FI77461B - Foerfarande foer framstaellning av nya (8s)-8-fluorierytromycinderivat. - Google Patents
Foerfarande foer framstaellning av nya (8s)-8-fluorierytromycinderivat. Download PDFInfo
- Publication number
- FI77461B FI77461B FI850828A FI850828A FI77461B FI 77461 B FI77461 B FI 77461B FI 850828 A FI850828 A FI 850828A FI 850828 A FI850828 A FI 850828A FI 77461 B FI77461 B FI 77461B
- Authority
- FI
- Finland
- Prior art keywords
- fluoroerythromycin
- formula
- salt
- methyl
- esters
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims abstract description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 13
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- 239000003765 sweetening agent Substances 0.000 description 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Amplifiers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (7)
1. Förfarande för framställning av som läkemedel användbara föreningar med formeln I 5 CH3 CH, N: / N 10 fch3
15 CH3</* (C"CH3 (I) CH3 Y CH3 ] j S<; oh 20 ch3 or' 25. vilken formel R är en rakkedjad eller förgrenad (C^-C^)alkyl R' är väte eller metyl; och R" är hydroxl, 30 samt de motsvarande farmaceutiskt godtagbara estrarna, addltlonssalterna av de organlska syrorna samt saltestrarna, kännetecknat därav, att förfarandet innefattar fluorering av en lösning av 8,9-anhydroerytromycin 6,9-hemiketal eller motsvarande N-oxid enligt formel II II 21 774 61 ctfu
5. I jn ho^ A ch3*J^'J/CHj cr^tr^cH-hcl Ar-" 3 10 ch^IcA jL >=) jQ^CH, (ID ?u K 3 . CHJ 'Vch,'''^°νCH3 1 ζΧ„ ch3 or* 20 varvid i nämnda formel R’ och R” är i enlighet med vad som presenterades i patentkravet I och x är 0 eller 1, med perklorylfluorid i närvaro av 25 en ekvimolära mängd av en förening med formeln RÖH, där R Mr 1 enlighet med vad som deflnlerades i patentkravet 1, i strikt anhydriska förhallan-den, och det erhallna mellanskedet reduceras, da x är 1, och valbart den erhällna föreningen överförs till dess farmaceutiskt godtagbara ester, salt eller saltester. 30
2. Forfarande enligt patentkravet 1, kännetecknat därav, att R’ Mr metyl.
3. Forfarande enligt patentkravet 1, kännetecknat därav, att 35 <jen absolute konfigurationen i C-9 är R.
4. Forfarande enligt patentkravet 1, kännetecknat därav, att
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1995084 | 1984-03-08 | ||
| IT19950/84A IT1196041B (it) | 1984-03-08 | 1984-03-08 | Emichetali di (8s)-8-fluoroeritromicine,il procedimento per la loro preparazione e le formulazioni adatte alla somministrazione orale che contengono i prodotti |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI850828A0 FI850828A0 (fi) | 1985-02-28 |
| FI850828L FI850828L (fi) | 1985-09-09 |
| FI77461B true FI77461B (fi) | 1988-11-30 |
| FI77461C FI77461C (sv) | 1989-03-10 |
Family
ID=11162576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI850828A FI77461C (sv) | 1984-03-08 | 1985-02-28 | Förfarande för framställning av nya (8S)-8-fluorierytromycinderivat. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4588712A (sv) |
| EP (1) | EP0158102B1 (sv) |
| JP (1) | JPH0641477B2 (sv) |
| AT (1) | ATE41012T1 (sv) |
| CA (1) | CA1229591A (sv) |
| DE (1) | DE3568440D1 (sv) |
| FI (1) | FI77461C (sv) |
| IT (1) | IT1196041B (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876245A (en) * | 1986-12-22 | 1989-10-24 | Daikin Industries Ltd. | Fluorine-containing macrolide compounds and their use |
| MY103197A (en) * | 1987-02-20 | 1993-05-29 | Kitasato Inst | A growth promoting composition and production thereof |
| US6047808A (en) * | 1996-03-07 | 2000-04-11 | Coinstar, Inc. | Coin sensing apparatus and method |
| US6168001B1 (en) | 1997-06-27 | 2001-01-02 | Coinstar, Inc. | Positive drive coin discrimination apparatus and method |
| US7066335B2 (en) * | 2001-12-19 | 2006-06-27 | Pretech As | Apparatus for receiving and distributing cash |
| EP1620111A4 (en) * | 2003-05-06 | 2012-03-21 | Nirmal Mulye | FORMULATION OF ERYTHROMYCIN DERIVATIVES WITH CONTROLLED RELEASE |
| US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
| JP2009518396A (ja) * | 2005-12-08 | 2009-05-07 | ファイザー・インク | エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法 |
| RU2422453C2 (ru) * | 2006-12-05 | 2011-06-27 | Пфайзер Инк. | Полиморфы мотилида |
| US9036890B2 (en) | 2012-06-05 | 2015-05-19 | Outerwall Inc. | Optical coin discrimination systems and methods for use with consumer-operated kiosks and the like |
| US8967361B2 (en) | 2013-02-27 | 2015-03-03 | Outerwall Inc. | Coin counting and sorting machines |
| US9022841B2 (en) | 2013-05-08 | 2015-05-05 | Outerwall Inc. | Coin counting and/or sorting machines and associated systems and methods |
| US9235945B2 (en) | 2014-02-10 | 2016-01-12 | Outerwall Inc. | Coin input apparatuses and associated methods and systems |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3268339D1 (en) * | 1981-01-09 | 1986-02-20 | Pierrel Spa | Novel semisynthetic macrolidic antibiotics, microbiological processes for their preparation and related microorganism, novel intermediate compounds for their preparation and related pharmaceutical compositions containing them |
| IT1195299B (it) * | 1981-11-27 | 1988-10-12 | Pierrel Spa | Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici |
| JPS5896098A (ja) * | 1981-12-03 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンａ誘導体 |
-
1984
- 1984-03-08 IT IT19950/84A patent/IT1196041B/it active
-
1985
- 1985-02-28 US US06/706,496 patent/US4588712A/en not_active Expired - Fee Related
- 1985-02-28 FI FI850828A patent/FI77461C/sv not_active IP Right Cessation
- 1985-03-01 EP EP85102321A patent/EP0158102B1/en not_active Expired
- 1985-03-01 DE DE8585102321T patent/DE3568440D1/de not_active Expired
- 1985-03-01 AT AT85102321T patent/ATE41012T1/de not_active IP Right Cessation
- 1985-03-07 JP JP60045715A patent/JPH0641477B2/ja not_active Expired - Lifetime
- 1985-03-08 CA CA000476108A patent/CA1229591A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0641477B2 (ja) | 1994-06-01 |
| DE3568440D1 (en) | 1989-04-06 |
| FI850828A0 (fi) | 1985-02-28 |
| CA1229591A (en) | 1987-11-24 |
| IT8419950A0 (it) | 1984-03-08 |
| ATE41012T1 (de) | 1989-03-15 |
| FI77461C (sv) | 1989-03-10 |
| IT1196041B (it) | 1988-11-10 |
| EP0158102B1 (en) | 1989-03-01 |
| EP0158102A3 (en) | 1986-03-19 |
| EP0158102A2 (en) | 1985-10-16 |
| FI850828L (fi) | 1985-09-09 |
| US4588712A (en) | 1986-05-13 |
| JPS60208995A (ja) | 1985-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: PIERREL S.P.A. |