Overview
- Includes supplementary material: sn.pub/extras
Part of the book series: Cancer Drug Discovery and Development (CDD&D)
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About this book
A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
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Table of contents (15 chapters)
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Front Matter
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Back Matter
Reviews
...gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field...The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. -Doody's Health Sciences Book Review Journal
"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy
"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori
"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy
"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori
Editors and Affiliations
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Bibliographic Information
Book Title: DNA Repair in Cancer Therapy
Editors: Lawrence C. Panasci, Moulay A. Alaoui-Jamali
Series Title: Cancer Drug Discovery and Development
DOI: https://doi.org/10.1007/978-1-59259-735-2
Publisher: Humana Totowa, NJ
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2004
Hardcover ISBN: 978-1-58829-298-8Published: 19 March 2004
Softcover ISBN: 978-1-61737-480-7Published: 19 November 2010
eBook ISBN: 978-1-59259-735-2Published: 19 March 2004
Series ISSN: 2196-9906
Series E-ISSN: 2196-9914
Edition Number: 1
Number of Pages: XI, 363
Number of Illustrations: 50 b/w illustrations
Topics: Oncology