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Cancer Therapy

Monoclonal Antibodies, Lymphokines New Developments in Surgical Oncology and Chemo- and Hormonal Therapy

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. Hans G. Beger

    1. Department of General Surgery, University of Ulm, Ulm, Germany

  2. Markus Büchler

    1. Department of General Surgery, University of Ulm, Ulm, Germany

  3. Ralph A. Reisfeld

    1. Division of Tumor Cell Biology, Scripps Clinic & Research Foundation, La Jolla, USA

  4. Gregor Schulz

    1. Clinical Research, Behringwerke AG Marburg, Marburg, Germany

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About this book

A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.

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Table of contents (34 papers)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  2. Monoclonal Antibodies

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Immunochemotherapy of Cancer: A Perspective

      • R. A. Reisfeld, B. Muller, H.-M. Yang
      Pages 3-9

    3. Quantitative Considerations Supporting the Irrelevance of Circulating Serum Carcinoembryonic Antigen for the Immunoscintigraphic Visualization of Carcinoembryonic Antigen-Expressing Carcinomas

      • K. Bosslet, A. Steinsträsser, A. Schwarz, H. P. Harthus, G. Lüben, L. Kuhlmann et al.
      Pages 10-17

    4. Radioimmunotherapy with Iodine 131-Labelled Antibodies in Ovarian, Colonic and Brain Tumours

      • H. Kalofonos, A. A. Epenetos
      Pages 18-26

    5. Radioimmunodetection and Radioimmunotherapy in Myosarcoma

      • A. Planting, J. Verweij, P. Cox, M. Pillay, G. Stoter
      Pages 27-31

    6. Immunotherapy of Pancreatic Cancer with Monoclonal Antibody BW 494: Results from a Multicentric Phase I–II Trial

      • M. Büchler, R. Kübel, R. Klapdor, K.-H. Muhrer, H. Friess, B. Lorenz et al.
      Pages 32-41

    7. Mab 17-1A Used for Therapy of Patients with Metastatic Colorectal Carcinomas

      • H. Mellstedt, J.-E. Frödin, G. Masucci, C. Lindemalm, C. Wedelin, B. Christensson et al.
      Pages 42-50

    8. Immunotherapy of Malignant Melanomas

      • W. G. Dippold, K.-H. Meyer zum Büschenfelde
      Pages 51-55

    9. Interaction of Monoclonal Antibodies with Biological Response Modifiers and Cytostatics

      • R. Klapdor
      Pages 56-70

  3. Lymphokines

    1. Front Matter

      Pages 71-71
      Download chapter PDF

    2. Cancer Treatment with Cytokines: Concepts and First Clinical Experience

      • A. Lindemann, F. Herrmann, H. Gamm, W. Oster, R. Mertelsmann
      Pages 73-84

    3. Low-dose Cyclophosphamide and IL-2 in the Treatment of Advanced Melanoma

      • M. S. Mitchell
      Pages 85-89

    4. Application of Granulocyte-Macrophage Colony-Stimulating Factor in Patients with Malignant Hematological Diseases

      • A. Ganser, B. Völkers, J. Greher, F. Walther, D. Hoelzer
      Pages 90-95

    5. Enhancement of Autologous Bone Marrow Transplantation with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhGM-CSF)

      • H. Link, M. Freund, H. Kirchner, M. Stoll, H. Schmid, P. Bucsky et al.
      Pages 96-102

    6. A Phase Ib Evaluation of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

      • R. G. Steis, J. Clark, D. L. Longo, J. Smith, R. Miller, F. Ruscetti et al.
      Pages 103-111

    7. The Role of Interferon in the Management of Patients with Hairy Cell Leukemia and Multiple Myeloma

      • N. Niederle, G. Kummer
      Pages 112-123

    8. Possible Mechanism of Interferon Action in Hairy Cell Leukemia

      • F. Porzsolt, W. Digel, C. Buck, A. Raghavachar, M. Stefanic, W. Schöniger
      Pages 124-131

    9. Tumor Vaccination in the Treatment of Colorectal Cancer

      • R. Schiessel
      Pages 132-139

  4. New Approaches in Surgical Oncology

    1. Front Matter

      Pages 141-141
      Download chapter PDF
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Editors and Affiliations

  • Department of General Surgery, University of Ulm, Ulm, Germany

    Hans G. Beger, Markus Büchler

  • Division of Tumor Cell Biology, Scripps Clinic & Research Foundation, La Jolla, USA

    Ralph A. Reisfeld

  • Clinical Research, Behringwerke AG Marburg, Marburg, Germany

    Gregor Schulz

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Bibliographic Information

  • Book Title: Cancer Therapy

  • Book Subtitle: Monoclonal Antibodies, Lymphokines New Developments in Surgical Oncology and Chemo- and Hormonal Therapy

  • Editors: Hans G. Beger, Markus Büchler, Ralph A. Reisfeld, Gregor Schulz

  • DOI: https://doi.org/10.1007/978-3-642-73721-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1989

  • Softcover ISBN: 978-3-642-73723-7Published: 22 November 2011

  • eBook ISBN: 978-3-642-73721-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 308

  • Topics: Oncology, Surgery

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