ES2301433A1 - Uso de aminoacido tipo micosporina (porfira 334) en productos para prevencion y tratamiento terapeutico de parkinson y alzheimer. - Google Patents

Uso de aminoacido tipo micosporina (porfira 334) en productos para prevencion y tratamiento terapeutico de parkinson y alzheimer. Download PDF

Info

Publication number: ES2301433A1
Authority: ES; Spain
Prior art keywords: porphyra; antioxidant; mycosporin; amino acid; isolated
Prior art date: 2005-08-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

ES200702943A

Other languages

English (en)

Spanish (es)

Inventor

Francisca De La Coba Luque

Jose Aguilera Arjona

Felix Lopez Figueroa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Universidad de Malaga

Original Assignee

Universidad de Malaga

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-31

Filing date

2005-08-31

Publication date

2008-06-16

2005-08-31 Application filed by Universidad de Malaga filed Critical Universidad de Malaga

2008-06-16 Publication of ES2301433A1 publication Critical patent/ES2301433A1/es

Status Pending legal-status Critical Current

Links

VIZAVBQHHMQOQF-KKUJBODISA-N porphyra-334 Chemical compound COC1=C(NCC(O)=O)CC(O)(CO)C\C1=N\[C@H]([C@H](C)O)C(O)=O VIZAVBQHHMQOQF-KKUJBODISA-N 0.000 title claims abstract description 21
VIZAVBQHHMQOQF-UHFFFAOYSA-N porphyra-334 Natural products COC1=C(CC(O)(CO)C/C/1=NC(C(C)O)C(=O)O)NCC(=O)O VIZAVBQHHMQOQF-UHFFFAOYSA-N 0.000 title claims abstract description 21
150000001413 amino acids Chemical class 0.000 title claims abstract description 16
230000003078 antioxidant effect Effects 0.000 title description 36
239000003963 antioxidant agent Substances 0.000 title description 26
230000001225 therapeutic effect Effects 0.000 claims abstract description 8
238000002360 preparation method Methods 0.000 claims abstract description 7
230000002265 prevention Effects 0.000 claims abstract description 6
235000013376 functional food Nutrition 0.000 claims abstract description 5
239000002417 nutraceutical Substances 0.000 claims abstract description 5
235000021436 nutraceutical agent Nutrition 0.000 claims abstract description 5
241001491795 Pyropia leucosticta Species 0.000 claims description 19
239000000284 extract Substances 0.000 claims description 15
239000000047 product Substances 0.000 claims description 9
VVTDHOIRNPCGTH-UHFFFAOYSA-N Mycosporin 1 Natural products COC1=C(NC(CO)CO)CC(O)(CO)CC1=O VVTDHOIRNPCGTH-UHFFFAOYSA-N 0.000 claims description 5
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 5
241001474374 Blennius Species 0.000 claims description 4
239000000825 pharmaceutical preparation Substances 0.000 claims description 2
239000002537 cosmetic Substances 0.000 claims 1
229940127557 pharmaceutical product Drugs 0.000 claims 1
241000206609 Porphyra Species 0.000 abstract description 6
235000006708 antioxidants Nutrition 0.000 description 25
150000003254 radicals Chemical class 0.000 description 24
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 21
101150018863 maa gene Proteins 0.000 description 19
150000001875 compounds Chemical class 0.000 description 16
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 13
239000011648 beta-carotene Substances 0.000 description 13
235000013734 beta-carotene Nutrition 0.000 description 13
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 13
229960002747 betacarotene Drugs 0.000 description 13
WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 13
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 13
238000000034 method Methods 0.000 description 12
239000000126 substance Substances 0.000 description 12
-1 superoxide anions Chemical class 0.000 description 12
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 11
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 11
230000000694 effects Effects 0.000 description 10
230000009102 absorption Effects 0.000 description 9
238000010521 absorption reaction Methods 0.000 description 9
238000006243 chemical reaction Methods 0.000 description 9
235000013305 food Nutrition 0.000 description 9
230000003647 oxidation Effects 0.000 description 9
238000007254 oxidation reaction Methods 0.000 description 9
241000195493 Cryptophyta Species 0.000 description 7
238000002835 absorbance Methods 0.000 description 7
229940079877 pyrogallol Drugs 0.000 description 7
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
230000003859 lipid peroxidation Effects 0.000 description 6
102000004169 proteins and genes Human genes 0.000 description 6
108090000623 proteins and genes Proteins 0.000 description 6
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 5
102000004190 Enzymes Human genes 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 5
OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 5
102000003992 Peroxidases Human genes 0.000 description 5
229940087168 alpha tocopherol Drugs 0.000 description 5
230000004075 alteration Effects 0.000 description 5
230000006870 function Effects 0.000 description 5
235000020778 linoleic acid Nutrition 0.000 description 5
OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 5
238000000746 purification Methods 0.000 description 5
229960000984 tocofersolan Drugs 0.000 description 5
235000004835 α-tocopherol Nutrition 0.000 description 5
239000002076 α-tocopherol Substances 0.000 description 5
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
102000019197 Superoxide Dismutase Human genes 0.000 description 4
108010012715 Superoxide dismutase Proteins 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
238000004587 chromatography analysis Methods 0.000 description 4
230000002255 enzymatic effect Effects 0.000 description 4
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
238000004128 high performance liquid chromatography Methods 0.000 description 4
108040007629 peroxidase activity proteins Proteins 0.000 description 4
239000013641 positive control Substances 0.000 description 4
230000005855 radiation Effects 0.000 description 4
239000012429 reaction media Substances 0.000 description 4
238000000926 separation method Methods 0.000 description 4
WXEQFJUHQIGKNG-MZNRBSSJSA-N shinorine Chemical compound COC1=C(C[C@@](O)(CO)C\C1=N/[C@@H](CO)C(O)=O)NCC(O)=O WXEQFJUHQIGKNG-MZNRBSSJSA-N 0.000 description 4
WXEQFJUHQIGKNG-UHFFFAOYSA-N shinorine Natural products COC1=C(CC(O)(CO)C/C/1=NC(CO)C(=O)O)NCC(=O)O WXEQFJUHQIGKNG-UHFFFAOYSA-N 0.000 description 4
238000012360 testing method Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
XZQILKYKJYHEHD-JTQLQIEISA-N 2-[[(5s)-5-hydroxy-5-(hydroxymethyl)-2-methoxy-3-oxocyclohexen-1-yl]amino]acetic acid Chemical compound COC1=C(NCC(O)=O)C[C@@](O)(CO)CC1=O XZQILKYKJYHEHD-JTQLQIEISA-N 0.000 description 3
235000014653 Carica parviflora Nutrition 0.000 description 3
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
241000206613 Pyropia yezoensis Species 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000008346 aqueous phase Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
238000004061 bleaching Methods 0.000 description 3
230000015556 catabolic process Effects 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
210000000170 cell membrane Anatomy 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
238000002845 discoloration Methods 0.000 description 3
150000004676 glycans Chemical class 0.000 description 3
125000004435 hydrogen atom Chemical class [H]* 0.000 description 3
238000000338 in vitro Methods 0.000 description 3
239000003112 inhibitor Substances 0.000 description 3
230000005764 inhibitory process Effects 0.000 description 3
229940126707 lipid peroxidation inhibitor Drugs 0.000 description 3
230000014759 maintenance of location Effects 0.000 description 3
230000004048 modification Effects 0.000 description 3
238000012986 modification Methods 0.000 description 3
XZQILKYKJYHEHD-UHFFFAOYSA-N mycosporine glycine Natural products COC1=C(NCC(O)=O)CC(O)(CO)CC1=O XZQILKYKJYHEHD-UHFFFAOYSA-N 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
238000004321 preservation Methods 0.000 description 3
230000009919 sequestration Effects 0.000 description 3
241000894007 species Species 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
241000242757 Anthozoa Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
102000016938 Catalase Human genes 0.000 description 2
108010053835 Catalase Proteins 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
241000233866 Fungi Species 0.000 description 2
102000006587 Glutathione peroxidase Human genes 0.000 description 2
108700016172 Glutathione peroxidases Proteins 0.000 description 2
241000028378 Lichina pygmaea Species 0.000 description 2
KYCBIRYKYQCBFO-KPKJPENVSA-N Palythine Chemical compound COC1=C(N)CC(O)(CO)C\C1=[NH+]/CC([O-])=O KYCBIRYKYQCBFO-KPKJPENVSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
238000000862 absorption spectrum Methods 0.000 description 2
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
239000012620 biological material Substances 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
HKZLNGQCWGVZIW-UHFFFAOYSA-N cyclohex-2-en-1-imine Chemical group N=C1CCCC=C1 HKZLNGQCWGVZIW-UHFFFAOYSA-N 0.000 description 2
FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical compound O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 description 2
230000006378 damage Effects 0.000 description 2
238000004042 decolorization Methods 0.000 description 2
230000007423 decrease Effects 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
231100000673 dose–response relationship Toxicity 0.000 description 2
235000013399 edible fruits Nutrition 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000000605 extraction Methods 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
235000012631 food intake Nutrition 0.000 description 2
229960003180 glutathione Drugs 0.000 description 2
230000009931 harmful effect Effects 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
238000004255 ion exchange chromatography Methods 0.000 description 2
230000002427 irreversible effect Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
239000012528 membrane Substances 0.000 description 2
239000002207 metabolite Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
235000016709 nutrition Nutrition 0.000 description 2
230000001590 oxidative effect Effects 0.000 description 2
230000036542 oxidative stress Effects 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
AJGGWXHQTXRTPE-SNVBAGLBSA-N palythine Natural products COC1=C(C[C@@](O)(CO)CC1=N)NCC(=O)O AJGGWXHQTXRTPE-SNVBAGLBSA-N 0.000 description 2
229940097156 peroxyl Drugs 0.000 description 2
239000012071 phase Substances 0.000 description 2
230000003711 photoprotective effect Effects 0.000 description 2
229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000002243 precursor Substances 0.000 description 2
230000008569 process Effects 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
230000004044 response Effects 0.000 description 2
238000002390 rotary evaporation Methods 0.000 description 2
239000003352 sequestering agent Substances 0.000 description 2
238000002798 spectrophotometry method Methods 0.000 description 2
230000035882 stress Effects 0.000 description 2
239000013589 supplement Substances 0.000 description 2
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
235000013311 vegetables Nutrition 0.000 description 2
235000019155 vitamin A Nutrition 0.000 description 2
239000011719 vitamin A Substances 0.000 description 2
229940045997 vitamin a Drugs 0.000 description 2
OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
HWSJJSITUUMTSO-UHFFFAOYSA-N 2-[[5-hydroxy-5-(hydroxymethyl)-3-(1-hydroxypropan-2-ylamino)-2-methoxycyclohex-2-en-1-ylidene]amino]acetic acid Chemical compound COC1=C(NC(C)CO)CC(O)(CO)CC1=NCC(O)=O HWSJJSITUUMTSO-UHFFFAOYSA-N 0.000 description 1
MBPQVWGCNCNOQG-UHFFFAOYSA-N 2-aminocyclohex-2-en-1-one Chemical class NC1=CCCCC1=O MBPQVWGCNCNOQG-UHFFFAOYSA-N 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
RVBUGGBMJDPOST-UHFFFAOYSA-N 2-thiobarbituric acid Chemical compound O=C1CC(=O)NC(=S)N1 RVBUGGBMJDPOST-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
241001661607 Bostrychia scorpioides Species 0.000 description 1
208000002177 Cataract Diseases 0.000 description 1
241000192703 Chlorogloeopsis Species 0.000 description 1
241000243321 Cnidaria Species 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
230000033616 DNA repair Effects 0.000 description 1
241001428241 Gelidium sesquipedale Species 0.000 description 1
108010024636 Glutathione Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
241001428248 Gymnogongrus Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
241001147489 Mastocarpus stellatus Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
VVTDHOIRNPCGTH-NSHDSACASA-N Mycosporine Chemical compound COC1=C(NC(CO)CO)C[C@@](O)(CO)CC1=O VVTDHOIRNPCGTH-NSHDSACASA-N 0.000 description 1
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
241000206754 Palmaria palmata Species 0.000 description 1
108700020962 Peroxidase Proteins 0.000 description 1
206010051246 Photodermatosis Diseases 0.000 description 1
241000434565 Platygyra ryukyuensis Species 0.000 description 1
241000321455 Plectropomus leopardus Species 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
241000277331 Salmonidae Species 0.000 description 1
241000490569 Stylophora pistillata Species 0.000 description 1
OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
239000012670 alkaline solution Substances 0.000 description 1
125000000746 allylic group Chemical group 0.000 description 1
150000001414 amino alcohols Chemical class 0.000 description 1
230000006851 antioxidant defense Effects 0.000 description 1
239000006286 aqueous extract Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
238000006701 autoxidation reaction Methods 0.000 description 1
150000001579 beta-carotenes Chemical class 0.000 description 1
239000003181 biological factor Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
150000001723 carbon free-radicals Chemical class 0.000 description 1
230000005779 cell damage Effects 0.000 description 1
208000037887 cell injury Diseases 0.000 description 1
239000013626 chemical specie Substances 0.000 description 1
230000001934 delay Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000001066 destructive effect Effects 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
230000002542 deteriorative effect Effects 0.000 description 1
229910001882 dioxygen Inorganic materials 0.000 description 1
239000012154 double-distilled water Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
230000037149 energy metabolism Effects 0.000 description 1
238000007824 enzymatic assay Methods 0.000 description 1
230000005284 excitation Effects 0.000 description 1
238000005562 fading Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
229930003935 flavonoid Natural products 0.000 description 1
235000017173 flavonoids Nutrition 0.000 description 1
150000002215 flavonoids Chemical class 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000003574 free electron Substances 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
230000012010 growth Effects 0.000 description 1
230000036541 health Effects 0.000 description 1
150000002432 hydroperoxides Chemical class 0.000 description 1
OUUQCZGPVNCOIJ-UHFFFAOYSA-N hydroperoxyl Chemical compound O[O] OUUQCZGPVNCOIJ-UHFFFAOYSA-N 0.000 description 1
TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
238000011534 incubation Methods 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
230000037427 ion transport Effects 0.000 description 1
SUBFIBLJQMMKBK-UHFFFAOYSA-K iron(3+);trithiocyanate Chemical compound [Fe+3].[S-]C#N.[S-]C#N.[S-]C#N SUBFIBLJQMMKBK-UHFFFAOYSA-K 0.000 description 1
210000002510 keratinocyte Anatomy 0.000 description 1
238000003367 kinetic assay Methods 0.000 description 1
238000012417 linear regression Methods 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000000401 methanolic extract Substances 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000011859 microparticle Substances 0.000 description 1
230000035772 mutation Effects 0.000 description 1
239000013642 negative control Substances 0.000 description 1
235000008935 nutritious Nutrition 0.000 description 1
YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
235000019645 odor Nutrition 0.000 description 1
230000000065 osmolyte Effects 0.000 description 1
NKJVQFFOGWSVTJ-AMIZOPFISA-N palythinol Natural products COC1=C(C[C@](O)(CO)CC1=N[C@H](C)CO)NCC(=O)O NKJVQFFOGWSVTJ-AMIZOPFISA-N 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
229960003330 pentetic acid Drugs 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
230000008845 photoaging Effects 0.000 description 1
230000000243 photosynthetic effect Effects 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000002516 radical scavenger Substances 0.000 description 1
238000006479 redox reaction Methods 0.000 description 1
230000027272 reproductive process Effects 0.000 description 1
230000008054 signal transmission Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000036561 sun exposure Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
229960003080 taurine Drugs 0.000 description 1
230000008646 thermal stress Effects 0.000 description 1
230000008719 thickening Effects 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
229910001428 transition metal ion Inorganic materials 0.000 description 1
238000013519 translation Methods 0.000 description 1
230000014616 translation Effects 0.000 description 1
OMPMQQQHTAPTHR-UHFFFAOYSA-N usujirene Natural products COC1=C(CC(O)(CO)C/C/1=NC=C/C)NCC(=O)O OMPMQQQHTAPTHR-UHFFFAOYSA-N 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/04—Rhodophycota or rhodophyta (red algae), e.g. Porphyra
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Natural Medicines & Medicinal Plants (AREA)
Biotechnology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Mycology (AREA)
Alternative & Traditional Medicine (AREA)
Microbiology (AREA)
Medical Informatics (AREA)
Botany (AREA)
Birds (AREA)
Ophthalmology & Optometry (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Food Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Psychiatry (AREA)
Psychology (AREA)
Nutrition Science (AREA)
Toxicology (AREA)
Polymers & Plastics (AREA)
Hospice & Palliative Care (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Medicines Containing Plant Substances (AREA)

ES200702943A 2005-08-31 2005-08-31 Uso de aminoacido tipo micosporina (porfira 334) en productos para prevencion y tratamiento terapeutico de parkinson y alzheimer. Pending ES2301433A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES200502161A ES2301293B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porphyra 334) como antioxidante.

Publications (1)

Publication Number	Publication Date
ES2301433A1 true ES2301433A1 (es)	2008-06-16

Family

ID=37809229

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
ES200502161A Expired - Fee Related ES2301293B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porphyra 334) como antioxidante.
ES200702943A Pending ES2301433A1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfira 334) en productos para prevencion y tratamiento terapeutico de parkinson y alzheimer.
ES200702947A Expired - Fee Related ES2301437B1 (es)	2005-08-31	2005-08-31	Uso de aminoacidos tipo micosporina (porfira 334) en la prevencion de la oxidacion de productos cosmeticos y farmaceuticos.
ES200702944A Expired - Fee Related ES2301434B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfina 334) en productos para prevencion de cataratas.
ES200702945A Expired - Fee Related ES2301435B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfira 334) en productos para prevencion y tratamiento de eritema actinico, fotocarcinogenesis y fotoenvejecimiento.
ES200702946A Expired - Fee Related ES2301436B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfira 334) como antioxidante o aditivo en productos alimentarios.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES200502161A Expired - Fee Related ES2301293B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porphyra 334) como antioxidante.

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
ES200702947A Expired - Fee Related ES2301437B1 (es)	2005-08-31	2005-08-31	Uso de aminoacidos tipo micosporina (porfira 334) en la prevencion de la oxidacion de productos cosmeticos y farmaceuticos.
ES200702944A Expired - Fee Related ES2301434B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfina 334) en productos para prevencion de cataratas.
ES200702945A Expired - Fee Related ES2301435B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfira 334) en productos para prevencion y tratamiento de eritema actinico, fotocarcinogenesis y fotoenvejecimiento.
ES200702946A Expired - Fee Related ES2301436B1 (es)	2005-08-31	2005-08-31	Uso de aminoacido tipo micosporina (porfira 334) como antioxidante o aditivo en productos alimentarios.

Country Status (2)

Country	Link
ES (6)	ES2301293B1 (fr)
WO (1)	WO2007026035A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2317741B1 (es) *	2006-06-20	2010-02-10	Universidad De Malaga	Composicion para proteccion solar a base de extractos de algas y liquenes.
KR102196422B1 (ko) *	2019-07-15	2020-12-30	주식회사 바이오에프디엔씨	포피라334를 이용한 성체세포를 유도만능 줄기세포로 역분화시키는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2054485T3 (es) *	1989-12-06	1994-08-01	Engrais Composes Mineraux Et A	Utilizacion de extractos de algas para la preparacion de composiciones farmaceuticas, cosmeticas, alimentarias o de uso agricola.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2251457A1 (fr) *	1998-10-23	2000-04-23	Norman Huner	Compositions comprenant des composes d'origine naturelle tires de plantes, d'algues et de cyanobacteries pour la protection contre les rayons solaires
FR2803201B1 (fr) *	1999-12-30	2004-11-26	Gelyma	Extrait d'algue a activite filtrante vis a vis des radiations ultraviolettes
GB0028161D0 (en) *	2000-11-17	2001-01-03	Natural Environment Res	Personal care compositions
CA2467102C (fr) *	2001-11-14	2012-07-10	Larena	Un produit contenant un extrait d'algue rouge du genre porphyra et ses utilisations pour proteger les cellules
FR2882894B1 (fr) *	2005-03-11	2009-04-03	Larena Sa	Composition alimentaire suppletive

2005
- 2005-08-31 ES ES200502161A patent/ES2301293B1/es not_active Expired - Fee Related
- 2005-08-31 ES ES200702943A patent/ES2301433A1/es active Pending
- 2005-08-31 ES ES200702947A patent/ES2301437B1/es not_active Expired - Fee Related
- 2005-08-31 ES ES200702944A patent/ES2301434B1/es not_active Expired - Fee Related
- 2005-08-31 ES ES200702945A patent/ES2301435B1/es not_active Expired - Fee Related
- 2005-08-31 ES ES200702946A patent/ES2301436B1/es not_active Expired - Fee Related
2006
- 2006-08-28 WO PCT/ES2006/000488 patent/WO2007026035A2/fr not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2054485T3 (es) *	1989-12-06	1994-08-01	Engrais Composes Mineraux Et A	Utilizacion de extractos de algas para la preparacion de composiciones farmaceuticas, cosmeticas, alimentarias o de uso agricola.

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHRISTEN, Y. Oxidative stress and Alzheimer disease. The American Journal of Clinicla Nutrition, 2000, vol. 71 (suppl): 621S-9S. *
DUNLAP, W y YAMAMOTO, Y. Small-molecule antioxidants in marine organisms: antioxidant activity of mycosporine-glycine. *
JIMÉNEZ-ESCRIG, A. et al. Antioxidant activity of fresh and processed edible seaweeds. Journal of the Science of Food and Agriculture, 2001, Vol. 81, páginas 530-534. *
KUDA T. et al. Antioxidant propierties of four edible algae harvested in the Noto Peninsula, Japan. Journal of food composition and analysis, 2005, Vol. 18, páginas 625-633. *

Also Published As

Publication number	Publication date
WO2007026035A3 (fr)	2007-05-10
ES2301436A1 (es)	2008-06-16
ES2301437A1 (es)	2008-06-16
ES2301435A1 (es)	2008-06-16
WO2007026035A2 (fr)	2007-03-08
ES2301293B1 (es)	2009-05-01
ES2301435B1 (es)	2009-05-01
ES2301434A1 (es)	2008-06-16
ES2301436B1 (es)	2009-05-08
ES2301434B1 (es)	2009-05-01
ES2301437B1 (es)	2009-05-01
ES2301293A1 (es)	2008-06-16

Publication	Publication Date	Title
Hidayati et al.	2020	Comparative study on antioxidant activities, total phenolic compound and pigment contents of tropical Spirulina platensis, Gracilaria arcuata and Ulva lactuca extracted in different solvents polarity
Lee et al.	2010	Antioxidant properties of tidal pool microalgae, Halochlorococcum porphyrae and Oltamannsiellopsis unicellularis from Jeju Island, Korea
Zhao et al.	2011	In-vitro free radical scavenging activities of anthocyanins from three berries
ES2301434B1 (es)	2009-05-01	Uso de aminoacido tipo micosporina (porfina 334) en productos para prevencion de cataratas.
ES2301294B1 (es)	2009-05-01	Uso de aminoacido tipo micosporina(m-gly) en productos para prevenciony tratamiento de eritema actinico, fotocarcinogenesis y fotoenvejecimiento.
ES2301427B1 (es)	2009-05-01	Uso de aminoacido tipo micosporina (shinorine) como antioxidante o aditivo en productos alimentarios.
ES2307438B1 (es)	2009-09-28	Uso de una mezcla purificada de aminoacidos tipos micosporina (asterina 330 + palitina) en la prevencion de la oxidacion de productos cosmeticos y farmaceuticos.
Vinayagam et al.	2011	Antioxidant activity of methanolic extracts of leaves and flowers of Nerium indicum
이주희	2019	Antioxidant Potential of Sargassum horneri Ethanol Extract against Urban Particulate Matter Induced Oxidation
Kernel	2014	Some Bioactive Compounds and Antioxidant Activities of the Bitter
Seo et al.	2011	Antioxidant and Xanthine Oxidase Inhibition Activities of Cynomorium songaricum Extracts
KR20120108139A (ko)	2012-10-05	구멍쇠미역 추출물을 유효성분으로 포함하는 항산화용 조성물

Legal Events

Date	Code	Title	Description
2008-06-16	EC2A	Search report published	Date of ref document: 20080616 Kind code of ref document: A1
2009-11-16	FC2A	Grant refused	Effective date: 20091019

Date

Code

Title

Description