CN105169457A - Cationic medical dressing and preparation method thereof - Google Patents
Cationic medical dressing and preparation method thereof Download PDFInfo
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Abstract
本发明涉及一种阳离子医用敷料及其制备方法。阳离子医用敷料由以下原料(重量比)组成:壳聚糖季铵盐1.2%~2%、聚六亚甲基胍0.2%~0.35%、维生素C磷酸酯镁0.2%~0.7%、细胞生长因子0.005%~0.015%、神经酰胺0.2%~0.5%、尿囊素0.15%~0.25%、山茶油0.08%~0.16%、甘油6%~10%、薄荷油0.5%~0.7%、纯化水余量。本发明能够对受伤皮肤进行快速修复以及杀菌处理,且不留下伤疤。能隔离和杀灭细菌、真菌、病毒,防止皮肤和黏膜感染,具有止血和保持创面湿润,还能促进创面皮肤修复愈合。可广泛用于皮肤创面感染和口腔、咽喉、牙龈等局部黏膜感染的预防和治疗。The present invention relates to a cationic medical dressing and a preparation method thereof. The cationic medical dressing is composed of the following raw materials (by weight): 1.2% to 2% of chitosan quaternary ammonium salt, 0.2% to 0.35% of polyhexamethylene guanidine, 0.2% to 0.7% of vitamin C magnesium phosphate, 0.005% to 0.015% of cell growth factor, 0.2% to 0.5% of ceramide, 0.15% to 0.25% of allantoin, 0.08% to 0.16% of camellia oil, 6% to 10% of glycerol, 0.5% to 0.7% of peppermint oil, and the remainder of purified water. The present invention can quickly repair and sterilize the injured skin without leaving scars. It can isolate and kill bacteria, fungi, and viruses, prevent skin and mucous membrane infection, stop bleeding and keep the wound moist, and can also promote wound skin repair and healing. It can be widely used in the prevention and treatment of skin wound infection and local mucous membrane infection such as oral cavity, throat, and gums.
Description
技术领域 technical field
本发明涉及皮肤护理技术领域,尤其涉及一种阳离子医用敷料及其制备方法。 The invention relates to the technical field of skin care, in particular to a cationic medical dressing and a preparation method thereof.
背景技术 Background technique
在人的成长过程中,难免受到外界的伤害,如擦伤、烧烫伤、褥疮、痔疮等,皮肤受到严重创伤后,其创伤部位容易遭受细菌、真菌以及病毒的感染,感染后,需要较长时间恢复,同时可能留下伤疤。 In the process of human growth, it is inevitable to be injured by the outside world, such as abrasions, burns, bedsores, hemorrhoids, etc. After the skin is severely traumatized, the wound site is prone to infection by bacteria, fungi and viruses. After infection, it takes a long time Time recovers, while possible scarring.
发明内容 Contents of the invention
本发明的目的在于解决现有技术的不足,提供一种阳离子医用敷料及其制备方法,能够对创伤部位进行护理,对细菌、真菌、病毒的隔离;使得创伤部位快速复原;且可避免留下伤疤。 The purpose of the present invention is to solve the deficiencies of the prior art, to provide a cationic medical dressing and a preparation method thereof, which can care for the wound site, isolate bacteria, fungi, and viruses; make the wound site recover quickly; and avoid leaving scar.
为达到上述目的,本发明采用的技术方案为: In order to achieve the above object, the technical scheme adopted in the present invention is:
一种阳离子医用敷料,由以下原料(重量比)组成: A cationic medical dressing is composed of the following raw materials (weight ratio):
壳聚糖季铵盐1.2%~2% Chitosan quaternary ammonium salt 1.2%~2%
聚六亚甲基胍0.2%~0.35% Polyhexamethyleneguanidine 0.2%~0.35%
维生素C磷酸酯镁0.2%~0.7% Vitamin C Magnesium Phosphate 0.2%~0.7%
细胞生长因子0.005%~0.015% Cell growth factor 0.005%~0.015%
神经酰胺0.2%~0.5% Ceramide 0.2%~0.5%
尿囊素0.15%~0.25% Allantoin 0.15%~0.25%
山茶油0.08%~0.16% Camellia oil 0.08%~0.16%
甘油6%~10% Glycerin 6%~10%
薄荷油0.5%~0.7% Peppermint oil 0.5%~0.7%
纯化水余量。 Purified water balance.
水速溶阳离子壳聚糖季铵盐具有良好的抗菌性、成膜性、阳离子吸附性、吸湿保湿性、絮凝性、抗静电性等性能。其抗菌性能优于壳聚糖及其它壳聚糖衍生物。壳聚糖季铵盐溶于水后,发生电离,溶液中含有大量的四级铵阳离子。铵阳离子对细菌、真菌、病毒具有一定杀伤效果。 Water instant cationic chitosan quaternary ammonium salt has good antibacterial properties, film-forming properties, cationic adsorption properties, moisture absorption and moisturizing properties, flocculation properties, antistatic properties and other properties. Its antibacterial properties are superior to chitosan and other chitosan derivatives. After the chitosan quaternary ammonium salt is dissolved in water, ionization occurs, and the solution contains a large amount of quaternary ammonium cations. Ammonium cations have a certain killing effect on bacteria, fungi, and viruses.
其次聚六亚甲基胍,具有杀菌广谱;有效浓度低;作用速度快;性质稳定;易溶于水的优良性能;可在常温下使用;长期抑菌、无副作用;聚六亚甲基胍为多胍类高分子聚合物,在水溶液中能产生电离,它的亲水基部分含有强烈的正电性,吸附通常呈负电性的各类细菌、病毒,进入细胞膜,抑制膜内脂质体合成,造成菌体凋亡,达到最佳的杀菌效果。 Secondly, polyhexamethylene guanidine has a broad spectrum of sterilization; low effective concentration; fast action speed; stable properties; excellent performance of being easily soluble in water; can be used at room temperature; Guanidine is a polyguanidine polymer, which can generate ionization in aqueous solution. Its hydrophilic group contains strong positive charge, absorbs various bacteria and viruses that are usually negative charge, enters the cell membrane, and inhibits the lipids in the membrane. Cell synthesis, resulting in cell apoptosis, to achieve the best bactericidal effect.
壳聚糖季铵盐、聚六亚甲基胍产生并形成阳离子,可对细菌、真菌、以及病毒进行杀灭和隔离。 Chitosan quaternary ammonium salt and polyhexamethylene guanidine produce and form cations, which can kill and isolate bacteria, fungi, and viruses.
维生素C磷酸酯镁为维生素C衍生物,是以维生素C为原料用现代科学技术加工而成,本品无论口服还是通过皮肤吸收进入人体后,均能通过磷酸酯酶迅速酶解游离出维生素C,发挥维生素C特有的生理生化功能。 Magnesium Vitamin C Phosphate is a vitamin C derivative, which is processed with vitamin C as a raw material by modern science and technology. Whether this product is taken orally or absorbed through the skin into the human body, it can be rapidly enzymatically hydrolyzed by phosphatase to release vitamin C. , to play the unique physiological and biochemical functions of vitamin C.
维生素C磷酸酯镁是一种水溶性美白剂。本品经皮肤吸收后,能有效地抵抗紫外线侵袭,并可捕获氧自由基,促进胶原蛋白生成,能有效防治色素沉着,祛除各种皮肤色斑,能使皮肤滋润、白嫩、光洁、且本品稳定,无毒、无刺激,为现代功能性美白化妆品的优良添加剂,还具有:1、制酪氨酸酶活性,还原黑色素,具祛斑美白作用。2、进入体内后可消除氧自由基,从而具有去皱、抗衰老功能。3、与维生素E有协同作用。 Magnesium Vitamin C Phosphate is a water-soluble whitening agent. After the product is absorbed by the skin, it can effectively resist the invasion of ultraviolet rays, and can capture oxygen free radicals, promote collagen production, effectively prevent pigmentation, remove various skin spots, and make the skin moist, white and tender, smooth and natural. The product is stable, non-toxic and non-irritating. It is an excellent additive for modern functional whitening cosmetics. It also has: 1. Inhibiting tyrosinase activity, reducing melanin, and having freckle-removing and whitening effects. 2. After entering the body, it can eliminate oxygen free radicals, thus having anti-wrinkle and anti-aging functions. 3. It has a synergistic effect with vitamin E.
细胞生长因子是一种多功能强力细胞因子,对促进成纤维细胞的代谢和胶原蛋白的形成发挥着重要功能。细胞生长因子能促进皮肤组织的生长繁殖,它通过与细胞表面特异受体结合,调控皮肤上皮,内皮和基质细胞的分裂、繁殖和生长分化,促进细胞代谢,增强氧化作用;能促进与皮肤损伤有关细胞的迅速生长繁殖,并调节细胞间基质的合成、分泌及分解;能促进角质层细胞的再生,加速皮肤角质层和基质层的修复,促进人体皮肤细胞的生长;能增强皮肤细胞的蛋白质的合成和细胞代谢,具有延缓皮肤细胞衰老、促进表皮细胞的修复和生长作用,使皮肤光滑丰润。 Cell growth factor is a multifunctional and powerful cytokine that plays an important role in promoting the metabolism of fibroblasts and the formation of collagen. Cell growth factor can promote the growth and reproduction of skin tissue. By binding to specific receptors on the cell surface, it regulates the division, reproduction, growth and differentiation of epithelial, endothelial and stromal cells in the skin, promotes cell metabolism, and enhances oxidation; it can promote skin damage. The rapid growth and reproduction of related cells, and regulate the synthesis, secretion and decomposition of intercellular matrix; it can promote the regeneration of stratum corneum cells, accelerate the repair of stratum corneum and matrix layer, and promote the growth of human skin cells; it can strengthen the protein of skin cells It can delay the aging of skin cells, promote the repair and growth of epidermal cells, and make the skin smooth and plump.
甘油,即丙三醇是无色味甜澄明黏稠液体、无臭;有暖甜味。甘油可以吸取空气中的水份给皮肤保湿,也能将皮肤中的水份锁住,不让它流失。具有保湿的功效。对婴儿的皮肤可以起到保湿、滋润的作用。 Glycerin, that is, glycerin, is a colorless, sweet, clear, viscous liquid, odorless; it has a warm and sweet taste. Glycerin can absorb moisture in the air to moisturize the skin, and also lock the moisture in the skin so that it does not lose. Has moisturizing effect. It can moisturize and moisturize the baby's skin.
薄荷油,可以调理不洁、阻塞的肌肤,其清凉的感觉,能收缩微血管、舒缓发痒、发炎和灼伤,也可柔软肌肤,对于清除黑头粉刺及油性肤质也极具效果。 Peppermint oil can regulate unclean and blocked skin. Its cool feeling can shrink capillaries, relieve itching, inflammation and burns, and soften the skin. It is also very effective in removing blackheads and oily skin.
薄荷油对单纯性疱疹病毒、森林病毒、流行性腮腺炎病毒有抑制作用,对金黄色葡萄球菌、白色葡萄球菌、甲型链球菌、乙型链球菌、卡他球菌、肠炎球菌、福氏痢疾杆菌、炭疽杆菌、白喉杆菌、伤寒杆菌、绿脓杆菌、大肠杆菌等有抑菌作用;水溶性薄荷油能刺激神经末梢的冷感受器而产生冷感,并反射性地造成深部组织血管的变化而起到消炎、止痛、止痒的作用。 Peppermint oil has inhibitory effects on herpes simplex virus, forest virus, and mumps virus, and has inhibitory effects on Staphylococcus aureus, Staphylococcus albus, Streptococcus A, Streptococcus B, catarrhal coccus, enterococcus, and flexner's dysentery Bacillus, Bacillus anthracis, Bacillus diphtheria, Bacillus typhoid, Pseudomonas aeruginosa, Escherichia coli, etc. have antibacterial effects; water-soluble peppermint oil can stimulate the cold receptors of nerve endings to produce cold sensation, and reflexively cause changes in blood vessels in deep tissues. Play the role of anti-inflammatory, pain relief, antipruritic.
神经酰胺又称神经鞘脂类,是存在于皮肤的一种脂类,在表皮角质层形成过程中发挥着重要作用。当皮肤出现干燥、脱屑、开裂现象,其屏障功能明显降低时,皮肤补充神经酰胺可迅速恢复保湿和屏障功能。 Ceramides, also known as sphingolipids, are lipids present in the skin and play an important role in the formation of the stratum corneum of the epidermis. When the skin is dry, desquamated, and cracked, and its barrier function is significantly reduced, supplementing the skin with ceramide can quickly restore moisturizing and barrier function.
导致皮肤干燥主要原因是表皮角质层中神经酰胺含量减少,神经酰胺含量高低与皮肤干燥程度直接相关。使用神经酰胺可明显增强角化细胞之间粘着力,改善皮肤干燥程度,减少皮肤脱屑现象。神经酰胺具有很强缔合水分子能力,它通过在角质层中形成网状结构维持皮肤水分。因此,神经酰胺具有保持皮肤水分作用。使用神经酰胺能使表皮角质层中神经酰胺含量增高,可改善皮肤干燥、脱屑、粗糙等状况;同时神经酰胺能增加表皮角质层厚度,提高皮肤持水能力,减少皱纹,增强皮肤弹性,延缓皮肤衰老。 The main cause of skin dryness is the reduction of ceramide content in the stratum corneum of the epidermis, and the level of ceramide content is directly related to the dryness of the skin. The use of ceramide can significantly enhance the adhesion between keratinocytes, improve skin dryness, and reduce skin desquamation. Ceramide has a strong ability to associate water molecules, and it maintains skin moisture by forming a network structure in the stratum corneum. Therefore, ceramides have the effect of maintaining skin moisture. The use of ceramide can increase the content of ceramide in the stratum corneum of the epidermis, which can improve dryness, desquamation, and roughness of the skin; at the same time, ceramide can increase the thickness of the stratum corneum of the epidermis, improve the skin's water holding capacity, reduce wrinkles, enhance skin elasticity, and delay aging. Skin aging.
神经酰胺是一种水溶性脂质物质,它和构成皮肤角质层的物质结构相近,能很快渗透进皮肤,和角质层中的水结合,形成一种网状结构,锁住水分。 Ceramide is a water-soluble lipid substance. It is similar in structure to the substance that makes up the stratum corneum of the skin. It can quickly penetrate into the skin and combine with the water in the stratum corneum to form a network structure to lock in moisture.
尿囊素:别名5-尿基乙内酰胺、脲基醋酸内酰胺、脲基海因、脲咪唑二酮,是一种乙内酰脲衍生物。是一种无毒、无味、无刺激性、无过敏性的白色晶体,水中结晶为单棱柱体或无色结晶性粉末。能溶于热水、热醇和稀氢氧化钠溶液。微溶于常温的水和醇,难溶于乙醚和氯仿等有机溶剂;其饱和水溶液(浓度为0.6%)呈微酸性;PH为5.5。在PH值为4-9的水溶液中稳定。在非水溶剂和干燥空气中亦稳定;在强碱性溶液中煮沸及日光曝晒下可分解。为细胞生长因子提高弱酸环境。 Allantoin: alias 5-ureidohydantoin, ureidoacetolactam, ureidohydantoin, ureidoimidazole dione, is a hydantoin derivative. It is a non-toxic, tasteless, non-irritating, non-allergic white crystal, crystallized in water as a single prism or colorless crystalline powder. Soluble in hot water, hot alcohol and dilute sodium hydroxide solution. Slightly soluble in water and alcohol at room temperature, hardly soluble in organic solvents such as ether and chloroform; its saturated aqueous solution (concentration: 0.6%) is slightly acidic; pH is 5.5. It is stable in aqueous solution with a pH value of 4-9. It is also stable in non-aqueous solvents and dry air; it can be decomposed when boiled in a strong alkaline solution and exposed to sunlight. Enhances weak acid environment for cell growth factors.
尿囊素具有促进细胞生长,加快伤口愈合,软化角质蛋白等生理功能,是皮肤创伤的良好愈合剂和抗溃疡药剂。可用作缓解和治疗皮肤干燥症、鳞屑性肤疾患、皮肤溃疡、消化道溃疡及炎症,对骨髓炎、糖尿病、肝硬化、痤疮均有较好疗效。 Allantoin has physiological functions such as promoting cell growth, accelerating wound healing, and softening keratin. It is a good healing agent and anti-ulcer agent for skin wounds. It can be used to alleviate and treat dry skin, scaly skin diseases, skin ulcers, digestive tract ulcers and inflammation, and has good curative effects on osteomyelitis, diabetes, liver cirrhosis and acne.
由于尿囊素是一种两性化合物,能结合多种物质形成复盐,具有避光、杀菌防腐、止痛、抗氧化作用,能使皮肤保持水份,滋润和柔软,是美容美发等化妆品的特效添加剂,广泛用于雀斑霜、粉刺液、香波、香皂、牙膏、刮脸洗剂、护发剂、收敛剂、抗汗除臭洗剂等的添加剂。添加尿囊素的化妆品具有保护组织、亲水、吸水和防止水分散发等作用;添加尿囊素的发乳、发膏、洗发露,对头发有保护作用,可使头发不分叉、不断发;添加尿囊素的唇膏、面霜能使皮肤、嘴唇柔软且富有弹性,并有美丽的光泽。尿囊素促进组织生长,细胞新陈代谢,软化角质层蛋白。 Since allantoin is an amphoteric compound, it can combine various substances to form a double salt, which has the functions of avoiding light, sterilizing and antisepsis, analgesic and anti-oxidation, and can keep the skin moist, moist and soft. It is a special effect of cosmetics such as beauty salons Additive, widely used in freckle cream, acne lotion, shampoo, soap, toothpaste, shaving lotion, hair conditioner, astringent, antiperspirant and deodorant lotion, etc. Cosmetics added with allantoin have the functions of protecting tissue, hydrophilicity, absorbing water and preventing moisture dissipation; Hair; lipstick and face cream added with allantoin can make the skin and lips soft and elastic, and have a beautiful luster. Allantoin promotes tissue growth, cell metabolism, and softens cuticle proteins.
山茶油营养丰富,含脂肪酸(不饱和脂肪酸93%,其中油酸82%,亚油酸11%)、山茶甙、茶多酚、皂甙、鞣质,及富含抗氧化剂和具有消炎功效的角鲨烯,角鲨烯与黄酮类物质,对抗癌有着极佳的作用。山茶油还富含维生素E和钙、铁、锌等微量元素,被医学家和营养学家誉为“生命之花”的锌元素,含量是大豆油的10倍,山茶油由于含有大量的脂肪酸因此具有良好的润滑效果。 Camellia oil is rich in nutrients and contains fatty acids (93% unsaturated fatty acids, including 82% oleic acid and 11% linoleic acid), camellia glycosides, tea polyphenols, saponins, tannins, and horns rich in antioxidants and anti-inflammatory effects. Squalene, squalene and flavonoids have excellent anti-cancer effects. Camellia oil is also rich in vitamin E, calcium, iron, zinc and other trace elements. It is called the "flower of life" by medical scientists and nutritionists. The content of zinc is 10 times that of soybean oil. Therefore, it has a good lubricating effect.
在皮肤受到创伤后,创伤处容易滋生细菌等,壳聚糖季铵盐、聚六亚甲基胍产生大量阳离子,可以用于杀菌;使得创面不受感染避免人体组织产生大量的白细胞形成疤痕;同时薄荷油辅助杀菌。甘油、山茶油起到润滑、滋润皮肤的效果,与神经酰胺配合,保持皮肤的水分,避免干燥、色素沉淀;其次山茶油还起到消炎,其有效成分角鲨烯可以促进胶原蛋白的生成,促进新皮肤组织生长;神经酰胺还可以起到抗过敏作用。尿囊素与细胞生长因子配合,促进皮肤细胞生长,修复受创伤的细胞,促进伤口愈合;尿囊素还起到软化角质层蛋白,去除死皮的效果,防止死皮阻碍新皮肤组织生长。维生素C磷酸酯镁可捕获氧自由基,促进胶原蛋白生成,能有效防治色素沉着,祛除各种皮肤色斑,能使皮肤滋润;主要起到抗氧化及美白效果。 After the skin is traumatized, bacteria are easy to breed in the wound. Chitosan quaternary ammonium salt and polyhexamethylene guanidine produce a large amount of cations, which can be used for sterilization; make the wound surface free from infection and avoid the formation of a large number of white blood cells in human tissues to form scars; At the same time, peppermint oil assists in sterilization. Glycerin and camellia oil have the effect of lubricating and moisturizing the skin, cooperate with ceramide to maintain skin moisture, avoid dryness and pigmentation; secondly, camellia oil also acts as an anti-inflammatory, and its active ingredient squalene can promote the production of collagen, Promotes the growth of new skin tissue; ceramides also have an anti-allergic effect. Allantoin cooperates with cell growth factors to promote skin cell growth, repair traumatized cells, and promote wound healing; allantoin also softens cuticle protein and removes dead skin, preventing dead skin from hindering the growth of new skin tissue. Magnesium vitamin C phosphate can capture oxygen free radicals, promote collagen production, effectively prevent pigmentation, remove various skin spots, and moisturize the skin; it mainly has anti-oxidation and whitening effects.
优选地,壳聚糖季铵盐和聚六亚甲基胍的含量总和不超过2.3%。该两种成分在杀菌的同时,可能伤害到皮肤细胞以及皮肤组织中的白细胞;通过临床试验分析,当其重量超过一定时,会影响到白细胞工作。 Preferably, the total content of chitosan quaternary ammonium salt and polyhexamethylene guanidine is no more than 2.3%. While these two ingredients are sterilizing, they may harm skin cells and white blood cells in skin tissue; through clinical test analysis, when their weight exceeds a certain level, it will affect the work of white blood cells.
优选地,一种阳离子医用敷料,由以下原料(重量比)组成: Preferably, a cationic medical dressing is composed of the following raw materials (weight ratio):
壳聚糖季铵盐1.3%~1.8% Chitosan quaternary ammonium salt 1.3%~1.8%
聚六亚甲基胍0.3%~0.32% Polyhexamethyleneguanidine 0.3%~0.32%
维生素C磷酸酯镁0.3%~0.6% Vitamin C Magnesium Phosphate 0.3%~0.6%
细胞生长因子0.008%~0.012% Cell growth factor 0.008%~0.012%
神经酰胺0.2%~0.4% Ceramide 0.2%~0.4%
尿囊素0.17%~0.23% Allantoin 0.17%~0.23%
山茶油0.08%~0.12% Camellia oil 0.08%~0.12%
甘油7%~9% Glycerin 7%~9%
薄荷油0.5%~0.7% Peppermint oil 0.5%~0.7%
纯化水余量。 Purified water balance.
再优选地,一种阳离子医用敷料,由以下原料(重量比)组成: More preferably, a cationic medical dressing is composed of the following raw materials (weight ratio):
壳聚糖季铵盐1.5% Chitosan quaternary ammonium salt 1.5%
聚六亚甲基胍0.3% Polyhexamethyleneguanidine 0.3%
维生素C磷酸酯镁0.5% Ascotyl Magnesium Phosphate 0.5%
细胞生长因子0.01% Cell Growth Factor 0.01%
神经酰胺0.3% Ceramide 0.3%
尿囊素0.2% Allantoin 0.2%
山茶油0.1% Camellia oil 0.1%
甘油8% Glycerin 8%
薄荷油0.6% Peppermint Oil 0.6%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油; Step 1, taking by weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
优选地,一种阳离子医用敷料,由以下原料(重量比)组成: Preferably, a cationic medical dressing is composed of the following raw materials (weight ratio):
壳聚糖季铵盐1.3%~1.8% Chitosan quaternary ammonium salt 1.3%~1.8%
聚六亚甲基胍0.3%~0.32% Polyhexamethyleneguanidine 0.3%~0.32%
维生素C磷酸酯镁0.3%~0.6% Vitamin C Magnesium Phosphate 0.3%~0.6%
细胞生长因子0.008%~0.012% Cell growth factor 0.008%~0.012%
神经酰胺0.2%~0.4% Ceramide 0.2%~0.4%
尿囊素0.17%~0.23% Allantoin 0.17%~0.23%
山茶油0.08%~0.12% Camellia oil 0.08%~0.12%
甘油7%~9% Glycerin 7%~9%
薄荷油0.5%~0.7% Peppermint oil 0.5%~0.7%
芦荟素0.8%~1% Aloe vera 0.8%~1%
纯化水余量。 Purified water balance.
芦荟素能帮助排出体内污物,净化血液、软化血管,降低血压和血液粘度,促进血液循环;活性成分以芦荟苷为主的混合物,为双子叶植物芦荟提取物。杀菌作用,抗炎作用,湿润美容作用,健胃下泄作用,强心活血作用,免疫和再生作用,免疫与抗肿瘤作用,解毒作用,抗衰老作用,镇痛、镇静作用,防晒作用。芦荟中含的多糖和多种维生素对人体皮肤有良好的营养、滋润、增白作用。翠叶芦荟是最适宜直接美容的芦荟鲜叶,即库拉索芦荟,它具有使皮肤收敛、柔软化、保湿、消炎、漂白的性能。还有解除硬化、角化、改善伤痕的作用,不仅能防止小皱纹、眼袋、皮肤松弛,还能保持皮肤湿润、娇嫩,同时,还可以治疗皮肤炎症,对粉刺、雀斑、痤疮以及烫伤、刀伤、虫咬等亦有很好的疗效。对头发也同样有效,能使头发保持湿润光滑,预防脱发。 Aloe vera can help expel dirt from the body, purify blood, soften blood vessels, lower blood pressure and blood viscosity, and promote blood circulation; the active ingredient is a mixture of aloin, which is dicotyledon aloe extract. Bactericidal effect, anti-inflammatory effect, moisturizing and beautifying effect, invigorating the stomach and draining effect, strengthening the heart and promoting blood circulation, immune and regeneration effect, immune and anti-tumor effect, detoxification effect, anti-aging effect, analgesic, sedative effect, sunscreen effect. The polysaccharides and multivitamins contained in aloe have good nutrition, moisturizing and whitening effects on human skin. Aloe vera is the most suitable fresh aloe leaf for direct beauty treatment, that is, Aloe vera. It has the properties of astringent, softening, moisturizing, anti-inflammatory and bleaching of the skin. It can also relieve hardening, keratinization, and improve scars. It can not only prevent small wrinkles, bags under the eyes, and sagging skin, but also keep the skin moist and tender. It also has a good curative effect on wounds and insect bites. It is also effective on hair, which can keep hair moist and smooth and prevent hair loss.
当皮肤受到创伤时,有时会伴随着出血;尤其烫伤,还会伴随着炎症;在敷料中增加一定量的芦荟素,可以起到一定止血效果以及抗菌、消炎;通过临床试验,不与其他药物成分冲突。 When the skin is traumatized, sometimes it will be accompanied by bleeding; especially when it is burned, it will be accompanied by inflammation; adding a certain amount of aloin in the dressing can have a certain hemostatic effect, antibacterial and anti-inflammatory; through clinical trials, it does not mix with other drugs Conflicting ingredients.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素; Step 1, weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
进一步优选地,一种阳离子医用敷料,由以下原料(重量比)组成: Further preferably, a cationic medical dressing is composed of the following raw materials (weight ratio):
壳聚糖季铵盐1.3%~1.8% Chitosan quaternary ammonium salt 1.3%~1.8%
聚六亚甲基胍0.3%~0.32% Polyhexamethyleneguanidine 0.3%~0.32%
维生素C磷酸酯镁0.3%~0.6% Vitamin C Magnesium Phosphate 0.3%~0.6%
细胞生长因子0.008%~0.012% Cell growth factor 0.008%~0.012%
神经酰胺0.2%~0.4% Ceramide 0.2%~0.4%
尿囊素0.17%~0.23% Allantoin 0.17%~0.23%
山茶油0.08%~0.12% Camellia oil 0.08%~0.12%
甘油7%~9% Glycerin 7%~9%
薄荷油0.5%~0.7% Peppermint oil 0.5%~0.7%
芦荟素0.8%~1% Aloe vera 0.8%~1%
双氧水1%~2% Hydrogen peroxide 1%~2%
纯化水余量。 Purified water balance.
双氧水具有较好的氧化效果,采用低浓度(尤其指重量比低于3%)的双氧水与皮肤的伤口、脓液或污物相遇时,立即分解生成氧。这种尚未结合成氧分子的氧原子,具有很强的氧化能力,与细菌接触时,能破坏细菌菌体,杀死细菌。同时可以提供一个有氧环境,杀死厌氧菌以及辅助皮肤的胶原蛋白形成。这里双氧水的含量是指:双氧水在整个敷料中的重量含量:1%~2%。 Hydrogen peroxide has a good oxidation effect. When hydrogen peroxide with a low concentration (especially less than 3% by weight) meets skin wounds, pus or dirt, it will immediately decompose and generate oxygen. This oxygen atom, which has not yet been combined into oxygen molecules, has a strong oxidizing ability. When it comes into contact with bacteria, it can destroy the bacterial cells and kill the bacteria. At the same time, it can provide an aerobic environment, kill anaerobic bacteria and assist the collagen formation of the skin. The content of hydrogen peroxide here refers to: the weight content of hydrogen peroxide in the whole dressing: 1%~2%.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素、双氧水; Step 1, weigh chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin, hydrogen peroxide;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
由于含量100%双氧水很难获得,步骤一中的双氧水采用等质量的双氧水,其他浓度双氧水替代;即步骤一,在配取双氧水时,可以配取等量的其他浓度双氧水,如配取等含量双氧水的30%双氧水(含有双氧水的质量相等);步骤二替换为:称取余量的纯化水。 Since hydrogen peroxide with a content of 100% is difficult to obtain, the hydrogen peroxide in step 1 is replaced with hydrogen peroxide of other concentrations; that is, in step 1, when dispensing hydrogen peroxide, you can prepare the same amount of hydrogen peroxide of other concentrations. 30% hydrogen peroxide of hydrogen peroxide (the quality of hydrogen peroxide is equal); Step 2 is replaced by: Weigh the remaining purified water.
本发明的有益效果为: The beneficial effects of the present invention are:
1)、采用壳聚糖季铵盐、聚六亚甲基胍等对皮肤创伤部位有杀菌效果,避免再次感染; 1) The use of chitosan quaternary ammonium salt, polyhexamethylene guanidine, etc. has a bactericidal effect on skin wounds and avoids re-infection;
2)、采用甘油、山茶油等可对皮肤创伤部位进行保养,避免皮肤从创伤部位丢失水分。 2) Glycerin, camellia oil, etc. can be used to maintain the wounded part of the skin to prevent the skin from losing moisture from the wounded part.
3)、其次,采用修复成分,对皮肤进行修复,避免出现疤痕。 3) Secondly, use repairing ingredients to repair the skin and avoid scars.
可达到快速皮肤修复,且不留下伤痕。 Can achieve rapid skin repair without leaving scars.
具体实施方式 Detailed ways
下面对本发明做进一步地说明。 The present invention will be further described below.
实施例1:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 1: A kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.2% Chitosan quaternary ammonium salt 1.2%
聚六亚甲基胍0.35% Polyhexamethyleneguanidine 0.35%
维生素C磷酸酯镁0.2% Ascotyl Magnesium Phosphate 0.2%
细胞生长因子0.015% Cell Growth Factor 0.015%
神经酰胺0.5% Ceramide 0.5%
尿囊素0.15% Allantoin 0.15%
山茶油0.08% Camellia oil 0.08%
甘油10% Glycerin 10%
薄荷油0.5% Peppermint Oil 0.5%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油; Step 1, taking by weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例1: Case 1:
黄某,男,11岁,手臂被开水烫伤,伤口有化脓,伤口清理后,涂抹本实施例的阳离子医用敷料一个月,每天3次;伤口愈合,且基本无伤痕。 Huang, man, 11 years old, his arm was scalded by boiling water, and the wound had suppuration. After the wound was cleaned, he applied the cationic medical dressing of the present embodiment for one month, 3 times a day; the wound healed without scars.
实施例2:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 2: a kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐2% Chitosan quaternary ammonium salt 2%
聚六亚甲基胍0.2% Polyhexamethyleneguanidine 0.2%
维生素C磷酸酯镁0.7% Magnesium Ascorbyl Phosphate 0.7%
细胞生长因子0.005% Cell growth factor 0.005%
神经酰胺0.2% Ceramide 0.2%
尿囊素0.25% Allantoin 0.25%
山茶油0.16% Camellia oil 0.16%
甘油10% Glycerin 10%
薄荷油0.6% Peppermint Oil 0.6%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油; Step 1, taking by weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例2 Case 2
张某,女,10岁,手臂被油烫伤;手臂起水泡;伤口处理后,涂敷本实施例的阳离子医用敷料3周,每天3次,伤口好转;新皮组织生长,且伤痕很淡;再持续使用2周,伤口愈合,无伤痕。 Zhang, female, 10 years old, her arm was scalded by oil; her arm had blisters; after the wound was treated, she applied the cationic medical dressing of the present embodiment for 3 weeks, 3 times a day, and the wound took a turn for the better; new skin tissue grew, and the scar was very light; Continue to use for another 2 weeks, the wound heals without scars.
实施例3:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 3: a kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.3% Chitosan quaternary ammonium salt 1.3%
聚六亚甲基胍0.32% Polyhexamethyleneguanidine 0.32%
维生素C磷酸酯镁0.6% Magnesium Ascorbyl Phosphate 0.6%
细胞生长因子0.012% Cell Growth Factor 0.012%
神经酰胺0.4% Ceramide 0.4%
尿囊素0.17% Allantoin 0.17%
山茶油0.12% Camellia oil 0.12%
甘油7% Glycerin 7%
薄荷油0.5% Peppermint Oil 0.5%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油; Step 1, taking by weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例3 Case 3
林某,男,10岁,身上受伤后,受伤处溃疡,创伤皮肤周边出现色素沉淀;涂敷本实施例的阳离子医用敷料一周,每天至少3次,溃疡处开始消减;持续使用3周,色素消失,伤口愈合。 Lin, male, 10 years old, after being injured on his body, ulcers appeared on the injured part, and pigmentation appeared around the wounded skin; the cationic medical dressing of this embodiment was applied for a week, at least 3 times a day, and the ulcer began to decrease; after continuous use for 3 weeks, the pigmentation Gone, wounds healed.
实施例4:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 4: a kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.5% Chitosan quaternary ammonium salt 1.5%
聚六亚甲基胍0.3% Polyhexamethyleneguanidine 0.3%
维生素C磷酸酯镁0.5% Ascotyl Magnesium Phosphate 0.5%
细胞生长因子0.01% Cell Growth Factor 0.01%
神经酰胺0.3% Ceramide 0.3%
尿囊素0.2% Allantoin 0.2%
山茶油0.1% Camellia oil 0.1%
甘油8% Glycerin 8%
薄荷油0.6% Peppermint Oil 0.6%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油; Step 1, taking by weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例4: Case 4:
李某,男,15岁,跑行中摔倒手臂擦伤;皮肤开始有溃疡迹象并伴有炎症;对创伤部清洗后,涂膜本实施例的阳离子医用敷料一周,每天3次,炎症开始消减,新皮组织生长;4周后治愈。 Lee, man, 15 years old, fell down and scratched his arm during running; the skin began to have signs of ulcers and accompanied by inflammation; after the wound was cleaned, the cationic medical dressing of this embodiment was coated for one week, 3 times a day, and the inflammation began Decreases, neodermis grows; heals after 4 weeks.
实施例5:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 5: a kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.3% Chitosan quaternary ammonium salt 1.3%
聚六亚甲基胍0.32% Polyhexamethyleneguanidine 0.32%
维生素C磷酸酯镁0.6% Magnesium Ascorbyl Phosphate 0.6%
细胞生长因子0.008% Cell growth factor 0.008%
神经酰胺0.4% Ceramide 0.4%
尿囊素0.17% Allantoin 0.17%
山茶油0.12% Camellia oil 0.12%
甘油9% Glycerin 9%
薄荷油0.5% Peppermint Oil 0.5%
芦荟素0.8% Aloe vera 0.8%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素; Step 1, weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例5 Case 5
张某,男,15岁,患有痔疮;皮肤有抓伤,瘙痒,且有色素开始沉淀;使用本实施例的阳离子医用敷料一周后,每天涂敷至少3次,瘙痒逐渐消退或减弱、色素消除;4周后,疥疮开始结疤治愈且无色素沉淀。 Zhang, male, 15 years old, suffers from hemorrhoids; the skin has scratches, itching, and pigmentation begins to precipitate; after using the cationic medical dressing of this embodiment for a week, apply it at least 3 times a day, the itching gradually subsides or weakens, and the pigmentation Eliminate; after 4 weeks, scabies began to scab and heal without pigmentation.
实施例6:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 6: A kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.8% Chitosan quaternary ammonium salt 1.8%
聚六亚甲基胍0.3% Polyhexamethyleneguanidine 0.3%
维生素C磷酸酯镁0.3% Magnesium Vitamin C Phosphate 0.3%
细胞生长因子0.012% Cell Growth Factor 0.012%
神经酰胺0.2% Ceramide 0.2%
尿囊素0.17% Allantoin 0.17%
山茶油0.08% Camellia oil 0.08%
甘油7% Glycerin 7%
薄荷油0.7% Peppermint Oil 0.7%
芦荟素1% Aloe vera 1%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素; Step 1, weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例6 Case 6
林某,男,32岁,患有皮肤湿疹;皮肤有抓伤,瘙痒,且有炎症;使用本实施例的阳离子医用敷料一周后,每天至少3次,瘙痒逐渐消退或减弱、炎症减缓;4周后,开始结疤治愈。 Lin, male, 32 years old, suffers from skin eczema; the skin has scratches, itching, and inflammation; after using the cationic medical dressing of this embodiment for a week, at least 3 times a day, the itching gradually subsided or weakened, and the inflammation slowed down; 4 After a week, the scarring begins to heal.
实施例7:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 7: A kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.6% Chitosan quaternary ammonium salt 1.6%
聚六亚甲基胍0.31% Polyhexamethyleneguanidine 0.31%
维生素C磷酸酯镁0.4% Ascotyl Magnesium Phosphate 0.4%
细胞生长因子0.01% Cell Growth Factor 0.01%
神经酰胺0.3% Ceramide 0.3%
尿囊素0.2% Allantoin 0.2%
山茶油0.1% Camellia oil 0.1%
甘油8% Glycerin 8%
薄荷油0.6% Peppermint Oil 0.6%
芦荟素0.9% Aloe vera 0.9%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素; Step 1, weighing chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
病例7 Case 7
田某,女,41岁,患有湿疹;皮肤有抓伤,瘙痒,且出现红点;使用本实施例的阳离子医用敷料一小时后,瘙痒逐渐消退或减弱;6小时后,红点消退。 Tian, female, 41 years old, suffered from eczema; the skin was scratched, itchy, and red spots appeared; after using the cationic medical dressing of this embodiment for one hour, the itching gradually subsided or weakened; after 6 hours, the red spots subsided.
实施例8:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 8: A kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.3% Chitosan quaternary ammonium salt 1.3%
聚六亚甲基胍0.3% Polyhexamethyleneguanidine 0.3%
维生素C磷酸酯镁0.6% Magnesium Ascorbyl Phosphate 0.6%
细胞生长因子0.012% Cell Growth Factor 0.012%
神经酰胺0.2% Ceramide 0.2%
尿囊素0.17% Allantoin 0.17%
山茶油0.08% Camellia oil 0.08%
甘油9% Glycerin 9%
薄荷油0.7% Peppermint Oil 0.7%
芦荟素1% Aloe vera 1%
双氧水2% Hydrogen peroxide 2%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素、双氧水; Step 1, weigh chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin, hydrogen peroxide;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
由于含量100%双氧水很难获得,步骤一中的双氧水采用等质量的双氧水,其他浓度双氧水替代;即步骤一,在配取双氧水时,可以配取等量的其他浓度双氧水,如配取等含量双氧水的30%双氧水(含有双氧水的质量相等);步骤二替换为:称取余量的纯化水。 Since hydrogen peroxide with a content of 100% is difficult to obtain, the hydrogen peroxide in step 1 is replaced with hydrogen peroxide of other concentrations; that is, in step 1, when dispensing hydrogen peroxide, you can prepare the same amount of hydrogen peroxide of other concentrations. 30% hydrogen peroxide of hydrogen peroxide (the quality of hydrogen peroxide is equal); Step 2 is replaced by: Weigh the remaining purified water.
病例8:张某,女,32岁,被烫伤,表皮有溃疡、水泡;伤口清理后,涂抹本实施例的阳离子医用敷料,伤口结疤,每天至少3次,一周后,伤口开始愈合,新皮组织生长,伤口周边出现色素沉淀;4周后,伤口愈合;色素消失;无疤痕。 Case 8: Zhang, female, 32 years old, was scalded, with ulcers and blisters on the epidermis; after the wound was cleaned, the cationic medical dressing of this embodiment was applied, and the wound was scarred at least 3 times a day. After a week, the wound began to heal, and the new Skin tissue grew, and pigmentation appeared around the wound; after 4 weeks, the wound healed; the pigment disappeared; there was no scar.
实施例9: Embodiment 9:
一种阳离子医用敷料,由以下原料(重量比)组成: A cationic medical dressing is composed of the following raw materials (weight ratio):
壳聚糖季铵盐1.8% Chitosan quaternary ammonium salt 1.8%
聚六亚甲基胍0.32% Polyhexamethyleneguanidine 0.32%
维生素C磷酸酯镁0.3% Ascotyl Magnesium Phosphate 0.3%
细胞生长因子0.008% Cell growth factor 0.008%
神经酰胺0.4% Ceramide 0.4%
尿囊素0.23% Allantoin 0.23%
山茶油0.12% Camellia oil 0.12%
甘油7% Glycerin 7%
薄荷油0.5% Peppermint Oil 0.5%
芦荟素0.8% Aloe vera 0.8%
双氧水1% Hydrogen peroxide 1%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素、双氧水; Step 1, weigh chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin, hydrogen peroxide;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
由于含量100%双氧水很难获得,步骤一中的双氧水采用等质量的双氧水,其他浓度双氧水替代;即步骤一,在配取双氧水时,可以配取等量的其他浓度双氧水,如配取等含量双氧水的30%双氧水(含有双氧水的质量相等);步骤二替换为:称取余量的纯化水。 Since hydrogen peroxide with a content of 100% is difficult to obtain, the hydrogen peroxide in step 1 is replaced with hydrogen peroxide of other concentrations; that is, in step 1, when dispensing hydrogen peroxide, you can prepare the same amount of hydrogen peroxide of other concentrations. 30% hydrogen peroxide of hydrogen peroxide (the quality of hydrogen peroxide is equal); Step 2 is replaced by: Weigh the remaining purified water.
病例9:关某,女,63岁,摔倒皮肤被擦伤,且部分伤口较深;伤口清理后,涂敷本实施例的阳离子医用敷料,每天至少3次,伤口开始结疤,一周后愈合;无感染并发症;且无疤痕。 Case 9: Guan, female, 63 years old, fell down and was bruised on the skin, and part of the wound was deep; after the wound was cleaned, the cationic medical dressing of this embodiment was applied at least 3 times a day, and the wound began to scab. Healed; no infectious complications; and no scarring.
实施例10:一种阳离子医用敷料,由以下原料(重量比)组成: Embodiment 10: A kind of cationic medical dressing, is made up of following raw material (weight ratio):
壳聚糖季铵盐1.5% Chitosan quaternary ammonium salt 1.5%
聚六亚甲基胍0.3% Polyhexamethyleneguanidine 0.3%
维生素C磷酸酯镁0.5% Ascotyl Magnesium Phosphate 0.5%
细胞生长因子0.01% Cell Growth Factor 0.01%
神经酰胺0.3% Ceramide 0.3%
尿囊素0.2% Allantoin 0.2%
山茶油0.1% Camellia oil 0.1%
甘油8% Glycerin 8%
薄荷油0.6% Peppermint Oil 0.6%
芦荟素1% Aloe vera 1%
双氧水2% Hydrogen peroxide 2%
纯化水余量。 Purified water balance.
一种上述阳离子医用敷料的制备方法,包括: A preparation method of the above-mentioned cationic medical dressing, comprising:
步骤一、称取配方量的壳聚糖季铵盐、聚六亚甲基胍、维生素C磷酸酯镁、神经酰胺、细胞生长因子、尿囊素、山茶油、甘油、薄荷油、芦荟素、双氧水; Step 1, weigh chitosan quaternary ammonium salt, polyhexamethylene guanidine, vitamin C phosphate magnesium, ceramide, cell growth factor, allantoin, camellia oil, glycerin, peppermint oil, aloin, hydrogen peroxide;
步骤二、称取配方量的纯化水; Step 2, taking the purified water of formula quantity;
步骤三,将步骤一的配方依次倒入纯化水混合。 Step 3, pour the formula in step 1 into purified water and mix.
由于含量100%双氧水很难获得,步骤一中的双氧水采用等质量的双氧水,其他浓度双氧水替代;即步骤一,在配取双氧水时,可以配取等量的其他浓度双氧水,如配取等含量双氧水的30%双氧水(含有双氧水的质量相等);步骤二替换为:称取余量的纯化水。 Since hydrogen peroxide with a content of 100% is difficult to obtain, the hydrogen peroxide in step 1 is replaced with hydrogen peroxide of other concentrations; that is, in step 1, when dispensing hydrogen peroxide, you can prepare the same amount of hydrogen peroxide of other concentrations. 30% hydrogen peroxide of hydrogen peroxide (the quality of hydrogen peroxide is equal); Step 2 is replaced by: Weigh the remaining purified water.
病例10:张某,男,41岁,患有疱疹;局部有溃疡;涂敷本实施例的阳离子医用敷料,每天至少3次,连续5天后,溃疡伤口开始结疤,3周后疱疹开始消除;且无疤痕。 Case 10: Zhang, male, 41 years old, suffering from herpes; local ulcers; apply the cationic medical dressing of this embodiment, at least 3 times a day, after 5 consecutive days, the ulcer wound began to scar, and the herpes began to disappear after 3 weeks ; and no scars.
以上仅是本申请的较佳实施例,在此基础上的等同技术方案仍落入申请保护范围。 The above are only preferred embodiments of the present application, and equivalent technical solutions on this basis still fall within the protection scope of the application.
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| CN107198790A (en) * | 2017-05-25 | 2017-09-26 | 李美英 | A kind of degradable dressing of animal doctor's antibiotic-free |
| WO2017206017A1 (en) * | 2016-05-30 | 2017-12-07 | 江苏奇力康皮肤药业有限公司 | Ointment for rapidly repairing surfaces of burn and scald wounds |
| CN108619083A (en) * | 2018-04-19 | 2018-10-09 | 江苏理工学院 | A kind of medical reparation dressing of skin and preparation method thereof |
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