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DNA Repair

  • Book
  • © 1998

Overview

Editors:
  1. Fritz Eckstein

    1. Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

  2. David M. J. Lilley

    1. Biochemistry Department, University of Dundee, Dundee, UK

  • DNA is the central repository of genetic information in the cell, and the maintenance of its integrity is vital.
  • Since 80% of human cancers are caused by DNA damage, the processes of recognition and repair of these damages is of great importance.

Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 12)

  • 4833 Accesses

  • 15 Citations

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About this book

DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished. These recognition processes are now finally yielding their secrets to structural analysis. This volume focuses on DNA repair, with an emphasis on structural data where available.

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Repair of Alkylated DNA by the E. coli Ada Protein

    • P. E. Verdemato, P. C. E. Moody
    Pages 1-27

  3. Structural Phylogenetics of DNA Base Excision Repair

    • C. D. Mol, S. S. Parikh, T. P. Lo, J. A. Tainer
    Pages 29-69

  4. Protein Interactions in Mammalian Pathways of DNA Base Excision Repair

    • R. A. O. Bennett, B. Demple
    Pages 71-82

  5. Poly(ADP-Ribose) Polymerase Is Required for Maintenance of Genomic Integrity During Base Excision Repair

    • G. De Murcia, F. Dantzer, C. Trucco, V. Rolli, F. J. Oliver, C. Niedergang et al.
    Pages 83-102

  6. Functional Domains of the E. coli UvrABC Proteins in Nucleotide Excision Repair

    • N. Goosen, G. F. Moolenaar, R. Visse, P. van de Putte
    Pages 103-123

  7. Nucleotide Excision Repair in Yeast: Recent Progress and Implications

    • E. C. Friedberg, W. J. Feaver, W. Huang, M. S. Reagan, W. A. Ramos, K. Rodriguez et al.
    Pages 125-139

  8. Nucleotide Excision Repair in Man

    • T. Bessho, A. Sancar
    Pages 141-155

  9. Transcription-Coupled and Global Genome Nucleotide Excision Repair

    • R. A. Verhage, M. Tijsterman, P. van de Putte, J. Brouwer
    Pages 157-172

  10. DNA Mismatch Repair

    • M. O’Driscoll, O. Humbert, P. Karran
    Pages 173-197

  11. Eukaryotic Mismatch Repair

    • P. Schär, J. Jiricny
    Pages 199-247

  12. Conflicting Roles of Mismatch and Nucleotide Excision Repair in Cellular Susceptibility to Anticancer Drugs

    • J. A. Mello, E. E. Trimmer, M. Kartalou, J. M. Essigmann
    Pages 249-274

  13. Crystallographic Studies of Proteins Involved in Recombinational Repair and Excision Repair

    • K. Morikawa
    Pages 275-299

  14. Eukaryotic DNA Ligases and DNA Repair

    • R. Bowater
    Pages 301-314

  15. Back Matter

    Pages 315-319
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Editors and Affiliations

  • Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

    Fritz Eckstein

  • Biochemistry Department, University of Dundee, Dundee, UK

    David M. J. Lilley

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Bibliographic Information

  • Book Title: DNA Repair

  • Editors: Fritz Eckstein, David M. J. Lilley

  • Series Title: Nucleic Acids and Molecular Biology

  • DOI: https://doi.org/10.1007/978-3-642-48770-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-642-48772-9Published: 19 April 2012

  • eBook ISBN: 978-3-642-48770-5Published: 06 December 2012

  • Series ISSN: 0933-1891

  • Series E-ISSN: 1869-2486

  • Edition Number: 1

  • Number of Pages: XI, 317

  • Number of Illustrations: 19 illustrations in colour

  • Topics: Cell Biology, Biochemistry, general

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