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FI3929573T3 - Hermoviljelyjärjestelmä - Google Patents

Hermoviljelyjärjestelmä Download PDF

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Publication number
FI3929573T3
FI3929573T3 FIEP21191782.8T FI21191782T FI3929573T3 FI 3929573 T3 FI3929573 T3 FI 3929573T3 FI 21191782 T FI21191782 T FI 21191782T FI 3929573 T3 FI3929573 T3 FI 3929573T3
Authority
FI
Finland
Prior art keywords
nerve
amount
test structure
graft segment
group
Prior art date
Application number
FIEP21191782.8T
Other languages
English (en)
Finnish (fi)
Inventor
Curt Deister
Kasra Tajdaran
Original Assignee
Axogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axogen Corp filed Critical Axogen Corp
Application granted granted Critical
Publication of FI3929573T3 publication Critical patent/FI3929573T3/fi

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56341Diffusion imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Optics & Photonics (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Wood Science & Technology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
FIEP21191782.8T 2015-05-28 2016-05-25 Hermoviljelyjärjestelmä FI3929573T3 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14/724,365 US11156595B2 (en) 2015-05-28 2015-05-28 Organotypic DRG-peripheral nerve culture system

Publications (1)

Publication Number Publication Date
FI3929573T3 true FI3929573T3 (fi) 2024-05-03

Family

ID=57394218

Family Applications (2)

Application Number Title Priority Date Filing Date
FIEP21191795.0T FI3929574T3 (fi) 2015-05-28 2016-05-25 Hermoviljelyjärjestelmä
FIEP21191782.8T FI3929573T3 (fi) 2015-05-28 2016-05-25 Hermoviljelyjärjestelmä

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FIEP21191795.0T FI3929574T3 (fi) 2015-05-28 2016-05-25 Hermoviljelyjärjestelmä

Country Status (11)

Country Link
US (4) US11156595B2 (fr)
EP (3) EP3304059B1 (fr)
JP (3) JP6971975B2 (fr)
CN (2) CN107709978B (fr)
AU (3) AU2016267075B2 (fr)
CA (1) CA2987604A1 (fr)
DK (3) DK3929573T3 (fr)
ES (3) ES2891848T3 (fr)
FI (2) FI3929574T3 (fr)
IL (2) IL255966B (fr)
WO (1) WO2016191483A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11156595B2 (en) * 2015-05-28 2021-10-26 Axogen Corporation Organotypic DRG-peripheral nerve culture system
JP7044518B2 (ja) * 2017-11-10 2022-03-30 オリンパス株式会社 細胞集塊の突起形成能評価方法
KR102406052B1 (ko) * 2018-11-15 2022-06-07 옥소젠 코포레이션 동물 기원 신경 이식편으로 신경을 수복하기 위한 재료 및 방법
JP7564633B2 (ja) 2020-03-30 2024-10-09 株式会社安川電機 細胞製造装置、細胞製造方法、細胞製造装置用プログラム、および、細胞製造システム
JP7580930B2 (ja) 2020-03-30 2024-11-12 株式会社安川電機 処理物製造装置、処理物製造方法、処理物製造装置用プログラム、および、処理物製造システム
JP7094502B1 (ja) * 2021-08-20 2022-07-04 株式会社安川電機 ロボットプログラム生成システム、ロボットプログラム生成方法、プロトコル変換判定装置、ロボットプログラム、プロトコル、および、製造システム
WO2025049203A1 (fr) * 2023-08-31 2025-03-06 Axogen Corporation Procédé d'évaluation de l'activité biologique de biomatériaux

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225122B1 (en) * 1998-03-02 2001-05-01 Signal Pharmaceuticals, Inc. Human spinal cord cell lines and methods of use therefor
US6264944B1 (en) 1999-08-17 2001-07-24 Trustees Of The University Of Pennsylvania Mechanically elongated neuronal cells
US6878543B1 (en) * 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
JP5442173B2 (ja) 2000-09-14 2014-03-12 敏一 中村 筋萎縮性側索硬化症治療剤
ATE543509T1 (de) 2001-08-13 2012-02-15 Univ Florida Material und verfahren zur förderung der reparatur von nervengewebe
WO2003031584A2 (fr) 2001-10-11 2003-04-17 Duke University Reparation d'axone
US7429267B2 (en) 2001-12-04 2008-09-30 The Trustees Of The University Of Pennsylvania Device and method using integrated neuronal cells and an electronic device
US7338517B2 (en) 2003-06-04 2008-03-04 University Of South Carolina Tissue scaffold having aligned fibrils and artificial tissue comprising the same
CN1910272A (zh) * 2003-10-10 2007-02-07 细胞生物工程公司 用于细胞培养和组织培养平台的组合物和方法
US20070155010A1 (en) 2005-07-29 2007-07-05 Farnsworth Ted R Highly porous self-cohered fibrous tissue engineering scaffold
CN101246159B (zh) * 2008-03-07 2012-03-28 华中科技大学 一种快速鉴别周围神经束性质的方法
US20110065645A1 (en) * 2009-09-10 2011-03-17 The Regents Of The University Of California Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance
CN102114268A (zh) * 2010-01-05 2011-07-06 卢世璧 一种组织工程神经支架及其制备方法和应用
WO2012050981A1 (fr) * 2010-09-29 2012-04-19 Massachusetts Institute Of Technology Dispositif d'analyse à haut débit d'interactions cellulaires
CN102614032B (zh) * 2011-01-28 2015-04-15 清华大学 神经移植体的制备方法
CN102911912B (zh) * 2011-08-01 2014-12-31 清华大学 培养基体及使用该培养基体的神经移植体
JP6258224B2 (ja) 2012-01-31 2018-01-10 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ 工学的構造物の神経支配
ES2881079T3 (es) 2013-03-15 2021-11-26 Univ Florida Método de descelularización de injertos de tejidos
WO2015066627A1 (fr) 2013-11-04 2015-05-07 The Trustees Of The University Of Pennsylvania Remplacement neuronal et rétablissement de connexions axonales
US11156595B2 (en) * 2015-05-28 2021-10-26 Axogen Corporation Organotypic DRG-peripheral nerve culture system

Also Published As

Publication number Publication date
AU2021215201A1 (en) 2021-09-02
ES2983469T3 (es) 2024-10-23
IL282476A (en) 2021-06-30
DK3929574T3 (da) 2024-05-06
EP3304059A4 (fr) 2018-11-07
JP2022009864A (ja) 2022-01-14
IL282476B (en) 2022-02-01
JP2018521685A (ja) 2018-08-09
ES2891848T3 (es) 2022-01-31
JP2023029514A (ja) 2023-03-03
JP7209799B2 (ja) 2023-01-20
US20160349231A1 (en) 2016-12-01
JP6971975B2 (ja) 2021-11-24
US20220003743A1 (en) 2022-01-06
US11959903B2 (en) 2024-04-16
ES2983679T3 (es) 2024-10-24
AU2021215200A1 (en) 2021-09-02
AU2016267075B2 (en) 2021-09-02
EP3929574A1 (fr) 2021-12-29
US11156595B2 (en) 2021-10-26
US12326440B2 (en) 2025-06-10
US20240241104A1 (en) 2024-07-18
IL255966A (en) 2018-01-31
CA2987604A1 (fr) 2016-12-01
CN113325166A (zh) 2021-08-31
AU2021215201B2 (en) 2023-07-13
CN107709978A (zh) 2018-02-16
HK1246397A1 (zh) 2018-09-07
EP3304059A1 (fr) 2018-04-11
IL255966B (en) 2021-05-31
JP7478859B2 (ja) 2024-05-07
AU2016267075A1 (en) 2018-01-18
EP3929573A1 (fr) 2021-12-29
EP3929573B1 (fr) 2024-04-10
AU2021215200B2 (en) 2023-07-13
WO2016191483A1 (fr) 2016-12-01
EP3304059B1 (fr) 2021-09-01
DK3929573T3 (da) 2024-04-15
DK3304059T3 (da) 2021-10-04
US20220003742A1 (en) 2022-01-06
EP3929574B1 (fr) 2024-04-10
FI3929574T3 (fi) 2024-05-21
CN107709978B (zh) 2021-05-11
US11885792B2 (en) 2024-01-30

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