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MX346700B - Metodo para mejorar el rendimiento de un polipeptido. - Google Patents

Metodo para mejorar el rendimiento de un polipeptido.

Info

Publication number
MX346700B
MX346700B MX2011009059A MX2011009059A MX346700B MX 346700 B MX346700 B MX 346700B MX 2011009059 A MX2011009059 A MX 2011009059A MX 2011009059 A MX2011009059 A MX 2011009059A MX 346700 B MX346700 B MX 346700B
Authority
MX
Mexico
Prior art keywords
improving
yield
polypeptide
value
protein
Prior art date
Application number
MX2011009059A
Other languages
English (en)
Other versions
MX2011009059A (es
Inventor
Metske Laan Van Der Jan
Wu Liang
Andries Roubos Johannes
Parenicova Lucie
Pieter Los Alrik
Nicolaas Maria Elisabeth Peij Van Noël
Jan Pel Herman
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of MX2011009059A publication Critical patent/MX2011009059A/es
Publication of MX346700B publication Critical patent/MX346700B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un método para mejorar el rendimiento de una proteína. El método comprende modificar el valor de un conjunto de características de proteína relevantes que cae dentro de un rango óptimo o llega a estar más cerca de un valor óptimo para una o más características de proteína en el anfitrión eucariótico.
MX2011009059A 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido. MX346700B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09154783 2009-03-10
PCT/EP2010/052918 WO2010102982A1 (en) 2009-03-10 2010-03-08 Method for improving the yield of a polypeptide

Publications (2)

Publication Number Publication Date
MX2011009059A MX2011009059A (es) 2011-11-18
MX346700B true MX346700B (es) 2017-03-28

Family

ID=40912127

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011009059A MX346700B (es) 2009-03-10 2010-03-08 Metodo para mejorar el rendimiento de un polipeptido.

Country Status (11)

Country Link
US (1) US9181573B2 (es)
EP (1) EP2406386B1 (es)
JP (1) JP2012520064A (es)
CN (1) CN102741421B (es)
AU (1) AU2010223354A1 (es)
BR (1) BRPI1009189A2 (es)
CA (1) CA2754851A1 (es)
DK (1) DK2406386T3 (es)
EA (1) EA021205B1 (es)
MX (1) MX346700B (es)
WO (1) WO2010102982A1 (es)

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Publication number Priority date Publication date Assignee Title
CN103459600B (zh) 2010-07-01 2016-10-19 帝斯曼知识产权资产管理有限公司 用于生产感兴趣的化合物的方法
EP2683732B1 (en) 2011-03-11 2016-08-24 DSM IP Assets B.V. Vector-host system
DK2875119T3 (en) 2012-07-19 2018-04-03 Dsm Ip Assets Bv AGSE-DEFICIENT TRIALS
CN104640990B (zh) 2012-09-19 2017-12-26 帝斯曼知识产权资产管理有限公司 使用必需基因作为标记并任选地将其再循环的细胞修饰方法
WO2014202623A2 (en) * 2013-06-19 2014-12-24 Dsm Ip Assets B.V. Rasamsonia gene and use thereof
DK3077517T3 (en) 2013-12-02 2019-02-11 Dsm Ip Assets Bv ISSTRUCTURING PROTEIN
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
CA2964119C (en) 2014-11-03 2022-10-18 Merck Patent Gmbh Soluble intein fusion proteins and methods for purifying biomolecules
US11396665B2 (en) 2015-01-06 2022-07-26 Dsm Ip Assets B.V. CRISPR-CAS system for a filamentous fungal host cell
DK3242948T3 (da) 2015-01-06 2022-03-07 Dsm Ip Assets Bv Crispr-cas-system til en yarrowia-værtscelle
EP3280264B1 (en) 2015-04-10 2021-01-13 DSM IP Assets B.V. Method for preparing a dough
US20180160695A1 (en) * 2015-06-02 2018-06-14 Dsm Ip Assets B.V. Use of ice structuring protein afp19 expressed in filamentous fungal strains for preparing food
BR112019000430A2 (pt) 2016-07-13 2019-07-09 Dsm Ip Assets Bv sistema crispr-cas para uma célula hospedeira de algas
EP3516056B1 (en) 2016-09-23 2024-11-27 DSM IP Assets B.V. A guide-rna expression system for a host cell
WO2018166943A1 (en) 2017-03-13 2018-09-20 Dsm Ip Assets B.V. Zinc binuclear cluster transcriptional regulator-deficient strain
CN110462044A (zh) 2017-04-06 2019-11-15 帝斯曼知识产权资产管理有限公司 自引导整合构建体(sgic)
WO2019012162A2 (en) 2017-12-20 2019-01-17 Dsm Ip Assets B.V. GENOMIC EDITING METHOD IN HOST CELL
WO2019063849A1 (en) 2017-12-20 2019-04-04 Dsm Ip Assets B.V. PURIFICATION OF A POLYPEPTIDE OF INTEREST
CN112088215A (zh) 2018-05-09 2020-12-15 帝斯曼知识产权资产管理有限公司 Crispr瞬时表达构建体(ctec)
WO2020114893A1 (en) 2018-12-05 2020-06-11 Dsm Ip Assets B.V. Crispr guide-rna expression strategies for multiplex genome engineering
EP3715464B1 (en) 2019-03-28 2021-05-05 DSM IP Assets B.V. Greenhouse gas improved fermentation
US20230212634A1 (en) * 2020-01-14 2023-07-06 The Protein Brewery B.V. Expression of Ovalbumin and its Natural Variants
WO2021228880A1 (en) 2020-05-14 2021-11-18 Dsm Ip Assets B.V. Fed-batch fermentation process
CN112480139B (zh) * 2021-01-05 2022-04-19 遵义医科大学 罗丹明类荧光探针的制备方法及其检测有机自由基方法
PE20251535A1 (es) 2022-05-14 2025-06-05 Novozymes As Composiciones y metodos para prevenir, tratar, suprimir y/o eliminar infecciones e infestaciones fitopatogenas
WO2025099224A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants
WO2025099225A1 (en) 2023-11-08 2025-05-15 Dsm Ip Assets B.V. Improved enzyme variants

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DK0635574T3 (da) 1993-07-23 2003-08-11 Dsm Ip Assets Bv Selektionsmarkørgenfri rekombinantstammer, en fremgangsmåde til fremstilling af disse og anvendelse af disse stammer
US5888773A (en) 1994-08-17 1999-03-30 The United States Of America As Represented By The Department Of Health And Human Services Method of producing single-chain Fv molecules
ES2176484T3 (es) * 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces
JP5303084B2 (ja) 1997-04-11 2013-10-02 コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ 工業的組み換え生物を溝築するための手段としての遺伝子変換
ES2287989T3 (es) 1997-12-22 2007-12-16 Dsm Ip Assets B.V. Clonacion de expresion en hongos filamentosos.
US6544765B1 (en) 1999-02-22 2003-04-08 Novozymes, A/S Oxaloacetate hydrolase deficient fungal host cells
JP4741082B2 (ja) 1999-02-22 2011-08-03 ノボザイムス アクティーゼルスカブ オキサロ酢酸ヒドロラーゼ欠陥真菌宿主細胞
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AU2002243205A1 (en) * 2000-10-10 2002-07-24 Genencor International, Inc. Enhanced secretion of a polypeptide by a microorganism
RU2225442C2 (ru) * 2001-02-22 2004-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Рекомбинантная днк для контроля экспрессии, способ контроля экспрессии целевого гена, способ получения целевого вещества
US6797493B2 (en) * 2001-10-01 2004-09-28 Lee-Hwei K. Sun Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
JP2007530065A (ja) 2004-04-02 2007-11-01 ディーエスエム アイピー アセッツ ビー．ブイ． 改善された相同的組換え効率を有する糸状菌変異体
CN102286483B (zh) 2004-04-16 2014-06-04 中化帝斯曼制药有限公司荷兰公司 用于在真菌细胞中表达基因的真菌启动子
CN101094919B (zh) 2004-10-12 2014-09-03 帝斯曼知识产权资产管理有限公司 在生产多肽的方法中有用的真菌转录活化因子
JP2008527985A (ja) * 2005-01-24 2008-07-31 ディーエスエム アイピー アセッツ ビー．ブイ． 糸状菌細胞において目的の化合物を産生させるための方法
EP2035561A1 (en) 2006-06-29 2009-03-18 DSMIP Assets B.V. A method for achieving improved polypeptide expression
JP2010508043A (ja) * 2006-10-31 2010-03-18 イミュノジェン・インコーポレーテッド 抗体産生を改善するための方法
CN101848936B (zh) * 2007-08-20 2017-05-03 葛兰素集团有限公司 生产方法

Also Published As

Publication number Publication date
CA2754851A1 (en) 2010-09-16
US9181573B2 (en) 2015-11-10
MX2011009059A (es) 2011-11-18
US20110318752A1 (en) 2011-12-29
CN102741421A (zh) 2012-10-17
BRPI1009189A2 (pt) 2015-09-15
AU2010223354A1 (en) 2011-09-08
EP2406386A1 (en) 2012-01-18
DK2406386T3 (en) 2019-04-23
EP2406386B1 (en) 2019-01-23
EA021205B1 (ru) 2015-04-30
EA201101306A1 (ru) 2012-02-28
JP2012520064A (ja) 2012-09-06
WO2010102982A1 (en) 2010-09-16
CN102741421B (zh) 2015-03-25

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