Overview
- Nominated as an outstanding PhD thesis by the Italian National Institute of Nuclear Physics and the University of Trieste
- Makes important contribution to the optimization of x-ray tomography using synchrotron radiation
- Adds to the weight of evidence supporting the transition of phase contrast imaging from synchrotrons to hospitals
Part of the book series: Springer Theses (Springer Theses)
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About this book
X-ray imaging is a corner stone of breast cancer diagnosis. By exploiting the phase shift of X-rays rather than their attenuation, phase-contrast tomography has the potential to dramatically increase the visibility of small and low contrast features, thus leading to better diagnosis. This thesis presents research on the first synchrotron-based project developing a clinical phase-contrast breast computed tomography (CT) setup at Elettra, the Italian Syncrotron Radiation Facility. This book includes a comprehensive theoretical background on propagation-based phase-contrast imaging, exploring and extending the most recent image formation models. Along with theory, many practical implementation and optimization issues, ranging from detector-specific processing to setup geometry, are tackled on the basis of a large number of experimental evidences. Most of the modelling results and data analysis have general validity, being a valuable framework for optimization of phase-contrast setups. Results obtained at synchrotron are also compared with "real world" laboratory sources: both a first-of-its-kind comparison with one of the few hospital breast CT systems and a state-of-the-art implementation of monochromatic phase-contrast micro-tomography with a conventional rotating anode source are presented. On a more general level, this work sheds a light on the importance of synchrotron-based clinical programs, which are key to trigger the long-anticipated transition of phase-contrast imaging from synchrotrons to hospitals.
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Authors and Affiliations
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Bibliographic Information
Book Title: X-Ray Phase-Contrast Tomography
Book Subtitle: Underlying Physics and Developments for Breast Imaging
Authors: Luca Brombal
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-030-60433-2
Publisher: Springer Cham
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-60432-5Published: 17 November 2020
Softcover ISBN: 978-3-030-60435-6Published: 17 November 2021
eBook ISBN: 978-3-030-60433-2Published: 16 November 2020
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIII, 140
Number of Illustrations: 15 b/w illustrations, 53 illustrations in colour
Topics: Biological and Medical Physics, Biophysics, Cancer Research, Imaging / Radiology, Atomic, Molecular, Optical and Plasma Physics