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GTPases in Biology II

  • Book
  • © 1993

Overview

Editors:
  1. Burton F. Dickey

    1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Houston, USA

  2. Lutz Birnbaumer

    1. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, Houston, USA

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 108 / 2)

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  • 7 Citations

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About this book

Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life it- self, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring ac- curacy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become t h e reference work for GTPases.

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Table of contents (37 chapters)

  1. Front Matter

    Pages I-XL
    Download chapter PDF

  2. Signal Transduction by Trimeric G Proteins

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Cellular Architecture and its Role in Signal Transduction

      1. G-Proteins Have Properties of Multimeric Proteins: An Explanation for the Role of GTPases in their Dynamic Behavior
        • M. Rodbell, S. Jahangeer, S. Coulter
        Pages 3-14

    3. G-Protein Coupled Receptors

      1. The Superfamily: Molecular Modelling
        • J. B. C. Findlay, D. Donnelly
        Pages 17-31
      2. The Role of Receptor Kinases and Arrestin-Like Proteins in G-Protein-Linked Receptor Desensitization
        • R. J. Lefkowitz, M. G. Caron
        Pages 33-42

    4. Trimeric G-Proteins

      1. Qualitative and Quantitative Characterization of the Distribution of G-Protein α Subunits in Mammals
        • G. Milligan
        Pages 45-64
      2. Subunit Interactions of Heterotrimeric G-Proteins
        • E. J. Neer
        Pages 65-78
      3. G-Protein α Subunit Chimeras Reveal Specific Regulatory Domains Encoded in the Primary Sequence
        • M. Russell, G. L. Johnson
        Pages 79-97
      4. The GTPase Cycle: Transducin
        • T. D. Ting, R. H. Lee, Y.-K. Ho
        Pages 99-117
      5. Transcriptional, Posttranscriptional, and Posttranslational Regulation of G-Proteins and Adrenergic Receptors
        • J. R. Hadcock, C. C. Malbon
        Pages 119-130
      6. G-Protein Subunit Lipidation in Membrane Association and Signaling
        • J. A. Thissen, P. J. Casey
        Pages 131-146
      7. Phosphorylation of Heterotrimeric G-Protein
        • M. D. Houslay
        Pages 147-165
      8. Receptor to Effector Signaling Through G-Proteins: βγ Dimers Join α Subunits in the World of Higher Eukaryotes
        • L. Birnbaumer
        Pages 167-186

    5. Effectors of G-Proteins

      1. Molecular Diversity of Mammalian Adenylyl Cyclases: Functional Consequences
        • R. T. Premont, J. Chen, O. Jacobowitz, R. Iyengar
        Pages 189-212
      2. The Light-Regulated cGMP Phosphodiesterase of Vertebrate Photoreceptors: Structure and Mechanism of Activation by Gtα
        • T. G. Wensel
        Pages 213-223
      3. High-Voltage Activated Ca2+ Channel
        • F. Hofmann, M. Biel, E. Bosse, R. Hullin, P. Ruth, A. Welling et al.
        Pages 225-238
      4. Phospholipase C-β Isozymes Activated by Gαq Members
        • D. Park
        Pages 239-249
      5. Stimulation of Phospholipase C by G-Protein βγ Subunits
        • P. Gierschik, M. Camps
        Pages 251-264

    6. Specialized Systems

      1. Rhodopsin/G-Protein Interaction
        • K. P. Hofmann
        Pages 267-290
      2. Fast Kinetics of G-Protein Function In Vivo
        • G. Szabo, Y. Li, A. S. Otero
        Pages 291-302
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Editors and Affiliations

  • Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Houston, USA

    Burton F. Dickey

  • Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, Houston, USA

    Lutz Birnbaumer

Accessibility Information

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Bibliographic Information

  • Book Title: GTPases in Biology II

  • Editors: Burton F. Dickey, Lutz Birnbaumer

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-78345-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-78347-0Published: 28 January 2012

  • eBook ISBN: 978-3-642-78345-6Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XL, 618

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Cell Biology

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