Overview
- Unique comprehensive state-of-the-art-work on NADPH oxidases
- Offers knowledge on molecular function and activation
- Discusses the pathophysiological role of NADPH oxidases
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About this book
This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field.
The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research.
Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.
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Table of contents (34 chapters)
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Front Matter
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History, Recollections, and Homages
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Front Matter
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Canonical NADPH Oxidases
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Front Matter
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Editors and Affiliations
About the editor
Edgar Pick, MD, PhD is Professor Emeritus of Immunology at the Sackler Faculty of Medicine at Tel Aviv University, Israel. He was Director of the “Julius Friedrich Cohnheim-Minerva Center for Cellular and Molecular Phagocyte Research”, Head of the “Kodesz Institute of Host Defense against Infectious Diseases”, and Incumbent of the “Roberts-Guthman Chair in Immunopharmacology”.
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Bibliographic Information
Book Title: NADPH Oxidases Revisited: From Function to Structure
Editors: Edgar Pick
DOI: https://doi.org/10.1007/978-3-031-23752-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Hardcover ISBN: 978-3-031-23751-5Published: 23 June 2023
Softcover ISBN: 978-3-031-23754-6Published: 23 June 2024
eBook ISBN: 978-3-031-23752-2Published: 22 June 2023
Edition Number: 1
Number of Pages: XV, 593
Number of Illustrations: 28 b/w illustrations, 117 illustrations in colour
Topics: Cell Biology, Life Sciences, general, Protein Science, Protein Science