (en)
WO (1) WO1998030255A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852878B2 (en) 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
CZ301183B6 (en) 1997-05-14 2009-12-02 Atherogenics, Inc. Compound and pharmaceutical composition containing thereof
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
AU5687199A (en) * 1998-08-24 2000-03-14 Global Vascular Concepts, Inc. Use of anti-angiogenic agents for inhibiting vessel wall injury
EP1272465A2 (en) 2000-04-11 2003-01-08 Atherogenics, Inc. Compounds and methods to increase plasma hdl cholesterol levels and improve hdl functionality
FI20010898A0 (en) * 2001-04-30 2001-04-30 Ylae Herttuala Seppo Extracellular superoxide dismutase (EC-SOD) gene therapy to prevent restenosis
AU2003224587A1 (en) * 2002-04-30 2003-11-17 Fit Biotech Oyj Plc Medical device
WO2005016400A1 (en) * 2003-08-14 2005-02-24 Blue Medical Devices B.V. Endoluminal prosthesis comprising a therapeutic agent
EP2879616A4 (en) * 2012-08-06 2016-03-30 South Dakota Board Of Regents ASCORBIC ACID-IMPLANTABLE MEDICAL DEVICES, SYSTEMS AND RELATED METHODS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5573772A (en) * 1993-03-15 1996-11-12 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5573772A (en) * 1993-03-15 1996-11-12 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage

Also Published As

Publication number Publication date
WO1998030255A2 (en) 1998-07-16
AU5959398A (en) 1998-08-03

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