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EP0776200A4 - Composition and method for protection against drug dependency - Google Patents

Composition and method for protection against drug dependency

Info

Publication number
EP0776200A4
EP0776200A4 EP95929519A EP95929519A EP0776200A4 EP 0776200 A4 EP0776200 A4 EP 0776200A4 EP 95929519 A EP95929519 A EP 95929519A EP 95929519 A EP95929519 A EP 95929519A EP 0776200 A4 EP0776200 A4 EP 0776200A4
Authority
EP
European Patent Office
Prior art keywords
composition
protection against
against drug
drug dependency
dependency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95929519A
Other languages
German (de)
French (fr)
Other versions
EP0776200A1 (en
Inventor
David Reed Helton
Mary Jeanne Kallman
James Allen Monn
Darryle Darwin Schoepp
Joseph Patrick Tizzano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/496,642 external-priority patent/US5661184A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0776200A1 publication Critical patent/EP0776200A1/en
Publication of EP0776200A4 publication Critical patent/EP0776200A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/38Unsaturated compounds containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/18All rings being cycloaliphatic the ring system containing six carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP95929519A 1994-08-12 1995-08-14 Composition and method for protection against drug dependency Withdrawn EP0776200A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US28995794A 1994-08-12 1994-08-12
US289957 1994-08-12
US33734994A 1994-11-10 1994-11-10
US337349 1994-11-10
US496642 1995-06-29
US08/496,642 US5661184A (en) 1994-08-12 1995-06-29 Psychiatric agents
PCT/US1995/010317 WO1996004900A1 (en) 1994-08-12 1995-08-14 Composition and method for protection against drug dependency

Publications (2)

Publication Number Publication Date
EP0776200A1 EP0776200A1 (en) 1997-06-04
EP0776200A4 true EP0776200A4 (en) 2001-01-17

Family

ID=27403948

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95929519A Withdrawn EP0776200A4 (en) 1994-08-12 1995-08-14 Composition and method for protection against drug dependency

Country Status (5)

Country Link
EP (1) EP0776200A4 (en)
JP (1) JP3618104B2 (en)
AU (1) AU3325095A (en)
CA (1) CA2195779A1 (en)
WO (1) WO1996004900A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA969485B (en) * 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
KR19990067598A (en) * 1995-11-16 1999-08-25 피터 지. 스트링거 Excitatory amino acid derivatives
CN1202103A (en) * 1995-11-16 1998-12-16 伊莱利利公司 Excitatory amino acid receptor antagonists
GB9605429D0 (en) * 1995-11-16 1996-05-15 Lilly Co Eli Excitatory amino acid receptor antagonists
US5912248A (en) * 1995-11-16 1999-06-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5688826A (en) * 1995-11-16 1997-11-18 Eli Lilly And Company Excitatory amino acid derivatives
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
JP4192331B2 (en) 1999-04-16 2008-12-10 住友化学株式会社 Process for producing optically active 2-oxobicyclo [3.1.0] hexane-6-carboxylic acid derivative
WO2019025931A1 (en) 2017-07-31 2019-02-07 Novartis Ag Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MORI-OKAMOTO J., ET AL.: "Intracellular mechanisms underlying the suppression of AMPA responses by trans-APCD in cultured chick purkinje neurons", MOLECULAR AND CELLULAR NEUROSCIENCES, vol. 4, no. 4, 1993, pages 375 - 386, XP000943572 *
See also references of WO9604900A1 *
TASCHENBERGER H., ET AL.: "Effect of a metabotropic glutamate agonist, trans-ACPD, on cortical epileptiform activity", NEUROREPORT, vol. 3, no. 7, 1992, pages 629 - 632, XP000943585 *
TIZZANO J. P. ET AL.: "Intracerebral 1S, 3R-1-aminocyclopenane-1,3-dicarboxylic acid (1S-3R, ACPD) produces limbic seizures that are not blocked by ionotropic glutamate receptor antagonists", NEUROSCIENCE LETTERS, vol. 162, no. 1-2, 1993, pages 12 - 16, XP000943579 *

Also Published As

Publication number Publication date
WO1996004900A1 (en) 1996-02-22
JPH10504038A (en) 1998-04-14
AU3325095A (en) 1996-03-07
CA2195779A1 (en) 1996-02-22
JP3618104B2 (en) 2005-02-09
EP0776200A1 (en) 1997-06-04

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