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AU2001247651B2 - Thioketals and thioethers for inhibiting the expression of vcam-1 - Google Patents

Thioketals and thioethers for inhibiting the expression of vcam-1 Download PDF

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Publication number
AU2001247651B2
AU2001247651B2 AU2001247651A AU2001247651A AU2001247651B2 AU 2001247651 B2 AU2001247651 B2 AU 2001247651B2 AU 2001247651 A AU2001247651 A AU 2001247651A AU 2001247651 A AU2001247651 A AU 2001247651A AU 2001247651 B2 AU2001247651 B2 AU 2001247651B2
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AU
Australia
Prior art keywords
compound
composition
substituted
disease
vcam
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Ceased
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AU2001247651A
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AU2001247651A1 (en
Inventor
Lee K. Hoong
Charles Q. Meng
James A Sikorski
Patricia K. Somers
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Atherogenics Inc
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Atherogenics Inc
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Publication of AU2001247651B2 publication Critical patent/AU2001247651B2/en
Anticipated expiration legal-status Critical
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/08—Bronchodilators
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

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  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
AU2001247651A 2000-03-21 2001-03-21 Thioketals and thioethers for inhibiting the expression of vcam-1 Ceased AU2001247651B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19104600P 2000-03-21 2000-03-21
US60/191,046 2000-03-21
PCT/US2001/009049 WO2001070757A2 (fr) 2000-03-21 2001-03-21 Thiocetals et thioethers permettant d'inhiber l'expression de la molecule-1 d'adhesion cellulaire vasculaire (vcam-1)

Publications (2)

Publication Number Publication Date
AU2001247651A1 AU2001247651A1 (en) 2001-12-13
AU2001247651B2 true AU2001247651B2 (en) 2007-01-04

Family

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Family Applications (2)

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AU4765101A Pending AU4765101A (en) 2000-03-21 2001-03-21 Thioketals and thioethers for inhibiting the expression of vcam-1
AU2001247651A Ceased AU2001247651B2 (en) 2000-03-21 2001-03-21 Thioketals and thioethers for inhibiting the expression of vcam-1

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AU4765101A Pending AU4765101A (en) 2000-03-21 2001-03-21 Thioketals and thioethers for inhibiting the expression of vcam-1

Country Status (5)

Country Link
EP (1) EP1289944A2 (fr)
JP (1) JP2003528109A (fr)
AU (2) AU4765101A (fr)
CA (1) CA2403823A1 (fr)
WO (1) WO2001070757A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1275596C (zh) * 1997-05-14 2006-09-20 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
CN100415227C (zh) * 2001-10-25 2008-09-03 阿特罗吉尼克斯公司 化合物在制备用于治疗移植排斥的药物中的应用
ITMI20020597A1 (it) 2002-03-22 2003-09-22 Nicox Sa Derivati del probucolo
JP4467429B2 (ja) 2002-07-12 2010-05-26 アセロジエニクス・インコーポレイテツド 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態
US7273948B2 (en) 2003-01-13 2007-09-25 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US20070260087A1 (en) 2004-04-20 2007-11-08 Atherogenics, Inc. Process of Preparing Esters and Ethers of Probucol and Derivatives Thereof
WO2006007508A2 (fr) * 2004-07-01 2006-01-19 Atherogenics, Inc. Composes et methodes de traitement des maladies vasculaires diabetiques
US20100004333A1 (en) * 2004-12-17 2010-01-07 Stocker Roland O Compositions and methods for treating cardiovascular disorders
AU2008230861A1 (en) 2007-03-26 2008-10-02 Salutria Pharmaceuticals, Llc Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008130718A1 (fr) 2007-04-23 2008-10-30 Atherogenics, Inc. Composés contenant du sulfonamide pour le traitement de troubles inflammatoires
CN105859639A (zh) * 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
CN113616779A (zh) 2013-02-28 2021-11-09 哈佛学院校长同事会 用于动员干细胞的方法和组合物
US10947311B2 (en) 2015-11-20 2021-03-16 The Board Of Trustees Of The Leland Stanford Junior University VCAM-1 mediated methods and compositions for treating aging-associated impairments
CN110452877A (zh) * 2018-05-07 2019-11-15 北京吉尚立德生物科技有限公司 一种肺癌实体瘤原代细胞的培养方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0418648A1 (fr) * 1989-09-08 1991-03-27 Hoechst Aktiengesellschaft 4-Hydroxy-tétra-hydro-pyranne-2-ones, ainsi que les dérivés de dihydroxyacides correspondants, des sels et des esters, procédé pour leur préparation, des préparations pharmaceutiques ainsi que des précurseurs
WO1998051662A2 (fr) * 1997-05-14 1998-11-19 Atherogenics, Inc. Composes et methodes d'inhibition de l'expression de vcam-1
AU1911200A (en) * 1998-11-09 2000-05-29 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2704224B1 (fr) * 1993-04-20 1995-08-25 Adir Nouveaux acides et esters phénoxy isobutyriques substitués.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0418648A1 (fr) * 1989-09-08 1991-03-27 Hoechst Aktiengesellschaft 4-Hydroxy-tétra-hydro-pyranne-2-ones, ainsi que les dérivés de dihydroxyacides correspondants, des sels et des esters, procédé pour leur préparation, des préparations pharmaceutiques ainsi que des précurseurs
WO1998051662A2 (fr) * 1997-05-14 1998-11-19 Atherogenics, Inc. Composes et methodes d'inhibition de l'expression de vcam-1
AU1911200A (en) * 1998-11-09 2000-05-29 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels

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Publication number Publication date
WO2001070757A3 (fr) 2002-03-14
WO2001070757A2 (fr) 2001-09-27
CA2403823A1 (fr) 2001-09-27
JP2003528109A (ja) 2003-09-24
EP1289944A2 (fr) 2003-03-12
AU4765101A (en) 2001-10-03

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