Overview
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 155)
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About this book
"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr.
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Table of contents (17 chapters)
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Front Matter
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Mechanic Approaches to CNS Neuroprotection
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Front Matter
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Neuroprotective Agents
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Front Matter
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CNS Delivery of Neuroprotective Therapies
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Front Matter
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Disease Targeting of Neuroprotective Therapies
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Front Matter
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Editors and Affiliations
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Bibliographic Information
Book Title: CNS Neuroprotection
Editors: Frank W. Marcoux, Dennis W. Choi
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-662-06274-6
Publisher: Springer Berlin, Heidelberg
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eBook Packages: Springer Book Archive
Copyright Information: Springer-Verlag Berlin Heidelberg 2002
Hardcover ISBN: 978-3-540-42412-3Published: 10 July 2002
Softcover ISBN: 978-3-642-07625-1Published: 01 December 2010
eBook ISBN: 978-3-662-06274-6Published: 11 November 2013
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XXII, 500
Number of Illustrations: 78 b/w illustrations, 5 illustrations in colour
Topics: Pharmacology/Toxicology, Neurosciences, Neurology