NO20054533L - Oral insulinsammensetning og metoder for a lage og bruke den - Google Patents
Oral insulinsammensetning og metoder for a lage og bruke denInfo
- Publication number
- NO20054533L NO20054533L NO20054533A NO20054533A NO20054533L NO 20054533 L NO20054533 L NO 20054533L NO 20054533 A NO20054533 A NO 20054533A NO 20054533 A NO20054533 A NO 20054533A NO 20054533 L NO20054533 L NO 20054533L
- Authority
- NO
- Norway
- Prior art keywords
- making
- methods
- mammal
- oral insulin
- insulin composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229940125395 oral insulin Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 229920002307 Dextran Polymers 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45124503P | 2003-03-04 | 2003-03-04 | |
| US46760103P | 2003-05-05 | 2003-05-05 | |
| US46901703P | 2003-05-09 | 2003-05-09 | |
| US49509703P | 2003-08-15 | 2003-08-15 | |
| PCT/IB2004/000933 WO2004078196A1 (fr) | 2003-03-04 | 2004-03-04 | Composition d'insuline a administration orale et ses procedes de production et d'utilisation. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20054533D0 NO20054533D0 (no) | 2005-10-03 |
| NO20054533L true NO20054533L (no) | 2005-12-02 |
Family
ID=32831112
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054534A NO20054534L (no) | 2003-03-04 | 2005-10-03 | Leveringssystem for legemiddel og celleterapi |
| NO20054539A NO20054539L (no) | 2003-03-04 | 2005-10-03 | Langtidsvirkende injekterbar insulinpreparat og fremgangsmate for fremstilling og anvendelse derav |
| NO20054533A NO20054533L (no) | 2003-03-04 | 2005-10-03 | Oral insulinsammensetning og metoder for a lage og bruke den |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054534A NO20054534L (no) | 2003-03-04 | 2005-10-03 | Leveringssystem for legemiddel og celleterapi |
| NO20054539A NO20054539L (no) | 2003-03-04 | 2005-10-03 | Langtidsvirkende injekterbar insulinpreparat og fremgangsmate for fremstilling og anvendelse derav |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7544656B2 (fr) |
| EP (3) | EP1454631A1 (fr) |
| JP (3) | JP2006519253A (fr) |
| KR (3) | KR20060015469A (fr) |
| AR (1) | AR046485A1 (fr) |
| AT (1) | ATE485051T1 (fr) |
| AU (3) | AU2004216908A1 (fr) |
| BR (3) | BRPI0408105A (fr) |
| CA (3) | CA2518148A1 (fr) |
| DE (1) | DE602004029630D1 (fr) |
| EA (3) | EA200501420A1 (fr) |
| EC (3) | ECSP056077A (fr) |
| MX (1) | MXPA05009493A (fr) |
| NO (3) | NO20054534L (fr) |
| PT (1) | PT1454630E (fr) |
| TW (1) | TW200529869A (fr) |
| WO (3) | WO2004078196A1 (fr) |
Families Citing this family (101)
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|---|---|---|---|---|
| US7339033B2 (en) * | 1998-06-26 | 2008-03-04 | Genentech, Inc. | Pro1481 |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| ATE385193T1 (de) | 2002-03-20 | 2008-02-15 | Mannkind Corp | Inhalationsgerät |
| DE602004029630D1 (de) * | 2003-03-04 | 2010-12-02 | Technology Dev Co Ltd | Injizierbare Insulinzubereitung mit Langzeitwirkung und Verfahren zur dessen Herstellung und Verwendung |
| CA2531988C (fr) * | 2003-08-05 | 2016-06-28 | Novo Nordisk A/S | Nouveaux derives de l'insuline |
| TW200603843A (en) * | 2004-04-20 | 2006-02-01 | Technology Dev Company Ltd | Tissue enhancement implant and method |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| BRPI0514293B1 (pt) | 2004-08-23 | 2022-07-19 | Mannkind Corporation | Sistema microparticulado para distribuição de droga |
| FR2880272A1 (fr) * | 2005-01-04 | 2006-07-07 | Jean Marc Ruiz | Preparation contenant des microparticules d'un sel de polymere insoluble portant un principe actif, ainsi que son procede de fabrication |
| CA2621786A1 (fr) * | 2005-08-29 | 2007-03-08 | Tuo Jin | Microparticules de polysaccharide contenant des agents biologiques, leur preparation et leurs applications |
| DK1928423T3 (en) | 2005-09-14 | 2016-02-29 | Mannkind Corp | A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces |
| JP4808785B2 (ja) * | 2005-12-28 | 2011-11-02 | ノボ・ノルデイスク・エー/エス | インスリン組成物および組成物の製造方法 |
| SE529040C2 (sv) | 2006-01-18 | 2007-04-17 | Bows Pharmaceuticals Ag | Förfarande för framställning av en dextranmatris för kontrollerad frisättning av insulin |
| CA2643464C (fr) | 2006-02-22 | 2018-09-04 | Mannkind Corporation | Procede pour ameliorer les proprietes pharmaceutiques de microparticules comprenant de la dicetopiperazine et un agent actif |
| EP2069062A2 (fr) * | 2006-10-06 | 2009-06-17 | The President and Fellows of Harvard College | Auto-assemblage électrostatique de matériaux mené chimiquement |
| ES2744384T3 (es) | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
| EP2025334A1 (fr) * | 2007-07-25 | 2009-02-18 | OctoPlus Sciences B.V. | Systèmes d'administration de médicaments à libération prolongée pour une administration répétée |
| WO2011163272A1 (fr) | 2010-06-21 | 2011-12-29 | Mannkind Corporation | Système et procédé d'administration de médicament sous la forme d'une poudre sèche |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CN106039494B (zh) | 2008-06-13 | 2019-12-24 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| BRPI0914308B8 (pt) | 2008-06-20 | 2021-06-22 | Mannkind Corp | sistema de inalação |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| FR2940802A1 (fr) * | 2008-10-10 | 2010-07-09 | Adocia | Complexe entre l'insuline humaine et un polymere amphiphile et utilisation de ce complexe pour la preparation d'une formulation d'insuline humaine rapide. |
| LT3228320T (lt) | 2008-10-17 | 2020-03-10 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
| EP2352513B1 (fr) * | 2008-10-30 | 2016-09-14 | Novo Nordisk A/S | Traitement du diabète à l'aide d'injections d'insuline avec une fréquence inférieure à une injection par jour |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| WO2010105094A1 (fr) | 2009-03-11 | 2010-09-16 | Mannkind Corporation | Appareil, système et procédé de mesure de résistance d'un inhalateur |
| US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
| FR2943538B1 (fr) * | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| MY186975A (en) | 2009-06-12 | 2021-08-26 | Mannkind Corp | Diketopiperazine microparticles with defined specific surface areas |
| US9068182B2 (en) * | 2009-07-28 | 2015-06-30 | Corning Incorporated | Synthetic polysaccharide microcarriers for culturing cells |
| HUP0900482A2 (en) | 2009-08-03 | 2011-03-28 | Cera Med Kft | Pharmaceutical formulation for oral administration |
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| EP2498801B1 (fr) | 2009-11-13 | 2018-01-24 | Sanofi-Aventis Deutschland GmbH | COMPOSITION PHARMACEUTIQUE COMPRENANT desPro36Exendin-4(1-39)-Lys6-NH2 ET DE LA MÉTHIONINE |
| PL2498802T3 (pl) | 2009-11-13 | 2015-06-30 | Sanofi Aventis Deutschland | Kompozycja farmaceutyczna zawierająca agonistę GLP-1, insulinę i metioninę |
| AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
| SI2611458T1 (sl) | 2010-08-30 | 2017-01-31 | Sanofi-Aventis Deutschland Gmbh | Uporaba AVE0010 za izdelavo zdravila za zdravljenje sladkorne bolezni tipa 2 |
| HRP20191793T1 (hr) | 2010-10-27 | 2019-12-27 | Novo Nordisk A/S | Liječenje dijabetesa melitusa injekcijama inzulina koje se primijenjuje u različitim intervalima injiciranja |
| MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| WO2012174472A1 (fr) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | Microparticules de dicétopipérazine de capacité élevée |
| WO2013021346A2 (fr) * | 2011-08-07 | 2013-02-14 | Transgene Biotek Ltd | Nouveau procédé d'administration perorale d'insuline et de ses analogues pour une utilisation thérapeutique |
| HUE027989T2 (en) | 2011-08-29 | 2016-11-28 | Sanofi Aventis Deutschland | A pharmaceutical composition for use in glycemic control in patients with type 2 diabetes |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| JP6018640B2 (ja) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
| US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
| DK2872205T3 (en) | 2012-07-12 | 2017-02-27 | Mannkind Corp | DRY POWDER FORMAL ADMINISTRATION SYSTEM |
| US9157939B2 (en) * | 2012-08-09 | 2015-10-13 | Infineon Technologies Ag | System and device for determining electric voltages |
| WO2014066856A1 (fr) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Compositions et procédés de vaccin antigrippal inhalable |
| CN104902922B (zh) | 2012-11-13 | 2017-12-12 | 阿道恰公司 | 包含经取代阴离子化合物的速效胰岛素制剂 |
| KR102391750B1 (ko) | 2013-03-15 | 2022-04-28 | 맨카인드 코포레이션 | 미세결정성 디케토피페라진 조성물 및 방법 |
| EP3517122A1 (fr) | 2013-04-03 | 2019-07-31 | Sanofi | Traitement du diabète sucré par des formulations à action prolongée d'insulines |
| EP2991672A1 (fr) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Schéma d'administration d'un nouveau type |
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| WO2015148905A1 (fr) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Utilisation d'insuline à action ultrarapide |
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| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
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| CN105617362B (zh) * | 2014-10-27 | 2021-05-11 | 中国医学科学院药物研究所 | 一种新型的胰岛素-磷脂-壳聚糖自组装微粒载体及其制剂 |
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| US10660941B2 (en) | 2016-02-19 | 2020-05-26 | Indian Institute Of Technology, Bombay | Orally administrable pharmaceutical preparation containing protein |
| RU2647466C1 (ru) * | 2016-12-01 | 2018-03-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) | Способ получения нативного белка пролонгирующего действия в составе полимерных наносфер и резорбируемых микросфер для доставки |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| WO2021009027A1 (fr) | 2019-07-12 | 2021-01-21 | Novo Nordisk A/S | Formulation d'insuline à concentration élevée |
| KR20200056360A (ko) | 2020-04-29 | 2020-05-22 | 김용원 | 자전거바퀴(회전자)와 바퀴덮개(고정자)에 설치하는 발전기 |
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| EP4274663A4 (fr) * | 2021-01-07 | 2024-10-16 | Ramot at Tel-Aviv University Ltd. | Procédés et compositions pour la synthèse de mélanine |
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| KR20210055643A (ko) | 2021-04-27 | 2021-05-17 | 김용원 | 모터가 장착된 회전축에 다량의 회전자바퀴와 다량의 고정자바퀴발전기를 설치한 전동보드 |
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| CN115702880B (zh) * | 2021-08-12 | 2023-11-03 | 山东新时代药业有限公司 | 一种重组甘精胰岛素注射液及其制备工艺 |
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| KR20220038026A (ko) | 2022-02-24 | 2022-03-25 | 김용원 | 4합 공기터빈 : 공기터빈 축에 1. 인너 팬들의 인너 실린더와 2. 아웃터 팬들의 아웃터 실린더와 3. 양쪽 1. 인너 실린더들과 2. 아웃터 실린더들의 사이에 아웃터 팬들에 덕트팬들과 덕트흡입구와 4 1. 인너 실린더들과 2. 아웃터 실린더들의 사이에 아웃터 팬들의 3. 덕트팬들에 블레이드와 블레이드 외부 형틀 |
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| KR20220056835A (ko) | 2022-04-18 | 2022-05-06 | 김용원 | 공기추진기(공기펌프와 여러 공기터빈들)들을 장착한 수상 자전거 |
| KR20220076421A (ko) | 2022-05-11 | 2022-06-08 | 김용원 | 공기추진기(공기펌프와 공기터빈들)들을 장착한 페달자전차 |
| KR20220080053A (ko) | 2022-05-27 | 2022-06-14 | 김용원 | 다중 에어 레이어 튜브보트 |
| WO2024167359A1 (fr) * | 2023-02-08 | 2024-08-15 | 주식회사 인벤테라 | Agent de contraste pour vaisseau lymphatique sans contamination veineuse |
| KR20250070006A (ko) | 2025-04-23 | 2025-05-20 | 김용원 | 수륙양용 전동보드 |
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